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公开(公告)号：US20140046018A1
公开(公告)日：2014-02-13
申请号：US13966540
申请日：2013-08-14
申请人： Michael Shane O'Shea , Florian Hans Maximillian Graichen , Russell John Tait , Heng Chy Taing , Justine Leigh Jeffery
发明人： Michael Shane O'Shea , Florian Hans Maximillian Graichen , Russell John Tait , Heng Chy Taing , Justine Leigh Jeffery
IPC分类号： A61K47/48
CPC分类号： A61K47/482 , A61K47/59 , C07C69/40 , C07C69/67 , C07C69/675 , C07C2601/14 , C07D215/56 , C07D317/24 , C07D317/26 , C07D319/06 , C07D405/12 , C07D498/06 , C07F9/4075 , C07F9/4081 , C08G18/284 , C08G18/4277 , C08G18/428 , C08G2230/00
摘要： The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.
摘要翻译： 本发明涉及包含多个可释放的生物活性部分的可生物降解的聚合物，所述可释放的生物活性部分从所述可生物降解的聚合物主链悬挂并共价键合，其中所述可生物降解的聚合物主链由通过可生物降解的部分连接的单体单元形成， 并且其中生物活性部分能够以等于或快于聚合物主链的生物降解速率的速率释放。
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公开(公告)号：US08535655B2
公开(公告)日：2013-09-17
申请号：US13082841
申请日：2011-04-08
申请人： Michael Shane O'Shea , Florian Hans Maximilian Graichen , Russell John Tait , Heng Chy Taing , Justine Leigh Jeffery
发明人： Michael Shane O'Shea , Florian Hans Maximilian Graichen , Russell John Tait , Heng Chy Taing , Justine Leigh Jeffery
IPC分类号： A61K31/65 , A61K31/787 , A61K31/785 , C07D401/10 , C07D498/06 , C07C69/30 , C07C69/675 , C07F9/141 , A61P27/02 , A61P35/00 , A61P23/02 , C08G18/66 , C08G18/34 , C08G18/32 , C08G18/38
CPC分类号： A61K47/482 , A61K47/59 , C07C69/40 , C07C69/67 , C07C69/675 , C07C2601/14 , C07D215/56 , C07D317/24 , C07D317/26 , C07D319/06 , C07D405/12 , C07D498/06 , C07F9/4075 , C07F9/4081 , C08G18/284 , C08G18/4277 , C08G18/428 , C08G2230/00
摘要： The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.
摘要翻译： 本发明涉及包含多个可释放的生物活性部分的可生物降解的聚合物，所述可释放的生物活性部分从所述可生物降解的聚合物主链悬挂并共价键合，其中所述可生物降解的聚合物主链由通过可生物降解的部分连接的单体单元形成， 并且其中生物活性部分能够以等于或快于聚合物主链的生物降解速率的速率释放。
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公开(公告)号：US20110243884A1
公开(公告)日：2011-10-06
申请号：US13082841
申请日：2011-04-08
申请人： Michael Shane O'Shea , Florian Hans Maximilian Graichen , Russell John Tait , Heng Chy Taing , Justine Leigh Jeffery
发明人： Michael Shane O'Shea , Florian Hans Maximilian Graichen , Russell John Tait , Heng Chy Taing , Justine Leigh Jeffery
IPC分类号： A61K31/765 , A61K31/787 , C07D401/10 , C07C69/30 , C07C69/675 , A61K31/785 , C07D498/06 , C07F9/141 , A61P27/02 , A61P35/00 , A61P23/02 , C08G18/66 , C08G18/34 , C08G18/32 , C08G18/38
CPC分类号： A61K47/482 , A61K47/59 , C07C69/40 , C07C69/67 , C07C69/675 , C07C2601/14 , C07D215/56 , C07D317/24 , C07D317/26 , C07D319/06 , C07D405/12 , C07D498/06 , C07F9/4075 , C07F9/4081 , C08G18/284 , C08G18/4277 , C08G18/428 , C08G2230/00
摘要： The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.
