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    Amino acid derivatives
    1.
    发明授权
    Amino acid derivatives 失效
    氨基酸衍生物

    公开(公告)号：US06245810B1

    公开(公告)日：2001-06-12

    申请号：US09106454

    申请日：1998-06-30

    申请人： Masaaki Ishizuka ,  Masaji Kawazu ,  Toshiaki Katsumi ,  Yoshihide Fuse ,  Kenji Maeda ,  Tomio Takeuchi

    发明人： Masaaki Ishizuka ,  Masaji Kawazu ,  Toshiaki Katsumi ,  Yoshihide Fuse ,  Kenji Maeda ,  Tomio Takeuchi

    IPC分类号： A61K3124

    CPC分类号： C07C237/12 ,  C07C233/47 ,  C07C235/12 ,  C07C323/59

    摘要： A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. wherein y is 0 or 1; R1 represents an unsubstituted C1-C8 alkyl group or others; R2 represents a hydrogen atom, a C1-C5 alkyl group or others; R3 represents a hydrogen atom, a C1-C8 alkyl group or others; R4 represents a hydrogen atom, a C1-C3 alkyl group or others; R5 represents a group —OR42, a group  or others.

    摘要翻译： 现在已经通过化学合成提供了由下述通式（I）表示的新型氨基酸衍生物或其盐，并且已经发现这些新化合物刺激哺乳动物T细胞的增殖和生理活性，具有 免疫调节活性，也具有抗肿瘤活性或制癌活性。 还发现这些新化合物具有刺激造血干细胞增殖的作用，其中0或1; R1代表未取代的C 1 -C 8烷基或其它; R 2表示氢原子，C 1 -C 5烷基 基团或其它基团; R 3表示氢原子，C 1〜C 8烷基等; R 4表示氢原子，C 1〜C 3烷基等; R 5表示基团-OR 42，基团等。

    Amino acid derivatives
    2.
    发明授权
    Amino acid derivatives 失效
    氨基酸衍生物

    公开(公告)号：US5798387A

    公开(公告)日：1998-08-25

    申请号：US753381

    申请日：1996-11-25

    申请人： Masaaki Ishizuka ,  Masaji Kawazu ,  Toshiaki Katsumi ,  Yoshihide Fuse ,  Kenji Maeda ,  Tomio Takeuchi

    发明人： Masaaki Ishizuka ,  Masaji Kawazu ,  Toshiaki Katsumi ,  Yoshihide Fuse ,  Kenji Maeda ,  Tomio Takeuchi

    IPC分类号： C07C233/47 ,  C07C235/12 ,  C07C237/12 ,  C07C323/59 ,  A61K31/22

    CPC分类号： C07C235/12 ,  C07C233/47 ,  C07C237/12 ,  C07C323/59

    摘要： A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. ##STR1## wherein y is 0 or 1; R.sup.1 represents an unsubstituted C.sub.1 -C.sub.8 alkyl group or others; R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or others; R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or others; R.sup.4 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group or others; R.sup.5 represents a group --OR.sup.42, a group ##STR2## or others.

    摘要翻译： 现在已经通过化学合成提供了由下述通式（I）表示的新型氨基酸衍生物或其盐，并且已经发现这些新化合物刺激哺乳动物T细胞的增殖和生理活性，具有 免疫调节活性，也具有抗肿瘤活性或制癌活性。 还发现这些新化合物具有刺激造血干细胞增殖的作用。 （I）其中y为0或1; R1表示未取代的C1-C8烷基等; R2表示氢原子，C1-C5烷基等; R3表示氢原子，C1-C8烷基等; R4表示氢原子，C1-C3烷基等; R5表示基团-OR42，组等。

    IMAGE DISPLAY APPARATUS
    8.
    发明申请
    IMAGE DISPLAY APPARATUS 审中-公开
    图像显示设备

    公开(公告)号：US20140139915A1

    公开(公告)日：2014-05-22

    申请号：US14131169

    申请日：2012-07-06

    申请人： Yuichi Sato ,  Kenji Maeda ,  Masayuki Natsumi ,  Tatsuo Watanabe ,  Kazuya Takayama ,  Takashi Yasumoto ,  Yoshimitsu Inamori

