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公开(公告)号：US5095003A
公开(公告)日：1992-03-10
申请号：US604394
申请日：1990-10-23
申请人： Michael A. Goetz , Lawrence R. Koupal , Cheryl D. Schwartz , Jerrold M. Liesch , Otto D. Hensens , Paul S. Anderson , Roger Freidinger , Douglas J. Pettibone
发明人： Michael A. Goetz , Lawrence R. Koupal , Cheryl D. Schwartz , Jerrold M. Liesch , Otto D. Hensens , Paul S. Anderson , Roger Freidinger , Douglas J. Pettibone
CPC分类号： C12R1/465 , C07K7/16 , A61K38/00 , Y10S514/807
摘要： Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.
摘要翻译： 循环肽通过受链霉素链霉菌（Streptomyces silvensis）ATTCC 53525或ATCC No.55326的有氧发酵产生。这些化合物是催产素的拮抗剂，可用于治疗早产和加压素，因此可用于治疗和预防 可能涉及血管加压素的疾病状态，例如充血性心力衰竭，高血压，水肿和低钠血症。
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公开(公告)号：US5130445A
公开(公告)日：1992-07-14
申请号：US660201
申请日：1991-02-25
摘要： There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds structures are presented based upon analytical studies. The compounds have antifungal activity.
摘要翻译： 公开了从鉴定为MA-5000的微生物的发酵液中分离出的一系列大环内酯类，其形态学分析显示为吸水链霉菌菌株。 化合物结构基于分析研究提出。 该化合物具有抗真菌活性。
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3.发明授权Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .beta. inventory enzyme 失效γ - 吡喃酮-3-乙酸作为抑制剂或白细胞介素-1β库存酶
公开(公告)号：US5411985A
公开(公告)日：1995-05-02
申请号：US62881
申请日：1993-05-17
申请人： Gerald F. Bills , Otto D. Hensens , Jerrold M. Liesch , Russel B. Lingham , Jon D. Polishook , Michael J. Salvatore , Susan L. Raghoobar
发明人： Gerald F. Bills , Otto D. Hensens , Jerrold M. Liesch , Russel B. Lingham , Jon D. Polishook , Michael J. Salvatore , Susan L. Raghoobar
IPC分类号： A61K31/35 , C07D309/38 , C12P17/06
CPC分类号： C12R1/645 , A61K31/35 , C07D309/38 , C12P17/06
摘要： Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##
摘要翻译： 发现式I的新型肽基衍生物是白细胞介素-1β转换酶（ICE）的有效抑制剂。 式I化合物可用于治疗肺和气道炎性或免疫性疾病; 中枢神经系统和周围膜; 眼睛和耳朵 关节，骨骼和结缔组织; 包括心包的心血管系统; 胃肠道和泌尿生殖系统; 皮肤和粘膜。 式I化合物也可用于治疗感染（例如，革兰氏阴性休克）的并发症和其中IL1作为自分泌生长因子或作为恶病质介质的肿瘤。
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公开(公告)号：US5306708A
公开(公告)日：1994-04-26
申请号：US630457
申请日：1990-12-19
申请人： Robert E. Schwartz , David F. Sesin , Prakash S. Masurekar , Jerrold M. Liesch , Thomas C. Hallada , Otto D. Hensens
发明人： Robert E. Schwartz , David F. Sesin , Prakash S. Masurekar , Jerrold M. Liesch , Thomas C. Hallada , Otto D. Hensens
IPC分类号： A61K38/00 , A61P31/04 , A61P31/10 , A61P33/02 , C07K7/56 , C07K14/37 , C07K14/41 , C12N1/14 , C12P21/04 , C12R1/645 , A61K37/02 , C07K7/54
摘要： A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H SEQ ID NO:1 or OH SEQ ID NO:2 and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
摘要翻译： 描述了具有式（*化学结构*）（*化学结构*）的新型抗生素环状脂肽，其中R为H SEQ ID NO：1或OH SEQ ID NO：2及其制备方法。 该药剂对人类病原体的活性非常高，哺乳动物的毒性非常低。
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5.发明授权
公开(公告)号：US4847284A
公开(公告)日：1989-07-11
申请号：US172164
申请日：1988-03-23
申请人： Robert E. Schwartz , Janet C. Onishi , Richard L. Monaghan , Jerrold M. Liesch , Otto D. Hensens
发明人： Robert E. Schwartz , Janet C. Onishi , Richard L. Monaghan , Jerrold M. Liesch , Otto D. Hensens
CPC分类号： C12P17/10 , C07D207/12
摘要： A novel pyrrolidinol isolated from the fermentation of Aspergillus ochraceus and certain derivatives thereof are described. The compounds are broad spectrum antifungal agents.
