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公开(公告)号：US20070184490A1
公开(公告)日：2007-08-09
申请号：US11653553
申请日：2007-01-16
IPC分类号： G01N33/53 , A61K31/4439
CPC分类号： A61K31/40 , A61K31/435 , A61K31/4439 , G01N33/944 , G01N2500/00
摘要： The invention relates to neuronal nicotinic receptor ligands, methods of identifying such ligands for neuronal nicotinic receptor modulation, particularly such ligands demonstrating beneficial side effect tolerability, and methods of using such neuronal nicotinic receptor ligands to provide pharmaceutical compositions and products.
摘要翻译： 本发明涉及神经元烟碱受体配体，鉴定神经元烟碱受体调节的这种配体的方法，特别是显示出有益的副作用耐受性的这种配体，以及使用这种神经元烟碱受体配体提供药物组合物和产品的方法。
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公开(公告)号：US20050245531A1
公开(公告)日：2005-11-03
申请号：US11153762
申请日：2005-06-15
申请人： Jianguo Ji , Tao Li , Kathleen Mortell , Michael Schrimpf , Diana Nersesian , Liping Pan , William Bunnelle
发明人： Jianguo Ji , Tao Li , Kathleen Mortell , Michael Schrimpf , Diana Nersesian , Liping Pan , William Bunnelle
IPC分类号： C07D453/02 , C07D453/04 , A61K31/501 , A61K31/506
CPC分类号： C07D453/02
摘要： Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+—O—; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译： 其中n为0,1或2的式（I）化合物; A是N或N + O，-O-; X是O，S，-NH-和-N-烷基 - ; Ar 1是6元芳环; 并且Ar 2是稠合的双环杂环。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。
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公开(公告)号：US20070072892A1
公开(公告)日：2007-03-29
申请号：US11517064
申请日：2006-09-07
IPC分类号： A61K31/4745 , C07D221/22
CPC分类号： C07D487/04
摘要： The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to α7 nicotinic acetylcholine receptors also are described.
摘要翻译： 本发明涉及胺取代的氮杂 - 金刚烷衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。 还描述了可用于评估对α7烟碱乙酰胆碱受体的结合亲和力的放射性标记化合物。
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4.发明申请公开(公告)号：US20050234168A1
公开(公告)日：2005-10-20
申请号：US11043407
申请日：2005-01-26
申请人： William Bunnelle
发明人： William Bunnelle
摘要： A contact lens blocking composition with desirable melt properties can comprise a water soluble polymer such as a polyalkylpolyimine combined with an absorbent disintegrant or with a filler such as a highly soluble salt composition or both. The blocking composition can be readily removed from a shaped contact lens after machining and from the mandrel or other tool used in shaping the lens. The blocking composition is readily removed using an aqueous wash, aqueous washing solutions or ultrasonic cleaning procedures.
摘要翻译： 具有期望的熔融性质的隐形眼镜阻挡组合物可以包含水溶性聚合物，例如与吸收性崩解剂组合的聚烷基聚亚胺或与诸如高度可溶性盐组合物或两者的填料。 阻挡组合物可以在加工后从成型的隐形眼镜中以及用于成形透镜的心轴或其它工具容易地移除。 使用水性洗涤剂，水性洗涤溶液或超声清洗方法容易地除去封闭组合物。
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公开(公告)号：US20050065178A1
公开(公告)日：2005-03-24
申请号：US10666884
申请日：2003-09-19
申请人： Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje
发明人： Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje
IPC分类号： A61K31/435 , A61P25/00 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D471/02 , A61K31/4745
CPC分类号： C07D487/08 , C07D471/04 , C07D471/08 , C07D487/04
摘要： Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译： 式（I）Z-Ar1-Ar2（Ⅰ）化合物其中Z是二氮杂双环胺，Ar1是5-或6-元芳环，Ar2选自未取代或取代的5元杂芳基环; 未取代或取代的6元杂芳基环; 3,4-（亚甲二氧基）苯基; 和在间位或对位取代有0,1,2或3个取代基的苯基。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式（I）化合物和使用这些化合物和组合物的方法的药物组合物。
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公开(公告)号：US20070135563A1
公开(公告)日：2007-06-14
申请号：US11702306
申请日：2007-02-05
申请人： Eugene Simmons , William Bunnelle , David Malcolm , Keith Knutson , Thomas Harleysville , Mark Kroll , Michael Keehr , Deepak Parikh , Jimmy Allen , David Speth , Selim Yalvac , Malcolm Finlayson , Cyndi Rickey
发明人： Eugene Simmons , William Bunnelle , David Malcolm , Keith Knutson , Thomas Harleysville , Mark Kroll , Michael Keehr , Deepak Parikh , Jimmy Allen , David Speth , Selim Yalvac , Malcolm Finlayson , Cyndi Rickey
IPC分类号： B60C1/00
CPC分类号： C08F210/16 , B32B7/12 , C08K5/0008 , C08K5/0016 , C08L23/04 , C08L23/0853 , C08L23/0869 , C08L77/00 , C08L2666/02 , C09J7/35 , C09J123/0815 , C09J2423/00 , C08L2666/04 , C08F210/14 , C08F2500/08 , C08F2500/02 , C08F2500/03 , C08F2500/12
摘要： Disclosed are adhesives and processes for preparing the same, comprising at least one first homogeneous ethylene/α-olefin interpolymer, and optionally at least one tackifier, and optionally at least one plasticizer. The claimed adhesives are useful as adhesives such as are employed in various applications, such as in masking tape, clear office tape, labels, decals, bandages, decorative and protective sheets (such as shelf and drawer liners), floor tiles, sanitary napkin/incontinence device placement strips, sun control films, the joining of gaskets to automobile windows, packaging, bookbinding, construction of nonwoven articles, and insulation bonding.
