公开(公告)号：US08221990B2

公开(公告)日：2012-07-17

申请号：US12257351

申请日：2008-10-23

申请人： Masatomo Mori ,  Hiroshi Eguchi

发明人： Masatomo Mori ,  Hiroshi Eguchi

IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/566 ,  C12Q1/02

CPC分类号： G01N33/566 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2500/10

摘要： An object of the present invention is to identify a Nesfatin-1 receptor, and to provide a method for screening or designing a Nesfatin-1-action regulating substance or a Nesfatin-1-like action substance using the Nesfatin-1 receptor.A method for screening a Nesfatin-1-like action substance comprising steps of making a test substance act on a receptor protein selected from the group consisting of GPR3, GPR6 and GPR12, and of identifying the Nesfatin-1-like action substance based on a change of Nesfatin-1 action.

摘要翻译： 本发明的目的是鉴定Nesfatin-1受体，并提供使用Nesfatin-1受体筛选或设计Nesfatin-1作用调节物质或Nesfatin-1样作用物质的方法。 一种筛选Nesfatin-1样作用物质的方法，包括使测试物质作用于选自GPR3，GPR6和GPR12的受体蛋白质的步骤，以及基于以下步骤鉴定Nesfatin-1样作用物质 改变Nesfatin-1的作用。

公开(公告)号：US08383119B2

公开(公告)日：2013-02-26

申请号：US12838760

申请日：2010-07-19

申请人： Masatomo Mori ,  Hiroyuki Shimizu ,  Hiroshi Eguchi ,  Masanori Yamamoto

发明人： Masatomo Mori ,  Hiroyuki Shimizu ,  Hiroshi Eguchi ,  Masanori Yamamoto

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K38/17 ,  C07K16/18 ,  C07K16/26

CPC分类号： C12Q1/6883 ,  A01K67/027 ,  A01K2227/105 ,  A01K2267/035 ,  C07K14/4702 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N2800/02 ,  G01N2800/044

摘要： The present invention relates to a novel method of obtaining a factor involved in appetite control and/or body weight control, as well as genes obtained by said method, polypeptides encoded by said genes, or novel polypeptides obtained from the information on polypeptides encoded by said genes as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control. Also the present invention relates to substances that inhibit the effects of said genes or said polypeptides as a means for treating, controlling or diagnosing diseases associated with appetite control and/or body weight control. By using thiazolidine diones having a PPAR γ agonist activity, genes and polypeptides involved in appetite regulation and/or body weight reduction can be obtained. NESFATIN or the like obtained by said method can be used as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control.

摘要翻译： 本发明涉及一种获得涉及食欲控制和/或体重控制的因子的新方法，以及通过所述方法获得的基因，由所述基因编码的多肽或从由所述基因编码的多肽编码的信息获得的新多肽 基因作为治疗，控制或诊断与进食障碍和/或体重控制相关的疾病的手段。 本发明还涉及抑制所述基因或所述多肽作为治疗，控制或诊断与食欲控制和/或体重控制相关的疾病的手段的物质。 通过使用具有PPARγ激动剂活性的噻唑烷二酮，可以获得参与食欲调节和/或体重减轻的基因和多肽。 通过所述方法获得的NESFATIN等可以用作治疗，控制或诊断与进食障碍和/或体重控制相关的疾病的手段。

公开(公告)号：US07795390B2

公开(公告)日：2010-09-14

申请号：US11474282

申请日：2006-06-26

申请人： Masatomo Mori ,  Hiroyuki Shimizu ,  Hiroshi Eguchi ,  Masanori Yamamoto

发明人： Masatomo Mori ,  Hiroyuki Shimizu ,  Hiroshi Eguchi ,  Masanori Yamamoto

IPC分类号： C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07K14/00 ,  C07H21/02

CPC分类号： C12Q1/6883 ,  A01K67/027 ,  A01K2227/105 ,  A01K2267/035 ,  C07K14/4702 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N2800/02 ,  G01N2800/044

摘要： The present invention relates to a novel method of obtaining a factor involved in appetite control and/or body weight control, as well as genes obtained by said method, polypeptides encoded by said genes, or novel polypeptides obtained from the information on polypeptides encoded by said genes as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control. Also the present invention relates to substances that inhibit the effects of said genes or said polypeptides as a means for treating, controlling or diagnosing diseases associated with appetite control and/or body weight control. By using thiazolidine diones having a PPAR γ agonist activity, genes and polypeptides involved in appetite regulation and/or body weight reduction can be obtained. NESFATIN or the like obtained by said method can be used as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control.

