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公开(公告)号：US07846454B2
公开(公告)日：2010-12-07
申请号：US11784809
申请日：2007-04-09
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , C07K2319/00 , C12N7/00 , C12N2770/24221 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
摘要翻译： 本发明公开了编码感染性丙型肝炎病毒的核酸序列，以及这些序列的使用以及由全部或部分序列编码的多肽在开发用于HCV的疫苗和诊断中的用途，以及用于鉴定的筛选测定 的HCV抗病毒剂。
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公开(公告)号：US6153421A
公开(公告)日：2000-11-28
申请号：US14416
申请日：1998-01-27
CPC分类号： C07K14/005 , C12N7/00 , A61K2039/525 , A61K39/00 , C07K2319/00 , C12N2770/24221 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
摘要翻译： 本发明公开了编码感染性丙型肝炎病毒的核酸序列，以及这些序列的使用以及由全部或部分序列编码的多肽在开发用于HCV的疫苗和诊断中的用途，以及用于鉴定的筛选测定 的HCV抗病毒剂。
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公开(公告)号：US07201911B1
公开(公告)日：2007-04-10
申请号：US09662454
申请日：2000-09-14
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , C07K2319/00 , C12N7/00 , C12N2770/24221 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
摘要翻译： 本发明公开了编码感染性丙型肝炎病毒的核酸序列，以及这些序列的使用以及由全部或部分序列编码的多肽在开发用于HCV的疫苗和诊断中的用途，以及用于鉴定的筛选测定 的HCV抗病毒剂。
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4.发明授权Cloned genome of infectious hepatitus C virus of genotype 2A and uses thereof 有权基因型2A的感染性肝炎C病毒的克隆基因组及其用途公开(公告)号：US07084266B1
公开(公告)日：2006-08-01
申请号：US09980559
申请日：2000-02-06
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/53 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, gentotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
摘要翻译： 本发明公开了编码感染性丙型肝炎病毒的菌株HC-J6CH，gentotype 2a的核酸序列，以及该序列的全部或部分编码的多肽， 开发用于HCV的疫苗和诊断，以及开发用于鉴定HCV抗病毒剂的筛选试验。
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公开(公告)号：US07129342B1
公开(公告)日：2006-10-31
申请号：US10009002
申请日：2000-06-02
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/53 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24234
摘要： The present invention relates to nucleic acid sequence which comprises the genome of an infectious GB virus B clone. The invention also relates to the use of the nucleic acid sequence of the infectious GB virus B clone to indirectly study the molecular properties of HCV, and in the production of HCV/GBV-B chimeras. The invention further relates to the use of the infectious nucleic acid sequence of GB virus B clone and the HCV/GBV-B chimeras in the development of vaccines and therapeutics for HCV.
摘要翻译： 本发明涉及包含感染性GB病毒B克隆的基因组的核酸序列。 本发明还涉及感染性GB病毒B克隆的核酸序列用于间接研究HCV的分子性质和HCV / GBV-B嵌合体的生产中的用途。 本发明还涉及GB病毒B克隆和HCV / GBV-B嵌合体的感染性核酸序列在开发用于HCV的疫苗和治疗剂中的用途。
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6.发明申请CLONED GENOME OF INFECTIOUS HEPATITIS C VIRUS STRAIN HC-TN AND USES THEREOF 审中-公开感染性HEPATITIS C病毒株HC-TN的克隆基因及其用途公开(公告)号：US20100291130A1
公开(公告)日：2010-11-18
申请号：US12637696
申请日：2009-12-14
CPC分类号： G01N33/5767 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24234 , G01N2500/04 , G01N2500/10
摘要： Embodiments described herein include nucleic acid sequences, which encode hepatitis C virus of strain HC-TN, genotype 1a, proteins and polypeptides and fragments thereof. Use of these compositions, and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV are also contemplated.