摘要翻译： 公开了粘合剂及其制备方法，其包括至少一种第一均相乙烯/α-烯烃互聚物和任选的至少一种增粘剂，以及任选的至少一种增塑剂。 所要求保护的粘合剂可用作各种应用中的粘合剂，例如胶带，透明办公带，标签，贴花，绷带，装饰和保护片（例如搁板和抽屉衬里），地砖，卫生巾/ 失禁装置放置条，太阳控制膜，垫圈连接到汽车窗户，包装，装订，非织造制品的构造和绝缘粘合。
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公开(公告)号：US20050234031A1
公开(公告)日：2005-10-20
申请号：US11051437
申请日：2005-02-04
申请人： Michael Schrimpf , Kevin Sippy , Jianguo Ji , Tao Li , Jennifer Frost , Clark Briggs , William Bunnelle
发明人： Michael Schrimpf , Kevin Sippy , Jianguo Ji , Tao Li , Jennifer Frost , Clark Briggs , William Bunnelle
IPC分类号： A61K31/4745 , A61K31/496 , A61K31/55 , A61K31/551 , C07D487/04
CPC分类号： C07D453/02 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/14 , C07D209/88 , C07D211/14 , C07D243/08 , C07D333/76 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D451/06 , C07D487/04 , C07D487/08
摘要： Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
摘要翻译： 其中A和B是胺取代的侧链，Y 1和Y 2的式（I）化合物形成各种三环核，X 1和 如本文所定义，C 1-6烷基是C，CH或N，并且R x是任选的取代基。 考虑式（I）的化合物和组合物以及用于治疗由包括式（I）化合物和其它三环衍生物的α7nAChR配体防止或改善的病症或病症的方法。 使用氨基取代的三环衍生物的方法也在本文中描述。
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公开(公告)号：US20050101602A1
公开(公告)日：2005-05-12
申请号：US10942035
申请日：2004-09-16
申请人： Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje , Kathleen Mortell , Diana Nersesian , Michael Schrimpf
发明人： Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje , Kathleen Mortell , Diana Nersesian , Michael Schrimpf
IPC分类号： A61K31/4178 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D43/14
CPC分类号： A61K31/501 , A61K31/4178 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/53
摘要： Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译： 式（I）化合物<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-Ar 1 -Ar 2 I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中Z是二氮杂双环胺，Ar 1是5或6元芳环 和Ar 2 2选自未取代或取代的5或6元杂芳基环; 未取代或取代的双环杂芳基环; 3,4-（亚甲二氧基）苯基; 咔唑基; 四氢咔唑基; 萘基; 和苯基; 其中苯基在间位或对位被0,1,2或3个取代基取代。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式（I）化合物和使用这些化合物和组合物的方法的药物组合物。
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公开(公告)号：US20080234308A2
公开(公告)日：2008-09-25
申请号：US11517064
申请日：2006-09-07
IPC分类号： A61K31/4745 , C07D221/22
CPC分类号： C07D487/04
摘要： The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to α7 nicotinic acetylcholine receptors also are described.
摘要翻译： 本发明涉及胺取代的氮杂 - 金刚烷衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。 还描述了可用于评估对α7烟碱乙酰胆碱受体的结合亲和力的放射性标记化合物。
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公开(公告)号：US20080097094A1
公开(公告)日：2008-04-24
申请号：US11957424
申请日：2007-12-15
申请人： Michael Schrimpf , Karin Tietje , Richard Toupence , Jianguo Ji , Anwer Basha , William Bunnelle , Jerome Daanen , Jennifer Frost , Kevin Sippy
发明人： Michael Schrimpf , Karin Tietje , Richard Toupence , Jianguo Ji , Anwer Basha , William Bunnelle , Jerome Daanen , Jennifer Frost , Kevin Sippy
IPC分类号： A61K31/55 , A61K31/4353 , A61P25/00 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
摘要翻译： 式I化合物，这些化合物的药物组合物，以及所述组合物用于控制哺乳动物突触传递的用途。
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