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17 条记录 (耗时 0.035 秒)

    COATINGS AND METHODS FOR CONTROLLED ELUTION OF HYDROPHILIC ACTIVE AGENTS
    4.
    发明申请
    COATINGS AND METHODS FOR CONTROLLED ELUTION OF HYDROPHILIC ACTIVE AGENTS 审中-公开
    水解活性剂的控制涂层和方法

    公开(公告)号：US20120100187A1

    公开(公告)日：2012-04-26

    申请号：US13281802

    申请日：2011-10-26

    申请人： Ralph A. Chappa ,  Michael J. Burkstrand ,  David E. Babcock

    发明人： Ralph A. Chappa ,  Michael J. Burkstrand ,  David E. Babcock

    IPC分类号： A61K9/00 ,  A61K31/7052 ,  B05D5/00 ,  A61K38/02

    CPC分类号： A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L31/16 ,  A61L2420/02 ,  C08L31/04

    摘要： Embodiments of the invention include multi-layer coatings and methods for controlling the elution of hydrophilic active agents. In an embodiment, the invention includes a medical device including a substrate, a primer polymer layer disposed on the substrate, an expandable layer disposed on the primer polymer layer, and a hydrophilic active agent dispersed within the expandable layer. In an embodiment, the invention includes a method of forming a medical device including depositing a primer layer onto a substrate, the primer layer comprising a primer polymer. The method can further include depositing an expandable layer onto the primer layer, the expandable layer including an expandable polymer, and a hydrophilic active agent. The expandable layer can be deposited with a solvent that is effective to solvate both the expandable polymer and the primer polymer. Other embodiments are also included herein.

    摘要翻译： 本发明的实施方案包括多层涂层和控制亲水性活性剂洗脱的方法。 在一个实施方案中，本发明包括医疗装置，其包括基材，设置在基材上的底漆聚合物层，设置在底漆聚合物层上的可膨胀层，以及分散在可膨胀层内的亲水性活性剂。 在一个实施方案中，本发明包括形成医疗装置的方法，包括将底漆层沉积在基底上，底层包含底漆聚合物。 该方法还可以包括将可膨胀层沉积到底漆层上，该可膨胀层包括可膨胀聚合物和亲水性活性剂。 可膨胀层可以用有效溶剂化可发性聚合物和底漆聚合物的溶剂沉积。 本文还包括其它实施例。

    Method for making tamper-evident container closure
    5.
    发明授权
    Method for making tamper-evident container closure 失效
    制造防篡改容器封闭的方法

    公开(公告)号：US4904435A

    公开(公告)日：1990-02-27

    申请号：US139275

    申请日：1987-12-29

    申请人： David E. Babcock ,  Daniel Luch

    发明人： David E. Babcock ,  Daniel Luch

    IPC分类号： B26F1/18 ,  B26F1/20 ,  B65D41/34

    CPC分类号： B65D41/3447 ,  B26F1/18 ,  B26F1/20 ,  B26F2210/04 ,  Y10S425/809

    摘要： A method of making a tamper-evident closure cap including the steps of forming a one piece closure cap from a plastic material having a top, a skirt depending from the top and a tamper-evident band depending from the skirt. The band has a radially inward directed rib and an annular portion between the skirt and the tamper-evident band. The annular portion is engaged with a cutting blade which has a cutting edge and series of spaced notches. The blade and the cap are rotated to form a plurality of circumferentially spaced bridges with a series of angularly inwardly disposed tabs.

    摘要翻译： 一种制造防拆封闭盖的方法，包括以下步骤：从具有顶部的塑料材料形成单件封闭盖，从顶部垂下的裙部和从裙部垂下的防窃启带。 带具有径向向内定向的肋和在裙部和防窃启带之间的环形部分。 环形部分与具有切割刃和一系列间隔开的切口的切割刀片接合。 叶片和盖旋转以形成多个具有一系列角度向内设置的突出部的周向隔开的桥。

    LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES
    6.
    发明申请
    LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES 有权
    具有低颗粒度的润滑性医疗器械涂层

    公开(公告)号：US20130197433A1

    公开(公告)日：2013-08-01

    申请号：US13745397

    申请日：2013-01-18

    申请人： David E. Babcock

    发明人： David E. Babcock

    IPC分类号： A61L29/08

    CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L29/14 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/06 ,  A61L2420/08 ,  C08L39/06

    摘要： Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

    摘要翻译： 本发明的实施例包括光滑的医疗装置涂层。 在一个实施方案中，本发明包括用于医疗装置的涂层，其包括由光反应性基团衍生的聚乙烯吡咯烷酮的第一层; 和包含至少两个光反应性基团的第一交联剂; 设置在第一层上的第二层包含用光反应性基团衍生的聚乙烯吡咯烷酮; 包含至少两个光反应性基团的第二交联剂; 和包含聚丙烯酰胺的聚合物，所述聚合物用至少一种光反应性基团衍生化。 本文还包括其它实施例。

    Venting plastic closure
    9.
    发明授权
    Venting plastic closure 有权
    通风塑料封闭

    公开(公告)号：US06769559B2

    公开(公告)日：2004-08-03

    申请号：US10303278

    申请日：2002-11-25

    申请人： John D. Ziegler ,  David E. Babcock ,  Coy Herald

    发明人： John D. Ziegler ,  David E. Babcock ,  Coy Herald

    IPC分类号： B65D5300

    CPC分类号： B65D41/3409 ,  B65D41/045

    摘要： A venting plastic closure for use with an associated container includes an outer plastic cap having a top wall portion and an annular depending skirt including an internal thread formation. A disc-shaped sealing liner is positioned on the inside surface of the top wall portion for creating a top/inside seal with the associated container. In order to facilitate venting of gas pressure from within the container, and to facilitate removal of the closure from the container by consumers, the closure includes one or more positive stop elements which engage the container after the sealing liner of the closure has been sealingly engaged therewith. The stop elements act to limit the degree of sealing engagement between the sealing lines of the closure and the finish of the closure.

    摘要翻译： 用于与相关容器一起使用的排气塑料盖包括外塑料盖，其具有顶壁部分和包括内螺纹结构的环形悬垂裙部。 盘形密封衬套位于顶壁部分的内表面上，用于与相关联的容器形成顶部/内部密封。 为了便于从容器内排出气体压力，并且为了便于消费者从容器中取出封闭件，封闭件包括一个或多个止动件，其在封闭件的密封衬垫已密封接合之后与容器接合 随之而来。 止动元件用于限制封闭件的密封线和封闭件的封边之间的密封接合程度。