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公开(公告)号：US5670486A
公开(公告)日：1997-09-23
申请号：US483440
申请日：1995-06-07
申请人： Jon S. Mynderse , James A. Mabe , Jan R. Turner , Mary L. B. Huber , Mary C. Broughton , Walter M. Nakatsukasa , Lawrence Creemer , Herbert A. Kirst , James W. Martin
发明人： Jon S. Mynderse , James A. Mabe , Jan R. Turner , Mary L. B. Huber , Mary C. Broughton , Walter M. Nakatsukasa , Lawrence Creemer , Herbert A. Kirst , James W. Martin
CPC分类号： C07H17/08 , A01N43/22 , C12P19/62 , C12R1/01 , Y10S424/08 , Y10S424/10 , Y10S435/822
摘要： New A83543 components, including fermentation products A83543K, A83543O, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
摘要翻译： 包括发酵产物A83543K，A83543O，A83543P，A83543U，A83543V，A83543W和A83543Y和N-甲基衍生物及其盐的新A83543组分可用于防治昆虫和螨虫。 新的A83543组分的假脂肪酸可用于制备A83543组分。 提供了通过在合适的培养基中培养多孢孢杆菌NRRL 18395，NRRL 18537，NRRL 18538或NRRL 18539或NRRL 18743或NRRL 18719或NRRL 18823来制备新的A83543成分的方法。 还提供了含有新A83543组分的杀虫剂和灭寄生组合物。
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公开(公告)号：US5312738A
公开(公告)日：1994-05-17
申请号：US521202
申请日：1990-05-09
IPC分类号： C12N1/20 , A23K20/195 , A61K35/74 , A61K38/00 , A61P31/04 , C07K9/00 , C07K14/195 , C07K14/41 , C12N1/14 , C12P1/06 , C12P21/02 , C12P21/04 , C12R1/365 , C12P19/60
CPC分类号： C12R1/365 , C07K9/008 , A61K38/00 , Y10S435/872
摘要： New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.
摘要翻译： 包含A82846A，A82846B和A82846C的新糖肽抗生素A82846由诺卡氏菌（Nocardia orientalis）NRRL 18098，NRRL 18099和NRRL 18100产生.A82846抗生素具有与万古霉素相当的革兰氏阳性菌的活性。
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公开(公告)号：US4141907A
公开(公告)日：1979-02-27
申请号：US844087
申请日：1977-10-20
IPC分类号： C07D493/20 , A23K20/195 , A61K31/35 , A61K36/06 , A61P31/04 , A61P33/02 , A61P43/00 , C07D493/10 , C07H19/01 , C12P1/06 , C12P17/18 , C12R1/485 , C07D309/22
CPC分类号： C07D493/10 , C07H19/01 , C12P17/181 , C12R1/485 , Y10S435/889
摘要： Deoxynarasin antibiotic complex, comprising 20-deoxynarasin and 20-deoxy-epi-17-narasin, is produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 11181. 20-Deoxynarasin and 20-deoxy-epi-17-narasin are separated and isolated by chromatography. The deoxynarasin complex, 20-deoxynarasin and 20-deoxy-epi-17-narasin are antibacterial and anticoccidial agents and also increase feed-utilization efficiency in ruminants.
摘要翻译： 通过潜在的好氧发酵生产{PG，1脱氧ar as素抗生素复合物，其包含20-脱氧n as素和20-脱氧表i -17- n as in is 17 17 17 obic of of 1. 1. 1. 1. 1. 1. {{1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 17 17 17 17 - 通过色谱分离和分离。 脱氧镰刀菌素复合物，20-脱氧ar as素和20-脱氧表i -17- n in素是抗菌和抗球虫剂，也提高反刍动物的饲料利用效率。
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公开(公告)号：US5571901A
公开(公告)日：1996-11-05
申请号：US479500
申请日：1995-06-07
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A83543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ectoparasiticidal combinations, compositions and methods are provided.
摘要翻译： 包含主要成分A83543A和A83543D以及次要成分A83543B，A83543C，A83543E，A83543F，A83543G，A83543H和A83543J的发酵产品A83543由新描述的种类，酿酒酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫，杀螨或外寄生疫苗组合，组合物和方法。
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5.发明授权Recombinant DNA cloning vectors containing selectable genetic markers for use in streptomyces and related organisms 失效含有用于链霉菌和相关生物体的可选遗传标记的重组DNA克隆载体
公开(公告)号：US4698307A
公开(公告)日：1987-10-06
申请号：US639631
申请日：1984-08-10
IPC分类号： C12N15/76 , C12N1/20 , C07H21/04 , C12N1/00 , C12N15/00 , C12P19/34 , C12P21/00 , C12R1/465 , C12R1/485 , C12R1/54
CPC分类号： C12N15/76 , Y10S435/886 , Y10S435/889 , Y10S435/896
摘要： The present invention disclosed novel recombinant DNA cloning vectors including pMND1000 and vectors derived therefrom for use in Streptomyces and related organisms. These novel cloning vectors contain genetic markers that provide antibiotic resistance or colorimetric selectivity to the host cells. The invention further comprises transformants of the aforementioned vectors.
