Apparatus and Method for Polymer Synthesis Using Arrays
    3.
    发明申请
    Apparatus and Method for Polymer Synthesis Using Arrays 失效
    使用阵列的聚合物合成装置和方法

    公开(公告)号:US20090054605A1

    公开(公告)日:2009-02-26

    申请号:US12177768

    申请日:2008-07-22

    申请人: Thomas M. Brennan

    发明人: Thomas M. Brennan

    摘要: A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having an array of reaction wells (26). A transport mechanism (27) aligns the reaction wells (26) and selected nozzles (22) for deposition of the liquid reagent (24) into selected reaction wells (26). A sliding seal (30) is positioned between the head assembly (21) and the base assembly (25) to form a common chamber (31) enclosing both the reaction well (26) and the nozzles (22) therein. A gas inlet (70) into the common chamber (31), upstream from the nozzles (22), and a gas outlet (71) out of the common chamber (31), downstream from the nozzles (22), sweeps the common chamber (31) of toxic fumes emitted by the reagents. Each reaction well (26) includes an orifice (74) extending into the well (26) which is of a size and dimension to form a capillary liquid seal to retain the reagent solution (76) in the well (26) for polymer chain growth therein. A pressure regulating device (82) is provided for controlling a pressure differential, between a first gas pressure exerted on the reaction well (26) and a second gas pressure exerted on an exit (80) of the orifice, such that upon the pressure differential exceeding a predetermined amount, the reagent solution (76) is expelled from the well (26) through the orifice (74). A method of synthesis of a polymer chain in a synthesis apparatus (20) is also included.

    摘要翻译: 一种用于构建聚合物链的聚合物合成设备(20),其包括具有喷嘴阵列(22)的头组件(21),每个喷嘴连接到液体试剂(24)的容器(23),以及基座组件 )具有反应孔阵列(26)。 输送机构(27)对准反应孔(26)和选定的喷嘴(22),用于将液体试剂(24)沉积到选定的反应孔(26)中。 滑动密封件(30)定位在头部组件(21)和基座组件(25)之间,以形成在其中包围反应井(26)和喷嘴(22)的公共腔室(31)。 从喷嘴(22)的上游进入公共室(31)的气体入口(70)和在公共室(31)之外的喷嘴(22)的下游的气体出口(71)扫过公共室 (31)试剂发出的有毒烟雾。 每个反应井(26)包括延伸到井(26)中的孔(74),其具有尺寸和尺寸以形成毛细管液体密封,以将试剂溶液(76)保持在井(26)中用于聚合物链增长 其中。 提供压力调节装置(82),用于控制施加在反应井(26)上的第一气体压力和施加在孔口出口(80)上的第二气体压力之间的压力差,使得在压差 超过预定量的试剂溶液(76)通过孔口(74)从孔26排出。 也包括在合成装置(20)中合成聚合物链的方法。

    Method and apparatus for substrate handling and printing
    5.
    发明申请
    Method and apparatus for substrate handling and printing 审中-公开
    用于基板处理和印刷的方法和装置

    公开(公告)号:US20060153621A1

    公开(公告)日:2006-07-13

    申请号:US10529363

    申请日:2003-09-25

    申请人: Howard Manning

    发明人: Howard Manning

    IPC分类号: B41J13/10

    摘要: An apparatus and method are described for transferring substrates to and from a printer. In a described embodiment, the apparatus includes a pair of storage units for vertically stacking substrates, and a laterally moveable platen. The storage units are moveable vertically with respect to the platen in order to transfer substrates to and from the platen. The apparatus and method have particular application in the handling and printing large numbers of biological samples on glass slides.

    摘要翻译: 描述了用于将基板传送到打印机和从打印机传送基板的装置和方法。 在所描述的实施例中,该装置包括用于垂直堆叠基板的一对存储单元和可横向移动的压板。 存储单元相对于压板垂直移动,以便将基板传送到压板和从压板传送基板。 该装置和方法特别适用于在玻璃载片上处理和印刷大量生物样品。