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公开(公告)号：US5656034A
公开(公告)日：1997-08-12
申请号：US414663
申请日：1995-03-31
CPC分类号： F04B53/143 , F04B9/02 , G01N30/36 , G01N2030/326 , G01N2030/347
摘要： A syringe pump particularly adapted for delivery of small volumes at a high pressure in an accurate and reproducible manner. The syringe pump includes a frame, a motor attached to the frame, and a lead screw drivably connected to the motor. A cover seal is mounted to the front end of the lead screw, the cover seal having grooves formed therein to facilitate mounting and demounting of the cover seal. The pump further includes a cylindrical barrel within which the cover seal reciprocates, the barrel being made of a ceramic material, wherein the barrel is fixedly attached to the frame at the front end and floatably mounted to the frame at the back end. A barrel head is mounted to the front end of the barrel for closing off that end of the barrel, the barrel head including an outlet port for allowing fluid to enter and exit the barrel. In addition, the present invention includes a multi-syringe gradient syringe pump, a liquid chromatography system, a cover seal, and a mixer for mixing multiple flow streams.
摘要翻译： 一种注射泵，特别适用于以高精度和可重复的方式输送小体积。 注射器泵包括框架，安装在框架上的马达和可驱动地连接到马达的导螺杆。 盖密封件安装在导螺杆的前端，盖密封件具有形成在其中的槽，以便于盖密封件的安装和拆卸。 泵还包括圆柱形筒，其中盖密封件在其中往复运动，筒体由陶瓷材料制成，其中筒体在前端固定地附接到框架并且在后端可浮动地安装到框架。 桶头安装在桶的前端，用于封闭桶的端部，桶头包括用于允许流体进入和离开桶的出口。 此外，本发明包括多注射器梯度注射泵，液相色谱系统，盖密封件和用于混合多个流动流的混合器。
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公开(公告)号：US07002671B2
公开(公告)日：2006-02-21
申请号：US10643304
申请日：2003-08-18
IPC分类号： G01N21/00
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/48728 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2021/6484 , G01N2201/0639
摘要： The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.
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公开(公告)号：US06349160B2
公开(公告)日：2002-02-19
申请号：US09122544
申请日：1998-07-24
IPC分类号： G02B632
CPC分类号： G01N21/253 , G01N2021/6484 , G01N2201/0639
摘要： The present invention is relates to an optical fiber assembly which may be used in an optical detection system. The optical fiber assembly may comprise a trifurcated cable and a ball lens in optical communication with the trifurcated cable. The trifurcated cable may comprise an excitation bundle, a first emission bundle for receiving light and a second emission bundle for receiving light.
摘要翻译： 本发明涉及可用于光学检测系统中的光纤组件。 光纤组件可以包括与三叉电缆光学连通的三叉电缆和球透镜。 三叉电缆可以包括激励束，用于接收光的第一发射束和用于接收光的第二发射束。
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4.发明授权Low background multi-well plates with greater than 864 wells for spectroscopic measurements 失效具有大于864个孔的低背景多孔板进行光谱测量公开(公告)号：US06229603B1
公开(公告)日：2001-05-08
申请号：US08867584
申请日：1997-06-02
IPC分类号： G01N110
CPC分类号： B01L3/5085 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L2200/12 , B01L2300/0829 , B01L2300/12 , C40B60/14
摘要： The invention provides for multi-well plates with greater than 864 wells that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates are particularly well suited for fluorescent measurements.
摘要翻译： 本发明提供了具有大于864个孔的多孔板，其包含具有低荧光和高透射率的环烯烃层。 这些多孔板特别适用于荧光测量。
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5.发明授权公开(公告)号：US06517781B1
公开(公告)日：2003-02-11
申请号：US09476959
申请日：2000-01-03
IPC分类号： B01L300
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L9/523 , B01L2300/021 , B01L2300/0829 , B01L2300/12 , C12M23/12 , C12Q1/00 , C40B60/14 , G01N1/30 , G01N21/03 , G01N21/6428 , G01N21/6452 , G01N33/5308 , G01N33/542 , G01N2021/0346
摘要： One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.
