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1.发明申请Bioactive Compositions, Natural Methods of Producing Them and Computational Methods for Designing Natural Production Processes 审中-公开生物活性成分，自然生产方法及设计自然生产过程的计算方法公开(公告)号：US20070286935A1
公开(公告)日：2007-12-13
申请号：US11576902
申请日：2005-10-07
申请人： Martin Grigorov , Peter Van Bladeren , Sunil Kochhar , Laurent-Bernard Fay , Irene Corthesy-Theulaz , Marcel-Alexandre Juillerat , Michael Affolter , Ulrich Zachariae
发明人： Martin Grigorov , Peter Van Bladeren , Sunil Kochhar , Laurent-Bernard Fay , Irene Corthesy-Theulaz , Marcel-Alexandre Juillerat , Michael Affolter , Ulrich Zachariae
CPC分类号： C07K14/415 , A23L7/101 , A23L29/045 , A23L29/06 , A23L33/10 , A61K36/48 , A61K36/74 , A61K36/81 , A61K36/899 , A61K38/00 , C07K14/575 , A61K2300/00
摘要： The present invention is directed to procedures for the controlled natural bioprocessing of naturally occurring biological molecules by processing activities present in select organisms, extracts of such organisms or other natural processing agents. The invention also covers the methods for developing these procedures and compositions prepared by the procedures.
摘要翻译： 本发明涉及通过加工选择生物体中存在的活性，这种生物体的提取物或其它天然加工剂来控制天然存在的生物分子的天然生物处理的方法。 本发明还包括用于开发这些方法和通过该方法制备的组合物的方法。
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公开(公告)号：US07258996B2
公开(公告)日：2007-08-21
申请号：US10978319
申请日：2004-10-28
CPC分类号： A23J3/344 , A23L33/18 , A23L33/19 , A61K8/64 , A61K38/57 , A61K2800/782 , A61Q11/00 , C07K14/4732 , C07K14/8146 , C12P21/06
摘要： The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The invention also relates to the manufacture of an active agent, in which a food grade bacteria of the genus Lactobacillus helveticus is contacted with casein in order to perform a hydrolysis and obtain casein-derived peptides exhibiting metalloproteinases inhibitory property. The present invention also includes isolated and purified inhibitory peptides obtained by hydrolysis of casein by the bacteria.
摘要翻译： 本发明涉及通过食品级细菌水解酪蛋白得到的酪蛋白衍生肽的活性剂，特别是金属蛋白酶抑制剂。 本发明还涉及一种活性剂的制造，其中将瑞士乳杆菌属食品级细菌与酪蛋白接触以进行水解，并获得表现出金属蛋白酶抑制性质的酪蛋白衍生肽。 本发明还包括通过细菌水解酪蛋白获得的分离和纯化的抑制肽。
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公开(公告)号：US07597904B2
公开(公告)日：2009-10-06
申请号：US11739368
申请日：2007-04-24
CPC分类号： A23J3/344 , A23L33/18 , A23L33/19 , A61K8/64 , A61K38/57 , A61K2800/782 , A61Q11/00 , C07K14/4732 , C07K14/8146 , C12P21/06
摘要： The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The invention also relates to the manufacture of an active agent, in which a food grade bacteria of the genus Lactobacillus helveticus is contacted with casein in order to perform a hydrolysis and obtain casein-derived peptides exhibiting metalloproteinases inhibitory property. The present invention also includes isolated and purified inhibitory peptides obtained by hydrolysis of casein by the bacteria.
摘要翻译： 本发明涉及通过食品级细菌水解酪蛋白得到的酪蛋白衍生肽的活性剂，特别是金属蛋白酶抑制剂。 本发明还涉及一种活性剂的制造，其中将瑞士乳杆菌属食品级细菌与酪蛋白接触以进行水解，并获得表现出金属蛋白酶抑制性质的酪蛋白衍生肽。 本发明还包括通过细菌水解酪蛋白获得的分离和纯化的抑制肽。
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公开(公告)号：US20050187155A1
公开(公告)日：2005-08-25
申请号：US10978319
申请日：2004-10-28
IPC分类号： A23J3/34 , A23L1/305 , A61K6/00 , A61K8/64 , A61K38/08 , A61K38/10 , A61K38/17 , A61K38/57 , A61Q11/00 , C07K14/47 , C07K14/81 , C12P21/06
CPC分类号： A23J3/344 , A23L33/18 , A23L33/19 , A61K8/64 , A61K38/57 , A61K2800/782 , A61Q11/00 , C07K14/4732 , C07K14/8146 , C12P21/06
摘要： The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The invention also relates to the manufacture of an active agent, in which a food grade bacteria of the genus Lactobacillus helveticus is contacted with casein in order to perform a hydrolysis and obtain casein-derived peptides exhibiting metalloproteinases inhibitory property. The present invention also includes isolated and purified inhibitory peptides obtained by hydrolysis of casein by the bacteria.
摘要翻译： 本发明涉及通过食品级细菌水解酪蛋白得到的酪蛋白衍生肽的活性剂，特别是金属蛋白酶抑制剂。 本发明还涉及一种活性剂的制造，其中将瑞士乳杆菌属食品级细菌与酪蛋白接触以进行水解，并获得表现出金属蛋白酶抑制性质的酪蛋白衍生肽。 本发明还包括通过细菌水解酪蛋白获得的分离和纯化的抑制肽。
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公开(公告)号：US20070258914A1
公开(公告)日：2007-11-08
申请号：US11739368
申请日：2007-04-24
CPC分类号： A23J3/344 , A23L33/18 , A23L33/19 , A61K8/64 , A61K38/57 , A61K2800/782 , A61Q11/00 , C07K14/4732 , C07K14/8146 , C12P21/06
摘要： The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The invention also relates to the manufacture of an active agent, in which a food grade bacteria of the genus Lactobacillus helveticus is contacted with casein in order to perform a hydrolysis and obtain casein-derived peptides exhibiting metalloproteinases inhibitory property. The present invention also includes isolated and purified inhibitory peptides obtained by hydrolysis of casein by the bacteria.
摘要翻译： 本发明涉及通过食品级细菌水解酪蛋白得到的酪蛋白衍生肽的活性剂，特别是金属蛋白酶抑制剂。 本发明还涉及一种活性剂的制造，其中将瑞士乳杆菌属食品级细菌与酪蛋白接触以进行水解，并获得表现出金属蛋白酶抑制性质的酪蛋白衍生肽。 本发明还包括由细菌水解酪蛋白获得的分离和纯化的抑制肽。
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