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173 条记录 (耗时 0.036 秒)

    3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
    2.
    发明授权
    3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds 失效
    3,7-二取代-2或3-头孢烯-4-羧酸化合物

    公开(公告)号：US4327093A

    公开(公告)日：1982-04-27

    申请号：US85684

    申请日：1979-10-17

    申请人： Ikuo Ueda ,  Masakazu Kobayashi ,  Hisashi Yamada ,  Hiroki Ono

    发明人： Ikuo Ueda ,  Masakazu Kobayashi ,  Hisashi Yamada ,  Hiroki Ono

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/14 ,  C07D501/18 ,  C07D501/20 ,  C07D501/26 ,  C07D501/28 ,  C07D501/30 ,  C07D501/34 ,  C07D501/38 ,  C07D501/60

    CPC分类号： C07D501/14

    摘要： 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is acylamino or ar(lower)alkylamino; R.sup.2 is carboxy or carboxy protected by a pharmaceutically acceptable group; --N--R.sup.3, R.sup.4 is di(lower)alkylamino(lower)alkylamino, an unsaturated or saturated 3 to 8 membered heteromonocyclic (lower)alkylamino group containing 1 to 4 nitrogen atoms, an unsaturated or saturated 3 to 8 membered heteromonocyclic (lower)alkylamino group containing 1 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower) alkyl, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower)alkyl or hydroxypiperidino, and X is --S-- or ##STR2## and pharmaceutically acceptable salts thereof. The present compounds are useful for the treatment of infectious diseases in animals and human beings.

    摘要翻译： 3,7-二取代的2-或3-头孢烯-4-羧酸化合物，其结构式如下：其中R 1是酰氨基或芳（低级）烷基氨基; R2是被药学上可接受的基团保护的羧基或羧基; -N-R3，R4是二（低级）烷基氨基（低级）烷基氨基，含有1-4个氮原子的不饱和或饱和的3至8元杂单环（低级）烷基氨基，不饱和或饱和的3至8元杂单环（低级） 由低级烷基或羟基（低级）烷基取代的含有1至4个氮原子的烷基氨基，含2-4个氮原子的不饱和或饱和5至6元杂单环基团，含有2至4个不饱和或饱和的5至6元杂单环基团 被低级烷基或羟基（低级）烷基或羟基哌啶子基取代的氮原子，X是-S-或其药学上可接受的盐。 本发明化合物可用于治疗动物和人类的感染性疾病。

    Hematopoietic stem cell proliferating agents
    5.
    发明授权
    Hematopoietic stem cell proliferating agents 失效
    造血干细胞增殖剂

    公开(公告)号：US06495365B1

    公开(公告)日：2002-12-17

    申请号：US09147689

    申请日：1999-05-13

    申请人： Yoshimasa Saito ,  Yoshiko Ueda ,  Kouichi Tamura ,  Yoko Takata ,  Hisashi Yamada ,  Tatsuo Yamashita ,  Masakazu Kobayashi

    发明人： Yoshimasa Saito ,  Yoshiko Ueda ,  Kouichi Tamura ,  Yoko Takata ,  Hisashi Yamada ,  Tatsuo Yamashita ,  Masakazu Kobayashi

    IPC分类号： C12N500

    CPC分类号： A61K38/30 ,  A61K2300/00

    摘要： This invention relates to a hematopoietic stem cell proliferating agent comprising IGF-I, a hematopoietic stem cell proliferating agent comprising IGF-I and at least one protein selected from among SCF, M-CSF, and G-CSF, and a method of growing hematopoietic stem cells which comprises culturing hematopoietic stem cells in a medium containing IGF-I and at least one protein selected from the group consisting of SCF and M-CSF. The hematopoietic stem cell proliferating agent of the invention causes hematopoietic stem cells to proliferate in the undifferentiated state whether in vivo or in vitro and can, therefore, be used for amelioration of the cytopenia induced by radiotherapy or chemotherapy using anticancer drugs, prevention of infectious diseases associated with lymphopenia, or in vitro culture for multiplication of hematopoietic stem cells and extrasomatic culture of recombinant stem cells in gene therapy.

    摘要翻译： 本发明涉及造血干细胞增殖剂，其包含IGF-I，包含IGF-I的造血干细胞增殖剂和选自SCF，M-CSF和G-CSF中的至少一种蛋白质，以及造血造血干细胞增殖的方法 干细胞，其包括在含有IGF-I和至少一种选自SCF和M-CSF的蛋白质的培养基中培养造血干细胞。本发明的造血干细胞增殖剂引起造血干细胞在未分化的细胞中增殖 说明是否在体内或体外，因此可以用于改善由放射治疗或化疗引起的血细胞减少症，使用抗癌药物，预防与淋巴细胞减少有关的感染性疾病，或体外培养造血干细胞和外植体培养物 基因治疗中的重组干细胞。

    Printing method and device having first and second printing units
    6.
    发明授权
    Printing method and device having first and second printing units 失效
    具有第一和第二印刷单元的印刷方法和装置

    公开(公告)号：US08459886B2

    公开(公告)日：2013-06-11

    申请号：US11920743

    申请日：2006-07-03

    申请人： Ichirou Furuki ,  Takaaki Kase ,  Keiki Yamada ,  Hisashi Yamada ,  Makoto Sakuwa ,  Yoshihito Matsuura

    发明人： Ichirou Furuki ,  Takaaki Kase ,  Keiki Yamada ,  Hisashi Yamada ,  Makoto Sakuwa ,  Yoshihito Matsuura

