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公开(公告)号：US08445581B2
公开(公告)日：2013-05-21
申请号：US12309794
申请日：2007-08-02
申请人： Pathiraja Arachchillage Gunatillake , Roshan Tyrrel Anton Mayadunne , Raju Adhikari , Heng Chy Taing , Tam Phuong Thi Le , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Jacinta Frances White , Tracy Ann Tebb
发明人： Pathiraja Arachchillage Gunatillake , Roshan Tyrrel Anton Mayadunne , Raju Adhikari , Heng Chy Taing , Tam Phuong Thi Le , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Jacinta Frances White , Tracy Ann Tebb
IPC分类号： C08F290/02 , C08F299/00 , C08G63/08 , C08L33/04
CPC分类号： C08G18/4277 , A61L27/16 , C08F290/00 , C08F290/02 , C08F299/00 , C08G18/10 , C08G18/4833 , C08G18/771 , C08G18/8116 , C08G63/08 , C08G63/664 , C08G2230/00 , C08L53/00 , C08L53/005 , C08L53/02 , C08L2666/02
摘要： The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.
摘要翻译： 本发明提供了包含亲水和疏水链段的生物相容性预聚物，其中疏水链段具有至少一个烯键式不饱和官能团，并且至少5％的链段具有两个或多个烯键式不饱和官能团和水。 本发明还提供了包含亲水和疏水预聚物的生物相容性预聚物组合物，其中至少一种疏水性预聚物具有至少一个烯键式不饱和官能团，并且至少5％的预聚物具有两个或更多个烯属不饱和官能团和水。 本发明进一步提供本发明的预聚物或预聚物组合物在生物医学应用如组织工程，骨替代物或支架中的用途，以及在伤口治疗中的用途。
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公开(公告)号：US20090324675A1
公开(公告)日：2009-12-31
申请号：US12309794
申请日：2007-08-02
申请人： Pathiraja Arachchillage Gunatillake , Roshan Tyrrel Anton Mayadunne , Raju Adhikari , Heng Chy Taing , Tam Phuong Thi Le , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Jacinta Frances White , Tracy Ann Tebb
发明人： Pathiraja Arachchillage Gunatillake , Roshan Tyrrel Anton Mayadunne , Raju Adhikari , Heng Chy Taing , Tam Phuong Thi Le , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Jacinta Frances White , Tracy Ann Tebb
CPC分类号： C08G18/4277 , A61L27/16 , C08F290/00 , C08F290/02 , C08F299/00 , C08G18/10 , C08G18/4833 , C08G18/771 , C08G18/8116 , C08G63/08 , C08G63/664 , C08G2230/00 , C08L53/00 , C08L53/005 , C08L53/02 , C08L2666/02
摘要： The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.
摘要翻译： 本发明提供了包含亲水和疏水链段的生物相容性预聚物，其中疏水链段具有至少一个烯键式不饱和官能团，并且至少5％的链段具有两个或多个烯键式不饱和官能团和水。 本发明还提供了包含亲水和疏水预聚物的生物相容性预聚物组合物，其中至少一种疏水性预聚物具有至少一个烯键式不饱和官能团，并且至少5％的预聚物具有两个或更多个烯属不饱和官能团和水。 本发明进一步提供本发明的预聚物或预聚物组合物在生物医学应用如组织工程，骨替代物或支架中的用途，以及在伤口治疗中的用途。
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3.发明授权公开(公告)号：US08729202B2
公开(公告)日：2014-05-20
申请号：US11070217
申请日：2005-03-03
IPC分类号： C08F10/00
CPC分类号： C08G18/10 , C08G18/3206 , C08G18/4277 , C08G18/428 , C08G18/4854 , C08G18/7671 , C08G18/771 , C08G18/8116 , C08L75/16 , C08L101/16
摘要： The present invention provides a biocompatible polymer composition for use in biomedical applications comprising a base molecule, a linker molecule and at least one initiator compound, said base molecule having at least two differing functionalities, and said linker molecule having a functionality reactive with at least one functionality of said base molecule, the first of said at least two functionalities of said base molecule enabling a first curing stage of said polymer composition by reaction with said linker molecule, and the second and any further functionality of said base molecule enabling second and further curing stages of said polymer composition, said first, second and any further curing stages being capable of activation simultaneously or independently of each other as required.
