公开(公告)号：US20110240247A1

公开(公告)日：2011-10-06

申请号：US13160966

申请日：2011-06-15

申请人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

发明人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

IPC分类号： B22D25/02

CPC分类号： B32B3/00 ,  B22D11/007 ,  B23K20/04 ,  B23K35/22 ,  B23K35/40 ,  B23K2101/16 ,  B32B15/016 ,  C22C21/00 ,  C22F1/04 ,  Y10T428/12736 ,  Y10T428/12764 ,  Y10T428/12993

摘要： Skin material of a clad material is composed of one or more layers, each layer of the skin materials is made of a metal different from the core material in their component compositions, and at least one layer of the skin material has a cast microstructure, when the skin material is superposed on either of one or both faces of the core material.

摘要翻译： 包层材料的表皮材料由一层或多层组成，每层表层材料由其组分组成中不同于核心材料的金属制成，并且至少一层表层材料具有铸造微结构，当 表皮材料叠合在芯材的一个或两个面上。

公开(公告)号：US08091612B2

公开(公告)日：2012-01-10

申请号：US12095983

申请日：2006-12-07

申请人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

发明人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

IPC分类号： B22D11/00 ,  B22D11/12 ,  B22D11/126 ,  B22D19/16

CPC分类号： B32B3/00 ,  B22D11/007 ,  B23K20/04 ,  B23K35/22 ,  B23K35/40 ,  B23K2101/16 ,  B32B15/016 ,  C22C21/00 ,  C22F1/04 ,  Y10T428/12736 ,  Y10T428/12764 ,  Y10T428/12993

摘要： A method for manufacturing a clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material, includes a clad material preparation process where an ingot for core material is manufactured by melting and casting a metal, and an ingot for skin material is manufactured by melting and casting a different metal for skin material, without hot rolling. The ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material and the superposed material is hot-rolled to manufacture a clad material.

摘要翻译： 一种由芯材构成的复合材料和叠层在芯材的一面或两面上的一种或多种表皮材料的包覆材料的制造方法，包括：通过熔融铸造制造芯材用铸锭的复合材料制备方法 金属和用于表皮材料的锭是通过熔化和铸造用于表皮材料的不同金属而不进行热轧而制造的。 将表皮材料锭作为表皮材料叠置在用于芯材的锭的一个或两个面的预定位置，并且叠加的材料被热轧以制造包覆材料。

公开(公告)号：US08381797B2

公开(公告)日：2013-02-26

申请号：US13160966

申请日：2011-06-15

申请人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

发明人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

IPC分类号： B22D11/00 ,  B22D11/12 ,  B22D19/16

CPC分类号： B32B3/00 ,  B22D11/007 ,  B23K20/04 ,  B23K35/22 ,  B23K35/40 ,  B23K2101/16 ,  B32B15/016 ,  C22C21/00 ,  C22F1/04 ,  Y10T428/12736 ,  Y10T428/12764 ,  Y10T428/12993

摘要： Skin material of a clad material is composed of one or more layers, each layer of the skin materials is made of a metal different from the core material in their component compositions, and at least one layer of the skin material has a cast microstructure, when the skin material is superposed on either of one or both faces of the core material.

摘要翻译： 包层材料的表皮材料由一层或多层组成，每层表层材料由其组分组成中不同于核心材料的金属制成，并且至少一层表层材料具有铸造微结构，当 表皮材料叠合在芯材的一个或两个面上。

公开(公告)号：US08191609B2

公开(公告)日：2012-06-05

申请号：US13239540

申请日：2011-09-22

申请人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

发明人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

IPC分类号： B22D11/00 ,  B22D11/12 ,  B22D19/16

CPC分类号： B32B3/00 ,  B22D11/007 ,  B23K20/04 ,  B23K35/22 ,  B23K35/40 ,  B23K2101/16 ,  B32B15/016 ,  C22C21/00 ,  C22F1/04 ,  Y10T428/12736 ,  Y10T428/12764 ,  Y10T428/12993

摘要： A method for manufacturing a clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material, includes a clad material preparation process where an ingot for core material is manufactured by dissolving and casting a metal, and an ingot for skin material is manufactured by dissolving and casting a different metal for skin material, without hot rolling. The ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material and the superposed material is hot-rolled to manufacture a clad material.