摘要翻译： 本文描述的实施方案包括编码菌株HC-TN的丙型肝炎病毒，基因型1a，蛋白质和多肽及其片段的核酸序列。 还考虑使用这些组合物和HCV的诊断以及开发用于鉴定HCV的抗病毒剂的筛选测定法。
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7.发明申请CLONED GENOME OF INFECTIOUS HEPATITIS C VIRUS STRAIN HC-TN AND USES THEREOF 失效感染性HEPATITIS C病毒株HC-TN的克隆基因及其用途公开(公告)号：US20090252755A1
公开(公告)日：2009-10-08
申请号：US12061504
申请日：2008-04-02
申请人： Jens Bukh , Robert H. Purcell , Suzanne U. Emerson , Akito Sakai
发明人： Jens Bukh , Robert H. Purcell , Suzanne U. Emerson , Akito Sakai
IPC分类号： A61K39/00 , C12N15/11 , C12N15/00 , C12N5/06 , C07K14/00 , A61P37/00 , C12N15/87 , C12Q1/70 , C12Q1/34 , C12Q1/37
CPC分类号： G01N33/5767 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24234 , G01N2500/04 , G01N2500/10
摘要： Embodiments described herein include nucleic acid sequences, which encode hepatitis C virus of strain HC-TN, genotype 1a, proteins and polypeptides and fragments thereof. Use of these compositions, and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV are also contemplated.
摘要翻译： 本文描述的实施方案包括编码菌株HC-TN的丙型肝炎病毒，基因型1a，蛋白质和多肽及其片段的核酸序列。 还考虑使用这些组合物和HCV的诊断以及开发用于鉴定HCV的抗病毒剂的筛选测定法。
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公开(公告)号：US07009044B1
公开(公告)日：2006-03-07
申请号：US10009011
申请日：2000-02-06
申请人： Jae-Hwan Nam , Jens Bukh , Suzanne U. Emerson , Robert H. Purcell
发明人： Jae-Hwan Nam , Jens Bukh , Suzanne U. Emerson , Robert H. Purcell
CPC分类号： C07K14/005 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2770/24222 , C12N2770/24262 , C12N2770/24322 , C12Q1/707
摘要： The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV/BVDV). The invention also relates to the use of these chimeric nucleic acid sequences to produce chimeric virions in cells and the use of these chimeric virions in HCV antibody neutralization assays, and for the development of vaccines and therapeutics for HCV.
摘要翻译： 本发明涉及生产包含嵌合丙型肝炎病毒 - 牛病毒性腹泻病毒（HCV / BVDV）的基因组的核酸序列的分子方法。 本发明还涉及这些嵌合核酸序列在细胞中产生嵌合病毒粒子的用途以及这些嵌合病毒粒子在HCV抗体中和测定中的用途，以及用于开发用于HCV的疫苗和治疗剂。
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9.发明授权Cloned genome of infectious hepatitis C virus strain HC-TN and uses thereof 失效感染性丙型肝炎病毒株HC-TN的克隆基因组及其用途公开(公告)号：US07678569B2
公开(公告)日：2010-03-16
申请号：US12061504
申请日：2008-04-02
申请人： Jens Bukh , Robert H. Purcell , Suzanne U. Emerson , Akito Sakai
发明人： Jens Bukh , Robert H. Purcell , Suzanne U. Emerson , Akito Sakai
CPC分类号： G01N33/5767 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24234 , G01N2500/04 , G01N2500/10
摘要： Embodiments described herein include nucleic acid sequences, which encode hepatitis C virus of strain HC-TN, genotype 1a, proteins and polypeptides and fragments thereof. Use of these compositions, and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV are also contemplated.
摘要翻译： 本文描述的实施方案包括编码菌株HC-TN的丙型肝炎病毒，基因型1a，蛋白质和多肽及其片段的核酸序列。 还考虑使用这些组合物和HCV的诊断以及开发用于鉴定HCV的抗病毒剂的筛选测定法。
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公开(公告)号：US20110243840A1
公开(公告)日：2011-10-06
申请号：US13038613
申请日：2011-03-02
IPC分类号： A61K51/00 , C07K16/08 , C07K16/46 , A61K39/395 , A61K49/16 , A61P31/20 , A61P37/04 , A61P43/00 , C12Q1/70
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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