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    Erysipelothrix rhusiopathiae-haemophilus parasuis vaccine and methods of using the same
    2.
    发明授权
    Erysipelothrix rhusiopathiae-haemophilus parasuis vaccine and methods of using the same 有权
    欧氏结核杆菌血吸虫嗜血杆菌疫苗及其使用方法

    公开(公告)号：US08637047B2

    公开(公告)日：2014-01-28

    申请号：US10975702

    申请日：2004-10-28

    申请人： John Randall Swart ,  Eric Martin Vaughn ,  Karen E. Freking ,  Michael B. Roof ,  Phillip Wayne Hayes ,  Reid C. Phillips

    发明人： John Randall Swart ,  Eric Martin Vaughn ,  Karen E. Freking ,  Michael B. Roof ,  Phillip Wayne Hayes ,  Reid C. Phillips

    IPC分类号： A61K39/116 ,  A61K39/102

    CPC分类号： A61K39/102 ,  A61K39/0241 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55566

    摘要： The present invention provides a composition and an improved single dose vaccine against E. rhusiopathiae and an improved single dose vaccine against E. rhusiopathiae and H. parasuis which provides one or more of the following: 1) confers effective immunity against E. rhusiopathiae and/or H. parasuis; 2) decreases the risk of developing clinical signs of E. rhusiopathiae and/or H. parasuis infection; 3) induces an immune response against E. rhusiopathiae and/or H. parasuis; and 4) has a DOI against E. rhusiopathiae and/or H. parasuis of at least four months. The composition or E. rhusiopathiae vaccine as well as the combined E. rhusiopathiae-H. parasuis composition or vaccine each includes a bacterial component of inactivated E. rhusiopathiae bacteria and a suitable adjuvant. The combined E. rhusiopathiae-H. parasuis composition or vaccine further includes an amount of H. parasuis antigen. The vaccines can be administered to animals in any conventional manner. The amount of the dose for intramuscular administration is preferably less than 5 ml. The amount of E. rhusiopathiae and/or H. parasuis antigen in each dose should be enough to induce an immune response in the animal receiving the vaccine or composition and will preferably confer effective immunity against and decrease the risk of developing clinical signs resulting from E. rhusiopathiae and/or H. parasuis infection for a suitable duration of immunity.

    摘要翻译： 本发明提供组合物和改进的针对埃氏杆菌病的单一剂量疫苗和针对针对埃希氏杆菌和副猪嗜血杆菌的改进的单剂量疫苗，其提供以下一种或多种：1）赋予针对E.杆菌病和/ 或副猪嗜血菌 2）降低发生脑炎病毒和/或副猪嗜血杆菌感染的临床症状的风险; 3）诱导针对埃氏杆菌和/或副猪嗜血杆菌的免疫应答; 和4）具有至少四个月的针对埃氏杆菌和/或副猪嗜血杆菌的DOI。 组合物或E.杆菌病疫苗以及组合的脑炎病毒H。 副产物组合物或疫苗各自包括灭活的肠球菌属细菌的细菌组分和合适的佐剂。 合并的脑炎病毒H。 副产物组成或疫苗还包括一定量的副猪嗜血杆菌抗原。 疫苗可以以任何常规方式施用于动物。 肌内给药的剂量优选小于5ml。 每种剂量的肠球菌和/或副猪嗜血杆菌抗原的量应足以在接受疫苗或组合物的动物中诱导免疫应答，并且优选地赋予有效的免疫力并降低由E引起的临床体征的风险 rhusiopathiae和/或副猪嗜血杆菌感染，具有合适的免疫持续时间。

    Use of Mycoplasma bovis antigen
    5.
    发明授权
    Use of Mycoplasma bovis antigen 有权
    使用支原体牛支原体抗原

    公开(公告)号：US08815255B2

    公开(公告)日：2014-08-26

    申请号：US13056501

    申请日：2009-10-22

    申请人： Michael Beck ,  Phillip Wayne Hayes ,  Jeffrey P. Knittel

    发明人： Michael Beck ,  Phillip Wayne Hayes ,  Jeffrey P. Knittel

    IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/04 ,  A61K45/00 ,  A61K47/00

    CPC分类号： A61K39/0241 ,  A61K2039/522 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/552 ,  C12N1/36 ,  C12R1/35

    摘要： The present invention relates to combination vaccines and/or the combined use of immunogenic compositions for the treatment and/or prophylaxis of cattle against microbiological infections, wherein the infections are caused by M. bovis and at least one further cattle relevant pathogen. The combination vaccine as described herein comprises at least one M. bovis antigen, preferably the attenuated, avirulent M. bovis as provided herewith and one or more further immunologically active components effective for the treatment and/or prophylaxis of infections caused by a further pathogen of cattle.

    摘要翻译： 本发明涉及用于治疗和/或预防牛抗微生物感染的免疫原性组合物的组合疫苗和/或组合使用，其中所述感染由牛分枝杆菌和至少一种其他牛相关病原体引起。 如本文所述的组合疫苗包含至少一种牛分枝杆菌抗原，优选为本发明提供的减毒的无毒力牛分枝杆菌，以及一种或多种进一步的免疫活性组分，其有效用于治疗和/或预防由另一病原体 牛。

    Stable compositions for parenteral administration and their use
    8.
    发明授权
    Stable compositions for parenteral administration and their use 失效
    用于肠胃外给药的稳定组合物及其用途

    公开(公告)号：US06340671B1

    公开(公告)日：2002-01-22

    申请号：US08263574

    申请日：1994-06-22

    申请人： Susan Mancini Cady ,  William David Steber ,  Phillip Wayne Hayes ,  Mary Ehlers Doscher ,  Kurt Allen Schwinghammer

    发明人： Susan Mancini Cady ,  William David Steber ,  Phillip Wayne Hayes ,  Mary Ehlers Doscher ,  Kurt Allen Schwinghammer

    IPC分类号： A61K3170

    CPC分类号： A61K31/70 ,  A61K9/1617 ,  A61K31/35 ,  Y10S514/964 ,  Y10S514/965

    摘要： The invention relates to certain stable microsphere compositions containing a fat, a wax or a mixture thereof; an active ingredient selected from LL-F28249&agr;-&lgr; compounds, 23-oxo or 23-imino derivatives of LL-F28249&agr;-&lgr; compounds, milbemycin compounds and avermectin compounds; an antioxidant and, optionally, an oil, a semi-soft fat, a fatty acid derivative or mixture thereof. The invention also relates to a method for introducing and maintaining levels of the active compound in the blood of warm-blooded animals for extended periods of time and for the prevention or treatment of infections and infestations caused by helminths, nematodes, acarids and endo- and ectoparasitic arthropods in warm-blooded animals by the parenteral administration of compositions of the invention.

    摘要翻译： 本发明涉及含有脂肪，蜡或其混合物的某些稳定的微球组合物; 选自LL-F28249α-羔羊化合物的活性成分，LL-F28249α-羔羊化合物的23-氧代或23-亚氨基衍生物，米尔倍霉素化合物和除虫菌素化合物; 抗氧化剂和任选的油，半软脂肪，脂肪酸衍生物或其混合物。 本发明还涉及一种用于在温血动物的血液中长时间引入和维持活性化合物的水平并用于预防或治疗由蠕虫，线虫，螨虫和内含物引起的感染和侵袭的方法 通过肠胃外给药本发明的组合物在温血动物中的外寄生节肢动物。