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    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
    1.
    发明授权
    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices 失效
    用于电泳和电渗设备的无气泡和压力产生电极

    公开(公告)号：US07357852B2

    公开(公告)日：2008-04-15

    申请号：US10984239

    申请日：2004-11-09

    申请人： Timothy M. Woudenberg ,  Zbigniew T. Bryning ,  Reid B. Kowallis

    发明人： Timothy M. Woudenberg ,  Zbigniew T. Bryning ,  Reid B. Kowallis

    IPC分类号： G01N27/453 ,  C12Q1/68 ,  B01L3/00

    CPC分类号： G01N27/44704 ,  C02F1/46109 ,  C02F1/469

    摘要： Bubble-free electrodes, electrochemical cells including bubble-free electrodes, analytical devices, and methods for preparing and using them are provided. The analytical devices each include at least one bubble-free electrode. Analytical devices that include an electrochemical cell and a sample containment device are also provided, wherein the electrochemical cell includes an anodic reservoir, a cathodic reservoir, an electrical connection between the anodic reservoir and the cathodic reservoir, and a first bubble-free electrode disposed within one of the anodic reservoir and the cathodic reservoir. A second electrode is disposed within the other reservoir and a power source is provided having a positive terminal that is normally in electrical contact with the first electrode, and a negative terminal that is normally in electrical contact with the second electrode. The analytical device further includes a power source polarity-inverting device for switching the contacts between the terminals of the power source and the first and second electrodes. The sample containment device includes a sample containment chamber having an opening for introducing a sample into the chamber and being positioned with respect to the electrochemical cell such that an electrical field generated by the electrochemical cell can influence a property of a component of a sample disposed in the sample containment chamber. Pressure-generating cells are also provided.

    摘要翻译： 提供无气泡电极，包括无气泡电极的电化学电池，分析装置及其制备和使用方法。 分析装置各自包括至少一个无气泡电极。 还提供了包括电化学电池和样品容纳装置的分析装置，其中电化学电池包括阳极储存器，阴极储存器，阳极储存器和阴极储存器之间的电连接以及设置在阴极储存器内的第一无气泡电极 一个阳极储层和阴极储层。 第二电极设置在另一储存器内，并且提供具有通常与第一电极电接触的正端子的电源，以及通常与第二电极电接触的负极端子。 分析装置还包括用于切换电源的端子与第一和第二电极之间的触点的电源极性反转装置。 样品容纳装置包括样品容纳室，其具有用于将样品引入室中并且相对于电化学电池定位的开口，使得由电化学电池产生的电场可以影响设置在电化学电池中的样品的组分的性质 样品容纳室。 还提供了压力发生电池。

    Fluid Processing Device Comprising Radial Channels
    3.
    发明申请
    Fluid Processing Device Comprising Radial Channels 审中-公开
    包括径向通道的流体处理装置

    公开(公告)号：US20110124002A1

    公开(公告)日：2011-05-26

    申请号：US12826603

    申请日：2010-06-29

    申请人： Timothy M. Woudenberg ,  Reid B. KOWALLIS

    发明人： Timothy M. Woudenberg ,  Reid B. KOWALLIS

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： B01L3/502753 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0409 ,  B01L2400/0421 ,  C12Q1/686 ,  G01N27/44721 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/00069 ,  C12Q2565/629

    摘要： The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.

    摘要翻译： 在一个方面，本发明提供了一种装置，其包括盘形基底，其限定（1）中央储存区域，（2）多个通道，其与中央储存区域基本上径向流体连通并且基本上径向离开， 所述通道彼此共面，并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，优选（3）至少一个室，并且优选地 三个腔室通过与该通道的远端流体连通的通道连接。 优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且 当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。

    High density electrophoresis device and method
    4.
    发明授权
    High density electrophoresis device and method 失效
    高密度电泳装置及方法

    公开(公告)号：US07491305B2

    公开(公告)日：2009-02-17

    申请号：US10731420

    申请日：2003-12-08

    申请人： Timothy M. Woudenberg ,  Reid B. Kowallis

    发明人： Timothy M. Woudenberg ,  Reid B. Kowallis

    IPC分类号： G01N27/453

    CPC分类号： B01L3/502753 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0409 ,  B01L2400/0421 ,  C12Q1/686 ,  G01N27/44721 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/00069 ,  C12Q2565/629

    摘要： The present invention provides, in one aspect, an apparatus or electrophoretic separation of analytes. In one aspect, the apparatus comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of electrophoretic channels in fluid communication with, and emanating substantially radically from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.

