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公开(公告)号：US20130109672A1
公开(公告)日：2013-05-02
申请号：US13643594
申请日：2011-04-26
IPC分类号： C07D265/36 , C07D209/12 , C07D223/16 , C07D235/26 , C07D215/227 , C07D209/34
CPC分类号： C07D215/227 , C07D209/12 , C07D209/30 , C07D209/34 , C07D215/36 , C07D223/16 , C07D235/26 , C07D265/36
摘要： Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1-NR-L-A2 (I).
摘要翻译： 公开了作为式（I）化合物的丙酮酸激酶M2活化剂，包括式（II）的化合物，其中A1，A2，L，R，R1至R3，X1至X3，k，n和m如本文所定义 ，其可用于治疗可通过激活PKM2（例如癌症）治疗的许多疾病。 A1-NR-L-A2（I）。
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2.发明申请GALACTOKINASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF ASSOCIATED DISEASES AND DISORDERS 有权用于治疗和预防相关疾病和疾病的GALACTOKINASE抑制剂公开(公告)号：US20140288100A1
公开(公告)日：2014-09-25
申请号：US14346400
申请日：2011-09-23
申请人： Matthew B. Boxer , Martin J. Walsh , Li Liu , Cordelle D. Tanega , Min Shen , Kent Lai , Manshu Tang , Douglas S. Auld
发明人： Matthew B. Boxer , Martin J. Walsh , Li Liu , Cordelle D. Tanega , Min Shen , Kent Lai , Manshu Tang , Douglas S. Auld
IPC分类号： C07D495/10 , C07D417/14 , C07D403/12 , C07D413/14 , C07D413/12 , C07D491/107
CPC分类号： A61K31/517 , A61K31/506 , A61K31/527 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D491/107 , C07D493/10 , C07D495/10
摘要： Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I)
摘要翻译： 公开了可用于治疗或预防半乳糖激酶介导的疾病或病症例如半乳糖血症的式（1）的人类半乳糖激酶的抑制剂。 还公开了包含药学上可接受的载体和本发明的至少一种抑制剂的组合物，以及治疗或预防哺乳动物中的这种疾病或病症的方法。 式（I）
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3.发明授权Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders 有权用于治疗和预防相关疾病和障碍的半乳糖激酶抑制剂公开(公告)号：US09447087B2
公开(公告)日：2016-09-20
申请号：US14346400
申请日：2011-09-23
申请人： Matthew B. Boxer , Martin J. Walsh , Li Liu , Cordelle D. Tanega , Min Shen , Kent Lai , Manshu Tang , Douglas S. Auld
发明人： Matthew B. Boxer , Martin J. Walsh , Li Liu , Cordelle D. Tanega , Min Shen , Kent Lai , Manshu Tang , Douglas S. Auld
IPC分类号： C07D403/12 , A61K31/506 , C07D417/14 , C07D413/14 , C07D413/12 , C07D493/10 , C07D495/10 , C07D491/107
CPC分类号： A61K31/517 , A61K31/506 , A61K31/527 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D491/107 , C07D493/10 , C07D495/10
摘要： Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I).
摘要翻译： 公开了可用于治疗或预防半乳糖激酶介导的疾病或病症例如半乳糖血症的式（1）的人类半乳糖激酶的抑制剂。 还公开了包含药学上可接受的载体和本发明的至少一种抑制剂的组合物，以及治疗或预防哺乳动物中的这种疾病或病症的方法。 式（I）
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5.发明授权Honeycomb filters for reducing NOx and particulate matter in diesel engine exhaust 有权用于减少柴油机排气中的NOx和颗粒物的蜂窝过滤器公开(公告)号：US08591820B2
公开(公告)日：2013-11-26
申请号：US13046275
申请日：2011-03-11
申请人： Thorsten Rolf Boger , Suhao He , Min Shen
发明人： Thorsten Rolf Boger , Suhao He , Min Shen
CPC分类号： B01D53/9409 , B01D46/2474 , F01N3/0222 , F01N3/035 , F01N3/0821 , F01N3/0842 , F01N3/2066 , F01N2330/34 , F01N2510/063 , F01N2510/068 , Y02T10/24
摘要： Particulate filters for reducing NOx and particulate matter in diesel exhaust and methods for forming the same are disclosed. In one embodiment, a particulate filter may include a honeycomb body with a plurality of channel walls extending from an inlet end to an outlet end. At least a first set of the channels are plugged proximate at least one of the inlet end or the outlet end. A filter zone may extend from the inlet end in an axial direction of the particulate filter. A DeNOx zone may be located downstream of the filter zone. The channel walls of the particulate filter may include a DeNOx functional catalyst in the DeNOx zone and a ratio of the permeability κfz of the channel walls in the filter zone to the permeability κDz of the channel walls in the DeNOx zone (κfz:κDz) is at least 2.