摘要翻译： 本发明涉及一种获得涉及食欲控制和/或体重控制的因子的新方法，以及通过所述方法获得的基因，由所述基因编码的多肽或从由所述基因编码的多肽编码的信息获得的新多肽 基因作为治疗，控制或诊断与进食障碍和/或体重控制相关的疾病的手段。 本发明还涉及抑制所述基因或所述多肽作为治疗，控制或诊断与食欲控制和/或体重控制相关的疾病的手段的物质。 通过使用具有PPARγ激动剂活性的噻唑烷二酮，可以获得参与食欲调节和/或体重减轻的基因和多肽。 通过所述方法获得的NESFATIN等可以用作治疗，控制或诊断与进食障碍和/或体重控制相关的疾病的手段。

公开(公告)号：US20080115231A1

公开(公告)日：2008-05-15

申请号：US11474282

申请日：2006-06-26

申请人： Masatomo Mori ,  Hiroyuki Shimizu ,  Hiroshi Eguchi ,  Masanori Yamamoto

发明人： Masatomo Mori ,  Hiroyuki Shimizu ,  Hiroshi Eguchi ,  Masanori Yamamoto

IPC分类号： A01K67/027 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C12Q1/6883 ,  A01K67/027 ,  A01K2227/105 ,  A01K2267/035 ,  C07K14/4702 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N2800/02 ,  G01N2800/044

摘要： The present invention relates to a novel method of obtaining a factor involved in appetite control and/or body weight control, as well as genes obtained by said method, polypeptides encoded by said genes, or novel polypeptides obtained from the information on polypeptides encoded by said genes as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control. Also the present invention relates to substances that inhibit the effects of said genes or said polypeptides as a means for treating, controlling or diagnosing diseases associated with appetite control and/or body weight control. By using thiazolidine diones having a PPAR γ agonist activity, genes and polypeptides involved in appetite regulation and/or body weight reduction can be obtained. NESFATIN or the like obtained by said method can be used as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control.

摘要翻译： 本发明涉及一种获得涉及食欲控制和/或体重控制的因子的新方法，以及通过所述方法获得的基因，由所述基因编码的多肽或从由所述基因编码的多肽编码的信息获得的新多肽 基因作为治疗，控制或诊断与进食障碍和/或体重控制相关的疾病的手段。 本发明还涉及抑制所述基因或所述多肽作为治疗，控制或诊断与食欲控制和/或体重控制相关的疾病的手段的物质。 通过使用具有PPARγ激动剂活性的噻唑烷二酮，可以获得参与食欲调节和/或体重减轻的基因和多肽。 通过所述方法获得的NESFATIN等可以用作治疗，控制或诊断与进食障碍和/或体重控制相关的疾病的手段。

公开(公告)号：US20110110949A1

公开(公告)日：2011-05-12

申请号：US12674902

申请日：2008-08-25

申请人： Masatomo Mori ,  Hiroyuki Shimizu ,  Hiroshi Eguchi ,  Takashi Kawamura

发明人： Masatomo Mori ,  Hiroyuki Shimizu ,  Hiroshi Eguchi ,  Takashi Kawamura

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/16 ,  G01N33/566 ,  A61P3/00

CPC分类号： C07K16/26 ,  C07K16/18 ,  G01N33/566

摘要： The present application relates to an antibody performing an antigen-antibody reaction with Nesfatin-1, but not substantially performing the antigen-antibody reaction with Nesfatin and/or NucB1, and with the use of the antibody, an immunological detection method and a detection kit of Nesfatin-1, and further, an antibody performing an antigen-antibody reaction with Nesfatin, but not substantially performing the antigen-antibody reaction with NucB1, and an immunological detection method using the antibody, and a detection kit of Nesfatin comprising the antibody.

