公开(公告)号：US20110053864A1

公开(公告)日：2011-03-03

申请号：US12660866

申请日：2010-03-05

Applicant: Malcolm Finlayson ,  Bassam B. Damaj

Inventor： Malcolm Finlayson ,  Bassam B. Damaj

IPC: A61K38/08 ,  C07K7/06 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04

CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K38/17 ,  C07K14/00

Abstract: A peptide includes SEQ ID NO:3, substitution and addition variants thereof which maintain the ability to activate CD44. A complex includes this peptide or an Å6 polypeptide with a CD44 polypeptide. An isolated polypeptide includes the Link region sequence of human CD44, functionally active fragments thereof, substitution variants, and addition variants. A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3 or an Å6 polypeptide to bind to a CD44 polypeptide and modulate signal transduction activity for a sufficient period of time to treat the disease. Other methods include using the peptide of SEQ ID NO:3 or an Å6 polypeptide for diagnosing, identifying a subpopulation of subjects responsive to treatment, and screening for compounds that bind a CD44 polypeptide.

Abstract translation: 肽包括SEQ ID NO：3，其保持激活CD44的能力的取代和加成变体。 复合物包括该肽或具有CD44多肽的Å6多肽。 分离的多肽包括人CD44的链接区序列，其功能活性片段，取代变体和加成变体。 治疗以异常细胞迁移和/或侵袭为特征的疾病的方法包括向受试者施用有效量的SEQ ID NO：3或Aβ多肽的肽以结合CD44多肽并调节信号转导活性足够的 一段时间来治疗这种疾病。 其他方法包括使用SEQ ID NO：3或Aβ多肽的肽来诊断，鉴定对治疗有反应的受试者的亚群，以及筛选结合CD44多肽的化合物。

公开(公告)号：US5975353A

公开(公告)日：1999-11-02

申请号：US195798

申请日：1998-11-19

Applicant: Ian Malcolm Finlayson

Inventor： Ian Malcolm Finlayson

IPC: B67D7/74 ,  G05D11/13 ,  B67B7/00

CPC classification number: B67D7/744 ,  G05D11/132 ,  B67D2007/746

Abstract: A fluid system and method according to which a first fluid, a second fluid, or a blend of the fuels is passed to a first meter for measuring the flow thereof while the second fluid is passed through a second meter before it passes to the first meter. The flow of the first fluid to the first meter and the flow of the second fluid to the second meter and then to the first meter are controlled by valves and, as a result, a predetermined ratio of the blended fluids can be established and maintained. The second meter can be calibrated based on the first meter and therefore does not have to inherently provide relatively accurate volumetric measurements. Thus, the second meter can be less costly than the first meter.

Abstract translation: 一种流体系统和方法，根据该流体系统和方法，第一流体，第二流体或燃料的混合物被传递到第一流量计，用于测量其流量，同时第二流体在通过第二流量计之前通过第二流量计 。 第一流体到第一流量计的流量以及第二流体流向第二流量计，然后到第一流量计的流量由阀控制，结果可以建立和维持混合流体的预定比例。 第二米可以基于第一米进行校准，因此不必固有地提供相对精确的体积测量。 因此，第二仪表可以比第一仪表更便宜。

公开(公告)号：US20070135563A1

公开(公告)日：2007-06-14

申请号：US11702306

申请日：2007-02-05

Applicant: Eugene Simmons ,  William Bunnelle ,  David Malcolm ,  Keith Knutson ,  Thomas Harleysville ,  Mark Kroll ,  Michael Keehr ,  Deepak Parikh ,  Jimmy Allen ,  David Speth ,  Selim Yalvac ,  Malcolm Finlayson ,  Cyndi Rickey

Inventor： Eugene Simmons ,  William Bunnelle ,  David Malcolm ,  Keith Knutson ,  Thomas Harleysville ,  Mark Kroll ,  Michael Keehr ,  Deepak Parikh ,  Jimmy Allen ,  David Speth ,  Selim Yalvac ,  Malcolm Finlayson ,  Cyndi Rickey

IPC: B60C1/00

CPC classification number: C08F210/16 ,  B32B7/12 ,  C08K5/0008 ,  C08K5/0016 ,  C08L23/04 ,  C08L23/0853 ,  C08L23/0869 ,  C08L77/00 ,  C08L2666/02 ,  C09J7/35 ,  C09J123/0815 ,  C09J2423/00 ,  C08L2666/04 ,  C08F210/14 ,  C08F2500/08 ,  C08F2500/02 ,  C08F2500/03 ,  C08F2500/12

