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1.NOVEL 2,3-DIHYDRO-1H-IMIDAZO(1,2-A)PYRIMIDIN-5-ONE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF 有权
标题翻译: 新的2,3-二氢-1H-咪唑并(1,2-A)嘧啶-5-酮衍生物,其制备方法及其药物用途公开(公告)号:US20120142679A1
公开(公告)日:2012-06-07
申请号:US13381571
申请日:2010-07-01
申请人: Maurice Brolio , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
发明人: Maurice Brolio , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC分类号: A61K31/5377 , A61P35/00 , A61P33/06 , A61P43/00 , A61P33/00 , A61P33/02 , C07D487/04 , A61P35/04
CPC分类号: C07D487/04 , A61K31/519 , A61K31/5377 , C07D413/14 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415
摘要: The invention relates to the novel materials of formula (I), where R1 is an optionally substituted L-aryl or -heteroaryl, such that L is: an alkyl or CO, or LX, with Lbeing an alkyl and X being O or S; R2 is H or an alkyl; R3 is an alkyl optionally substituted by Hal; and R4 is Hou Hal, wherein said materials are in any isomeric form and the salts thereof, to be used as drugs.
摘要翻译: 本发明涉及式(I)的新型材料,其中R 1是任选取代的L-芳基或杂芳基,使得L是:烷基或CO或LX,其中烷基和X是O或S; R2是H或烷基; R3是任选被Hal取代的烷基; 并且R4是Hou Hal,其中所述材料是任何异构形式及其盐,用作药物。
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2.NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO(1,2-A)PYRIMIDIN-6-ONE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF 有权
标题翻译: 新的1,2,3,4-四氢吡喃糖(1,2-A)嘧啶-6-酮衍生物,其制备方法及其药物用途公开(公告)号:US20120208810A1
公开(公告)日:2012-08-16
申请号:US13381790
申请日:2010-07-01
申请人: Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
发明人: Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC分类号: A61K31/5377 , A61P35/00 , A61P33/02 , A61P3/00 , A61P33/00 , A61P33/06 , C07D487/04 , A61P35/04
CPC分类号: C07D487/04 , A61K31/519 , A61K31/5377 , C07D239/06 , C07D239/42 , C07D413/14
摘要: The invention relates to the novel materials of formula (I), where: R1 is an optionally substituted L-aryl or L-heteroaryl, such that L is a single bond, alkyl, CO, or CO-alk, or L-X, with L□ being an alkyl and X being O or S; R2 is H or alkyl; R3 is an alkyl optionally substituted by Hal; and R4 is Hou Hal, wherein said materials are in any isomeric form and the salts thereof, to be used as drugs.
摘要翻译: 本发明涉及式(I)的新型材料,其中:R1是任选取代的L-芳基或L-杂芳基,使得L是单键,烷基,CO或CO-或LX,与L □为烷基,X为O或S; R2是H或烷基; R3是任选被Hal取代的烷基; 并且R4是Hou Hal,其中所述材料是任何异构形式及其盐,用作药物。
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3.1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof 有权
标题翻译: 1,2,3,4-四氢 - 嘧啶并(1,2-a)嘧啶-6-酮衍生物及其药物用途公开(公告)号:US08846670B2
公开(公告)日:2014-09-30
申请号:US13381790
申请日:2010-07-01
申请人: Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
发明人: Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC分类号: A61K31/5377 , A61K31/519 , C07D413/14 , C07D487/04 , C07D239/06 , C07D239/42
CPC分类号: C07D487/04 , A61K31/519 , A61K31/5377 , C07D239/06 , C07D239/42 , C07D413/14
摘要: The invention relates to compounds of the formula: or their racemic, enantiomeric or diastereoisomeric isomers, or pharmaceutically acceptable salts of the compounds of formula I or the racemic, enantiomeric or diasteroisomeric isomers.
摘要翻译: 本发明涉及下式的化合物或其外消旋,对映异构体或非对映异构体异构体或式I化合物的药学上可接受的盐或外消旋,对映异构体或非对映体异构体。
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4.2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof 有权
标题翻译: 2,3-二氢-1H-咪唑并(1,2-a)嘧啶-5-酮衍生物及其药物用途公开(公告)号:US08828997B2
公开(公告)日:2014-09-09
申请号:US13381571
申请日:2010-07-01
申请人: Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
发明人: Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC分类号: A61K31/5377 , A61K31/519 , C07D413/14 , C07D487/04
CPC分类号: C07D487/04 , A61K31/519 , A61K31/5377 , C07D413/14 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415
摘要: The invention relates to a product of formula (I) where R1, R2, R3, and R4 are as defined herein, the therapeutic use of the product, a process to make the product, and a pharmaceutical composition comprising the product.