    摘要翻译： 本发明在一个方面提供了分析物的装置或电泳分离。 在一个方面，该装置包括盘形基底，其限定（1）中心储存器区域，（2）多个电泳通道，其与中央储存器区域基本上流体连通并且基本上从中央储存区域发出，所述通道与 并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，并且优选地（3）至少一个室，并且优选地三个室，通过 与该通道的远端流体连通的通道。 优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且 当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。

    High density electrophoresis device and method
    6.
    发明授权
    High density electrophoresis device and method 有权
    高密度电泳装置及方法

    公开(公告)号：US06660147B1

    公开(公告)日：2003-12-09

    申请号：US09616596

    申请日：2000-07-14

    申请人： Timothy M. Woudenberg ,  Reid B. Kowallis

    发明人： Timothy M. Woudenberg ,  Reid B. Kowallis

    IPC分类号： G01N2726

    CPC分类号： B01L3/502753 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0409 ,  B01L2400/0421 ,  C12Q1/686 ,  G01N27/44721 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/00069 ,  C12Q2565/629

    摘要： The present invention provides, in one aspect, an apparatus for electrophoretic separation of analytes. In one aspect, the apparatus comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of electrophoretic channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.

    摘要翻译： 本发明一方面提供一种用于电泳分离分析物的装置。 在一个方面，该装置包括一个盘形基底，其限定（1）中央储存区域，（2）多个电泳通道，其与中央储存区域基本上径向流体连通并且基本上径向地从中央储存区域发出，该通道与 并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，并且优选地（3）至少一个室，并且优选地三个室，通过 与该通道的远端流体连通的通道。 优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且 当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。

    High-pressure micro-volume syringe pump
    7.
    发明授权
    High-pressure micro-volume syringe pump 失效
    高压微量注射泵

    公开(公告)号：US5656034A

    公开(公告)日：1997-08-12

    申请号：US414663

    申请日：1995-03-31

    申请人： Michael L. Kochersperger ,  Reid B. Kowallis ,  Andrew A. Pham

    发明人： Michael L. Kochersperger ,  Reid B. Kowallis ,  Andrew A. Pham

    IPC分类号： G01N30/32 ,  F04B9/02 ,  F04B53/14 ,  G01N30/34 ,  G01N30/36 ,  A61M37/00 ,  B01D15/08

    CPC分类号： F04B53/143 ,  F04B9/02 ,  G01N30/36 ,  G01N2030/326 ,  G01N2030/347

    摘要： A syringe pump particularly adapted for delivery of small volumes at a high pressure in an accurate and reproducible manner. The syringe pump includes a frame, a motor attached to the frame, and a lead screw drivably connected to the motor. A cover seal is mounted to the front end of the lead screw, the cover seal having grooves formed therein to facilitate mounting and demounting of the cover seal. The pump further includes a cylindrical barrel within which the cover seal reciprocates, the barrel being made of a ceramic material, wherein the barrel is fixedly attached to the frame at the front end and floatably mounted to the frame at the back end. A barrel head is mounted to the front end of the barrel for closing off that end of the barrel, the barrel head including an outlet port for allowing fluid to enter and exit the barrel. In addition, the present invention includes a multi-syringe gradient syringe pump, a liquid chromatography system, a cover seal, and a mixer for mixing multiple flow streams.

