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公开(公告)号：US5239064A
公开(公告)日：1993-08-24
申请号：US507551
申请日：1990-04-11
申请人： Marvin M. Hoehn , Karl H. Michel , Raymond C. Yao
发明人： Marvin M. Hoehn , Karl H. Michel , Raymond C. Yao
CPC分类号： C07H17/08 , C12P19/62 , C12R1/365 , C12R1/465 , Y10S435/872
摘要： A novel antibiotic complex, A59770, individual factors and derivatives thereof, are provided. The A59770 compounds are useful as pesticides, particularly as rodenticides. Further provided are methods for reducing a rodent population, rodenticidal compositions, and an A59770-producing Amycolatopsis orientalis culture.
摘要翻译： 提供了一种新型抗生素复合物A59770，其个体因素及其衍生物。 A59770化合物可用作农药，特别是杀鼠剂。 还提供了减少啮齿动物种群，杀鼠剂组合物和产生A59770的副杆菌培养物的方法。
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公开(公告)号：US5362634A
公开(公告)日：1994-11-08
申请号：US773754
申请日：1991-10-10
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.
摘要翻译： 包含主要组分A83543A和A83543D以及次要组分A83543B，A83543C，A83543E，A983543F，A83543G，A83543H和A83543J的发酵产物A83543由新近描述的种类，多孢裂孢酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫剂，杀螨剂或除虫杀虫剂组合，组合物和方法。
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3.发明授权Insecticide and miticide A83543 compounds and their method of production by fermentation 失效杀虫剂和杀螨剂A83543化合物及其发酵方法
公开(公告)号：US5496931A
公开(公告)日：1996-03-05
申请号：US406760
申请日：1995-03-17
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.
摘要翻译： 包含主要组分A83543A和A83543D以及次要组分A83543B，A83543C，A83543E，A983543F，A83543G，A83543H和A83543J的发酵产物A83543由新近描述的种类，多孢裂孢酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫剂，杀螨剂或除虫杀虫剂组合，组合物和方法。
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公开(公告)号：US5286648A
公开(公告)日：1994-02-15
申请号：US722060
申请日：1991-06-27
申请人： Karl H. Michel , Raymond C. Yao
发明人： Karl H. Michel , Raymond C. Yao
IPC分类号： C12N1/20 , A61K38/00 , A61P31/04 , C07K9/00 , C07K14/00 , C07K14/37 , C07K14/41 , C12P21/00 , C12P21/02 , C12P21/04 , C12R1/62 , C12R1/01
CPC分类号： C07K9/008 , A61K38/00 , Y10S435/822
摘要： Newly discovered lipoglycopeptide antibiotic A84575 complex, comprising factors A, B, C, D, E, F, G, and H, is produced by submerged aerobic fermentation of a culture selected from Streptosporangeum carneum NRRL 18437, Streptosporangeum carneum NRRL 18505 or an A84575-producing mutant thereof. The antibiotics are active against Gram-positive bacteria.
摘要翻译： 新发现的含有A，B，C，D，E，F，G和H因子的脂多糖抗生素A84575复合物是通过浸没好氧发酵制备的，该发酵选自Streptosporornum carmonary NRRL 18437，Streptosporornum carr NR 18185或A84575- 产生其突变体。 抗生素对革兰氏阳性菌有活性。
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公开(公告)号：US5571901A
公开(公告)日：1996-11-05
申请号：US479500
申请日：1995-06-07
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A83543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ectoparasiticidal combinations, compositions and methods are provided.
摘要翻译： 包含主要成分A83543A和A83543D以及次要成分A83543B，A83543C，A83543E，A83543F，A83543G，A83543H和A83543J的发酵产品A83543由新描述的种类，酿酒酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫，杀螨或外寄生疫苗组合，组合物和方法。
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公开(公告)号：US4880735A
公开(公告)日：1989-11-14
申请号：US911180
申请日：1986-09-24
CPC分类号： C12R1/465 , C07K14/36 , Y10S435/886
摘要： Improved fermentation process for producing the Gram-positive antibiotic A47934 which comprises cultivating a new strain of Streptomyces toyocaensis, NRRL 18112, and a biologically purified culture of this microorganism are provided.
摘要翻译： 提供用于生产革兰氏阳性抗生素A47934的改进的发酵方法，其包括培养新的链霉菌Streptomyces toyocaensis菌株，NRRL 18112和该微生物的生物纯化培养物。
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公开(公告)号：US06800614B2
公开(公告)日：2004-10-05
申请号：US10217533
申请日：2002-08-13
申请人： Paul Lewer , Donald R. Hahn , Laura L. Karr , Paul R. Graupner , Jeffrey R. Gilbert , Thomas V. Worden , Raymond C. Yao , Dennis W. Norton
发明人： Paul Lewer , Donald R. Hahn , Laura L. Karr , Paul R. Graupner , Jeffrey R. Gilbert , Thomas V. Worden , Raymond C. Yao , Dennis W. Norton
IPC分类号： A01N4322
摘要： Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.
摘要翻译： 通过培养多孢子虫种类LW107129（NRRL 30141）产生的大环内酯类化合物具有杀虫和杀螨活性，是制备多杀菌素类似物的有用中间体。
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8.发明授权Method for treating swine dysentery with the derivatives of the antibiotic A82810 失效用抗生素A82810衍生物治疗猪痢疾的方法
公开(公告)号：US5314875A
公开(公告)日：1994-05-24
申请号：US752816
申请日：1991-08-30
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P19/445 , C12P19/60 , C12R1/03
摘要： New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
摘要翻译： 新型聚醚抗菌素A82810，其酰基和烷基酯，酰基酯和氨基甲酸酯衍生物及其盐是有用的抗菌和抗球虫剂，并增加动物的饲料利用效率。 通过培养Actinomodura fibrosa sp。制备A82810的方法 nov。 还提供了NRRL 18348和A82810化合物与氨基脲，4,4'-二硝基苯甲酰胺，某些萘胺和苯胺化合物和二氯吲哚醇的协同组合物。
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公开(公告)号：US4876273A
公开(公告)日：1989-10-24
申请号：US220650
申请日：1988-07-18
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
IPC分类号： C07D407/14 , C12P17/16
CPC分类号： C07D407/14 , C12P17/16 , C12R1/03
摘要： New polyether antibiotic A80577, its acyl ester and alkyl ether derivatives, and salts thereof, are useful antibacterial agents and increase feed-utilization efficiency in animals. Methods of making A80577 by culture of Actinomadura verrucosospora, NRRL 18236, and compositions containing an A80577 compound also are provided.
摘要翻译： 新型聚醚抗菌素A80577，其酰基酯和烷基醚衍生物及其盐是有用的抗菌剂，并增加动物的饲料利用效率。 还提供了通过培养Actinomadura verrucosospora，NRRL 18236和含有A80577化合物的组合物制备A80577的方法。
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公开(公告)号：US4677071A
公开(公告)日：1987-06-30
申请号：US638189
申请日：1984-08-06
CPC分类号： C12P1/06 , Y10S435/886
摘要： This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
摘要翻译： 本发明涉及在微生物发酵过程中，在控制条件下，使用新的菌株Streptomyces coeruleorubidus subspecies rubidus，命名为LL-BO2964α，LL-BO2964β，LL-BO2964γ的新型多肽抗生素及其名称为LL-BO2964的混合物 或其突变体。 新的抗生素对各种微生物有活性，也可用于治疗结核病。
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