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公开(公告)号：US06713019B2
公开(公告)日：2004-03-30
申请号：US10106062
申请日：2002-03-27
申请人： Masatsugu Ozasa , Tatsuya Kosako
发明人： Masatsugu Ozasa , Tatsuya Kosako
IPC分类号： G01N2117
CPC分类号： G01N15/1434 , G01N33/49 , G01N33/493 , G01N2021/4707 , G01N2201/0612
摘要： A flow cytometer includes a flow cell for flowing a sample liquid in a flowing direction, to form a sample flow the sample liquid containing particles to be analyzed, a laser diode radiating a laser beam having an elliptic cross section, a beam collimating section for collimating the laser beam radiated from the laser diode, a beam spot forming section for focusing the collimated beam at the sample flow in the flow cell to form a beam spot, and a light receiving section for receiving light generated from the particles at the beam spot to detect optical information of the particles, wherein the laser diode is arranged such that a minor diameter of the elliptic section of the laser beam is parallel to the sample flow.
摘要翻译： 流式细胞仪包括用于沿流动方向流动样品液体的流动池，以形成包含待分析颗粒的样品液体的样品流，放射具有椭圆截面的激光束的激光二极管，用于准直的光束准直部分 从激光二极管辐射的激光束，用于将准直光束聚焦在流动池中的样品流处以形成束斑的束斑形成部分，以及用于接收从光束点处的粒子产生的光的光接收部分 检测颗粒的光学信息，其中激光二极管被布置成使得激光束的椭圆形部分的较小直径平行于样品流。
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公开(公告)号：US20090050821A1
公开(公告)日：2009-02-26
申请号：US11798066
申请日：2007-05-10
CPC分类号： G01N21/6486 , G01N15/1459 , G01N33/493 , G01N2015/008 , G01N2015/1493 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/117497 , Y10T436/12
摘要： An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.
摘要翻译： 公开了一种用于分析尿液中的颗粒的装置，其包括：用于将尿液样品分配到第一等分试样和第二等分试样的样品分配部分; 第一标本制备部分，用于通过混合第一染色剂和第一等分试样来制备用于测量至少包含红细胞的尿颗粒的第一样本; 第二标本制备部，用于通过混合第二染色剂和第二等分试样来制备用于测量细菌的第二样本; 以及光检测部，其包括用于向被供给的样本照射光的光源，用于检测从样本发射的散射光的散射光接收元件和用于检测从样本发出的荧光的荧光接收元件。 还公开了一种用于分析尿液中颗粒的方法。
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公开(公告)号：US08501482B2
公开(公告)日：2013-08-06
申请号：US11798066
申请日：2007-05-10
IPC分类号： G01N33/48
CPC分类号： G01N21/6486 , G01N15/1459 , G01N33/493 , G01N2015/008 , G01N2015/1493 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/117497 , Y10T436/12
摘要： An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.
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公开(公告)号：US20070269897A1
公开(公告)日：2007-11-22
申请号：US11798113
申请日：2007-05-10
申请人： Yousuke Tanaka , Takamichi Naito , Masatsugu Ozasa , Rumi Takata
发明人： Yousuke Tanaka , Takamichi Naito , Masatsugu Ozasa , Rumi Takata
IPC分类号： G01N33/48
CPC分类号： G01N33/493
摘要： An apparatus for analyzing particles in urine comprising is disclosed that includes: a measurement specimen preparing section for preparing a measurement specimen by using a urine sample and a stain reagent; an optical detecting section comprising a light source for emitting a light to the prepared measurement specimen, a forward-scattered light receiving element for detecting forward-scattered light emitted from the specimen, a side-scattered light receiving element for detecting side-scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen; and a measurement section for measuring leukocytes in urine, based on the forward-scattered light, the side-scattered light and the fluorescence detected by the optical detecting section. A method for analyzing particles in urine is also disclosed.
