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1.发明申请Composition for restoring damaged skin comprising a saccaride and povidone-iodine 审中-公开用于恢复损伤皮肤的组合物，其包含骶骨和聚维酮碘公开(公告)号：US20090317354A1
公开(公告)日：2009-12-24
申请号：US12583729
申请日：2009-08-25
摘要： The present invention relates to a composition for repairing injured skin containing a saccharide and povidone-iodine. The present invention has the following characteristics: suppresses time-dependent increase of consistency, it is easy to use, it is a soft preparation, and has superior applicability to a deep wounded lesion and a granulation tissue. The composition of the present invention contains 50 to 90% by weight of saccharide, 0.5 to 10% by weight of povidone-iodine, 0.1 to 20% by weight of water and 0.01 to 10% by weight of phospholipid.
摘要翻译： 本发明涉及用于修复含有糖和聚维酮碘的受伤皮肤的组合物。 本发明具有以下特征：抑制时间依赖性增加，易于使用，是一种柔软的制剂，对深部伤口和肉芽组织具有优异的适用性。 本发明的组合物含有50〜90重量％的糖类，0.5〜10重量％的聚维酮碘，0.1〜20重量％的水和0.01〜10重量％的磷脂。
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公开(公告)号：US20060034945A1
公开(公告)日：2006-02-16
申请号：US10533659
申请日：2003-11-10
IPC分类号： A61K33/36 , A61K31/685 , A61K31/7012
摘要： The present invention provides a composition for repairing injured skin containing saccharide and povidone-iodine of the present invention having characteristices of suppressing time-dependent increase of consistency, easy to use, soft preparation, and superior applicability to a deep wounded lesion and a granulation tissue. The composition for repairing injured skin comprises 50 to 90% by weight of saccharide, 0.5 to 10% by weight of povidone-iodine, 0.1 to 20% by weight of water and 0.01 to 10% by weight of phospholipid.
摘要翻译： 本发明提供了本发明的含有糖和聚维酮碘的损伤皮肤的修复组合物，其具有抑制时间依赖性增加的一致性，易于使用，软制剂，以及对深部伤口和肉芽组织的适用性的特征 。 用于修复受伤皮肤的组合物包含50至90重量％的糖，0.5至10重量％的聚维酮碘，0.1至20重量％的水和0.01至10重量％的磷脂。
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3.发明授权公开(公告)号：US08105630B2
公开(公告)日：2012-01-31
申请号：US10554921
申请日：2004-04-28
申请人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Toshio Inagi , Hirofumi Takeuchi , Tsutomu Kajino , Yoshiaki Fukushima , Haruo Takahashi
发明人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Toshio Inagi , Hirofumi Takeuchi , Tsutomu Kajino , Yoshiaki Fukushima , Haruo Takahashi
CPC分类号： A61K31/50 , A61K9/1611 , A61K9/1694 , A61K9/2077 , Y10S977/906
摘要： A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2θ) corresponding to a d value of at least 1 nm.The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.
摘要翻译： 通过用超临界流体或二临界流体二氧化碳处理包含多孔二氧化硅材料和极难水溶性药物的混合物获得的组合物，其含有极差水溶性药物， 及其生产工艺。 多孔二氧化硅材料的平均孔径在1至20nm的范围内，直径在平均孔径的±40％范围内的孔占多孔二氧化硅材料的总孔体积的至少60％，并且在 X射线衍射法，多孔二氧化硅材料在与至少1nm的ad值相对应的衍射角（2θ）处具有至少一个峰。 含有极差水溶性药物的本发明组合物，极难溶于水的药物溶解性优异。
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公开(公告)号：US06582720B1
公开(公告)日：2003-06-24
申请号：US09600885
申请日：2000-09-07
IPC分类号： A61F1300
CPC分类号： A61K9/0065 , A61K9/5026
摘要： The present invention provides a gastric and/or duodenal adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach and/or duodenum and one or more of ingredients selected from water insoluble polymers, polyglycerin fatty acid esters, lipids and waxes, with a polymer having adhesive capacity onto the surface of the mucosa of a digestive tract under acid conditions and separates from the mucosa of the digestive tract in neutral or alkaline conditions. This composition adheres only to the mucosa of the stomach and/or duodenum and releases the medicament over long hours so that sufficient effects are available by a small amount of the medicament.
