公开(公告)号：US06282362B1

公开(公告)日：2001-08-28

申请号：US08949510

申请日：1997-10-10

申请人： Michael Murphy ,  Arthur N. Woo ,  Mark Nichols ,  John Schipper

发明人： Michael Murphy ,  Arthur N. Woo ,  Mark Nichols ,  John Schipper

IPC分类号： H04N576

CPC分类号： H04N5/9201 ,  H04N1/00323 ,  H04N5/772 ,  H04N5/781 ,  H04N5/85 ,  H04N5/907 ,  H04N2101/00

摘要： A geographical position/image capturing system stores object images and position coordinates as digital data. The system incorporates a geo-addressed map data base and geo-positioning device for relating the position of the system at the time the image is captured to the captured digital image data and the geo-addressed map. A point-of-interest feature data base is linked to the image data and the position data, by hyper-media links. Digital multi-media entities such as graphics, video clips, audio streams and the like can be digitally stored and retrieved based on hyper-media links coupling the entities to the object images, the map position and feature data base. A playback unit incorporating an image viewer communicates with the stored digital digital image data, the multi-media entities, the map data base, and the feature data base and allows modified images of selected portions of the images and other data to be viewed by a user. An audio reproduction device may be included to reproduce the audio media entities when they are selected by the appropriate hyper-media link. In one embodiment of the system, the image capturing function and the geo-positioning function are physically remote from the viewing function until the captured data is transferred to the retrieval and playback unit. In another embodiment, the capture functions and playback functions are combined in a compact, hand-held, portable unit for consumer or industrial field use. The images, position data and multi-media entities may be stored as a single, compressed, linked digital data file. The data file is provided with hyper-media connections between the various entities, which connections are actuated by clicking on icons displayed on the viewer, or by actuating buttons or switches provided on the system console. Angular orientation determining device for providing angular orientation data may also be incorporated such that the system angular orientation at the time of image capture may be captured and stored for subsequent retrieval and display.

公开(公告)号：US20070177133A1

公开(公告)日：2007-08-02

申请号：US11344626

申请日：2006-02-01

申请人： Gary Cain ,  Mark Nichols ,  Hiroyuki Takagi

发明人： Gary Cain ,  Mark Nichols ,  Hiroyuki Takagi

IPC分类号： G01B11/26 ,  G01B11/14

CPC分类号： E02F3/437 ,  E02F9/26 ,  G01C15/002 ,  G01S1/70 ,  G01S3/784

摘要： The present invention provides operators the ability to follow a predetermined path and achieve desired digging depth by watching steering and elevation indicators of just one system. The indicators are activated by data derived from the interception of signals generated by a single laser transmitter and a receiver array mounted on the machine. The system according to the present invention uses the multiple, tilted fan beams provided by the laser transmitter to calculate elevation angle and azimuth of the tool carried by machine.

摘要翻译： 本发明通过观察仅一个系统的转向和仰角指示，使操作者能够遵循预定的路径并达到期望的挖掘深度。 这些指示器是由拦截由单个激光发射器和安装在机器上的接收器阵列产生的信号的数据激活的。 根据本发明的系统使用由激光发射器提供的多个倾斜的风扇梁来计算由机器携带的工具的仰角和方位角。

公开(公告)号：US20060174239A1

公开(公告)日：2006-08-03

申请号：US11047131

申请日：2005-01-31

申请人： Christopher Dietsch ,  Mark Nichols ,  Arthur Taylor

发明人： Christopher Dietsch ,  Mark Nichols ,  Arthur Taylor

IPC分类号： G06F9/44

CPC分类号： G06Q10/06

摘要： A project data delivery apparatus for automatically delivering project data files to a construction machine based on the geographical location and identification of the construction machine. The apparatus includes a project data distributor for storing, maintaining and transmitting project data files that are associated with project site locations and project plan machine identifications.

摘要翻译： 一种项目数据传送装置，用于根据建筑机械的地理位置和识别自动地将工程数据文件交付给施工机械。 该装置包括用于存储，维护和传送与项目站点位置和项目计划机器标识相关联的项目数据文件的项目数据分发器。

公开(公告)号：USD292524S

公开(公告)日：1987-10-27

申请号：US717566

申请日：1985-03-29

申请人： Mark Nichols

设计人： Mark Nichols

公开(公告)号：US09125008B2

公开(公告)日：2015-09-01

申请号：US13183298

申请日：2011-07-14

申请人： Mark Nichols ,  Gregory C. Best

发明人： Mark Nichols ,  Gregory C. Best

IPC分类号： G08B1/08 ,  H04W4/02 ,  H04W64/00 ,  H04W4/12

CPC分类号： H04W4/02 ,  H04W4/12 ,  H04W64/00

摘要： A method and system for providing information about mobile communication devices with respect to an area of interest is disclosed. A first person associated with the mobile communication device located in the area of interest is identified, wherein the identifying occurs at a location and messaging center. A contact person associated with the first person is identified. Information is provided to the contact person that the mobile communication device associated with the first person is located in the area of interest.