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公开(公告)号：US5028537A
公开(公告)日：1991-07-02
申请号：US202612
申请日：1988-06-06
CPC分类号： A01N57/12 , C07F9/117 , C07F9/6552 , C12P13/00 , C12P17/06 , C12R1/55 , Y10S435/898
摘要： There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds' structures are present based upon analytical studies. The compounds have antifungal activity.
摘要翻译： 公开了从鉴定为MA-5000的微生物的发酵液中分离出的一系列大环内酯类，其形态学分析显示为吸水链霉菌菌株。 基于分析研究，化合物的结构存在。 该化合物具有抗真菌活性。
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公开(公告)号：US4952604A
公开(公告)日：1990-08-28
申请号：US346768
申请日：1989-05-03
申请人： Otto D. Hensens , Jerrold M. Liesch , James A. Milligan , Sagrario M. Del Val , Robert E. Schwartz , Carol Wichmann
发明人： Otto D. Hensens , Jerrold M. Liesch , James A. Milligan , Sagrario M. Del Val , Robert E. Schwartz , Carol Wichmann
IPC分类号： A01N43/16 , A61K31/35 , A61K31/351 , A61P31/04 , A61P31/10 , C07D309/10 , C12P17/06 , C12R1/80
CPC分类号： C12P17/06 , A01N43/16 , C07D309/10
摘要： Pyranyl ester compounds isolated from the fermentation of the species Penicillium are described. The compounds are useful as antifungal agents.
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8.发明授权
公开(公告)号：US4871727A
公开(公告)日：1989-10-03
申请号：US135949
申请日：1987-12-21
申请人： Richard W. Burg , Eugene L. Dulaney , Otto D. Hensens , Jerrold M. Liesch , John G. Ondeyka , Carol F. Wichmann
发明人： Richard W. Burg , Eugene L. Dulaney , Otto D. Hensens , Jerrold M. Liesch , John G. Ondeyka , Carol F. Wichmann
IPC分类号： A61K31/575 , A61K31/58 , A61P11/08 , A61P17/00 , A61P25/04 , A61P29/00 , C07J5/00 , C07J9/00 , C07J17/00 , C07J31/00 , C12P33/00 , C12R1/77
CPC分类号： C07J31/006 , C07J5/00 , C12P33/00
摘要： There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of sail microorganism L-681,512 under controlled fermentation conditions.
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9.发明授权Thermal isomer of difficidin and thermal isomer of oxydifficidin antibacterials 失效苦霉菌素的热异构体和oxydifficidin抗菌剂的热异构体
公开(公告)号：US4816448A
公开(公告)日：1989-03-28
申请号：US11189
申请日：1987-02-05
IPC分类号： C07D313/00 , C07F9/655 , C12P17/08 , A61K31/665 , C07F9/09
CPC分类号： C12R1/125 , C07D313/00 , C07F9/65525 , C12P17/08
摘要： The present invention relates to novel antibacterial compounds referred to herein generally as a thermal isomer of difficidin and thermal isomer of oxydifficidin. Also disclosed is process for preparing, isolating and purifying said compounds.
摘要翻译： 本发明涉及新颖的抗菌化合物，本文通常称作艰难小分子的热异构体和氧联吡啶的热异构体。 还公开了制备，分离和纯化所述化合物的方法。
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公开(公告)号：US5770587A
公开(公告)日：1998-06-23
申请号：US734701
申请日：1996-10-21
申请人： Angela Basilio , Fernando Pelaez , Maria Teresa Diez , Francisca Vicente , Sandra A. Morris , James E. Curotto , Gerald F. Bills , Sarah J. Dreikorn , Otto D. Hensens , Jerrold M. Liesch , Rosalind G. Jenkins , John R. Thompson
发明人： Angela Basilio , Fernando Pelaez , Maria Teresa Diez , Francisca Vicente , Sandra A. Morris , James E. Curotto , Gerald F. Bills , Sarah J. Dreikorn , Otto D. Hensens , Jerrold M. Liesch , Rosalind G. Jenkins , John R. Thompson
CPC分类号： C07J63/008
摘要： There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
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