摘要翻译： 本发明提供通过包衣组合物获得的胃和/或十二指肠粘合剂药物组合物，所述组合物包含在胃和/或十二指肠作用的药物和一种或多种选自水不溶性聚合物，聚甘油脂肪酸酯，脂质和 蜡，具有粘合能力的聚合物在酸性条件下在消化道粘膜的表面上，并在中性或碱性条件下与消化道粘膜分离。 该组合物仅粘附到胃和/或十二指肠的粘膜上并在长时间内释放药物，以便通过少量药物获得足够的效果。
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公开(公告)号：US4309414A
公开(公告)日：1982-01-05
申请号：US87574
申请日：1979-10-23
申请人： Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
发明人： Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
CPC分类号： A61K47/38 , A61K31/405 , A61K47/18 , A61K47/32 , A61K9/0014
摘要： An antiinflammatory analgesic gelled ointment is disclosed which comprises indomethacin, a medium consisting of a glycol, alcohol and water, a gelling agent selected from cellulose and a carboxyvinyl polymer which has been neutralized with an amine, and water sufficiently enough to make up the balance. Such gelled ointment has an excellent antiinflammatory activity.
摘要翻译： 公开了一种消炎止痛凝胶软膏，其包含吲哚美辛，由二醇，醇和水组成的培养基，选自纤维素和已用胺中和的羧基乙烯基聚合物的胶凝剂，以及足够足以构成平衡的水。 这种凝胶软膏具有优异的抗炎活性。
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公开(公告)号：US20120328675A1
公开(公告)日：2012-12-27
申请号：US13582689
申请日：2011-03-03
申请人： Tsutomu Awamura , Hisanobu Nishikawa , Kazuhiko Kokaji , Akihiro Ishise , Takayuki Arai , Seiji Miura , Toshio Inagi
发明人： Tsutomu Awamura , Hisanobu Nishikawa , Kazuhiko Kokaji , Akihiro Ishise , Takayuki Arai , Seiji Miura , Toshio Inagi
IPC分类号： A61K9/00 , A61P1/12 , A61K31/426 , A61P29/00 , A61K31/47 , A61P3/06 , A61K31/451 , A61K31/192
CPC分类号： A61K31/045 , A61K9/006
摘要： Provided is a film preparation in which an unpleasant taste derived from a medicament is masked. The film preparation includes coating layers containing no terpene formed on both sides of a medicament-containing layer containing a medicament having an unpleasant taste and a terpene.
摘要翻译： 提供了一种其中掩盖衍生自药物的不愉快味道的膜制剂。 膜制剂包括不含萜烯的包衣层，其含有含有不愉快味道的药物和萜烯的药物含有层的两侧。
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7.发明申请公开(公告)号：US20110034859A1
公开(公告)日：2011-02-10
申请号：US12988047
申请日：2009-04-17
申请人： Kenichi Suzuki , Makoto Kanebako , Toshio Inagi
发明人： Kenichi Suzuki , Makoto Kanebako , Toshio Inagi
CPC分类号： A61K45/06 , A61K9/0009 , A61K9/0041 , A61K31/555 , A61K31/675 , A61K33/24 , A61N1/044 , A61N1/0448 , A61K2300/00
摘要： Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis.An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.