摘要翻译： 一种由核心材料和一个或多个重叠在芯材的一个或两个表面上的表皮材料构成的包层材料的制造方法包括包覆材料制备方法，其中通过溶解和铸造制造芯材料锭 通过在不进行热轧的情况下将表皮材料的不同金属溶解并铸造而制造用于表皮材料的金属和锭料。 将表皮材料锭作为表皮材料叠置在用于芯材的锭的一个或两个面的预定位置，并且叠加的材料被热轧以制造包覆材料。

公开(公告)号：US08210237B2

公开(公告)日：2012-07-03

申请号：US13160884

申请日：2011-06-15

申请人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

发明人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

IPC分类号： B22D11/00 ,  B22D11/12 ,  B22D11/126 ,  B22D19/16

CPC分类号： B32B3/00 ,  B22D11/007 ,  B23K20/04 ,  B23K35/22 ,  B23K35/40 ,  B23K2101/16 ,  B32B15/016 ,  C22C21/00 ,  C22F1/04 ,  Y10T428/12736 ,  Y10T428/12764 ,  Y10T428/12993

摘要： Equipment for manufacturing skin material of a clad material includes a casting apparatus which melts and mixes a metal for the skin material different from the core material in their component compositions, and casts the skin material; an ingot-cutting apparatus which cuts an ingot for skin material which is cast by the casting apparatus; and a conveying apparatus which conveys the ingot for skin material among each apparatus. The ingot-cutting apparatus is a slicing apparatus which slices the ingot for skin material into a predetermined thickness.

摘要翻译： 用于制造包层材料的表皮材料的设备包括：熔融并混合其组分组成中与芯材不同的表皮材料的金属的铸造设备，并浇铸表皮材料; 切割装置，切割由铸造装置铸造的表皮材料的锭料; 以及在每个装置中输送用于表皮材料的锭的输送装置。 锭切割装置是将用于皮肤材料的锭切成预定厚度的切片装置。

公开(公告)号：US20120018497A1

公开(公告)日：2012-01-26

申请号：US13239540

申请日：2011-09-22

申请人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

发明人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

IPC分类号： B23K31/02 ,  B23K20/02

CPC分类号： B32B3/00 ,  B22D11/007 ,  B23K20/04 ,  B23K35/22 ,  B23K35/40 ,  B23K2101/16 ,  B32B15/016 ,  C22C21/00 ,  C22F1/04 ,  Y10T428/12736 ,  Y10T428/12764 ,  Y10T428/12993

摘要： A method for manufacturing a clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material, includes a clad material preparation process where an ingot for core material is manufactured by dissolving and casting a metal, and an ingot for skin material is manufactured by dissolving and casting a different metal for skin material, without hot rolling. The ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material and the superposed material is hot-rolled to manufacture a clad material.

摘要翻译： 一种由核心材料和一个或多个重叠在芯材的一个或两个表面上的表皮材料构成的包层材料的制造方法包括包覆材料制备方法，其中通过溶解和铸造制造芯材料锭 通过在不进行热轧的情况下将表皮材料的不同金属溶解并铸造而制造用于表皮材料的金属和锭料。 将表皮材料锭作为表皮材料叠置在用于芯材的锭的一个或两个面的预定位置，并且叠加的材料被热轧以制造包覆材料。

公开(公告)号：US20090130481A1

公开(公告)日：2009-05-21

申请号：US12095983

申请日：2006-12-07

申请人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

发明人： Masayuki Takada ,  Yasuhiro Nishioka ,  Tomohiro Nishimura ,  Kenji Tokuda ,  Toshiki Ueda ,  Makoto Morishita ,  Takashi Inaba ,  Akihiro Tsuruno ,  Yoshinori Kato ,  Fumihiro Koshigoe ,  Masaki Tanigawa ,  Naoki Sakashita ,  Kenji Harada ,  Jitsuto Shikata ,  Masanori Ikeda

IPC分类号： B32B15/01 ,  B22D25/00 ,  B22D45/00

CPC分类号： B32B3/00 ,  B22D11/007 ,  B23K20/04 ,  B23K35/22 ,  B23K35/40 ,  B23K2101/16 ,  B32B15/016 ,  C22C21/00 ,  C22F1/04 ,  Y10T428/12736 ,  Y10T428/12764 ,  Y10T428/12993

摘要： The present invention provides a method for manufacturing a clad material and the equipment for manufacturing the clad material, in which the productivity is excellent, the surface state and the flatness of the clad material can be readily controlled and the deterioration in adhesion rarely occurs in the clad material. The method for manufacturing the clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material includes: a clad material preparation process where an ingot for core material, which is manufactured by dissolving and casting a metal for core material in a core material preparation process, and an ingot for skin material, which is manufactured by dissolving and casting a metal for skin material different from the core material in their component composition, in a skin material preparation process, are prepared, respectively; a superposition process where the ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material to manufacture a superposed material; and a clad hot-rolling process where the superposed material is hot-rolled to manufacture a clad material.