摘要翻译： 公开了一种用于提供关于移动通信设备关于感兴趣区域的信息的方法和系统。 识别与位于感兴趣区域中的移动通信设备相关联的第一人，其中识别发生在位置和消息中心。 识别与第一人员相关联的联系人。 向联系人提供与第一人员相关联的移动通信设备位于感兴趣区域中的信息。

公开(公告)号：US20130333364A1

公开(公告)日：2013-12-19

申请号：US13527095

申请日：2012-06-19

申请人： Hamish John Carpenter ,  Richard Paul Piekutowski ,  Mark Nichols

发明人： Hamish John Carpenter ,  Richard Paul Piekutowski ,  Mark Nichols

IPC分类号： F15B3/00

CPC分类号： F15B3/00 ,  E02F3/435 ,  E02F9/2029 ,  E02F9/2203 ,  E02F9/265

摘要： A control for an excavator of the type having a plurality of hydraulic cylinders for moving excavator components such that digging is accomplished at a worksite with an excavator bucket or other excavator implement, includes a plurality of hydraulic control valves, each of which is associated with a respective one of the hydraulic cylinders for controlling the application of hydraulic fluid pressure to the respective one of the hydraulic cylinders, and a plurality of manually actuated joystick valves for supplying hydraulic fluid pressure to the respective hydraulic control valves to control the movement of the hydraulic cylinders. The control includes a sensor arrangement for sensing the position of one or more excavator components.

摘要翻译： 具有多个用于移动挖掘机部件的挖掘机的挖掘机的控制装置包括多个液压控制阀，每个液压控制阀与一个液压控制阀相关联，该多个液压缸与挖掘机铲斗或其他挖掘机工具在工地上完成挖掘 用于控制对相应的一个液压缸施加液压流体压力的液压缸中的相应一个;以及用于向相应的液压控制阀提供液压流体压力以控制液压缸的运动的多个手动操作的操纵杆阀 。 该控制器包括用于感测一个或多个挖掘机部件的位置的传感器装置。

公开(公告)号：US07881845B2

公开(公告)日：2011-02-01

申请号：US11959722

申请日：2007-12-19

申请人： Mark Nichols

发明人： Mark Nichols

IPC分类号： E02F9/26 ,  G01C21/00 ,  G06F19/00

CPC分类号： E02F3/3414 ,  E02F3/431 ,  E02F9/264

摘要： A loader and a control system for a loader provide for monitoring the position of a part of the implement carried by the loader. The loader has a body with left and right upright tower portions, and a loader drive system including ground engaging drive elements. Left and right interconnected lift arm assemblies each have an implement lift arm pivotally connected with a corresponding tower portion of the body at a lift arm pivot point. A lift actuator is connected between the body and the lift arm. The implement is pivotally connected with the lift arm assemblies about an implement pivot axis. The lift arm pivot point and the implement pivot axis in side elevation define a straight reference line. At least one implement tilt actuator is connected between at least one of the lift arm assemblies and the implement. A position sensor is mounted on the body at the level of, or above, the lift arm pivot points. An inclinometer is movable with the left and right interconnected lift arm assemblies to provide an indication of the inclination of the lift arm assemblies along the straight reference line. An angle sensor provides an indication of the orientation of said implement with respect to said left and right interconnected lift arm assemblies. The control is responsive to the position sensor, the inclinometer, and the angle sensor. The control determines the position of the position sensor and the position of a part of the implement with respect to the position sensor.

公开(公告)号：US07524653B2

公开(公告)日：2009-04-28

申请号：US10842353

申请日：2004-05-10

申请人： Mark Nichols ,  Richard Steinman

发明人： Mark Nichols ,  Richard Steinman

IPC分类号： C12N15/64 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12N15/1138 ,  C12N15/1093 ,  C12N15/111 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/31

摘要： In one aspect, the invention provides a random or semirandom siRNA (encoding) library. Another aspect of the invention pertains to methods for construction of random or semirandom siRNA (encoding) libraries. Another aspect of the invention is vector systems for use in constructing siRNA libraries and/or that can express single siRNAs and siRNA libraries both constitutively and in an inducible fashion. In another aspect, the invention provides a method of using an siRNA library. The siRNA library is introduced into a population of cells. The population of cells then is subjected to a selection process to select a subpopulation of cells exhibiting a different behavioral, biochemical, chemical, functional, molecular, morphological, phenotypic, or physical property from the remainder of population. Following the selection process, the subpopulation of cells can be isolated, analyzed, and/or cloned as desired. Such analysis of the subpopulation can be identification and sequencing of the siRNA species responsible for the different properties of the subpopulation relative to the remainder of the population. Alternatively, the subpopulation can be further analyzed by genomic, proteomic, and/or cellomic assays. Where such genomic, proteomic, and/or cellomic assays are employed, the method can produce several useful bioinformatics products. Specific siRNAs identified through this process may have direct therapeutic value.