Abstract: Disclosed are adhesives and processes for preparing the same, comprising at least one first homogeneous ethylene/α-olefin interpolymer, and optionally at least one tackifier, and optionally at least one plasticizer. The claimed adhesives are useful as adhesives such as are employed in various applications, such as in masking tape, clear office tape, labels, decals, bandages, decorative and protective sheets (such as shelf and drawer liners), floor tiles, sanitary napkin/incontinence device placement strips, sun control films, the joining of gaskets to automobile windows, packaging, bookbinding, construction of nonwoven articles, and insulation bonding.

Abstract translation: 公开了粘合剂及其制备方法，其包括至少一种第一均相乙烯/α-烯烃互聚物和任选的至少一种增粘剂，以及任选的至少一种增塑剂。 所要求保护的粘合剂可用作各种应用中的粘合剂，例如胶带，透明办公带，标签，贴花，绷带，装饰和保护片（例如搁板和抽屉衬里），地砖，卫生巾/ 失禁装置放置条，太阳控制膜，垫圈连接到汽车窗户，包装，装订，非织造制品的构造和绝缘粘合。

公开(公告)号：US4081496A

公开(公告)日：1978-03-28

申请号：US810478

申请日：1977-06-27

Applicant: Claude Malcolm Finlayson

Inventor： Claude Malcolm Finlayson

IPC: C08K5/00 ,  B01F17/54 ,  C08K3/00 ,  C08K3/34 ,  C08K5/17 ,  C08K5/19 ,  C08K9/04 ,  C08L67/00 ,  C08L67/06

CPC classification number: C08K5/19 ,  C08K3/34 ,  C08K3/346 ,  C08K9/04

Abstract: Thixotropic cross-linkable polyester compositions are provided comprising an unsaturated polyester and an unsaturated aromatic monomer such as styrene having dispersed therein an organophilic clay gellant comprising the reaction product of a smectite-type clay having a cation exchange capacity of at least 75 milliequivalents per 100 grams of clay and a methyl benzyl dialkyl ammonium compound or a dibenzyl dialkyl ammonium compound, said alkyl groups comprising a mixture of long chain alkyl radicals having from 14 to 22 carbon atoms, preferably 16 or 18 and most preferably wherein 20% to 35% of said long chain radicals contain 16 carbon atoms and 10% to 75% of said long chain radicals contain 18 carbon atoms, the amount of said ammonium compound reacted with said clay being from 100 to 120 milliequivalents per 100 grams of clay based on 100% active clay.The polyester compositions are prepared by a pregel method in which the organophilic clay gellant is mixed with the unsaturated aromatic monomer under high shear to form a pregel and the pregel is then combined with an unsaturated polyester to form the thixotropic compositions.

Abstract translation: 提供了触变性可交联聚酯组合物，其包含不饱和聚酯和不饱和芳族单体如苯乙烯，其中分散有亲有机粘土胶凝胶，其包含阳离子交换容量为至少75毫当量/ 100克的蒙皂石型粘土的反应产物 的粘土和甲基苄基二烷基铵化合物或二苄基二烷基铵化合物，所述烷基包含具有14至22个碳原子，优选16或18个并且最优选其中20％至35％的长链烷基的混合物， 长链基团含有16个碳原子，10％至75％的所述长链基团含有18个碳原子，所述铵化合物与所述粘土反应的量为100至120毫当量/ 100克粘土，基于100％活性粘土 。

公开(公告)号：US08313914B2

公开(公告)日：2012-11-20

申请号：US12660866

申请日：2010-03-05

Applicant: Malcolm Finlayson ,  Bassam B. Damaj

Inventor： Malcolm Finlayson ,  Bassam B. Damaj

IPC: G01N33/53 ,  A61K38/04

CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K38/17 ,  C07K14/00

Abstract: A peptide includes SEQ ID NO:3, substitution and addition variants thereof which maintain the ability to activate CD44. A complex includes this peptide or an Å6 polypeptide with a CD44 polypeptide. An isolated polypeptide includes the Link region sequence of human CD44, functionally active fragments thereof, substitution variants, and addition variants. A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3 or an Å6 polypeptide to bind to a CD44 polypeptide and modulate signal transduction activity for a sufficient period of time to treat the disease. Other methods include using the peptide of SEQ ID NO:3 or an Å6 polypeptide for diagnosing, identifying a subpopulation of subjects responsive to treatment, and screening for compounds that bind a CD44 polypeptide.

