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    Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS using permissive cells
    5.
    发明授权
    Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS using permissive cells 失效
    使用允许细胞从艾滋病和艾滋病患者连续生产逆转录病毒（HTLV-III）的方法

    公开(公告)号：US4652599A

    公开(公告)日：1987-03-24

    申请号：US643729

    申请日：1984-08-24

    申请人： Robert C. Gallo ,  Mikulas Popovic

    发明人： Robert C. Gallo ,  Mikulas Popovic

    IPC分类号： A61K39/21 ,  A61P31/12 ,  A61P31/18 ,  C12N5/06 ,  C12N7/00 ,  C12R1/91 ,  C12R1/92 ,  G01N33/569 ,  C12N7/02 ,  C12N5/00 ,  C12Q1/02 ,  C12Q1/70

    CPC分类号： C12N7/00 ,  C12N2740/10051 ,  Y10S435/948

    摘要： A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and in healthy carriers. One neoplastic aneuploid T-cell line derived from an adult with lymphoid leukemia, and termed HT, was susceptible to infection with HTLV-III, which is transformed and provides T-cell populations which are highly susceptible to and permissive for HTLV-III, and convenient for large scale production, isolation, and biological detection of the virus. Other operational neoplastic T-cell lines which are positive for OKT4 marker, e.g., Molt 3, CEM, Ti7.4 and HUT78, can produce HTLV-III in a large amount and retain its unlimited capability for growth.

    摘要翻译： 公开了一种细胞系统，用于从具有获得性免疫缺陷综合征（AIDS），艾滋病前期和健康携带者的患者中检测和分离具有细胞病变效应（HTLV-III）的人类T淋巴细胞逆转录病毒（HTLV家族）。 衍生自具有淋巴样白血病，称为HT的成年人的一种肿瘤非整倍体T细胞系易感染HTLV-III，HTLV-III被转化并提供对HTLV-III高度敏感和允许的T细胞群体，以及 方便大规模生产，隔离和生物检测病毒。 对于OKT4标志物，例如Molt 3，CEM，Ti7.4和HUT78而言为阳性的其他可操作的肿瘤性T细胞系可以大量产生HTLV-III并保持其无限的生长能力。

    Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
    6.
    发明授权
    Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS 失效
    从艾滋病和艾滋病前期继续生产逆转录病毒（HTLV-III）的方法

    公开(公告)号：US4647773A

    公开(公告)日：1987-03-03

    申请号：US602946

    申请日：1984-04-23

    申请人： Robert C. Gallo ,  Mikulas Popovic

    发明人： Robert C. Gallo ,  Mikulas Popovic

    IPC分类号： G01N33/50 ,  A61K39/21 ,  A61P31/12 ,  A61P31/18 ,  C12N5/00 ,  C12N5/09 ,  C12N7/00 ,  C12R1/91 ,  C12R1/92 ,  G01N33/569 ,  C12N7/02

    CPC分类号： C12N5/0694 ,  C12N7/00 ,  C12N2740/16051 ,  Y10S435/948

    摘要： A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and in healthy carriers. One neoplastic aneuploid T-cell line derived from an adult with lymphoid leukemia, and termed HT, was susceptible to infection with the new variants of HTLV, which are transformed and providing T-cell populations which are highly susceptible and permissive from HTLV-III, and convenience for large scale production, isolation and biological detection of the virus.

    摘要翻译： 公开了一种细胞系统，用于从具有获得性免疫缺陷综合征（AIDS），艾滋病前期和健康携带者的患者中检测和分离具有细胞病变效应（HTLV-III）的人类T淋巴细胞逆转录病毒（HTLV家族）。 衍生自具有淋巴样白血病，称为HT的成年人的一种肿瘤非整倍体T细胞系易感染HTLV的新变体，其被转化并提供从HTLV-III高度敏感和允许的T细胞群体， 并方便大规模生产，分离和生物检测病毒。