摘要翻译: 本发明涉及式(I)的产物,其中R 1,R 2,R 3和R 4如本文所定义,产物的治疗用途,制备该产品的方法以及包含该产品的药物组合物。
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5.NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS 有权
标题翻译: 新型吡啶衍生物,其制备方法及其作为AKT(PKB)磷酸化抑制剂的药物用途公开(公告)号:US20130274253A1
公开(公告)日:2013-10-17
申请号:US13977396
申请日:2011-12-22
申请人: Maurice Brollo , Jean-Christophe Carry , Victor Certal , Eric Didier , Gilles Doerflinger , Youssef EL Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Laurent Schio , Fabienne Thompson
发明人: Maurice Brollo , Jean-Christophe Carry , Victor Certal , Eric Didier , Gilles Doerflinger , Youssef EL Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Laurent Schio , Fabienne Thompson
IPC分类号: C07D403/06 , C07D403/14
CPC分类号: C07D403/06 , C07D209/30 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D471/10
摘要: The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.
摘要翻译: 本发明涉及衍生自嘧啶的新化合物,其制备方法,获得的新型中间体,作为药物的用途,含有其的药物组合物及其作为AKT抑制剂的治疗用途。
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6.Substituted Indazoles, Compositions Containing The Same, And The Preparation And Use Thereof 失效
标题翻译: 取代的吲唑,含有它的组合物及其制备和使用公开(公告)号:US20070161626A1
公开(公告)日:2007-07-12
申请号:US11566382
申请日:2006-12-04
申请人: Frank Halley , Michel Tabart , Herve Bouchard , Catherine Souaille , Alain Le Brun , Fabrice Viviani , Laurence Gauzy-Lazo , Pascal Desmazeau , Odile Angouillant-Boniface , Bruno Filoche-Romme
发明人: Frank Halley , Michel Tabart , Herve Bouchard , Catherine Souaille , Alain Le Brun , Fabrice Viviani , Laurence Gauzy-Lazo , Pascal Desmazeau , Odile Angouillant-Boniface , Bruno Filoche-Romme
IPC分类号: A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/416 , A61K31/4178 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号: C07D231/56 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.
摘要翻译: 公开了新的取代的吲唑化合物,包含这些化合物的药物组合物和包含这些化合物的治疗方法。
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7.Substituted indazoles, compositions containing the same, and the preparation and use thereof 失效
标题翻译: 取代的吲唑,含有它们的组合物及其制备和用途公开(公告)号:US07517902B2
公开(公告)日:2009-04-14
申请号:US11566382
申请日:2006-12-04
申请人: Frank Halley , Michel Tabart , Hervé Bouchard , Catherine Souaille , Alain Le Brun , Fabrice Viviani , Laurence Gauzy-Lazo , Pascal Desmazeau , Odile Angouillant-Boniface , Bruno Filoche-Romme
发明人: Frank Halley , Michel Tabart , Hervé Bouchard , Catherine Souaille , Alain Le Brun , Fabrice Viviani , Laurence Gauzy-Lazo , Pascal Desmazeau , Odile Angouillant-Boniface , Bruno Filoche-Romme
IPC分类号: A61K31/541 , A61K31/5377 , C07D417/02 , C07D413/02
CPC分类号: C07D231/56 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.
摘要翻译: 公开了新的取代的吲唑化合物,包含这些化合物的药物组合物和包含这些化合物的治疗方法。
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8.Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效
标题翻译: 吡咯(2,3-b)吡啶衍生物,其制备方法及其在激酶抑制剂形式中的用途公开(公告)号:US07968566B2
公开(公告)日:2011-06-28
申请号:US12410135
申请日:2009-03-24
申请人: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号: C07D401/14 , A61K31/437
CPC分类号: C07D471/04
摘要: Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译: 式(I)的新型化合物或其药学上可接受的盐,其中R,R 1,R 2,R 3,R 4,R 5和R 6具有说明书中给出的含义,包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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9.Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效
标题翻译: 新型吡咯(2,3-b)吡啶衍生物,其制备方法及其在激酶抑制剂形式中的用途公开(公告)号:US20070093480A1
公开(公告)日:2007-04-26
申请号:US11541051
申请日:2006-09-29
申请人: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号: A61K31/5377 , C07D471/02 , A61K31/4745
CPC分类号: C07D471/04
摘要: Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译: 式(I)的新型化合物或其药学上可接受的盐,其中R,R 1,R 2,R 3,R 4,R 5和R 6具有说明书中给出的含义,包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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10.NOVEL PYRROLO(2,3-b) PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS 失效
标题翻译: 新型吡咯(2,3-b)吡啶衍生物,其在激酶抑制剂形式中的制备及其药物应用公开(公告)号:US20090233956A1
公开(公告)日:2009-09-17
申请号:US12410135
申请日:2009-03-24
申请人: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
发明人: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC分类号: A61K31/437 , C07D401/14
CPC分类号: C07D471/04
摘要: Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译: 式(I)的新型化合物或其药学上可接受的盐,其中R,R 1,R 2,R 3,R 4,R 5和R 6具有说明书中给出的含义,包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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