摘要翻译： 本申请涉及与Nesfatin-1进行抗原 - 抗体反应的抗体，但实质上不进行与Nesfatin和/或NucB1的抗原 - 抗体反应，并且使用抗体，免疫检测方法和检测试剂盒 的Nesfatin-1，进一步，与Nesfatin进行抗原抗体反应，但基本上不进行与NucB1的抗原 - 抗体反应的抗体，以及使用该抗体的免疫检测方法，以及含有该抗体的Nesfatin检测试剂盒。

公开(公告)号：US20080009249A1

公开(公告)日：2008-01-10

申请号：US11898050

申请日：2007-09-07

申请人： Masaru Kanazawa ,  Yoshiyuki Yamashita ,  Tabito Tonooka ,  Masatomo Mori ,  Hisamitsu Takagi

发明人： Masaru Kanazawa ,  Yoshiyuki Yamashita ,  Tabito Tonooka ,  Masatomo Mori ,  Hisamitsu Takagi

IPC分类号： H01Q1/24

CPC分类号： H01Q13/10 ,  H01Q1/243 ,  H01Q1/244 ,  H04M1/0214 ,  H04M1/0216

摘要： A folding type portable radio machine, includes a chassis part formed by a first chassis and a second chassis, the second chassis being foldably connected to the first chassis. The chassis part includes a conductive part having conductivity whose full length is an approximately half wave length (λ/2) of a using frequency of the radio machine, and an electric notch.

摘要翻译： 一种折叠型便携式无线电机器，包括由第一机架和第二机架形成的底盘部分，第二机架可折叠地连接到第一机架。 底盘部分包括具有导电性的导电部件，其全长为无线电机器的使用频率的大约1/2波长（λ/ 2）和电切口。

公开(公告)号：US06230564B1

公开(公告)日：2001-05-15

申请号：US09367312

申请日：1999-08-11

申请人： Tadao Matsunaga ,  Takashi Kunimi ,  Masahiro Nezu ,  Masatomo Mori ,  Masayoshi Esashi

发明人： Tadao Matsunaga ,  Takashi Kunimi ,  Masahiro Nezu ,  Masatomo Mori ,  Masayoshi Esashi

IPC分类号： G01P1500

CPC分类号： H01H35/142 ,  G01P15/0802 ,  G01P15/135 ,  H01H1/0015 ,  H01H1/0036

摘要： The invention provides a semiconductor acceleration sensor which is small in size, light in weight, simple in manufacture, low in manufacturing cost, and high in accuracy, and which, with a switch-on time set to a predetermined value, is stable in operation. In a semiconductor acceleration sensor in which a central board 1 having a central contact section 11, and outside boards 2 at least one of which has an outside contact section 21 are stacked; the central board 1 has a weight 12 near the central contact section 11, and the outside board 2 having the outside contact section 21 has a weight confronting section 11 which confronts with the weight 12, for squeezed damping effect.

摘要翻译： 本发明提供一种尺寸小，重量轻，制造简单，制造成本低，精度高的半导体加速度传感器，其接通时间设定为规定值，操作稳定 在具有中央接触部11的中央板1和至少其中一个具有外部接触部21的外部板2的半导体加速度传感器中， 中心板1在中心接触部分11附近具有重物12，具有外接触部分21的外板2具有与重物12相对的重量面对部分11，用于挤压阻尼作用。

公开(公告)号：US6153917A

公开(公告)日：2000-11-28

申请号：US270659

申请日：1999-03-16

申请人： Tadao Matsunaga ,  Takashi Kunimi ,  Masahiro Nezu ,  Masatomo Mori ,  Masayoshi Esashi

发明人： Tadao Matsunaga ,  Takashi Kunimi ,  Masahiro Nezu ,  Masatomo Mori ,  Masayoshi Esashi

IPC分类号： G01P15/08 ,  G01P15/125 ,  H01L29/84 ,  H01L21/283

CPC分类号： G01P15/0802 ,  G01P15/125 ,  G01P2015/0828

摘要： A semiconductor acceleration sensor including a central board having a movable electrode section, an outside board having a stationary electrode section, and a sealing insulating section for joining the central board and the outside board which are laminated on each other, wherein the sealing insulating section has a conductive layer, and the conductive layer is a sealing member or an anodic bonding electrode.

