-
1.发明授权
公开(公告)号：US6160017A
公开(公告)日：2000-12-12
申请号：US402534
申请日：2000-02-14
IPC分类号： A61K31/198 , A61K31/195
CPC分类号： A61K31/198 , Y10S514/885 , Y10S514/925 , Y10S514/926
摘要： The invention relates to an agent for preventing and treating ulcerous colitis and/or Crohn's disease, comprising conagenin or a pharmaceutically acceptable salt thereof as an active ingredient. According to the present invention, there is provided an agent for preventing and treating ulcerous colitis and/or Crohn's disease, which has high therapeutic effect and safety.
摘要翻译： PCT No.PCT / JP98 / 01614 Sec。 371日期2000年2月14日 102（e）日期2000年2月14日PCT提交1998年4月8日PCT公布。 第WO98 / 44916号公报 日期：1998年10月15日本发明涉及用于预防和治疗溃疡性结肠炎和/或克罗恩病的药剂，其包含作为活性成分的络合蛋白酶或其药学上可接受的盐。 根据本发明，提供了具有高治疗效果和安全性的用于预防和治疗溃疡性结肠炎和/或克罗恩病的药剂。
-
公开(公告)号：US5952380A
公开(公告)日：1999-09-14
申请号：US825095
申请日：1997-03-27
IPC分类号： A61K45/00 , A61K31/195 , A61K31/198 , A61K31/435 , A61K31/475 , A61K31/505 , A61K31/675 , A61P1/12 , A61P35/00 , A61K31/045 , A61K31/16
CPC分类号： A61K31/475 , A61K31/198 , A61K31/505 , A61K31/675 , Y10S514/867
摘要： A pharmaceutical composition for treating diarrhea comprising an anti-diarrhea effective amount of conagenin or a salt thereof, and a pharmaceutically acceptable carrier. The pharmaceutical composition is particularly useful against diarrhea caused by the administration of cancer chemotherapeutic agents.
摘要翻译： PCT No.PCT / JP95 / 02107 Sec。 371日期1997年3月27日 102（e）日期1997年3月27日PCT提交1995年10月13日PCT公布。 公开号WO96 / 11681 日期：1996年04月25日用于治疗腹泻的药物组合物，其包含抗腹泻有效量的针对子或其盐和药学上可接受的载体。 药物组合物特别适用于通过给予癌症化学治疗剂引起的腹泻。
-
公开(公告)号：US07897169B2
公开(公告)日：2011-03-01
申请号：US10501669
申请日：2003-01-20
申请人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
发明人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
IPC分类号： A61K47/00
CPC分类号： A23G9/32 , A21D2/14 , A23C11/04 , A23C19/082 , A23D7/0056 , A23D7/015 , A23D9/007 , A23F3/163 , A23F5/243 , A23L7/111 , A23L7/122 , A23L7/13 , A23L7/165 , A23L9/12 , A23L9/22 , A23L19/03 , A23L19/14 , A23L23/00 , A23L27/60 , A23L33/10 , A23P20/11 , A23P30/40 , A23V2002/00 , C11B5/0092 , A23V2250/314
摘要： To provide a food which suitably supply ubiquinol, a substance indispensable to the living body but is liable to be decreased and fall short of the requirements, through ingestion in the same ways as the ordinary foods in daily living. A ubiquinol-enriched oil/fat-containing food.
摘要翻译： 提供适当地提供泛醌的食物，其通过以与日常生活中的普通食物相同的方式摄取，这是生物体不可缺少但易于降低并且不符合要求的物质。 富含ubiquinol的含油/脂肪的食物。
-
公开(公告)号：US20050181109A1
公开(公告)日：2005-08-18
申请号：US10501685
申请日：2003-01-20
CPC分类号： A23G1/30 , A21D2/14 , A23D7/011 , A23D7/013 , A23D9/007 , A23G1/426 , A23L33/10 , A23V2002/00 , C11B5/0021 , A23V2250/314 , A23V2250/194
摘要： To provide a ubiquinone supplementation food which is obtained by adding a composition containing ubiquinone and an oil/fat; an edible oil/fat composition which contains ubiquinone; a process for producing a ubiquinone supplementation food which comprises dissolving ubiquinone in an oil/fat under heating, and adding the obtained mixture to a food material; a method for preventing precipitation and/or localization of ubiquinone in a food which comprises producing a food by dissolving ubiquinone in an oil/fat under heating and adding the obtained mixture to a food material; and a method for supplying ubiquinone which comprises ingesting said foods.
摘要翻译： 提供通过添加含有泛醌和油/脂肪的组合物获得的泛醌补充食物; 含有泛醌的食用油/脂肪组合物; 一种生产泛醌补充食品的方法，其包括在加热下将泛醌溶解在油/脂中，并将所得混合物加入到食物中; 一种防止泛醌在食物中的沉淀和/或定位的方法，其包括通过在加热下将泛醌溶解在油/脂中并将所得混合物加入到食物中来生产食物; 以及提供泛醌的方法，其包括摄取所述食物。
-
公开(公告)号：US4123329A
公开(公告)日：1978-10-31
申请号：US801083
申请日：1977-05-27
CPC分类号： C12P13/08 , Y10S435/872
摘要： A process for producing L-lysine by fermentation, comprising the steps of aerobically cultivating a strain having the ability to produce L-lysine and derived from Nocardia alkanoglutinousa No. 223, in a culture medium containing an assimilable carbon source and an assimilable nitrogen source, to accumulate L-lysine in the culture medium and then recovering L-lysine.
