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公开(公告)号：US07914788B2
公开(公告)日：2011-03-29
申请号：US12142594
申请日：2008-06-19
IPC分类号： A61K39/395 , C12Q1/70 , C12N15/00
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US20110243840A1
公开(公告)日：2011-10-06
申请号：US13038613
申请日：2011-03-02
IPC分类号： A61K51/00 , C07K16/08 , C07K16/46 , A61K39/395 , A61K49/16 , A61P31/20 , A61P37/04 , A61P43/00 , C12Q1/70
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US08404818B2
公开(公告)日：2013-03-26
申请号：US13038613
申请日：2011-03-02
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US20090155250A1
公开(公告)日：2009-06-18
申请号：US12142594
申请日：2008-06-19
IPC分类号： A61K39/395 , C07K16/08 , C12N15/39 , C12N15/85 , C12Q1/70 , A61P31/20 , C12N5/10 , C12N5/16 , C12N7/01
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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5.发明授权Monoclonal antibodies that neutralize anthrax protective antigen (PA) toxin 有权中和炭疽保护性抗原（PA）毒素的单克隆抗体公开(公告)号：US08685396B2
公开(公告)日：2014-04-01
申请号：US11793735
申请日：2005-12-21
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N5/10 , G01N33/53
CPC分类号： C07K16/1278 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和炭疽保护性抗原（PA）毒素的单克隆抗体。 本发明提供了这样的抗体，这种抗体的片段，其保留了炭疽PA毒素结合能力，完全人或人源化抗体保留了炭疽杆菌PA毒素结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US08071100B2
公开(公告)日：2011-12-06
申请号：US12528427
申请日：2008-02-21
IPC分类号： A61K39/40
CPC分类号： C07K16/1278 , A61K51/1009 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56911 , G01N33/573 , G01N2333/32 , G01N2333/954 , G01N2469/10
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和炭疽致死因子（LF），水肿因子（EF）和/或保护性抗原（PA）的单克隆抗体。 本发明提供了这样的抗体，这种抗体的保留了炭疽毒素结合能力的片段，完全人或人源化抗体，保留了炭疽毒素结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US20100119520A1
公开(公告)日：2010-05-13
申请号：US12528427
申请日：2008-02-21
CPC分类号： C07K16/1278 , A61K51/1009 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56911 , G01N33/573 , G01N2333/32 , G01N2333/954 , G01N2469/10
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和炭疽致死因子（LF），水肿因子（EF）和/或保护性抗原（PA）的单克隆抗体。 本发明提供了这样的抗体，这种抗体的保留了炭疽毒素结合能力的片段，完全人或人源化抗体，保留了炭疽毒素结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US08574853B2
公开(公告)日：2013-11-05
申请号：US13310463
申请日：2011-12-02
IPC分类号： G01N33/53
CPC分类号： C07K16/1278 , A61K51/1009 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56911 , G01N33/573 , G01N2333/32 , G01N2333/954 , G01N2469/10
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
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9.发明申请Monoclonal Antibodies That Neutralize Anthrax Protective Antigen (PA) Toxin 有权中和炭疽保护性抗原（PA）毒素的单克隆抗体公开(公告)号：US20100074892A1
公开(公告)日：2010-03-25
申请号：US11793735
申请日：2005-12-21
CPC分类号： C07K16/1278 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和炭疽保护性抗原（PA）毒素的单克隆抗体。 本发明提供了这样的抗体，这种抗体的片段，其保留了炭疽PA毒素结合能力，完全人或人源化抗体保留了炭疽杆菌PA毒素结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US07846454B2
公开(公告)日：2010-12-07
申请号：US11784809
申请日：2007-04-09
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , C07K2319/00 , C12N7/00 , C12N2770/24221 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
摘要翻译： 本发明公开了编码感染性丙型肝炎病毒的核酸序列，以及这些序列的使用以及由全部或部分序列编码的多肽在开发用于HCV的疫苗和诊断中的用途，以及用于鉴定的筛选测定 的HCV抗病毒剂。
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