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公开(公告)号：US20070244544A1
公开(公告)日：2007-10-18
申请号：US11279769
申请日：2006-04-14
申请人： Matthew Birdsall , Mark Dolan , Justin Goshgarian , Michael Krivoruchko , Joseph Lessar , Darrel Untereker , Peter Urbanski
发明人： Matthew Birdsall , Mark Dolan , Justin Goshgarian , Michael Krivoruchko , Joseph Lessar , Darrel Untereker , Peter Urbanski
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2002/9528 , A61F2210/0061 , A61F2250/006 , A61F2250/0069 , A61L24/0031 , A61L24/08 , C08L5/08
摘要： A valve replacement system that can be used for treating abnormalities of the right ventricular outflow tract includes a prosthetic valve device having a sealant contacting at least a portion of the outer surface of the valve device. The sealant may be breakable, and may be a hydrogel, an expandable hydrogel, or a solid. One embodiment of the invention includes a flowable sealant that is injected within the vascular system. Another embodiment of the invention includes a method for replacing a pulmonary valve that includes forming a seal around the exterior surface of a replacement valve and preventing blood flow around the replacement valve.
摘要翻译： 可用于治疗右心室流出道异常的瓣膜置换系统包括具有与阀装置的外表面的至少一部分接触的密封剂的人造瓣膜装置。 密封剂可以是可破裂的，并且可以是水凝胶，可膨胀水凝胶或固体。 本发明的一个实施方案包括注射在血管系统内的可流动的密封剂。 本发明的另一个实施例包括一种用于替换肺动脉瓣的方法，该方法包括在置换瓣膜的外表面周围形成密封并防止置换瓣膜周围的血液流动。
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公开(公告)号：US07318837B2
公开(公告)日：2008-01-15
申请号：US11278052
申请日：2006-03-30
申请人： Michael Krivoruchko , Joseph Lessar , Richard Francis , Matthew Birdsall , Darrel Untereker , Jeffrey Allen
发明人： Michael Krivoruchko , Joseph Lessar , Richard Francis , Matthew Birdsall , Darrel Untereker , Jeffrey Allen
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91541 , A61F2002/91558 , A61F2230/0013 , A61L31/022
摘要： A balloon-expandable stent formed from a customized alloy formulation. The stent alloy has a either a high, variable or no work hardening rate, very high modulus of elasticity (Young's modulus), and a low yield point. A stent constructed of a material with this combination of properties undergoes significant plastic deformation upon deployment in vivo to its implantation diameter and exhibits minimum recoil for better sizing. The plastic deformation also raises the subsequent yield point of the stent material resulting in a stronger stent upon implantation that is more resistant to vascular loading.
摘要翻译： 由定制的合金制剂形成的球囊扩张支架。 支架合金具有高的，可变的或没有加工硬化率，非常高的弹性模量（杨氏模量）和低屈服点。 由具有这种性质组合的材料构成的支架在体内部署到其植入直径时经历显着的塑性变形，并且显示出最小的反冲以获得更好的上浆。 塑性变形也提高了支架材料的随后屈服点，从而导致植入时更坚固的支架，其更能抵抗血管负荷。
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公开(公告)号：US20070244545A1
公开(公告)日：2007-10-18
申请号：US11279776
申请日：2006-04-14
申请人： Matthew Birdsall , Mark Dolan , Darrel Untereker
发明人： Matthew Birdsall , Mark Dolan , Darrel Untereker
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61B90/39 , A61F2/06 , A61F2/2475 , A61F2230/0078 , A61F2250/006 , A61F2250/0098
摘要： A system and method for treating a vascular condition includes a conduit having an elongate tubular member with an outer surface and an inner surface, the inner surface defines a conduit lumen. The system further includes at least one symmetry indicator attached to the elongate tubular member and a replacement valve device. The replacement valve device includes a prosthetic valve connected to an expandable support structure. The replacement valve device is positioned within the conduit lumen adjacent the inner surface.