摘要翻译： 本发明公开了新型重组DNA克隆载体，包括pMND1000和其衍生的载体用于链霉菌和相关生物。 这些新的克隆载体含有提供抗生素抗性或对宿主细胞的比色选择性的遗传标记。 本发明还包括前述载体的转化体。
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公开(公告)号：US5843437A
公开(公告)日：1998-12-01
申请号：US466656
申请日：1995-06-06
IPC分类号： C12N1/20 , A23K20/195 , A61K35/74 , A61K38/00 , A61P31/04 , C07K9/00 , C07K14/195 , C07K14/41 , C12N1/14 , C12P1/06 , C12P21/02 , C12P21/04 , C12R1/365 , C12P1/04
CPC分类号： C12R1/365 , C07K9/008 , A61K38/00 , Y10S435/872
摘要： New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.
摘要翻译： 包含A82846A，A82846B和A82846C的新糖肽抗生素A82846由诺卡氏菌（Nocardia orientalis）NRRL 18098，NRRL 18099和NRRL 18100产生.A82846抗生素具有与万古霉素相当的革兰氏阳性菌的活性。
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7.发明授权Plasmid pEL7 and related cloning vectors for use in streptomyces and related organisms 失效质粒pEL7和用于链霉菌和相关生物体的相关克隆载体
公开(公告)号：US4416994A
公开(公告)日：1983-11-22
申请号：US312446
申请日：1981-10-19
IPC分类号： C12N15/09 , C07H21/04 , C12N1/20 , C12N15/76 , C12P19/34 , C12R1/01 , C12R1/07 , C12R1/19 , C12R1/29 , C12R1/365 , C12R1/44 , C12R1/54 , C12N1/00 , C12N15/00 , C12P21/00 , C12P21/02 , C12R1/465
CPC分类号： C12N15/76 , Y10S435/886
摘要： The present invention discloses selectable pairs of recombinant DNA cloning vectors for use in Streptomyces and related organisms.
摘要翻译： 本发明公开了用于链霉菌和相关生物体的可选择的重组DNA克隆载体对。
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公开(公告)号：US4404281A
公开(公告)日：1983-09-13
申请号：US409765
申请日：1982-08-19
IPC分类号： C07D455/02 , C07D471/04 , C12P17/18 , C12P17/12 , C12P17/10 , C12R1/465
CPC分类号： C07D471/04 , C07D455/02 , C12P17/182 , Y10S435/886
摘要： Angiotensin I converting enzyme inhibitor A-58365 factor A is produced in enhanced yields by culturing Streptomyces chromofuscus NRRL 15098 under submerged aerobic fermentation conditions in a proline supplemented aqueous nutrient culture medium containing assimilable sources of carbon, nitrogen and inorganic salts.
摘要翻译： 血管紧张素I转化酶抑制剂A-58365因子A通过在含有可同化的碳，氮和无机盐来源的脯氨酸补充营养培养基中，在淹没好氧发酵条件下培养链霉菌NRRL 15098而以增加的产量产生。
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公开(公告)号：US4110436A
公开(公告)日：1978-08-29
申请号：US762536
申请日：1977-01-26
CPC分类号： C12P1/06
摘要： Newly-discovered antibiotic A-28086 factor D, produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 8092, is an antibacterial and anticoccidial agent and also increases feed-utilization efficiency in ruminant animals.
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公开(公告)号：US5840861A
公开(公告)日：1998-11-24
申请号：US385497
申请日：1995-02-08
申请人： Jon S. Mynderse , Mary C. Broughton , Walter M. Nakatsukasa , James A. Mabe , Jan R. Turner , Lawrence Creemer , Mary L. B. Huber , Herbert A. Kirst , James W. Martin
发明人： Jon S. Mynderse , Mary C. Broughton , Walter M. Nakatsukasa , James A. Mabe , Jan R. Turner , Lawrence Creemer , Mary L. B. Huber , Herbert A. Kirst , James W. Martin
CPC分类号： C07H17/08 , A01N43/22 , C12P19/62 , C12R1/01 , Y10S424/08 , Y10S424/10 , Y10S435/822
摘要： New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
摘要翻译： 包括发酵产物A83543K，A835430，A83543P，A83543U，A83543V，A83543W和A83543Y和N-甲基衍生物及其盐的新A83543组分可用于防治昆虫和螨虫。 新的A83543组分的假脂肪酸可用于制备A83543组分。 提供了通过在合适的培养基中培养多孢孢杆菌NRRL 18395，NRRL 18537，NRRL 18538或NRRL 18539或NRRL 18743或NRRL 18719或NRRL 18823来制备新的A83543成分的方法。 还提供了含有新A83543组分的杀虫剂和灭寄生组合物。
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