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49 条记录 (耗时 0.024 秒)

    Vaccine, method for its preparation, and use thereof in vaccinating humans against rotavirus infection
    2.
    发明授权
    Vaccine, method for its preparation, and use thereof in vaccinating humans against rotavirus infection 失效
    疫苗，其制备方法及其在疫苗接种人体中对轮状病毒感染的应用

    公开(公告)号：US4636385A

    公开(公告)日：1987-01-13

    申请号：US702041

    申请日：1985-02-15

    申请人： Stanley A. Plotkin ,  H. Fred Clark

    发明人： Stanley A. Plotkin ,  H. Fred Clark

    IPC分类号： A61K39/15 ,  A61K39/225 ,  A61K39/42

    CPC分类号： A61K39/15 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/575 ,  C12N2720/12334 ,  Y10S424/813

    摘要： A live rotavirus vaccine against bovine and human rotaviruses comprising a strain of live bovine rotavirus which does not hemagglutinate primate red blood cells, gives at least about 20 fold higher titers when neutralized with antiserum therefor as compared to heterologous bovine or primate rotaviruses, and has a migration pattern of its RNA genome segments when determined by PAGE substantially as shown by lane WC3 in FIG. 1, the strain of bovine rotavirus having been serially passaged in primate kidney tissue culture a sufficient number of times that when administered to humans the vaccine is immunogenic without causing disease.

    摘要翻译： 一种针对牛和人类轮状病毒的活轮状病毒疫苗，其包含不会产生灵长类动物红血细胞的活牛轮状病毒株，与异源牛或灵长类动物轮状病毒相比，当用其抗血清中和时，产生至少约20倍的效价，并具有 当通过PAGE确定时其RNA基因组片段的迁移模式基本上如图3中的泳道WC3所示。 如图1所示，已经在灵长类动物肾组织培养物中连续传代牛轮状病毒菌株足够多的时间，当向人施用时，该疫苗是免疫原性的而不引起疾病。

    Broad spectrum antimicrobial compound and treatment
    5.
    发明授权
    Broad spectrum antimicrobial compound and treatment 失效

    公开(公告)号：US06660262B2

    公开(公告)日：2003-12-09

    申请号：US09965997

    申请日：2001-09-28

    申请人： Randy R. McKinney

    发明人： Randy R. McKinney

    IPC分类号： A61L901

    CPC分类号： A61K36/03 ,  A61K31/07 ,  A61K31/519 ,  A61K31/59 ,  A61K33/24 ,  A61K35/747 ,  Y10S424/813 ,  Y10S424/814 ,  Y10S424/815 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825 ,  Y10S424/829 ,  Y10S435/822 ,  A61K2300/00

    摘要： A new and improved formulation and method for making same, for a broad spectrum antimicrobial treatment for bacterial and viral infections in cattle, horses, pigs, sheep and other domestic and non-domestic animals. More particularly, the present invention relates to a treatment which enables rapid relief of symptoms in an affected animal with a mortality of less than 1 percent by providing trace organic minerals in microgram quantities which act as nutrients for the animal. The treatment provides further nutritional requirements in the form of vitamin A, folic acid and vitamin D3 supplements, cobalt amino acid chelates and dried kelp, a source of minerals, amino acids, simple and complex carbohydrates, iodine and fiber. In addition, a bacterial innoculum consisting of Acidophilus species is introduced which would inhibit growth of pathogenic or opportunistic species of bacteria by competition for nutrients as well as providing for required vitamins as a by-product of metabolism.

    Vaccine for infectious bovine rhinotracheitis
    7.
    发明授权
    Vaccine for infectious bovine rhinotracheitis 失效
    感染性牛鼻气管炎疫苗

    公开(公告)号：US4291019A

    公开(公告)日：1981-09-22

    申请号：US146141

    申请日：1980-05-02

    申请人： Harold W. Lupton ,  David E. Reed

    发明人： Harold W. Lupton ,  David E. Reed

    IPC分类号： A61K39/265

    CPC分类号： A61K39/265 ,  A61K39/12 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N2710/16734 ,  Y10S424/813

    摘要： A vaccine for infectious bovine rhinotracheitis (IBR) is prepared by non-ionic detergent extraction of IBR virus infected cells. The extracted viral envelope protein can be prepared in injectable dose form by combination with an oil-type adjuvant. The vaccine produces a high level of antibody response, and is capable of eliminating virus shed for animals infected after immunization.

    摘要翻译： 通过非离子洗涤剂提取IBR病毒感染细胞制备感染性牛鼻气管炎（IBR）疫苗。 提取的病毒包膜蛋白可以通过与油型佐剂组合而以可注射剂量形式制备。 该疫苗产生高水平的抗体应答，并且能够消除免疫后感染动物的病毒。

    Infectious bovine rhinotracheitis virus vaccine and method of preparing and using the same
    8.
    发明授权
    Infectious bovine rhinotracheitis virus vaccine and method of preparing and using the same 失效
    传染性牛鼻气管炎病毒疫苗及其制备与使用方法

    公开(公告)号：US4132775A

    公开(公告)日：1979-01-02

    申请号：US876998

    申请日：1978-02-13

    申请人： Frank J. Volenec ,  Judson D. Todd

    发明人： Frank J. Volenec ,  Judson D. Todd

    IPC分类号： A61K35/76 ,  A61K39/00 ,  A61K39/265 ,  C12N7/08 ,  A61K39/12

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/265 ,  A61K2039/5254 ,  A61K2039/543 ,  A61K2039/552 ,  C12N2710/16734 ,  C12N2710/16764 ,  Y10S424/813 ,  Y10S514/889

    摘要： Pathogenic infectious bovine rhinotracheitis (IBR) virus may be modified by serial passages in non-bovine tissue cultures until it becomes non-pathogenic when applied to the intranasal passages of bovines. Such application will result in the induction of high levels of interferon in nasal secretions as well as the production of local antibodies and a long lasting immunity against IBR infection by virtue of the induction of specific circulating antibodies. The invention includes the method of modifying the IBR virus, a method of preparing a vaccine therefrom and a method of immunizing bovines and promoting production of high levels of interferon in nasal secretions.

    摘要翻译： 致病性感染性牛鼻气管炎（IBR）病毒可以通过在非牛组织培养物中连续传代而被修饰，直到其应用于牛的鼻内通道时变得非致病性。 这种应用将导致在鼻分泌物中诱导高水平的干扰素以及由于诱导特异性循环抗体而导致局部抗体的产生和对IBR感染的长期免疫性。 本发明包括改变IBR病毒的方法，一种从其中制备疫苗的方法和免疫牛和促进鼻分泌物中高含量干扰素的产生的方法。