摘要翻译： 本发明的一个方面是用于荧光测量的多孔平台，其包括框架内的多个孔，其中所述多孔平台具有低荧光背景。 本发明的另一方面是用于光谱测量的系统，其包括用于测定的试剂和用于荧光测量的多孔平台。 本发明的另一方面是通过检测从样品发射的光来检测多孔平台中包含的样品中分析物的存在的方法。 本发明的另一方面是通过检测从样品发射的光来识别多孔平台中包含的样品中生物过程或靶的调节剂的方法。 本发明的另一方面是通过该方法鉴定的组合物。 本发明的另一方面是鉴定治疗剂的方法。 本发明的另一方面是通过使用本发明的方法鉴定治疗剂并监测治疗剂在体内模型中的毒理学和功效来测试治疗活性和毒理学治疗剂的方法。
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公开(公告)号：US06426050B1
公开(公告)日：2002-07-30
申请号：US09111553
申请日：1998-07-07
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Chari Stylli , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Chari Stylli , Roger Y. Tsien
IPC分类号： B01L900
CPC分类号： B01L3/5085 , B01J19/00 , B01J19/0046 , B01J2219/00011 , B01J2219/00315 , B01J2219/00317 , B01J2219/00328 , B01J2219/00659 , B01J2219/00691 , B01J2219/00695 , B01J2219/007 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01L9/523 , B01L2300/0829 , C12M23/12 , C40B60/14 , G01N35/0099 , G01N35/028 , G01N2035/042 , G01N2035/0425
摘要： The present invention relates to multi-well platforms, lids, caddies and any combination thereof The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.
摘要翻译： 本发明涉及多井平台，盖子，球童及其任何组合。多井平台包括可以是任何形状并且可以以任何装饰图案布置的多个井。 盖子包括对应于井场的区域。 球罐的尺寸大约是标准96孔微孔板的面积。 当多孔平台与球童接合时，当从组合的底部观察时，多孔平台的井场的井优选地不被球童遮蔽。
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7.发明授权公开(公告)号：US06232114B1
公开(公告)日：2001-05-15
申请号：US08868018
申请日：1997-06-03
IPC分类号： B01L314
CPC分类号： B01L3/5085 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L9/523 , B01L2200/12 , B01L2300/0829 , B01L2300/12 , C40B60/14
摘要： The invention provides for multi-well plates and platforms that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates and platforms are particularly well suited for fluorescent measurements.
摘要翻译： 本发明提供了包含具有低荧光和高透射率的环烯烃层的多孔板和平台。 这些多孔板和平台特别适用于荧光测量。
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公开(公告)号：US07854898B2
公开(公告)日：2010-12-21
申请号：US12271762
申请日：2008-11-14
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L3/50855 , B01L9/523 , B01L2300/0654 , B01L2300/0829 , C12M23/12 , C40B60/14
摘要： The present invention relates to multi-well platforms, lids, caddies and any combination thereof. The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.
摘要翻译： 本发明涉及多孔平台，盖子，球童及其任何组合。 多井平台包括可以是任何形状的多个井，并且可以以任何装饰图案排列。 盖子包括对应于井场的区域。 球罐的尺寸大约是标准96孔微孔板的面积。 当多孔平台与球童接合时，当从组合的底部观察时，多孔平台的井场的井优选地不被球童遮蔽。
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9.发明授权公开(公告)号：US06730520B2
公开(公告)日：2004-05-04
申请号：US10120644
申请日：2002-04-09
IPC分类号： G01N2176
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L9/523 , B01L2300/021 , B01L2300/0829 , B01L2300/12 , C12M23/12 , C12Q1/00 , C40B60/14 , G01N1/30 , G01N21/03 , G01N21/6428 , G01N21/6452 , G01N33/5308 , G01N33/542 , G01N2021/0346
摘要： One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.
摘要翻译： 本发明的一个方面是用于荧光测量的多孔平台，其包括框架内的多个孔，其中所述多孔平台具有低荧光背景。 本发明的另一方面是用于光谱测量的系统，其包括用于测定的试剂和用于荧光测量的多孔平台。 本发明的另一方面是通过检测从样品发射的光来检测多孔平台中包含的样品中分析物的存在的方法。 本发明的另一方面是通过检测从样品发射的光来识别多孔平台中包含的样品中生物过程或靶的调节剂的方法。 本发明的另一方面是通过该方法鉴定的组合物。 本发明的另一方面是鉴定治疗剂的方法。 本发明的另一方面是通过使用本发明的方法鉴定治疗剂并监测治疗剂在体内模型中的毒理学和功效来测试治疗活性和毒理学治疗剂的方法。
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公开(公告)号：US20090148350A1
公开(公告)日：2009-06-11
申请号：US12271762
申请日：2008-11-14
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L3/50855 , B01L9/523 , B01L2300/0654 , B01L2300/0829 , C12M23/12 , C40B60/14
摘要： The present invention relates to multi-well platforms, lids, caddies and any combination thereof. The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.
摘要翻译： 本发明涉及多孔平台，盖子，球童及其任何组合。 多井平台包括可以是任何形状的多个井，并且可以以任何装饰图案排列。 盖子包括对应于井场的区域。 球罐的尺寸大约是标准96孔微孔板的面积。 当多孔平台与球童接合时，当从组合的底部观察时，多孔平台的井场的井优选地不被球童遮蔽。
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