    IPC分类号： B41J11/70 ,  B41J11/42 ,  B41M7/00

    CPC分类号： B41J11/703 ,  B41J3/54 ,  B41J11/0015 ,  B41J11/42 ,  B41J11/70 ,  B41J13/0009 ,  B41J15/04 ,  B41J2202/33 ,  B41M7/0027 ,  B65H20/02 ,  B65H20/04

    摘要： A first cutter 130 (cutting unit) is provided between a color recording unit 120 (the first printing unit) and an overcoat recording unit 140 (the second printing unit). A portion whereon color printing is completed by the color recording unit 120 of a recording paper 200 (printing medium) is cut off by the first cutter 130 and detached. An overcoat recording unit 140 performs an overcoat process on the detached recording paper (printing medium strip). In parallel with this, the color recording unit 120 performs next color printing on the recording paper 200. This makes it possible to reduce a printing time in a printing device including a plurality of printing processes without deteriorating printing quality. Further, an useless paper feeding is eliminated by optimally arranging the color recording unit 120, the first cutter 130, the overcoat recording unit 140, and the second cutter 160, etc. in accordance with a size of a printing area.

    摘要翻译： 第一切割器130（切割单元）设置在彩色记录单元120（第一印刷单元）和外涂层记录单元140（第二印刷单元）之间。 由记录纸200（打印介质）的彩色记录单元120完成彩色打印的部分被第一切割器130切断并分离。 外涂层记录单元140对分离的记录纸（打印介质条）执行外涂层处理。 与此并行地，彩色记录单元120在记录纸张200上执行下一次彩色打印。这使得可以在不降低打印质量的情况下减少包括多个打印处理的打印装置中的打印时间。 此外，通过根据打印区域的尺寸优化布置彩色记录单元120，第一切割器130，外涂层记录单元140和第二切割器160等来消除无用的进纸。

    Wire electrical discharge machining apparatus
    8.
    发明授权
    Wire electrical discharge machining apparatus 有权
    线放电加工机

    公开(公告)号：US08258420B2

    公开(公告)日：2012-09-04

    申请号：US12375366

    申请日：2006-10-24

    申请人： Yasuo Onodera ,  Tatsushi Sato ,  Takashi Hashimoto ,  Hisashi Yamada ,  Koichiro Hattori ,  Yoshikazu Ukai

    发明人： Yasuo Onodera ,  Tatsushi Sato ,  Takashi Hashimoto ,  Hisashi Yamada ,  Koichiro Hattori ,  Yoshikazu Ukai

    IPC分类号： B23H7/04 ,  B23H1/02

    CPC分类号： B23H7/04 ,  B23H1/022 ,  B23H9/00 ,  B23H9/12 ,  B23H11/006

    摘要： A wire electrical discharge machining apparatus includes a unit capable of separately opening and closing each of a high impedance path and a low impedance path, a unit that sets an open/close pattern in which a combination of closing one of the feeding paths and opening another one of the feeding paths is designated for switching power feeding between the high impedance path and the low impedance path, a unit that changes pulse energy per feeding pulse in a present feeding path to reduce a difference in discharge pulse energy applied to an inter-electrode gap from a machining power supply between at a time of high-impedance-path feeding and at a time of low-impedance-path feeding, and a unit that controls opening and closing of the path open/close unit in accordance with the changed open/close pattern.

    摘要翻译： 线放电加工装置包括能够单独打开和关闭高阻抗路径和低阻抗路径的单元，设置打开/关闭图案的单元，其中关闭一个馈送路径并打开另一个的组合 馈送路径中的一个被指定用于在高阻抗路径和低阻抗路径之间切换供电，该单元改变当前馈送路径中每个馈送脉冲的脉冲能量，以减少施加到电极间的放电脉冲能量的差异 在高阻抗路径馈送时和低阻抗路径馈送时的来自加工电源的间隙以及根据改变的开路来控制路径打开/关闭单元的打开和关闭的单元 /关闭模式。

    FLUID-QUALITY CONTROL METHOD, FLUID-QUALITY CONTROL APPARATUS, AND ELECTRIC-DISCHARGE MACHINING APPARATUS EMPLOYING THE SAME
    10.
    发明申请
    FLUID-QUALITY CONTROL METHOD, FLUID-QUALITY CONTROL APPARATUS, AND ELECTRIC-DISCHARGE MACHINING APPARATUS EMPLOYING THE SAME 有权
    流体质量控制方法，流体质量控制装置和使用其的电动放料加工装置

    公开(公告)号：US20100219164A1

    公开(公告)日：2010-09-02

    申请号：US11997881

    申请日：2006-04-05

    申请人： Hisakatsu Kawarai ,  Shuuichiro Ishihara ,  Yooji Nakajima ,  Hisashi Yamada

    发明人： Hisakatsu Kawarai ,  Shuuichiro Ishihara ,  Yooji Nakajima ,  Hisashi Yamada

    IPC分类号： B23H1/02

    CPC分类号： B23H1/10 ,  B23H7/36

    摘要： Target fluid is made into electrolyte solution when measured fluid-quality value is lower than a first condition value, by substituting an impurity anion contained in the target fluid with a predetermined anion and substituting an impurity cation contained in the target fluid with a predetermined cation, and purified when the fluid-quality value is higher than a second condition value. The above procedures are repeated, so that the fluid-quality value of the target fluid falls within a predetermined range, to make the target fluid into electrolyte solution with a correlation between pH and conductivity.

    摘要翻译： 当测量的流体质量值低于第一条件值时，通过用预定的阴离子代替包含在目标流体中的杂质阴离子并用预定的阳离子代替目标流体中所含的杂质阳离子，将目标流体制成电解质溶液， 并且当流体质量值高于第二条件值时净化。 重复上述过程，使得目标流体的流体质量值落在预定范围内，以使目标流体以pH和电导率之间的相关性进入电解质溶液。