    摘要翻译： 一种注射泵，特别适用于以高精度和可重复的方式输送小体积。 注射器泵包括框架，安装在框架上的马达和可驱动地连接到马达的导螺杆。 盖密封件安装在导螺杆的前端，盖密封件具有形成在其中的槽，以便于盖密封件的安装和拆卸。 泵还包括圆柱形筒，其中盖密封件在其中往复运动，筒体由陶瓷材料制成，其中筒体在前端固定地附接到框架并且在后端可浮动地安装到框架。 桶头安装在桶的前端，用于封闭桶的端部，桶头包括用于允许流体进入和离开桶的出口。 此外，本发明包括多注射器梯度注射泵，液相色谱系统，盖密封件和用于混合多个流动流的混合器。

    Capillary electrophoresis
    8.
    发明授权
    Capillary electrophoresis 失效
    毛细管电泳

    公开(公告)号：US5384024A

    公开(公告)日：1995-01-24

    申请号：US850764

    申请日：1992-03-13

    申请人： Stephen E. Moring ,  Michael S. Albin ,  Reid B. Kowallis ,  Thomas E. Lee ,  Dennis E. Mead ,  John H. Nickel ,  Mark F. Oldham ,  Richard T. Reel ,  Timothy S. Orpin ,  Janice C. Woods

    发明人： Stephen E. Moring ,  Michael S. Albin ,  Reid B. Kowallis ,  Thomas E. Lee ,  Dennis E. Mead ,  John H. Nickel ,  Mark F. Oldham ,  Richard T. Reel ,  Timothy S. Orpin ,  Janice C. Woods

    IPC分类号： G01N27/447 ,  B01D61/46 ,  B01D57/02 ,  G01N27/26

    CPC分类号： G01N27/44782

    摘要： An instrument for capillary electrophoresis has a vertically translatable carrier holding one end of the capillary and an electrode connected to a power supply, and a rotary carousel for presenting containers of sample and buffer solutions to a load position where the end of the capillary and the electrode may be inserted by operating the carrier. The other end of the capillary and a second electrode connected to the power supply are immersed in an outlet buffer reservoir. The instrument has a vacuum supply for providing a relative vacuum over the solution in the outlet buffer reservoir, so simple material may be injected into the capillary either by electromigration or by differential pressure. After injection, the first end of the capillary and the electrode may be immersed in buffer to accomplish electrophoresis. By manipulating the carousel and carrier, multiple samples may be electrophoresed in series. In a preferred embodiment the instrument includes a flexible duck-billed septum for closing containers while permitting easy access for the electrode and the capillary tube. Also in a preferred embodiment the instrument is controlled by a microprocessor-based controller.

    摘要翻译： 用于毛细管电泳的仪器具有保持毛细管的一端和连接到电源的电极的可垂直平移的载体，以及用于将样品和缓冲溶液的容器呈现到毛细管和电极的端部的负载位置的旋转转盘 可以通过操作载体来插入。 毛细管的另一端和连接到电源的第二电极浸入出口缓冲储存器中。 该仪器具有用于在出口缓冲储存器中的溶液上提供相对真空的真空源，因此可以通过电迁移或通过差压将简单的材料注入毛细管。 注射后，将毛细管和电极的第一端浸入缓冲液中以完成电泳。 通过操纵转盘和载体，可以将多个样品串联进行电泳。 在优选实施例中，该仪器包括用于封闭容器的柔性鸭嘴孔隔膜，同时允许容易地接近电极和毛细管。 同样在优选实施例中，仪器由基于微处理器的控制器控制。

    Fluid Processing Device Comprising Radial Channels
    10.
    发明申请
    Fluid Processing Device Comprising Radial Channels 审中-公开
    包括径向通道的流体处理装置

    公开(公告)号：US20090317824A1

    公开(公告)日：2009-12-24

    申请号：US12548409

    申请日：2009-08-26

    申请人： Timothy M. Woudenberg ,  Reid B. Kowallis

    发明人： Timothy M. Woudenberg ,  Reid B. Kowallis

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： B01L3/502753 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0409 ,  B01L2400/0421 ,  C12Q1/686 ,  G01N27/44721 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/00069 ,  C12Q2565/629

    摘要： The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.

    摘要翻译： 在一个方面，本发明提供了一种装置，其包括盘形基底，其限定（1）中央储存区域，（2）多个通道，其与中央储存区域基本上径向流体连通并且基本上径向离开， 所述通道彼此共面，并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，优选（3）至少一个室，并且优选地 三个腔室通过与该通道的远端流体连通的通道连接。 优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且 当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。