摘要翻译： 用于治疗血管病症的系统和方法包括具有细长管状构件的管道，其具有外表面和内表面，所述内表面限定管腔。 该系统还包括附接到细长管状构件和替换阀装置的至少一个对称指示器。 置换瓣膜装置包括连接到可扩张支撑结构的假体瓣。 替换阀装置位于与内表面相邻的管腔内。
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4.发明授权Implants based on engineered metal matrix composite materials having enhanced imaging and wear resistance 有权基于具有增强的成像和耐磨性的工程金属基复合材料的植入物公开(公告)号：US07270679B2
公开(公告)日：2007-09-18
申请号：US10781595
申请日：2004-02-18
申请人： Naim Istephanous , Joseph Lessar , Greg Marik , Darrel Untereker
发明人： Naim Istephanous , Joseph Lessar , Greg Marik , Darrel Untereker
IPC分类号： A61F2/44
CPC分类号： A61B17/7052 , A61B17/7001 , A61B17/7049 , A61B17/7059 , A61B17/80 , A61F2/30965 , A61F2/32 , A61F2/38 , A61F2/442 , A61F2/4425 , A61F2002/30062 , A61F2002/3008 , A61F2002/30677 , A61F2002/30968 , A61F2002/30971 , A61F2002/443 , A61F2210/0004 , A61F2240/001 , A61F2250/0098 , A61F2310/00023 , A61F2310/00089 , A61F2310/00095 , A61F2310/00167 , A61F2310/00203 , A61F2310/00239 , A61F2310/00263 , A61F2310/00269 , A61F2310/00305 , A61F2310/00323 , A61L27/427 , A61L27/56 , A61L31/124 , A61L31/146 , A61N1/05 , B33Y80/00
摘要： This invention relates to an implantable medical device to treat a patient. The implantable device can be an orthopedic device such as a spinal implant including, but not restricted to, a disc or nucleus pulposus prosthesis, a spinal rod assembly, or a bone fixation plate. The orthopedic device can be formed to include a metal matrix composite that provides enhanced wear and diagnostic imaging techniques. In other forms, the present invention provides an implantable medical device that includes a porous metal matrix composite that can deliver a therapeutic composition to a patient. In still other forms, the present invention provides an implantable electrical device or lead formed to include a metal matrix composite that provides lower polarization and interfacial impedance and allows enhanced sensing of the physiological signals.
摘要翻译： 本发明涉及一种用于治疗患者的可植入医疗装置。 可植入装置可以是诸如脊椎植入物的矫形装置，包括但不限于圆盘或髓核假体，脊柱杆组件或骨固定板。 矫形装置可以形成为包括提供增强的磨损和诊断成像技术的金属基质复合材料。 在其它形式中，本发明提供了一种植入式医疗装置，其包括能将治疗组合物递送至患者的多孔金属基质复合物。 在其它形式中，本发明提供一种可植入电气装置或导线，其形成为包括提供较低极化和界面阻抗并允许对生理信号的增强感测的金属基质复合材料。
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公开(公告)号：US20090093871A1
公开(公告)日：2009-04-09
申请号：US11868742
申请日：2007-10-08
申请人： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
发明人： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2250/0068
摘要： A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.
摘要翻译： 用于治疗血管状态的系统包括导管和设置在导管上的支架。 支架包括具有限定中心腔和多个孔的壁的管。 该系统还包括设置在管的中心腔内的治疗剂。 制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔，并从中空管形成支架框架。
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公开(公告)号：US20090196899A1
公开(公告)日：2009-08-06
申请号：US12023268
申请日：2008-01-31
CPC分类号： B22F3/1121 , A61F2/82 , A61F2250/0023 , A61F2250/0067 , A61L31/022 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B22F3/1146 , B22F2999/00 , B22F1/0007
摘要： A method of manufacturing a stent includes determining a porosity characteristic and combining at least two predetermined alloy constituents based on the porosity characteristic. The method further determines a solidification profile based on the porosity characteristic and combined alloy constituents and solidifies the combined alloy constituents based on the solidification profile. In addition, the method includes forming a stent framework from the solidified alloy constituents, removing at least a portion of at least one of the alloy constituents, and forming pores within the stent framework based on the removal and consistent with the porosity characteristic.