摘要翻译： 一种通过发酵生产L-赖氨酸的方法，包括在含有可同化碳源和可同化氮源的培养基中有氧培养具有产生L-赖氨酸并产自诺卡氏诺卡氏菌诺氏诺病菌223号的菌株的步骤， 在培养基中积累L-赖氨酸，然后回收L-赖氨酸。
-
公开(公告)号：US20050112266A1
公开(公告)日：2005-05-26
申请号：US10501669
申请日：2003-01-20
申请人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
发明人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
IPC分类号： A23D9/00 , A21D2/14 , A23C11/04 , A23C19/082 , A23D7/005 , A23D7/015 , A23D9/007 , A23D9/02 , A23F3/16 , A23F5/24 , A23G9/32 , A23L1/00 , A23L1/16 , A23L1/164 , A23L1/18 , A23L1/187 , A23L1/19 , A23L1/212 , A23L1/216 , A23L1/24 , A23L1/30 , A23L1/39 , A61K31/122 , C11B5/00 , A23D7/00
CPC分类号： A23G9/32 , A21D2/14 , A23C11/04 , A23C19/082 , A23D7/0056 , A23D7/015 , A23D9/007 , A23F3/163 , A23F5/243 , A23L7/111 , A23L7/122 , A23L7/13 , A23L7/165 , A23L9/12 , A23L9/22 , A23L19/03 , A23L19/14 , A23L23/00 , A23L27/60 , A23L33/10 , A23P20/11 , A23P30/40 , A23V2002/00 , C11B5/0092 , A23V2250/314
摘要： To provide a food which suitably supply ubiquinol, a substance indispensable to the living body but is liable to be decreased and fall short of the requirements, through ingestion in the same ways as the ordinary foods in daily living.
摘要翻译： 提供适当地提供泛醌的食物，其通过以与日常生活中的普通食物相同的方式摄取，这是生物体不可缺少但易于降低并且不符合要求的物质。
-
7.发明授权1-phenyl-3,5-pyrazolidinedione hydroxystyrene compounds which have tyrosine kinase inhibiting activity 失效具有酪氨酸激酶抑制活性的1-苯基-3,5-二异氰酸酯化羟基苯乙烯化合物
公开(公告)号：US5089516A
公开(公告)日：1992-02-18
申请号：US584683
申请日：1990-09-19
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： A61K31/425 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12 , A61K31/415 , C07D231/04
CPC分类号： C07D277/20 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.
-
8.发明授权
公开(公告)号：US4971996A
公开(公告)日：1990-11-20
申请号：US283992
申请日：1988-11-10
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： B21B31/16 , A61K31/26 , A61K31/27 , A61K31/275 , A61K31/34 , A61K31/425 , B21B31/02 , B21B31/20 , B21B33/00 , B21B37/18 , B21B37/72 , C07C253/30 , C07C255/34 , C07C255/41 , C07C255/44 , C07C255/53 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/32 , C07D307/33 , C07D307/52 , C07D307/58 , C07D417/12 , C09K3/00
CPC分类号： C07D277/20 , B21B31/02 , B21B31/203 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tryosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.
-
公开(公告)号：US5057538A
公开(公告)日：1991-10-15
申请号：US587147
申请日：1990-09-24
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunoro Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunoro Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： B21B31/16 , A61K31/26 , A61K31/27 , A61K31/275 , A61K31/34 , A61K31/425 , B21B31/02 , B21B31/20 , B21B33/00 , B21B37/18 , B21B37/72 , C07C253/30 , C07C255/34 , C07C255/41 , C07C255/44 , C07C255/53 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/32 , C07D307/33 , C07D307/52 , C07D307/58 , C07D417/12 , C09K3/00 , C07C121/75
CPC分类号： C07D277/20 , B21B31/02 , B21B31/203 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## Wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sub.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O--(R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 --(Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxybenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.
-
公开(公告)号：US4981796A
公开(公告)日：1991-01-01
申请号：US275200
申请日：1988-11-23
CPC分类号： C12P7/18 , C12P41/00 , Y10S435/911 , Y10S435/921 , Y10S435/938
摘要： A process of manufacturing optically active (S)-1,2-diols, wherein (R)-1,2-diols represented by the general formula [I] ##STR1## (where: R represents a substituted or unsubstituted alkyl group, alkenyl group, aryl group or aralkyl group) or a mixture of diols of the general formula [I] and (S)-1,2-diols represented by the general formula [II] ##STR2## (Where: R represents the same as above) having an opposite configuration to the general formula [I] is subjected to the action of a microorganism capable of selectively metabolizing the diols of the general formula [I], or capable of converting the diols of the general formula [I] into the diols of the general formula [II], or having the both capabilities, and the formed and accumulated (S)-1,2-diols of the general formula [II] is collected. According to the present invention, optically active (S)-1,2-diols can be produced commercially and advantageously.
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.032 秒)