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14 条记录 (耗时 0.024 秒)

    Controlled-release garlic formulations
    4.
    发明授权
    Controlled-release garlic formulations 失效
    控释大蒜制剂

    公开(公告)号：US06270803B1

    公开(公告)日：2001-08-07

    申请号：US09392754

    申请日：1998-10-07

    申请人： Yoav Blatt ,  David Cohen ,  Eugene Kimmelman ,  Oded Friedman ,  Avner Rotman

    发明人： Yoav Blatt ,  David Cohen ,  Eugene Kimmelman ,  Oded Friedman ,  Avner Rotman

    IPC分类号： A61K914

    CPC分类号： A61K9/5073 ,  A61K9/2081 ,  A61K9/5042 ,  A61K9/5047 ,  A61K36/8962 ,  A61K2300/00

    摘要： There are provided orally-administrable formulations for the controlled release of granulated garlic, comprising particles of granulated garlic coated with a film comprising a mixture of at least one water soluble polymer and at least one water insoluble polymer, said at least one water soluble polymer and at least one water insoluble polymer being present in a ratio that produces a substantially zero order linear release pattern of at least one active ingredient. Preferably, the formulations are characterized in that the total in vitro dissolution time of said formulations required for release of 75% of the Allicin available from said formulations based upon the total amount of alliin initially present in said formulations is between about 4 and about 12 hours, as determined by U.S.P. XXIII paddle method at a paddle speed of 150 rpm, using simulated intestinal fluid without the digestive enzymes normally found in intestinal fluid, containing 0.1% w/w sodium dodecyl sulfate (SDS), at pH 6.8, and a temperature of 37° C. A process for preparing the formulations of the invention is also disclosed.

    摘要翻译： 提供了用于受控释放造粒大蒜的口服给药制剂，其包括用包含至少一种水溶性聚合物和至少一种水不溶性聚合物的混合物的膜的粒状大蒜颗粒，所述至少一种水溶性聚合物和 至少一种水不溶性聚合物以一定比例存在，其产生至少一种活性成分的基本零级线性释放模式。 优选地，制剂的特征在于，基于最初存在于所述制剂中的蒜素的总量，从所述制剂释放75％的大蒜素所需的所述制剂的总体外溶出时间为约4至约12小时 ，由USP确定 XXIII桨法以150rpm的桨叶速度，使用模拟肠液，不含肠液中通常存在的消化酶，含有0.1％w / w十二烷基硫酸钠（SDS），pH 6.8，温度为37℃。 还公开了制备本发明制剂的方法。

    Controlled release chromium picolinate
    9.
    发明授权
    Controlled release chromium picolinate 失效
    受控释放的吡啶甲酸铬

    公开(公告)号：US6156347A

    公开(公告)日：2000-12-05

    申请号：US10165

    申请日：1998-01-21

    申请人： Yoav Blatt ,  Oded Friedman ,  Eugene Kimelman ,  Avner Rotman

    发明人： Yoav Blatt ,  Oded Friedman ,  Eugene Kimelman ,  Avner Rotman

    IPC分类号： A61K9/22 ,  A61K9/50 ,  A61K31/4402 ,  A61K31/555 ,  A61K33/24

    CPC分类号： A61K31/555 ,  A61K31/4402 ,  A61K33/24 ,  A61K9/5078

    摘要： The present invention relates to controlled/extended release oral dosage forms of chromium picolinate. Chromium picolinate is a common and effective biologically active form of chromium. As such, it has beneficial nutritional and therapeutic effects including improved insulin metabolism and lipid lowering activity.The controlled dosage form of the present invention can be provided in various ways, including matrix formulations such as matrix tablets or multiparticulate formulations like micro capsules or coated pellets put into hard gelatin capsules. This provides effective drug delivery for extended periods of time, at relatively stable, optimal plasma peak values, with minimal undesirable side effects.The invention provides effective controlled/extended release oral dosage formulations of chromium picolinate and processes for their preparation.

    摘要翻译： 本发明涉及吡啶甲酸铬的受控/延长释放的口服剂型。 吡啶甲酸铬是一种常见且有效的生物活性形式的铬。 因此，它具有有益的营养和治疗效果，包括改善的胰岛素代谢和降脂活性。 本发明的受控剂型可以以各种方式提供，包括基质制剂如基质片剂或多颗粒制剂如微胶囊或放入硬明胶胶囊中的包衣丸剂。 这提供了在相对稳定的最佳血浆峰值下延长的时间段的有效药物递送，具有最小的不希望的副作用。 本发明提供了有效的控制/延长释放的吡啶甲酸铬的口服剂量制剂及其制备方法。