摘要翻译： 一方面，本发明提供了随机或半免疫siRNA（编码）文库。 本发明的另一方面涉及用于构建随机或半随机siRNA（编码）文库的方法。 本发明的另一方面是用于构建siRNA文库的载体系统和/或可组成型和诱导型表达单个siRNA和siRNA文库。 另一方面，本发明提供了使用siRNA文库的方法。 将siRNA文库导入细胞群。 然后对细胞群体进行选择过程，从其余群体中选择表现出不同行为，生物化学，化学，功能，分子，形态，表型或物理性质的细胞亚群。 在选择过程之后，可以根据需要分离，分析和/或克隆细胞亚群。 亚群的这种分析可以是负责亚群相对于其余群体的不同性质的siRNA物种的鉴定和测序。 或者，亚群可以通过基因组，蛋白质组学和/或纤维素测定进一步分析。 在使用这种基因组，蛋白质组学和/或纤维素测定法的情况下，该方法可以产生几种有用的生物信息学产物。 通过该方法鉴定的特异性siRNA可具有直接的治疗价值。

公开(公告)号：USD564484S1

公开(公告)日：2008-03-18

申请号：US29249577

申请日：2006-10-12

申请人： Eva Russell ,  Frank Tyneski ,  Russell Paik ,  Richard Watson ,  Scott Stropkay ,  Mark Nichols

设计人： Eva Russell ,  Frank Tyneski ,  Russell Paik ,  Richard Watson ,  Scott Stropkay ,  Mark Nichols

公开(公告)号：US20070166720A1

公开(公告)日：2007-07-19

申请号：US10842353

申请日：2004-05-10

申请人： Mark Nichols ,  Richard Steinman

发明人： Mark Nichols ,  Richard Steinman

IPC分类号： C40B30/06 ,  C40B40/08

CPC分类号： C12N15/1138 ,  C12N15/1093 ,  C12N15/111 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/31

摘要： In one aspect, the invention provides a random or semirandom siRNA (encoding) library. Another aspect of the invention pertains to methods for construction of random or semirandom siRNA (encoding) libraries. Another aspect of the invention is vector systems for use in constructing siRNA libraries and/or that can express single siRNAs and siRNA libraries both constitutively and in an inducible fashion. In another aspect, the invention provides a method of using an siRNA library. The siRNA library is introduced into a population of cells. The population of cells then is subjected to a selection process to select a subpopulation of cells exhibiting a different behavioral, biochemical, chemical, functional, molecular, morphological, phenotypic, or physical property from the remainder of population. Following the selection process, the subpopulation of cells can be isolated, analyzed, and/or cloned as desired. Such analysis of the subpopulation can be identification and sequencing of the siRNA species responsible for the different properties of the subpopulation relative to the remainder of the population. Alternatively, the subpopulation can be further analyzed by genomic, proteomic, and/or cellomic assays. Where such genomic, proteomic, and/or cellomic assays are employed, the method can produce several useful bioinformatics products. Specific siRNAs identified through this process may have direct therapeutic value.

摘要翻译： 一方面，本发明提供了随机或半免疫siRNA（编码）文库。 本发明的另一方面涉及用于构建随机或半随机siRNA（编码）文库的方法。 本发明的另一方面是用于构建siRNA文库的载体系统和/或可组成型和诱导型表达单个siRNA和siRNA文库。 另一方面，本发明提供了使用siRNA文库的方法。 将siRNA文库导入细胞群。 然后对细胞群体进行选择过程，从其余群体中选择表现出不同行为，生物化学，化学，功能，分子，形态，表型或物理性质的细胞亚群。 在选择过程之后，可以根据需要分离，分析和/或克隆细胞亚群。 亚群的这种分析可以是负责亚群相对于其余群体的不同性质的siRNA物种的鉴定和测序。 或者，亚群可以通过基因组，蛋白质组学和/或纤维素测定进一步分析。 在使用这种基因组，蛋白质组学和/或纤维素测定法的情况下，该方法可以产生几种有用的生物信息学产物。 通过该方法鉴定的特异性siRNA可具有直接的治疗价值。