摘要翻译： 本发明提供一种包覆材料的制造方法以及包覆材料的制造装置，其中生产率优异，容易控制包层材料的表面状态和平坦度，并且在 复合材料。 制造由芯材料构成的包层材料和叠层在芯材的一面或两面上的一种或多种表皮材料的包覆材料的制造方法包括：包覆材料制备方法，其中芯材锭通过溶解 并且在芯材制备方法中铸造用于芯材的金属，以及通过在表皮材料制备方法中将不同于芯材的表皮材料的金属溶解和铸造而制造的表皮材料锭， 分别准备好了 用于将表皮材料的锭作为表皮材料叠加在用于芯材的锭的一个或两个面的预定位置以制造重叠材料的叠加工艺; 以及包覆热轧方法，其中叠加材料被热轧以制造包覆材料。

公开(公告)号：US08420011B2

公开(公告)日：2013-04-16

申请号：US11814124

申请日：2006-01-13

申请人： Makoto Morishita ,  Katsushi Matsumoto ,  Shigenobu Yasunaga ,  Takashi Inaba

发明人： Makoto Morishita ,  Katsushi Matsumoto ,  Shigenobu Yasunaga ,  Takashi Inaba

IPC分类号： C22C21/06 ,  C22F1/04

CPC分类号： B22D11/003 ,  B21B2003/001 ,  B22D11/0622 ,  B22D11/0682 ,  C22C21/06 ,  C22C21/08 ,  C22F1/047

摘要： The present invention provides an Al—Mg series alloy sheet of high-Mg with improved press formability and homogeneity which can be applied to automobile outer panels and inner panels. This is an Al—Mg series aluminum alloy sheet having 0.5 to 3 mm in thickness cast by twin-roll continuous casting and cold rolled, comprising over 8% but not more than 14% Mg, 1.0% or less Fe, and 0.5% or less Si with the remainder being Al and unavoidable impurities wherein the mean conductivity of the aluminum alloy sheet is in the range of at least 20 IACS % but less than 26 IACS %, the strength-ductility balance (tensile strength×total elongation) as a material property of the aluminum alloy sheet is 11000 (MPa %) or more, and the homogeneity and press formability of the sheet have been improved.

摘要翻译： 本发明提供了可以应用于汽车外板和内板的具有改善的冲压成形性和均匀性的高Mg的Al-Mg系合金板。 这是通过双辊连续铸造和冷轧铸造的厚度为0.5至3mm的Al-Mg系铝合金板，包含超过8％但不超过14％的Mg，1.0％或更少的Fe和0.5％或 较少的Si，其余为Al和不可避免的杂质，其中铝合金板的平均导电率在至少20IACS％但小于26IACS％的范围内，强度 - 延展性平衡（拉伸强度×总伸长率）为 铝合金板的材料特性为11000（MPa％）以上，片材的均匀性和冲压成形性提高。

公开(公告)号：US20090071576A1

公开(公告)日：2009-03-19

申请号：US11814124

申请日：2006-01-13

申请人： Makoto Morishita ,  Katsushi Matsumoto ,  Shigenobu Yasunaga ,  Takashi Inaba

发明人： Makoto Morishita ,  Katsushi Matsumoto ,  Shigenobu Yasunaga ,  Takashi Inaba

IPC分类号： C22F1/047 ,  C22C21/08

CPC分类号： B22D11/003 ,  B21B2003/001 ,  B22D11/0622 ,  B22D11/0682 ,  C22C21/06 ,  C22C21/08 ,  C22F1/047

摘要： The present invention provides an Al—Mg series alloy sheet of high-Mg with improved press formability and homogeneity which can be applied to automobile outer panels and inner panels. This is an Al—Mg series aluminum alloy sheet having 3.5 to 3 mm in thickness cast by twin-roll continuous casting and cold rolled, comprising over 8% but not more than 14% Mg, 1.0% or less Fe, and 3.5% or less Si with the remainder being Al and unavoidable impurities wherein the mean conductivity of the aluminum alloy sheet is in the range of at least 20 IACS % but less than 26 IACS %, the strength-ductility balance (tensile strength×total elongation) as a material property of the aluminum alloy sheet is 11000 (MPa %) or more, and the homogeneity and press formability of the sheet have been improved.