摘要翻译： 本发明公开了一种用于分析尿液中的颗粒的装置，包括：用于通过使用尿样和染色试剂来制备测量样本的测量样本制备部分; 一个光学检测部分，包括用于向准备的测量样本发射光的光源，用于检测从样本发射的前向散射光的前向散射光接收元件，用于检测发射的侧向散射光的侧向散射光接收元件 以及用于检测从样本发出的荧光的荧光接收元件; 以及基于前向散射光，侧向散射光和由光学检测部检测出的荧光来测量尿中的白细胞的测定部。 还公开了分析尿中颗粒的方法。
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公开(公告)号：US08675196B2
公开(公告)日：2014-03-18
申请号：US12914269
申请日：2010-10-28
申请人： Masatsugu Ozasa
发明人： Masatsugu Ozasa
CPC分类号： G01N15/147 , G01N15/1475
摘要： An analyzer comprises: a sample stream forming section for forming a sample stream including particles; a light source; an optical fiber bundle formed by a plurality of optical fibers, into which light from the light source enters, and which emits light onto the sample stream; and an imaging device for imaging a particle in the irradiated sample stream.
摘要翻译： 分析器包括：用于形成包含颗粒的样品流的样品流形成部分; 光源; 由多个光纤形成的光纤束，来自光源的光进入该光纤，并将光发射到样品流上; 以及用于对被照射样品流中的颗粒进行成像的成像装置。
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公开(公告)号：US20110127444A1
公开(公告)日：2011-06-02
申请号：US12951779
申请日：2010-11-22
CPC分类号： G01N15/1475 , G01N1/31 , G01N15/147 , G01N2015/0092 , G01N2015/1438
摘要： A particle analyzing apparatus, comprising: a flow cell which forms a specimen flow including particles; first and second light sources; an irradiation optical system which applies lights emitted from the first and second light sources so that the lights are applied to the specimen flow; a detector which detects forward scattered light, the forward scattered light being emitted from the first light and scattered by the particle in the specimen flow, and generates a signal according to the detected scattered light; a light blocking member disposed between the flow cell and the detector; a controller which obtains characteristic parameters of the particle based on the signal from the detector; and an imaging device which captures an image of the particle in the specimen flow using the light from the second light source is disclosed. Particle imaging method is also disclosed.
摘要翻译： 一种颗粒分析装置，包括：流动池，其形成包含颗粒的样品流; 第一和第二光源; 照射光学系统，其施加从第一和第二光源发射的光，使得光被施加到样本流; 检测器，其检测前向散射光，前向散射光从第一光发射并由样品流中的粒子散射，并根据检测到的散射光产生信号; 设置在所述流通池和所述检测器之间的遮光部件; 控制器，其基于来自检测器的信号获得粒子的特征参数; 并且公开了使用来自第二光源的光捕获样品流中的颗粒的图像的成像装置。 还公开了粒子成像方法。
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公开(公告)号：US06750060B2
公开(公告)日：2004-06-15
申请号：US10395272
申请日：2003-03-25
申请人： Masatsugu Ozasa , Junya Inoue , Masakazu Fukuda
发明人： Masatsugu Ozasa , Junya Inoue , Masakazu Fukuda
IPC分类号： G01N3100
CPC分类号： G01N15/1404 , G01N2015/1409 , G01N2015/1415 , Y10T436/10 , Y10T436/101666 , Y10T436/108331
摘要： A sheath liquid for use with a particle analyzer has a refractive index of 1.3340 or more at the wavelength of sodium D line at 25° C.
摘要翻译： 用于粒子分析仪的鞘液在25℃下在D线波长处的折射率为1.3340以上。
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公开(公告)号：US08772738B2
公开(公告)日：2014-07-08
申请号：US12951779
申请日：2010-11-22
CPC分类号： G01N15/1475 , G01N1/31 , G01N15/147 , G01N2015/0092 , G01N2015/1438
摘要： A particle analyzing apparatus, comprising: a flow cell which forms a specimen flow including particles; first and second light sources; an irradiation optical system which applies lights emitted from the first and second light sources so that the lights are applied to the specimen flow; a detector which detects forward scattered light, the forward scattered light being emitted from the first light and scattered by the particle in the specimen flow, and generates a signal according to the detected scattered light; a light blocking member disposed between the flow cell and the detector; a controller which obtains characteristic parameters of the particle based on the signal from the detector; and an imaging device which captures an image of the particle in the specimen flow using the light from the second light source is disclosed. Particle imaging method is also disclosed.