Abstract translation: 肽包括SEQ ID NO：3，其保持激活CD44的能力的取代和加成变体。 复合物包括该肽或具有CD44多肽的Å6多肽。 分离的多肽包括人CD44的链接区序列，其功能活性片段，取代变体和加成变体。 治疗以异常细胞迁移和/或侵袭为特征的疾病的方法包括向受试者施用有效量的SEQ ID NO：3或Aβ多肽的肽以结合CD44多肽并调节信号转导活性足够的 一段时间来治疗这种疾病。 其他方法包括使用SEQ ID NO：3或Aβ多肽的肽来诊断，鉴定对治疗有反应的受试者的亚群，以及筛选结合CD44多肽的化合物。

公开(公告)号：US20080021137A1

公开(公告)日：2008-01-24

申请号：US11861021

申请日：2007-09-25

Applicant: Marlin Walters ,  Marius Sorenson ,  Malcolm Finlayson ,  Robin Lee ,  Clark Cummins

Inventor： Marlin Walters ,  Marius Sorenson ,  Malcolm Finlayson ,  Robin Lee ,  Clark Cummins

IPC: C08L23/04 ,  C08K5/09 ,  C08K5/13 ,  C08K5/1539 ,  C08L23/12 ,  C08K5/17 ,  C08K5/36

CPC classification number: C08K5/43 ,  C08J3/22 ,  C08J2323/00 ,  C08K5/0008 ,  C08K5/1345 ,  Y10S502/50 ,  C08L23/02

Abstract: The present invention includes a molecular melt composition comprising an antioxidant and a coupling agent. The molecular melt is partially amorphous in nature. The invention also includes a method for making the molecular melt composition and a method for using the molecular melt to produce coupled polymers. The invention further includes a method for using an antioxidant to phlagmatize a coupling agent.

Abstract translation: 本发明包括含有抗氧化剂和偶联剂的分子熔融组合物。 分子熔体在本质上是部分无定形的。 本发明还包括制备分子熔融组合物的方法和使用分子熔融物制备偶联聚合物的方法。 本发明还包括使用抗氧化剂来挥发偶联剂的方法。

公开(公告)号：US08697629B2

公开(公告)日：2014-04-15

申请号：US13041198

申请日：2011-03-04

Applicant: Malcolm Finlayson ,  Bassam B. Damaj

Inventor： Malcolm Finlayson ,  Bassam B. Damaj

IPC: A61K38/00 ,  C07K7/06

CPC classification number: G01N33/5029 ,  A61K38/1774

Abstract: A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3, an Å6 polypeptide, or an isolated polypeptide consisting essentially of the Link region of human CD44 as indicated in FIG. 17 to modulate a FAK signal transduction pathway for a sufficient period of time to treat the disease. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes measuring the effect of these polypeptides on FAK signal transduction activity; wherein a change in FAK signal transduction activity is indicative of said aberrant cell migration or invasion. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes imaging FAK signal transduction activity in the presence of these polypeptides.

Abstract translation: 治疗以异常细胞迁移和/或侵袭为特征的疾病的方法包括向受试者施用有效量的SEQ ID NO：3的肽，Å6多肽或基本上由人CD44的Link区组成的分离的多肽 如图1所示。 17调节FAK信号转导通路足够的时间来治疗疾病。 诊断以异常细胞迁移和/或侵袭为特征的病症的方法包括测定这些多肽对FAK信号转导活性的影响; 其中FAK信号转导活性的变化指示所述异常细胞迁移或侵袭。 诊断以异常细胞迁移和/或侵袭为特征的病症的方法包括在这些多肽存在下成像FAK信号转导活性。

公开(公告)号：US4116866A

公开(公告)日：1978-09-26

申请号：US812099

申请日：1977-07-01

Applicant: Claude Malcolm Finlayson

Inventor： Claude Malcolm Finlayson

IPC: C09K3/00 ,  A61K8/25 ,  A61K8/26 ,  A61K8/41 ,  A61Q19/00 ,  B01J13/00 ,  B22C1/18 ,  C01B33/20 ,  C01B33/40 ,  C01B33/44