摘要翻译： 一种半导体加速度传感器，包括具有可动电极部分的中心板，具有固定电极部分的外部板和用于接合中心板和外部板的彼此层压的密封绝缘部分，其中密封绝缘部分具有 导电层，并且导电层是密封构件或阳极接合电极。

公开(公告)号：US08165623B2

公开(公告)日：2012-04-24

申请号：US12405540

申请日：2009-03-17

申请人： Masaru Kanazawa ,  Tabito Tonooka ,  Masatomo Mori

发明人： Masaru Kanazawa ,  Tabito Tonooka ,  Masatomo Mori

IPC分类号： H04M1/00 ,  G08B1/08

CPC分类号： H04B17/23

摘要： A radio communication device that outputs an alarm when a reception level of a radio wave from a wireless unit is less than a threshold value, includes a reception level measuring section for measuring the reception level of the radio wave transmitted from the wireless unit at certain times. A threshold value setting section for setting a first threshold value or a second threshold value less than the first threshold value based on a difference between the reception level of the radio wave measured a previous time and the reception level of the radio wave measured a subsequent time. An alarm output requesting section for causing an alarm output section to output an alarm if the reception level of the radio wave measured a subsequent time is less than the first threshold value or the second threshold value.

摘要翻译： 一种无线电通信装置，当来自无线单元的无线电波的接收电平小于阈值时，输出警报，包括接收电平测量部分，用于测量在某些时间从无线单元发送的无线电波的接收电平 。 一个阈值设定部分，用于根据前一时间测得的无线电波的接收电平与随后的时间测得的无线电波的接收电平之间的差值来设定小于第一阈值的第一阈值或第二阈值 。 一个报警输出请求部分，用于使报警输出部分在下一次测量的无线电波的接收电平小于第一阈值或第二阈值时输出报警。

公开(公告)号：US06353782B1

公开(公告)日：2002-03-05

申请号：US09323930

申请日：1999-06-02

申请人： Takashi Kunimi ,  Masahiro Nezu ,  Masatomo Mori ,  Kazuya Kato

发明人： Takashi Kunimi ,  Masahiro Nezu ,  Masatomo Mori ,  Kazuya Kato

IPC分类号： B60R2132

CPC分类号： B60R21/0132 ,  B60R2021/0009 ,  B60R2021/01027 ,  Y10T307/799

摘要： To improve a response rate and an impact detection precision of an auxiliary acceleration sensor device for an air bag system, an auxiliary acceleration sensor device includes a longitudinal G sensor for sensing a longitudinal acceleration G of a vehicle, and lateral G sensor for sensing a lateral acceleration G of the vehicle. The longitudinal G sensor includes a constant current source circuit, a detector portion for outputting an electrical signal representative of a longitudinal acceleration G, and an amplifier portion for amplifying the signal received from the detecting portion. The comparator includes comparing elements that compare the voltage values corresponding to longitudinal threshold values Tf1 to Tf4 of the longitudinal acceleration G with an output signal of the amplifier portion. Lateral G sensor includes a constant current source circuit, a detector portion for outputting an electrical signal representative of a lateral acceleration G, and an amplifier portion for amplifying the signal received from the detecting portion. Comparator means includes comparing elements which compare the voltages corresponding to lateral threshold values Ts1 to Ts4 of the lateral acceleration G with the output signal of the amplifier portion. An OR circuit coupled for reception with the comparator means outputs a signal to a main controller of an air bag control system when predetermined conditions are satisfied.

摘要翻译： 为了提高用于气囊系统的辅助加速度传感器装置的响应速度和冲击检测精度，辅助加速度传感器装置包括用于感测车辆的纵向加速度G的纵向G传感器和用于感测侧向 车辆的加速度G。 纵向G传感器包括恒流源电路，用于输出表示纵向加速度G的电信号的检测器部分和用于放大从检测部分接收的信号的放大器部分。 比较器包括比较与纵向加速度G的纵向阈值Tf1至Tf4相对应的电压值与放大器部分的输出信号的元件。 横向G传感器包括恒流源电路，用于输出表示横向加速度G的电信号的检测器部分和用于放大从检测部分接收的信号的放大器部分。 比较器装置包括比较与横向加速度G的横向阈值Ts1至Ts4相对应的电压与放大器部分的输出信号进行比较的元件。 与比较器装置相连接的OR电路当满足预定条件时，将信号输出到气囊控制系统的主控制器。