摘要翻译： 本发明提供了用于生物医学应用的生物相容性聚合物组合物，其包含基础分子，连接分子和至少一种引发剂化合物，所述碱基分子具有至少两个不同的官能团，并且所述连接分子具有与至少一个 所述碱基分子的功能性，所述碱基分子的所述至少两个官能团中的第一个能够通过与所述连接分子的反应来实现所述聚合物组合物的第一固化阶段，并且所述碱基分子的第二和任何其它官能团能够进行第二次和进一步固化 所述聚合物组合物的阶段，所述第一，第二和任何其它固化阶段能够根据需要同时或彼此独立地活化。
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公开(公告)号：US08357767B2
公开(公告)日：2013-01-22
申请号：US12245491
申请日：2008-10-03
CPC分类号： C08G18/428 , A61L27/18 , A61L31/06 , B33Y70/00 , B33Y80/00 , C08G18/4283 , C08G18/664 , C08G18/722 , C08G2230/00 , C08L75/04
摘要： The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%. The invention further provides uses of the compositions of the invention in biomedical vascular stents, an orthopedic implant, a drug delivery coating or in tissue engineering.
摘要翻译： 本发明提供一种聚氨酯/聚氨酯/尿素组合物，其在0℃至60℃的温度下具有大于10MPa的拉伸强度，大于400MPa的弹性模量和断裂伸长率大于30％ 且相对湿度在0％至100％之间。 本发明还提供本发明组合物在生物医学血管支架，矫形植入物，药物递送涂层或组织工程中的用途。
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公开(公告)号：US20090175921A1
公开(公告)日：2009-07-09
申请号：US11992340
申请日：2006-09-20
IPC分类号： A61L27/54 , C07C69/675 , C07C69/732 , C09K3/00 , C08G18/67 , C08G18/32
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula (I)
摘要翻译： 本发明涉及扩链剂，其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲（例如支架，用于组织工程的支架）中的用途。 扩链剂包括式（I）化合物，
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公开(公告)号：US20130121969A1
公开(公告)日：2013-05-16
申请号：US13665531
申请日：2012-10-31
CPC分类号： A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要： The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
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公开(公告)号：US20090099600A1
公开(公告)日：2009-04-16
申请号：US12245491
申请日：2008-10-03
CPC分类号： C08G18/428 , A61L27/18 , A61L31/06 , B33Y70/00 , B33Y80/00 , C08G18/4283 , C08G18/664 , C08G18/722 , C08G2230/00 , C08L75/04
摘要： The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%.The invention further provides uses of the compositions of the invention in biomedical vascular stents, an orthopaedic implant, a drug delivery coating or in tissue engineering.
摘要翻译： 本发明提供一种聚氨酯/聚氨酯/尿素组合物，其在0℃至60℃的温度下具有大于10MPa的拉伸强度，大于400MPa的弹性模量和断裂伸长率大于30％ 且相对湿度在0％至100％之间。 本发明还提供本发明组合物在生物医学血管支架，矫形植入物，药物递送涂层或组织工程中的用途。
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公开(公告)号：US08962786B2
公开(公告)日：2015-02-24
申请号：US13164316
申请日：2011-06-20
IPC分类号： C08G18/00 , C07C69/675 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C08G18/10 , C08G18/32 , C08G18/42 , C08G18/66 , C08G18/77
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula(I)
摘要翻译： 本发明涉及扩链剂，其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲（例如支架，用于组织工程的支架）中的用途。 扩链剂包括式（I）化合物，
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公开(公告)号：US20110287102A1
公开(公告)日：2011-11-24
申请号：US13164316
申请日：2011-06-20
IPC分类号： A61K9/14 , C07C69/732 , A61K47/34 , C12N5/071 , C08G18/68 , C08G18/66 , A61L27/34 , A61L27/18 , C07C69/675 , A61P43/00
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula.(I)
摘要翻译： 本发明涉及扩链剂，其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲（例如支架，用于组织工程的支架）中的用途。 扩链剂包括式（I）化合物：
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公开(公告)号：US08529880B2
公开(公告)日：2013-09-10
申请号：US13665531
申请日：2012-10-31
IPC分类号： A61K31/74
CPC分类号： A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要： The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
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