CPC classification number: A61K8/26 ,  A61K8/042 ,  A61K8/416 ,  A61Q19/00 ,  B22C1/181 ,  C01B33/44

Abstract: An organophilic clay gellant having enhanced utility in alcohol compositions is prepared from the reaction product of a smectite-type clay having a cation exchange capacity of at least 0.75 milliequivalents per gram and from about 0.90 to less than about 1.20 milliequivalents per gram of clay of a castor fatty propylamido benzyl dialkyl, i.e., methyl or ethyl ammonium salt.

Abstract translation: 具有在醇组合物中具有增强效用的亲有机粘土胶凝胶由阳离子交换容量至少为0.75毫当量/克的绿土型粘土和约0.90至小于约1.20毫当量的每克粘土的反应产物制备 蓖麻脂肪丙基酰氨基苄基二烷基，即甲基或乙基铵盐。

公开(公告)号：US20110217233A1

公开(公告)日：2011-09-08

申请号：US13041198

申请日：2011-03-04

Applicant: Malcolm Finlayson ,  Bassam B. Damaj

Inventor： Malcolm Finlayson ,  Bassam B. Damaj

IPC: A61K51/08 ,  A61K38/08 ,  A61P43/00

CPC classification number: G01N33/5029 ,  A61K38/1774

Abstract: A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3, an Å6 polypeptide, or an isolated polypeptide consisting essentially of the Link region of human CD44 as indicated in FIG. 17 to modulate a FAK signal transduction pathway for a sufficient period of time to treat the disease. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes measuring the effect of these polypeptides on FAK signal transduction activity; wherein a change in FAK signal transduction activity is indicative of said aberrant cell migration or invasion. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes imaging FAK signal transduction activity in the presence of these polypeptides.

Abstract translation: 治疗以异常细胞迁移和/或侵袭为特征的疾病的方法包括向受试者施用有效量的SEQ ID NO：3的肽，Å6多肽或基本上由人CD44的Link区组成的分离的多肽 如图1所示。 17调节FAK信号转导通路足够的时间来治疗疾病。 诊断以异常细胞迁移和/或侵袭为特征的病症的方法包括测定这些多肽对FAK信号转导活性的影响; 其中FAK信号转导活性的变化指示所述异常细胞迁移或侵袭。 诊断以异常细胞迁移和/或侵袭为特征的病症的方法包括在这些多肽存在下成像FAK信号转导活性。

公开(公告)号：US20070149710A1

公开(公告)日：2007-06-28

申请号：US11592523

申请日：2006-11-03

Applicant: Bharat Chaudhary ,  Genaro Gutierrez ,  Malcolm Finlayson ,  Stephen Hahn ,  John Parent ,  Saurav Sengupta

Inventor： Bharat Chaudhary ,  Genaro Gutierrez ,  Malcolm Finlayson ,  Stephen Hahn ,  John Parent ,  Saurav Sengupta

IPC: C08F297/02

CPC classification number: C08F291/00 ,  C08F255/00 ,  C08F255/02 ,  C08F287/00 ,  C08L51/003 ,  C08L51/006 ,  C08L51/04 ,  C08L51/06 ,  C08L2666/02

Abstract: The present invention yields a coagent-mediated, grafted copolymer prepared from a free radical-mediated reaction of a mixture containing or made from (a) a first free-radical reactive organic polymer, (b) a second free-radical reactive organic polymer, and (c) a coagent selected from the group consisting of allyl, vinyl, and acrylate coagents, wherein the first and second organic polymers are chemically dissimilar polymers as determined by at least one physical property yet the organic polymers have similar reactivity in radical-mediated additions to the coagent.

Abstract translation: 本发明产生由含有或由（a）第一自由基反应性有机聚合物制成的混合物的自由基介导的反应制备的助剂介导的接枝共聚物，（b）第二自由基反应性有机聚合物， 和（c）选自烯丙基，乙烯基和丙烯酸酯助剂的助剂，其中第一和第二有机聚合物是通过至少一种物理性质确定的化学不相似的聚合物，但有机聚合物在自由基介导中具有相似的反应性 助剂的添加。