摘要翻译： 本发明提供了可以应用于汽车外板和内板的具有改善的冲压成形性和均匀性的高Mg的Al-Mg系合金板。 这是通过双辊连续铸造和冷轧铸造的厚度为3.5至3mm的Al-Mg系铝合金板，包含超过8％但不超过14％的Mg，1.0％或更少的Fe和3.5％或 较少的Si，其余为Al和不可避免的杂质，其中铝合金板的平均导电率在至少20IACS％但小于26IACS％的范围内，作为材料性能的强度 - 延展性平衡（拉伸强度×总伸长率） 的比例为11000（MPa％）以上，片材的均匀性和冲压成形性提高。

公开(公告)号：US20100105894A1

公开(公告)日：2010-04-29

申请号：US12457391

申请日：2009-06-09

申请人： Takashi Inaba ,  Julia Haas ,  Makoto Shiozaki ,  Nicole M. Littmann ,  Katsutaka Yasue ,  Steven W. Andrews ,  Atushi Sakai ,  Andrew M. Fryer ,  Takafuml Matsuo ,  Ellen R. Laird ,  Akira Suma ,  Yuichi Shinozaki ,  Yoshikazu Hori ,  Hiroto Imai ,  Tamotsu Negoro

发明人： Takashi Inaba ,  Julia Haas ,  Makoto Shiozaki ,  Nicole M. Littmann ,  Katsutaka Yasue ,  Steven W. Andrews ,  Atushi Sakai ,  Andrew M. Fryer ,  Takafuml Matsuo ,  Ellen R. Laird ,  Akira Suma ,  Yuichi Shinozaki ,  Yoshikazu Hori ,  Hiroto Imai ,  Tamotsu Negoro

IPC分类号： C07D243/08 ,  C07C229/02 ,  C07C307/00 ,  C07D409/02 ,  C07D231/10 ,  C07D401/02 ,  C07D261/06 ,  C07D333/34 ,  C07D241/04 ,  C07D271/06 ,  C07D257/04 ,  C07D295/00 ,  C07D215/14 ,  C07D205/04 ,  C07D413/02 ,  C07D241/36 ,  C07D413/14 ,  C07D223/14

CPC分类号： C07C311/29 ,  C07C311/13 ,  C07C311/20 ,  C07C311/22 ,  C07C311/46 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2603/08 ,  C07C2603/18 ,  C07C2603/30 ,  C07D205/04 ,  C07D207/48 ,  C07D209/44 ,  C07D211/58 ,  C07D211/96 ,  C07D213/18 ,  C07D213/65 ,  C07D213/71 ,  C07D213/74 ,  C07D213/81 ,  C07D213/82 ,  C07D217/08 ,  C07D231/12 ,  C07D233/64 ,  C07D237/12 ,  C07D239/22 ,  C07D243/08 ,  C07D257/04 ,  C07D261/08 ,  C07D271/06 ,  C07D271/107 ,  C07D277/26 ,  C07D277/36 ,  C07D277/82 ,  C07D295/26 ,  C07D307/79 ,  C07D307/91 ,  C07D333/18 ,  C07D333/34 ,  C07D333/36 ,  C07D333/38 ,  C07D333/62 ,  C07D401/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）所示的环丙烷化合物：其中，R 1为 - （CH 2 ）m-X-（CH 2）n -Al等，其中m和n相同或不同，各自为0〜6，X为单键等，而A1为取代的C3-14烃环基， 等等。; R2和R3相同或不同，各自为氢原子， - （CH2）p-X1-（CH2）q-A2等，其中p和q相同或不同，各自为0至6，X1 是单键等，A2是任选取代的C 3-14烃环基等; R4是-CO 2 R 9等，其中R9是氢原子等; 和R 20和R 21相同或不同，各自为氢原子， - （CH 2）m 12 -X 12 - （CH 2）m 12 -R 30等，其中m12和m12相同或不同，各自为0至6， X12为单键等，R30为氢原子等; 或其前药或其药学上可接受的盐。