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35 条记录 (耗时 0.025 秒)

    Protected amino acids or peptides
    5.
    发明授权
    Protected amino acids or peptides 失效
    受保护的氨基酸或肽

    公开(公告)号：US4159979A

    公开(公告)日：1979-07-03

    申请号：US897640

    申请日：1978-04-18

    申请人： Masahiko Fujino ,  Tsunehiko Fukuda ,  Chieko Kitada

    发明人： Masahiko Fujino ,  Tsunehiko Fukuda ,  Chieko Kitada

    IPC分类号： C07K1/06 ,  C07C67/00 ,  C07C301/00 ,  C07C303/38 ,  C07C309/81 ,  C07C311/13 ,  C07C103/52

    CPC分类号： C07C309/81 ,  Y02P20/55 ,  Y10S930/18

    摘要： In an amino acid having .omega.-amino group protected with a protective group or a peptide having the residue of such a protected amino acid, the improvement according to which the protective group is p-methylbenzylsulfonyl group. The .omega.-amino acids protected with p-methylbenzylsulfonyl or the peptides having residues of such protected amino acids are useful for production of various peptides by liquid phase method as well as by solid-phase method, because the protective group has specific selectivity of remaining stable under the conditions commonly employed in the removal of .alpha.-aminoprotecting group but is cleaved smoothly in a good yield by hydrogen fluoride without exerting untoward unfluences upon peptides.

    摘要翻译： 在用保护基保护的ω-氨基的氨基酸或具有这种被保护的氨基酸残基的肽中，保护基是对甲基苄基磺酰基的改进。 用对甲基苄基磺酰基保护的ω-氨基酸或具有这种保护氨基酸残基的肽可用于通过液相法和固相法生产各种肽，因为保护基具有保持稳定的特异选择性 在通常用于除去α-氨基保护基团的条件下，但是通过氟化氢以良好的产率平滑地切割，而不会对肽起不利影响。

    Tetrapeptidehydrazide derivatives
    6.
    发明授权
    Tetrapeptidehydrazide derivatives 失效
    四肽酰肼衍生物

    公开(公告)号：US4277394A

    公开(公告)日：1981-07-07

    申请号：US90021

    申请日：1979-10-31

    申请人： Masahiko Fujino ,  Susumu Shinagawa ,  Kiyohisa Kawai

    发明人： Masahiko Fujino ,  Susumu Shinagawa ,  Kiyohisa Kawai

    IPC分类号： C07K5/107 ,  C07C103/52 ,  A61K37/00 ,  C07G7/00

    CPC分类号： C07K5/1016 ,  Y10S514/809

    摘要： Novel tetrapeptidehydrazide derivatives, inclusive of a pharmacologically acceptable acid addition salt thereof, which has the general formula (I): ##STR1## [wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen or the side chain of a D-.alpha.-amino acid; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, or a saturated or unsaturated and straight or branched lower aliphatic acyl group which may optionally be substituted by hydroxy, amino, lower alkoxy, halogen, oxo, lower alkylthio or lower alkylthiooxide], are useful as analgesics.

    摘要翻译： 具有通式（I）的新型四肽酰肼衍生物，包括其药理学上可接受的酸加成盐：其中R 1是氢或低级烷基; R2是氢或D-α-氨基酸的侧链; R3是氢或低级烷基; R4是氢或可以被羟基，氨基，低级烷氧基，卤素，氧代，低级烷硫基或低级烷硫基氧化物任选取代的饱和或不饱和的直链或支链低级脂族酰基）可用作止痛剂。

    Reduction of chemically modified proteins
    7.
    发明授权
    Reduction of chemically modified proteins 失效
    减少化学修饰的蛋白质

    公开(公告)号：US5109120A

    公开(公告)日：1992-04-28

    申请号：US364707

    申请日：1989-06-09

    申请人： Hayao Ueno ,  Masahiko Fujino

    发明人： Hayao Ueno ,  Masahiko Fujino

    IPC分类号： A61K38/00 ,  C07C67/00 ,  C07C241/00 ,  C07C251/08 ,  C07K1/00 ,  C07K1/107 ,  C07K1/113 ,  C07K14/00 ,  C07K14/195 ,  C07K14/41 ,  C07K14/52 ,  C07K14/54 ,  C07K14/55 ,  C07K14/555 ,  C07K14/56 ,  C07K14/57 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19

    CPC分类号： C07K14/55 ,  C07K1/1077 ,  C07K14/555 ,  C07K14/56 ,  A61K38/00

    摘要： The invention provides chemically modified proteins having a group of the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer 1 to 4, the group being bonded to at least one primary amino group of the protein, and a method of producing the same. The chemically modified proteins according to the invention can be produced by reacting a protein with an imidoester of the formula: ##STR2## wherein R, n and m are as defined above, R' represents a group constituting an imidoester with an adjacent imidoyl group. The chemically modified proteins according to the invention are useful as drugs, among others.

    摘要翻译： 本发明提供具有下式基团的化学修饰的蛋白质：其中R表示氢原子或低级烷基，m表示任选的正整数，n表示1至4的整数，该基团与至少一个 该蛋白质的伯氨基及其制备方法。 根据本发明的化学修饰的蛋白质可以通过使蛋白质与下式的亚胺酯反应来制备：其中R，n和m如上定义，R'代表构成具有相邻亚氨基的亚氨基酯基团。 根据本发明的化学修饰的蛋白质可用作药物等。

    Novel polypeptides
    8.
    发明授权
    Novel polypeptides 失效
    新型多肽

    公开(公告)号：US4073890A

    公开(公告)日：1978-02-14

    申请号：US726052

    申请日：1976-09-23

    申请人： Masahiko Fujino ,  Mitsuhiro Wakimasu ,  Shigehisa Taketomi ,  Eiichiro Ishikawa

    发明人： Masahiko Fujino ,  Mitsuhiro Wakimasu ,  Shigehisa Taketomi ,  Eiichiro Ishikawa

    IPC分类号： A61K38/00 ,  C07K5/087 ,  C07K5/11 ,  C07K14/62 ,  A61K37/00 ,  C07C103/52

    CPC分类号： C07K5/1019 ,  C07K14/62 ,  C07K5/0812 ,  A61K38/00

    摘要： Novel polypeptides of the formulaR.sub.1 --Arg--R.sub.2 --Phe--Phe--R.sub.3wherein R.sub.1 is hydrogen, or a basic or neutral amino acid residue, R.sub.2 is a neutral amino acid residue and R.sub.3 is NH.sub.2, Tyr--NH.sub.2, a residue of tyrosyl peptides consisting of 1 to 5 amino acid residues or amides of the tyrosyl peptides, provided that when R.sub.1 is hydrogen, R.sub.2 is Pro, are effectively used for treatment of insufficiency of carbohydrate metabolism and of lipid metabolism, especially for the treatment of diabetes by not only parenteral administration but also oral administration.

    摘要翻译： 式R1-Arg-R2-Phe-Phe-R3的新型多肽，其中R1是氢，或碱性或中性氨基酸残基，R2是中性氨基酸残基，R3是NH2，Tyr-NH2，酪氨酰基的残基 由酪氨酰肽的1至5个氨基酸残基或酰胺组成的肽，条件是当R1为氢时，R2为Pro，可有效用于治疗碳水化合物代谢和脂质代谢不足，特别是用于治疗糖尿病 只有肠胃外给药，而且口服。