摘要翻译： 一种颗粒分析装置，包括：流动池，其形成包含颗粒的样品流; 第一和第二光源; 照射光学系统，其施加从第一和第二光源发射的光，使得光被施加到样本流; 检测器，其检测前向散射光，前向散射光从第一光发射并由样品流中的粒子散射，并根据检测到的散射光产生信号; 设置在所述流通池和所述检测器之间的遮光部件; 控制器，其基于来自检测器的信号获得粒子的特征参数; 并且公开了使用来自第二光源的光捕获样品流中的颗粒的图像的成像装置。 还公开了粒子成像方法。
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公开(公告)号：US08333926B2
公开(公告)日：2012-12-18
申请号：US11798113
申请日：2007-05-10
申请人： Yousuke Tanaka , Takamichi Naito , Masatsugu Ozasa , Rumi Takata
发明人： Yousuke Tanaka , Takamichi Naito , Masatsugu Ozasa , Rumi Takata
IPC分类号： G01N21/64
CPC分类号： G01N33/493
摘要： An apparatus for analyzing particles in urine comprising is disclosed that includes: a measurement specimen preparing section for preparing a measurement specimen by using a urine sample and a stain reagent; an optical detecting section comprising a light source for emitting a light to the prepared measurement specimen, a forward-scattered light receiving element for detecting forward-scattered light emitted from the specimen, a side-scattered light receiving element for detecting side-scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen; and a measurement section for measuring leukocytes in urine, based on the forward-scattered light, the side-scattered light and the fluorescence detected by the optical detecting section. A method for analyzing particles in urine is also disclosed.
摘要翻译： 本发明公开了一种用于分析尿液中的颗粒的装置，包括：用于通过使用尿样和染色试剂来制备测量样本的测量样本制备部分; 一个光学检测部分，包括用于向准备的测量样本发射光的光源，用于检测从样本发射的前向散射光的前向散射光接收元件，用于检测发射的侧向散射光的侧向散射光接收元件 以及用于检测从样本发出的荧光的荧光接收元件; 以及基于前向散射光，侧向散射光和由光学检测部检测出的荧光来测量尿中的白细胞的测定部。 还公开了分析尿中颗粒的方法。
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公开(公告)号：US20110104744A1
公开(公告)日：2011-05-05
申请号：US12914243
申请日：2010-10-28
申请人： Masatsugu Ozasa , Masaki Ishisaka , Tokihiro Kosaka , Takamichi Naito , Takeo Saitou , Shigehiro Numada
发明人： Masatsugu Ozasa , Masaki Ishisaka , Tokihiro Kosaka , Takamichi Naito , Takeo Saitou , Shigehiro Numada
CPC分类号： G01N15/1475 , G01N15/147 , G01N2015/1486
摘要： A cell analyzing apparatus, comprising: a parameter obtaining section for obtaining a characteristic parameter from a cell in a measurement sample; an imaging section for capturing an image of the cell in the measurement sample; an analyzing section for counting a cell in which the characteristic parameter meets a predetermined requirement among the cells in the measurement sample as a counting target and generating output data based on a counting result; a display section for displaying an image of the cell meeting the predetermined requirement and the output data; and an input section for receiving an instruction to specify the image displayed on the display section, wherein the analyzing section excludes a cell relevant to the specified image from the counting target and regenerates the output data is disclosed. A cell analyzing method is also disclosed.
摘要翻译： 一种电池分析装置，包括：参数获取部，用于从测量样本中的单元获得特征参数; 用于捕获测量样本中的单元的图像的成像部分; 一个分析部分，用于对特征参数满足预定要求的单元格的单元进行计数，作为计数目标并基于计数结果产生输出数据; 显示单元，用于显示满足预定要求的单元的图像和输出数据; 以及输入部分，用于接收指定显示在显示部分上的图像的指令，其中分析部分从计数目标中排除与指定图像相关的单元，并且重新生成输出数据。 还公开了细胞分析方法。
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