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    Process for preparing 3-methylenecepham compounds or a salt thereof
    7.
    发明授权
    Process for preparing 3-methylenecepham compounds or a salt thereof 失效
    制备3-亚甲基头孢烯化合物或其盐的方法

    公开(公告)号：US4354022A

    公开(公告)日：1982-10-12

    申请号：US270876

    申请日：1981-06-05

    申请人： Takao Takaya ,  Takashi Masugi ,  Toshiyuki Chiba ,  Akiteru Yoshioka ,  Masayuki Kato ,  Ikuo Ueda ,  Masakazu Kobayashi

    发明人： Takao Takaya ,  Takashi Masugi ,  Toshiyuki Chiba ,  Akiteru Yoshioka ,  Masayuki Kato ,  Ikuo Ueda ,  Masakazu Kobayashi

    IPC分类号： C07D501/04

    CPC分类号： C07D501/04

    摘要： A new process for preparing 3-methylenecepham compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group, andR.sup.2 is a carboxy or a protected carboxy group,or a salt thereof,which comprises reducing a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above, andR.sup.3 is halogen or heterocyclicthio which may have suitable sutstituent, or a salt thereof, with a combination of a metal selected from the group consisting of zinc, tin and iron, and an ammonium salt of an acid selected from the group consisting of ammonium halide, ammonium carbonate and ammonium acetate, said 3-methylenecepham compounds being useful as intermediates for preparing antimicrobially active 3-cephem compounds.

    摘要翻译： 一种制备下式的3-亚甲基头孢烯化合物的新方法：其中R1为氨基或被保护的氨基，R2为羧基或被保护的羧基，或其盐，其包括将式 ：其中R 1和R 2各自如上所定义，并且R 3是可以具有合适取代基的卤素或杂环硫基，或其盐与选自锌，锡和铁的金属的组合，和 选自卤化铵，碳酸铵和乙酸铵的酸的铵盐，所述3-亚甲基头孢烯化合物可用作制备抗微生物活性3-头孢烯化合物的中间体。

    Chromone derivatives
    8.
    发明授权
    Chromone derivatives 失效
    色酮衍生物

    公开(公告)号：US4001280A

    公开(公告)日：1977-01-04

    申请号：US371852

    申请日：1973-06-20

    申请人： Suminori Umio ,  Ikuo Ueda ,  Masaaki Matsuo ,  Masakazu Kobayashi ,  Osamu Nakaguti ,  Yoshinari Sato

    发明人： Suminori Umio ,  Ikuo Ueda ,  Masaaki Matsuo ,  Masakazu Kobayashi ,  Osamu Nakaguti ,  Yoshinari Sato

    IPC分类号： C07D311/24

    CPC分类号： C07D311/24

    摘要： Chromone derivatives of the formula: ##STR1## wherein R.sup.1 is alkoxy, an N,S-containing heterocyclic group or aryloxy in which heterocyclic group may be substituted with halogen or acyl, and aryl may be substituted with amino, alkylamino, acylamino, nitro or alkylenedioxy; R.sup.2 is alkylene; R.sup.3 is hydroxy, alkoxy or a group of the formula ##STR2## in which R.sup.4 is hydrogen, R.sup.5 is hydroxy or amino or R.sup.4 and R.sup.5 means taken together with the adjacent nitrogen atom, piperazinyl substituted with alkyl or hydroxyalkyl; provided that when R.sup.3 is hydroxy or alkoxy, R.sup.1 is an N,S-containing heterocyclic group or aryloxy in which heterocyclic group is substituted with halogen or acyl, and aryl is substituted with amino, alkylamino, acylamino, nitro or alkylenedioxy, and nontoxic, pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents.

    Cephem compounds
    9.
    发明授权
    Cephem compounds 失效
    头孢烯化合物

    公开(公告)号：US4729991A

    公开(公告)日：1988-03-08

    申请号：US423183

    申请日：1982-09-24

    申请人： Ikuo Ueda ,  Masakazu Kobayashi ,  Tadashi Kitaguchi

    发明人： Ikuo Ueda ,  Masakazu Kobayashi ,  Tadashi Kitaguchi

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D501/04 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36

    CPC分类号： C07D277/587

    摘要： The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is halogen,R.sup.3 is hydrogen or lower alkyl,R.sup.4 is hydrogen, lower alkyl or lower alkoxy,R.sup.5 is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxymethyl or unsaturated heterocyclicthiomethyl in which the heterocyclic moiety may be substituted with lower alkyl or lower alkenyl, andR.sup.6 is carboxy or functionally modified carboxy, and its pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及具有下式的高抗微生物活性的新型头孢烯化合物：其中R1是氨基或被保护的氨基，R2是卤素，R3是氢或低级烷基，R4是氢，低级烷基或低级烷氧基，R5是氢 卤素，低级烷基，低级烷氧基，羟甲基或不饱和杂环硫甲基，其中杂环部分可被低级烷基或低级链烯基取代，R6为羧基或官能改性羧基，及其药学上可接受的盐。