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公开(公告)号：US20120171218A1
公开(公告)日：2012-07-05
申请号：US13215841
申请日：2011-08-23
申请人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
发明人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
IPC分类号： A61K39/42 , A61P31/16 , G01N33/577 , C07K16/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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公开(公告)号：US20120121603A1
公开(公告)日：2012-05-17
申请号：US13321460
申请日：2010-05-20
申请人： Andres G. Grandea, III , Gordon King , Thomas c. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
发明人： Andres G. Grandea, III , Gordon King , Thomas c. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
CPC分类号： C07K16/1018 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
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公开(公告)号：US08858948B2
公开(公告)日：2014-10-14
申请号：US13321460
申请日：2010-05-20
申请人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
发明人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
IPC分类号： A61K39/42 , A61K39/145 , C12Q1/70
CPC分类号： C07K16/1018 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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公开(公告)号：US20140205612A1
公开(公告)日：2014-07-24
申请号：US13780776
申请日：2013-02-28
申请人： Po-Ying Chan-Hui , Katherine Doores , Michael Huber , Stephen Kaminsky , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Katherine Doores , Michael Huber , Stephen Kaminsky , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
CPC分类号： C07K16/1063 , A61K39/21 , A61K2039/505 , C07K16/1045 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供了一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以抵抗多种HIV-1物种的中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得到的单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染的能力。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：US20110044994A1
公开(公告)日：2011-02-24
申请号：US12726245
申请日：2010-03-17
申请人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
IPC分类号： A61K39/42 , C07K16/10 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , A61K39/395 , A61K39/21 , A61P31/18
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供了一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以抵抗多种HIV-1物质的中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：US20100178295A1
公开(公告)日：2010-07-15
申请号：US12726297
申请日：2010-03-17
申请人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
发明人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
IPC分类号： A61K39/395 , C07K16/10 , A61P31/16
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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7.发明授权Monoclonal antibodies directed against trimeric forms of the HIV-1 envelope glycoprotein with broad and potent neutralizing activity 有权针对三聚体形式的HIV-1包膜糖蛋白的单克隆抗体具有广泛和有效的中和活性公开(公告)号：US09051362B2
公开(公告)日：2015-06-09
申请号：US12726245
申请日：2010-03-17
申请人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以对多种HIV-1物质进行中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：US08329188B2
公开(公告)日：2012-12-11
申请号：US12617243
申请日：2009-11-12
申请人： Matthew Moyle , Jennifer Mitcham
发明人： Matthew Moyle , Jennifer Mitcham
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , A61K45/06 , C07K16/1018 , C07K2317/21 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , Y02A50/412 , Y02A50/472
摘要： The present invention provides novel peptide immunogens comprising influenza virus matrix 2 protein epitopes and related compositions and methods. The present invention relates to a composition comprising a peptide immunogen useful for the prevention and treatment of an influenza virus-mediated disease. The invention also relates to vaccines, immunogenic products and immunogenic compositions containing the peptide immunogens.
摘要翻译： 本发明提供新型肽免疫原，其包含流感病毒基质2蛋白表位及相关组合物和方法。 本发明涉及包含可用于预防和治疗流感病毒介导的疾病的肽免疫原的组合物。 本发明还涉及含有肽免疫原的疫苗，免疫原性产物和免疫原性组合物。
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公开(公告)号：US08114402B2
公开(公告)日：2012-02-14
申请号：US12726297
申请日：2010-03-17
申请人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
发明人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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10.发明申请公开(公告)号：US20110033476A1
公开(公告)日：2011-02-10
申请号：US12795618
申请日：2010-06-07
申请人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
发明人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
IPC分类号： A61K39/395 , C07K16/00 , A61K39/42 , A61P31/16 , C12Q1/70
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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