摘要翻译： 本发明涉及包含多个可释放的生物活性部分的可生物降解的聚合物，所述可释放的生物活性部分从所述可生物降解的聚合物主链悬挂并共价键合，其中所述可生物降解的聚合物主链由通过可生物降解的部分连接的单体单元形成， 并且其中生物活性部分能够以等于或快于聚合物主链的生物降解速率的速率释放。
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公开(公告)号：US08445581B2
公开(公告)日：2013-05-21
申请号：US12309794
申请日：2007-08-02
申请人： Pathiraja Arachchillage Gunatillake , Roshan Tyrrel Anton Mayadunne , Raju Adhikari , Heng Chy Taing , Tam Phuong Thi Le , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Jacinta Frances White , Tracy Ann Tebb
发明人： Pathiraja Arachchillage Gunatillake , Roshan Tyrrel Anton Mayadunne , Raju Adhikari , Heng Chy Taing , Tam Phuong Thi Le , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Jacinta Frances White , Tracy Ann Tebb
IPC分类号： C08F290/02 , C08F299/00 , C08G63/08 , C08L33/04
CPC分类号： C08G18/4277 , A61L27/16 , C08F290/00 , C08F290/02 , C08F299/00 , C08G18/10 , C08G18/4833 , C08G18/771 , C08G18/8116 , C08G63/08 , C08G63/664 , C08G2230/00 , C08L53/00 , C08L53/005 , C08L53/02 , C08L2666/02
摘要： The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.
摘要翻译： 本发明提供了包含亲水和疏水链段的生物相容性预聚物，其中疏水链段具有至少一个烯键式不饱和官能团，并且至少5％的链段具有两个或多个烯键式不饱和官能团和水。 本发明还提供了包含亲水和疏水预聚物的生物相容性预聚物组合物，其中至少一种疏水性预聚物具有至少一个烯键式不饱和官能团，并且至少5％的预聚物具有两个或更多个烯属不饱和官能团和水。 本发明进一步提供本发明的预聚物或预聚物组合物在生物医学应用如组织工程，骨替代物或支架中的用途，以及在伤口治疗中的用途。
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公开(公告)号：US20090324675A1
公开(公告)日：2009-12-31
申请号：US12309794
申请日：2007-08-02
申请人： Pathiraja Arachchillage Gunatillake , Roshan Tyrrel Anton Mayadunne , Raju Adhikari , Heng Chy Taing , Tam Phuong Thi Le , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Jacinta Frances White , Tracy Ann Tebb
发明人： Pathiraja Arachchillage Gunatillake , Roshan Tyrrel Anton Mayadunne , Raju Adhikari , Heng Chy Taing , Tam Phuong Thi Le , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Jacinta Frances White , Tracy Ann Tebb
CPC分类号： C08G18/4277 , A61L27/16 , C08F290/00 , C08F290/02 , C08F299/00 , C08G18/10 , C08G18/4833 , C08G18/771 , C08G18/8116 , C08G63/08 , C08G63/664 , C08G2230/00 , C08L53/00 , C08L53/005 , C08L53/02 , C08L2666/02
摘要： The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.
摘要翻译： 本发明提供了包含亲水和疏水链段的生物相容性预聚物，其中疏水链段具有至少一个烯键式不饱和官能团，并且至少5％的链段具有两个或多个烯键式不饱和官能团和水。 本发明还提供了包含亲水和疏水预聚物的生物相容性预聚物组合物，其中至少一种疏水性预聚物具有至少一个烯键式不饱和官能团，并且至少5％的预聚物具有两个或更多个烯属不饱和官能团和水。 本发明进一步提供本发明的预聚物或预聚物组合物在生物医学应用如组织工程，骨替代物或支架中的用途，以及在伤口治疗中的用途。
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