摘要翻译： 公开了用于减少柴油机废气中的NOx和颗粒物质的颗粒过滤器及其形成方法。 在一个实施例中，颗粒过滤器可以包括蜂窝体，其具有从入口端延伸到出口端的多个通道壁。 至少第一组通道在入口端或出口端中的至少一个处堵塞。 过滤区域可以从颗粒过滤器的轴向方向上的入口端延伸。 DeNOx区可以位于过滤区的下游。 颗粒过滤器的通道壁可以包括DeNOx区域中的DeNO x功能性催化剂，并且过滤区域中的通道壁的渗透性kappafz与DeNOx区域（kappafz：kappaDz）中的通道壁的渗透性kappaDz的比率是 至少2。
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公开(公告)号：US20130251761A1
公开(公告)日：2013-09-26
申请号：US13810587
申请日：2011-07-15
申请人： Barry S. Coller , Craig Thomas , Marta Filizola , Joshua Mccoy , Wenwei Huang , Min Shen
发明人： Barry S. Coller , Craig Thomas , Marta Filizola , Joshua Mccoy , Wenwei Huang , Min Shen
IPC分类号： A61K31/519 , A61K45/06 , C07D513/04
CPC分类号： A61K31/519 , A61K31/497 , A61K45/06 , C07D487/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
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公开(公告)号：US08297595B2
公开(公告)日：2012-10-30
申请号：US12694837
申请日：2010-01-27
申请人： Min Shen , Jiang Chen , Jingfang Wang
发明人： Min Shen , Jiang Chen , Jingfang Wang
IPC分类号： A62B3/00
摘要： An adjustable hydraulic horizontal jack including a frame, a hydraulic unit, a jib unit, link rods, and a handle. Here, the structures of the jib and the link rod(s) are improved according to an embodiment. With the improved structures, the jack has rational structures and can act reliably. In addition, under the parameters equivalent to those of conventional hydraulic horizontal jacks, the jack of an embodiment of the present invention can change the height of the lowest position and the load by adjusting the length of the jib and link rods. Therefore, the jack is adapted to jacking up not only a light automobile with a low chassis but also a heavy automobile with a high chassis, thus having a wider scope of application.
摘要翻译： 包括框架，液压单元，起重臂单元，连杆和手柄的可调节液压水平千斤顶。 这里，根据一个实施例，提升了起重臂和连杆的结构。 通过改进的结构，千斤顶具有合理的结构，可靠运行。 此外，在与现有的液压水平千斤顶相同的参数下，本发明实施例的千斤顶可以通过调整起重臂和连杆的长度来改变最低位置和负载的高度。 因此，千斤顶不仅适用于搭载低底盘的轻型汽车，而且搭载高底盘重型汽车，具有更广泛的应用范围。
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8.发明申请METHODS AND APPARATUS FOR DRYING LOGS WITH MICROWAVES USING FEEDBACK AND FEED FORWARD CONTROL 审中-公开使用反馈和进给前向控制用微波干燥日志的方法和装置公开(公告)号：US20120049415A1
公开(公告)日：2012-03-01
申请号：US12870282
申请日：2010-08-27
IPC分类号： H05B6/68
CPC分类号： H05B6/686 , H05B6/705 , H05B2206/046
摘要： Methods and apparatus for microwave drying of green cellular ceramic bodies (logs) using feedback and feed forward control are disclosed. The methods include measuring an amount of dissipated microwave power and measuring temperatures of the logs and inputting this information into a drying model. The drying model accounts for at least a heat capacitance, a water content and a mass of the logs, and relates changes in the dissipated microwave power to changes in the log temperature. The changes in microwave power generated by the adjustable microwave source are thus based on the calculated dissipated power changes.
摘要翻译： 公开了使用反馈和前馈控制的微蜂窝陶瓷体（原木）微波干燥的方法和装置。 这些方法包括测量耗散的微波功率的量和测量日志的温度，并将该信息输入到干燥模型中。 干燥模型至少考虑了热容量，含水量和原木质量，并将耗散的微波功率的变化与对数温度的变化相关联。 因此，由可调微波源产生的微波功率的变化因此基于计算的耗散功率变化。
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9.发明授权O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer 有权O-连接的嘧啶-4-胺类化合物，包含它们的组合物及其用于治疗癌症的方法公开(公告)号：US08093246B2
公开(公告)日：2012-01-10
申请号：US11954433
申请日：2007-12-12
申请人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
发明人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
IPC分类号： C07D403/14 , A61K31/506
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
摘要翻译： 描述了O-连接的嘧啶-4-胺类化合物，包含它们的药物组合物及其使用方法。 本发明的具体化合物具有式I：
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