摘要翻译： 提供用于治疗乳腺癌或乳腺炎的离子电渗疗法的治疗效果。 一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法制剂，其包含作为活性成分的非甾体抗炎止痛剂和/或抗癌剂，其中电解质通过乳头部分局部施用到乳腺中; 随后，将供体施加到乳头部分; 并且活性成分通过施加电流通过乳头部分局部施用到乳腺中。
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8.发明申请公开(公告)号：US20060293327A1
公开(公告)日：2006-12-28
申请号：US10554921
申请日：2004-04-28
申请人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Toshio Inagi , Hirofumi Takeuichi , Tsutomu Kajino , Yoshiaki Fukushima , Haruo Takahashi
发明人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Toshio Inagi , Hirofumi Takeuichi , Tsutomu Kajino , Yoshiaki Fukushima , Haruo Takahashi
CPC分类号： A61K31/50 , A61K9/1611 , A61K9/1694 , A61K9/2077 , Y10S977/906
摘要： A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2θ) corresponding to a d value of at least 1 nm. The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.
摘要翻译： 通过用超临界流体或二临界流体二氧化碳处理包含多孔二氧化硅材料和极难水溶性药物的混合物获得的组合物，其含有极差的水溶性药物， 及其生产工艺。 多孔二氧化硅材料的平均孔径在1至20nm的范围内，直径在平均孔径的±40％范围内的孔占多孔二氧化硅材料的总孔体积的至少60％，并且在 X射线衍射法，多孔二氧化硅材料在衍射角（2θ）的至少1nm的ad值处具有至少一个峰。 含有极差水溶性药物的本发明组合物，极难溶于水的药物溶解性优异。
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公开(公告)号：US4525347A
公开(公告)日：1985-06-25
申请号：US468491
申请日：1983-02-22
申请人： Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
发明人： Toshio Inagi , Toyojiro Muramatsu , Hidetaka Nagai
CPC分类号： A61K31/405 , A61K47/18 , A61K47/32 , A61K47/38 , A61K9/0014
摘要： An antiinflammatory analgesic ointment comprising: (a) an antiinflammatory amount of indomethacin; (b) a medium consisting of a hydroxy compound in the range of from 15 to 85% by weight, water in the range of 30 to 55% by weight and a gelating agent being present in an amount sufficient to effect gelation of said ointment and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia or an amine; (c) an adjuvant being present in the range of from 0.5 to 5% by weight and selected from the group consisting of a C.sub.1 -C.sub.5 alcohol ester of a C.sub.4 -C.sub.14 monocarboxylic acid and a C.sub.1 -C.sub.3 alcohol diester of a C.sub.4 -C.sub.10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of the ointment, said ointment being adjusted in its pH from an acidic to slightly basic level sufficient to solubilize said indomethacin in the composition but not too basic a pH level to cause decomposition of said indomethacin.
摘要翻译： 一种抗炎止痛软膏，其包含：（a）抗炎剂量的吲哚美辛; （b）由15至85重量％的羟基化合物，30至55重量％的水和80至55重量％的水，和足以使所述软膏发生凝胶化的量的凝胶剂， 选自纤维素化合物和已经用氨水或胺中和的羧基乙烯基聚合物; （c）佐剂以0.5-5重量％的范围存在，并且选自C 4 -C 14单羧酸的C 1 -C 5醇酯和C 4 -C 10的C 1 -C 3醇二酯 二羧酸 和（d）足以构成软膏平衡的量的水，所述软膏的pH值从酸性至碱性水平调节至足以将所述吲哚美辛溶解于组合物中，但不过多碱性的pH值导致分解 的所述吲哚美辛。
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10.发明授权公开(公告)号：US08101207B2
公开(公告)日：2012-01-24
申请号：US10551901
申请日：2004-04-28
申请人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
发明人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
CPC分类号： A61K31/50 , A61K9/1611 , A61K9/1694 , A61K9/2009 , A61K9/2095
摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition.The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.
摘要翻译： 含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料 该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上 的材料，当进行X射线衍射测定时，该材料在对应于d的衍射角（2θ）为1nm以上）表现出一个以上的峰值。 以及该组合物的制造方法。 本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。
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