摘要翻译： 制造支架的方法包括确定孔隙率特性，并且基于孔隙率特性组合至少两个预定的合金成分。 该方法还基于孔隙率特性和组合的合金成分进一步确定凝固曲线，并基于固化曲线固化组合的合金成分。 此外，该方法包括从固化的合金成分形成支架框架，去除合金成分中的至少一种的至少一部分，并且基于去除并与孔隙特性一致，在支架框架内形成孔。
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公开(公告)号：US20070156181A1
公开(公告)日：2007-07-05
申请号：US11323027
申请日：2005-12-30
申请人： John Norton , Ann Crespi , Darrel Untereker
发明人： John Norton , Ann Crespi , Darrel Untereker
IPC分类号： A61N1/00
CPC分类号： A61N1/3975 , H01G9/042 , H01G9/14
摘要： Wet-tantalum capacitors used in a medical device are charged to and maintained at a maintenance voltage between full energy charges so that deformation in the wet-tantalum capacitor is substantially inhibited.
摘要翻译： 在医疗装置中使用的湿钽电容器被充满并保持在全能量电荷之间的维持电压，从而基本上抑制了湿钽电容器的变形。
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公开(公告)号：US20050055080A1
公开(公告)日：2005-03-10
申请号：US10656730
申请日：2003-09-05
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2002/828 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2250/006 , A61F2250/0068 , A61F2250/0098
摘要： Manufacturing methods are provided to build modulated medical devices and segments of the devices for applications in the field of intraluminal intervention, reconstruction, or therapy. The methods, comprise steps of metal injection molding and processes of modulation, improve the manufacturability of the devices and/or expand the design alternatives for the devices. The modulated medical devices and their segments, made from the present method inventions, enhance the versatility in intraluminal treatments.
摘要翻译： 提供制造方法以构建用于管腔内干预，重建或治疗领域的应用的调制医疗装置和装置的部分。 这些方法包括金属注射成型和调制过程的步骤，提高器件的可制造性和/或扩展器件的设计替代方案。 由本方法发明制成的调制医疗器械及其片段增强了管腔内治疗的通用性。
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公开(公告)号：US20060190079A1
公开(公告)日：2006-08-24
申请号：US11040565
申请日：2005-01-21
申请人： Naim Istephanous , Joe Lessar , Darrel Untereker , Lukas Eisermann , Greg Marik
发明人： Naim Istephanous , Joe Lessar , Darrel Untereker , Lukas Eisermann , Greg Marik
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/4611 , A61F2002/30387 , A61F2002/30448 , A61F2002/30451 , A61F2002/30507 , A61F2002/30578 , A61F2002/30589 , A61F2002/30652 , A61F2002/30655 , A61F2002/30662 , A61F2002/30682 , A61F2002/30683 , A61F2002/30685 , A61F2002/30785 , A61F2002/30828 , A61F2002/30836 , A61F2002/30884 , A61F2002/30906 , A61F2002/30925 , A61F2002/3093 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2310/00023 , A61F2310/00071 , A61F2310/00077 , A61F2310/00089 , A61F2310/00796
摘要： Described are artificial disc implants for insertion between first and second adjacent vertebrae in a patient. The implants have a first member and a second member in articulating relationship. At least one member of the implant includes an amorphous metal element. Also described are related methods of making and using artificial disc implants.
摘要翻译： 描述了用于在患者中插入第一和第二相邻椎骨之间的人造椎间盘植入物。 植入物具有第一个成员和第二个成员的关系。 植入物的至少一个构件包括非晶金属元素。 还描述了制造和使用人造椎间盘植入物的相关方法。
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10.发明申请Medical devices with surface modification for regulating cell growth on or near the surface 审中-公开具有表面修饰的医疗器械用于调节表面上或附近的细胞生长公开(公告)号：US20060029640A1
公开(公告)日：2006-02-09
申请号：US11198090
申请日：2005-08-05
CPC分类号： A61L31/022 , A61F2/82 , A61F2002/009
摘要： High oxidation state metal-containing compounds are formed on or applied to the surfaces of medical devices. These compounds can cause cytostatic, cytotoxic, and anti-proliferative effects to the cells on or near the implanted medical devices and thus reduce or eliminate undesirable cell growth or accumulation on the medical devices.
摘要翻译： 高氧化态含金属化合物形成在医疗器械的表面上或应用于医疗器械的表面上。 这些化合物可以对植入的医疗装置上或附近的细胞产生细胞生长抑制，细胞毒性和抗增殖作用，从而减少或消除医疗装置上不期望的细胞生长或积累。
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