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公开(公告)号：US06528534B2
公开(公告)日：2003-03-04
申请号：US09899886
申请日：2001-07-06
申请人： Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Theo Schotten , Wolfgang Stenzel , Robert M. Scarborough
发明人： Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Theo Schotten , Wolfgang Stenzel , Robert M. Scarborough
IPC分类号： C07D26352
CPC分类号： C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要： This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
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2.发明授权Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation 失效螺环化合物作为纤维蛋白原依赖性血小板聚集的抑制剂公开(公告)号：US06693109B2
公开(公告)日：2004-02-17
申请号：US10354265
申请日：2003-01-29
申请人： Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Michael Paal , Gerd Ruhter , Kenneth J. Ruterbories , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
发明人： Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Michael Paal , Gerd Ruhter , Kenneth J. Ruterbories , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
IPC分类号： C07D22120
CPC分类号： C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要： This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
摘要翻译： 本发明涉及用碱性和酸性官能团取代的某些螺环化合物，其可用于抑制血小板聚集。
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3.发明授权Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation 有权螺环化合物作为纤维蛋白原依赖性血小板聚集的抑制剂公开(公告)号：US06291469B1
公开(公告)日：2001-09-18
申请号：US09043846
申请日：1998-10-05
申请人： Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
发明人： Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
IPC分类号： C07D22120
CPC分类号： C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要： This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I): wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.
摘要翻译： 本发明涉及由碱式和酸性官能团取代的某些螺环化合物，如式（I）所示：其中Q，L，Ai，Bj，R 0，R 3，R 10，m，n，p和q如 可用于抑制血小板聚集。
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公开(公告)号：US6020362A
公开(公告)日：2000-02-01
申请号：US47285
申请日：1998-03-24
申请人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Ruhter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff
发明人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Ruhter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff
IPC分类号： C07D487/04 , A61K31/195 , A61K31/215 , A61K31/335 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/495 , A61P7/02 , A61P9/10 , C07C257/18 , C07C257/20 , C07C271/64 , C07D211/22 , C07D211/32 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D221/00 , C07D311/22 , C07D311/58 , C07D311/66 , C07D311/70 , C07D319/16 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12 , C07D491/052 , C07D497/04 , G03F7/20 , C07D311/04
CPC分类号： C07D211/34 , C07C257/18 , C07C271/64 , C07D211/22 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D311/22 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12 , C07C2102/10
摘要： This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
摘要翻译： 本发明涉及具有由两个稠合的六元环形成的核的某些二环化合物，例如苯并吡喃，异喹啉，异喹诺酮，四氢萘，二氢萘或四氢萘酮，其被碱性和酸性官能团所取代，其可用于抑制血小板聚集 。
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公开(公告)号：US5731324A
公开(公告)日：1998-03-24
申请号：US376191
申请日：1995-01-19
申请人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Ruhter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff
发明人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Ruhter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff
IPC分类号： C07D487/04 , A61K31/195 , A61K31/215 , A61K31/335 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/495 , A61P7/02 , A61P9/10 , C07C257/18 , C07C257/20 , C07C271/64 , C07D211/22 , C07D211/32 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D221/00 , C07D311/22 , C07D311/58 , C07D311/66 , C07D311/70 , C07D319/16 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12 , C07D491/052 , C07D497/04 , G03F7/20 , C07D311/02
CPC分类号： C07D211/34 , C07C257/18 , C07C271/64 , C07D211/22 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D311/22 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12 , C07C2102/10
摘要： This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
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公开(公告)号：US06448269B1
公开(公告)日：2002-09-10
申请号：US09883639
申请日：2001-06-18
申请人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Rühter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff
发明人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Rühter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff
IPC分类号： C07D40112
CPC分类号： C07D311/22 , C07C257/18 , C07C271/64 , C07C2602/10 , C07D211/22 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12
摘要： This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
摘要翻译： 本发明涉及具有由两个稠合的六元环形成的核的某些二环化合物，例如苯并吡喃，异喹啉，异喹诺酮，四氢萘，二氢萘或四氢萘酮，其被碱性和酸性官能团所取代，其可用于抑制血小板聚集 。
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公开(公告)号：US06245809B1
公开(公告)日：2001-06-12
申请号：US09328197
申请日：1999-06-08
申请人： Robert M. Scarborough , Mark Smyth , Ting Su , Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffry Bernard Franciskovich
发明人： Robert M. Scarborough , Mark Smyth , Ting Su , Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffry Bernard Franciskovich
IPC分类号： C07C31104
CPC分类号： C07D211/62 , C07C311/06 , C07C311/19 , C07C2601/14
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.
摘要翻译： 公开了与哺乳动物整联蛋白有关的新型化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗血栓形成或再狭窄病症。
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公开(公告)号：US06552079B2
公开(公告)日：2003-04-22
申请号：US09855448
申请日：2001-05-15
申请人： Robert M. Scarborough , Mark Smyth , Ting Su , Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffry Bernard Franciskovich
发明人： Robert M. Scarborough , Mark Smyth , Ting Su , Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffry Bernard Franciskovich
IPC分类号： C07C31104
CPC分类号： C07D211/62 , C07C311/06 , C07C311/19 , C07C2601/14
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.
摘要翻译： 公开了与哺乳动物整联蛋白有关的新型化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗血栓形成或再狭窄病症。
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公开(公告)号：US06472405B1
公开(公告)日：2002-10-29
申请号：US09299404
申请日：1999-04-26
申请人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , John Michael Morin, Jr. , Daniel J. Sall , Marshall A. Skelton , Robert Theodore Vasileff
发明人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , John Michael Morin, Jr. , Daniel J. Sall , Marshall A. Skelton , Robert Theodore Vasileff
IPC分类号： C07D21716
CPC分类号： C07C257/18 , C07C271/64 , C07C2602/10 , C07D211/22 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D311/22 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12
摘要： This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
摘要翻译： 本发明涉及具有由两个稠合的六元环形成的核的二环化合物，例如异喹啉，异喹啉酮，四氢萘，二氢萘或四氢萘酮，其被碱性和酸性官能团所取代，其可用于抑制血小板聚集。
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公开(公告)号：US5618843A
公开(公告)日：1997-04-08
申请号：US255821
申请日：1994-07-08
申请人： Matthew J. Fisher , Anne M. Happ , Joseph A. Jakubowski , Michael D. Kinnick , Allen D. Kline , John M. Morin, Jr. , Daniel J. Sall , Marshall A. Skelton , Robert T. Vasileff
发明人： Matthew J. Fisher , Anne M. Happ , Joseph A. Jakubowski , Michael D. Kinnick , Allen D. Kline , John M. Morin, Jr. , Daniel J. Sall , Marshall A. Skelton , Robert T. Vasileff
IPC分类号： C07D487/04 , A61K31/015 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/335 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/44 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/495 , A61P7/02 , A61P9/10 , C07C257/18 , C07C271/64 , C07D211/22 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D221/00 , C07D311/22 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12 , C07D491/052 , C07D497/04 , G03F7/20 , C07C251/02
CPC分类号： C07C271/64 , C07C257/18 , C07D211/22 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D311/22 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12 , C07C2102/10
摘要： This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
摘要翻译： 本发明涉及具有由两个稠合的六元环形成的核的某些双环化合物，例如异喹啉，异喹啉酮，四氢萘，二氢萘或四氢萘酮，其被碱性和酸性官能团所取代，其可用于抑制血小板聚集。
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