    发明人： Yuichi Sato ,  Kenji Maeda ,  Masayuki Natsumi ,  Tatsuo Watanabe ,  Kazuya Takayama ,  Takashi Yasumoto ,  Yoshimitsu Inamori

    IPC分类号： G02B27/22

    CPC分类号： G02B27/2214 ,  G03B35/24 ,  G09G3/003 ,  G09G3/20 ,  G09G3/3607 ,  H04N13/305 ,  H04N13/324

    摘要： An image display apparatus having sub-pixels of four colors is provided in which the resolution when an image is two-dimensionally displayed is not affected, and deterioration in the color balance of a three-dimensionally displayed image is suppressed. In the image display apparatus, the arrangement of a sub-pixel for displaying red for a left eye and a sub-pixel for displaying green for a right eye has been replaced with the arrangement of a sub-pixel (Lg1) for displaying green for the left eye and a sub-pixel (Rr1) for displaying red for the right eye. The arrangement of a sub-pixel for displaying blue for the left eye and a sub-pixel for displaying yellow for the right eye has been replaced with the arrangement of a sub-pixel (Lx1) for displaying yellow for the left eye and a sub-pixel (Rb1) for displaying blue for the right eye. Replacement with the sub-pixel and the sub-pixel and replacement with the sub-pixel and the sub-pixel are made for every other pixel.

    摘要翻译： 提供一种具有四色子像素的图像显示装置，其中不影响图像二维显示时的分辨率，并且抑制三维显示图像的色平衡劣化。 在图像显示装置中，用于显示用于左眼的红色的子像素和用于显示用于右眼的绿色的子像素的布置已被替换为用于显示绿色的子像素（Lg1） 左眼和用于右眼显示红色的子像素（Rr1）。 用于显示用于左眼的蓝色的子像素和用于显示用于右眼的黄色的子像素的布置已被替换为用于显示用于左眼的黄色的子像素（Lx1）和用于显示黄色的子像素 用于显示右眼的蓝色的像素（Rb1）。 使用子像素和子像素进行替换，并且对于每个其他像素进行子像素和子像素的替换。

    COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER
    9.
    发明申请
    COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER 审中-公开
    包含吡喹酮或其盐的组合和用于治疗CNS疾病的第二种药物

    公开(公告)号：US20140120185A1

    公开(公告)日：2014-05-01

    申请号：US14009436

    申请日：2012-04-04

    申请人： Tsuyoshi Hirose ,  Kenji Maeda ,  Tetsuro Kikuchi ,  Masafumi Toda

    发明人： Tsuyoshi Hirose ,  Kenji Maeda ,  Tetsuro Kikuchi ,  Masafumi Toda

    IPC分类号： A61K31/496 ,  A61K45/06

    CPC分类号： A61K31/496 ,  A61K9/20 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/15 ,  A61K31/165 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4525 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides a medicament having a wider treatment spectrum, causing a fewer side effects and superior in tolerability and safety, as compared to known typical antipsychotic agents and atypical antipsychotic agents. The present invention related to a medicament containing (I) a compound which is 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof, and (II) at least one drug selected from the group consisting of a mood stabilizer, a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a serotonin and norepinephrine reuptake inhibitor, a noradrenergic and specific serotonergic antidepressant, an antianxiety drug, a tricyclic antidepressant, a tetracyclic antidepressant, an antipsychotic drug and an anti-ADHD drug, in combination.

    摘要翻译： 与已知的典型抗精神病药和非典型抗精神病药相比，本发明提供了具有更宽治疗谱的药物，其副作用较小，耐受性和安全性优异。 本发明涉及含有（I）7- [4-（4-苯并[b]噻吩-4-基 - 哌嗪-1-基）丁氧基] -1H-喹啉-2-酮的化合物或 其盐，和（II）选自情绪稳定剂，5-羟色胺再摄取抑制剂，去甲肾上腺素再摄取抑制剂，5-羟色胺和去甲肾上腺素再摄取抑制剂，去甲肾上腺素能和特异性5-羟色胺能抗抑郁药，抗焦虑药物， 三环抗抑郁药，四环抗抑郁药，抗精神病药和抗ADHD药。