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13 条记录 (耗时 0.043 秒)

    LIPOTEICHOIC ACID FROM LACTIC ACID BACTERIA AND ITS USE TO MODULATE IMMUNE RESPONSES MADIATED BY GRAM-NEGATIVE BACTERIA, POTENTIAL PATHOGENIC GRAM-POSITIVE BACTERIA
    2.
    发明申请
    LIPOTEICHOIC ACID FROM LACTIC ACID BACTERIA AND ITS USE TO MODULATE IMMUNE RESPONSES MADIATED BY GRAM-NEGATIVE BACTERIA, POTENTIAL PATHOGENIC GRAM-POSITIVE BACTERIA 失效
    来自酸乳杆菌的LIPOTEICHOIC酸及其用于调节由GRAM阴性细菌引起的免疫应答，潜在致病性细菌性细菌

    公开(公告)号：US20090142375A1

    公开(公告)日：2009-06-04

    申请号：US12246991

    申请日：2008-10-07

    申请人： Karine Vidal ,  Anne Donnet-Hughes ,  Dominique-Anne Granato ,  Irene Corthesy-Theulaz

    发明人： Karine Vidal ,  Anne Donnet-Hughes ,  Dominique-Anne Granato ,  Irene Corthesy-Theulaz

    IPC分类号： A61K39/02 ,  A61P37/02

    CPC分类号： A61K31/70 ,  A23L33/135 ,  A23V2002/00 ,  A61K8/72 ,  A61K8/99 ,  A61K9/0095 ,  A61K31/739 ,  A61Q11/00 ,  A61Q19/00 ,  C12P19/44 ,  A23V2250/206

    摘要： The invention relates to a composition for modulating the immune responses induced by Gram negative bacteria, potential pathogenic Gram positive bacteria and/or their derivatives, comprising lipoteichoic acid from lactic acid bacteria as an active ingredient. It also relates to the use of a lipoteichoic acid from lactic acid bacteria as an active ingredient and/or lactic acid bacteria producing it and/or its supernatant of culture, in the manufacture of a medicament, an oral or topical product for cosmetic, dermatological or ophtalmological applications, a food or petfood composition for modulating bacterial colonisation, immune responses and decreasing the inflammatory processes associated with bacterially-mediated disease and infection in the gastrointestinal tract, bone, skin, eye, ear, lung and oral cavity. The invention also relates to lipoteichoic acid selected thereof.

    摘要翻译： 本发明涉及一种用于调节由革兰氏阴性细菌诱导的免疫应答的组合物，其包含来自乳酸菌的脂磷壁酸作为活性成分的潜在致病革兰氏阳性菌和/或其衍生物。 它还涉及在制备用于化妆品，皮肤病学的药物，口服或局部产品中使用来自乳酸菌的脂磷壁酸作为活性成分和/或产生其的乳酸菌和/或其培养上清液 或眼科应用，用于调节细菌定植，免疫应答和减少与细菌介导的疾病和胃肠道，骨骼，皮肤，眼睛，耳朵，肺和口腔中的感染相关的炎症过程的食物或宠物食品组合物。 本发明还涉及其选择的脂磷壁酸。

    Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases
    10.
    发明授权
    Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases 失效
    与药物发现和检测和治疗胃肠道疾病有关的组成和方法

    公开(公告)号：US6060241A

    公开(公告)日：2000-05-09

    申请号：US834776

    申请日：1997-04-03

    申请人： Irene Corthesy-Theulaz

    发明人： Irene Corthesy-Theulaz

    IPC分类号： A61K38/00 ,  C12N9/00 ,  C12N9/10 ,  C12N15/54 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： C12N9/1029 ,  C12N9/00 ,  C12N9/10 ,  C12Q1/689 ,  A61K38/00 ,  C12Q2600/136

    摘要： A poly-3-hydroxybutyrate metabolic pathway essential for Helicobacter pylori survival in a host is provided. A novel Helicobacter pylori Coenzyme A transferase (Hp CoA-t), thiolase and PHB synthase as well as methods for their preparation and use are provided. Hp CoA-t and thiolase polynucleotides and proteins are provided as well as detection and preparative methods using such molecules. Methods for the determination of a propensity to develop gastritis, peptic ulcer disease, or gastric cancer is provided for by detection methods. Methods are also provided for the use of Hp CoA-t, thiolase or PHB synthase proteins and fragments retaining enzymatic activity in the identification of potential drug candidates for the treatment of some types of gastric disease. Pharmaceutical compositions containing Hp CoA-t protein fragments, antisense nucleic acids or other inhibitors of Hp CoA-t, thiolase and PHB synthase as well as methods for their use in the treatment of some types of gastric disease are also provided.

    摘要翻译： 提供了在宿主中幽门螺杆菌存活所必需的聚-3-羟基丁酸酯代谢途径。 提供了一种新型幽门螺杆菌辅酶A转移酶（Hp CoA-t），硫解酶和PHB合酶以及其制备和使用方法。 提供Hp CoA-t和硫解酶多核苷酸和蛋白质以及使用这种分子的检测和制备方法。 通过检测方法提供测定胃炎，消化性溃疡病或胃癌倾向的方法。 还提供了使用Hp CoA-t，硫解酶或PHB合酶蛋白的方法以及保留酶活性的片段，用于鉴定潜在的候选药物用于治疗某些类型的胃病。 还提供了含有Hp CoA-t蛋白片段，反义核酸或其他Hp CoA-t，硫解酶和PHB合成酶抑制剂的药物组合物，以及其用于治疗某些类型胃病的方法。