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1.发明授权公开(公告)号：US08628732B2
公开(公告)日：2014-01-14
申请号：US13119246
申请日：2009-10-19
申请人： Minoru Asogawa , Hayataro Kochi
发明人： Minoru Asogawa , Hayataro Kochi
IPC分类号： G01N15/06
CPC分类号： G01N35/04
摘要： Provided is an immobilization device for fitting a connecting member of a chip and a connecting member of a cover together, where a spatial clearance between the chip and cover is small. The immobilization device includes a substrate (102), a cover means (101) including a fitting means to fit with a chip (103) placed on the substrate (102), a rotating arm means (201) rotatably joined to a first joining means (301) of the substrate (102) and to a second joining means (302) of the cover means (101), and a parallel maintaining means (203) for fitting the fitting means and the chip (103) together with the fitting means and the chip (103) maintained in substantially parallel by the first joining means (301) or the second joining means (302) moving along a chip surface or a plane parallel to the chip surface. The fitting means rotates freely against the chip (103).
摘要翻译： 提供一种用于将芯片的连接构件和盖的连接构件配合在一起的固定装置，其中芯片和盖子之间的空间间隙小。 固定装置包括基板（102），包括装配有放置在基板（102）上的芯片（103）的装配装置的盖装置（101），旋转臂装置（201），其可旋转地连接到第一连接装置 （101）的第二连接装置（302）以及用于将装配装置和芯片（103）与装配装置（103）一起装配的平行保持装置（203） 并且所述芯片（103）通过所述第一接合装置（301）或所述第二接合装置（302）基本平行地保持，所述第一接合装置沿着芯片表面或平行于所述芯片表面的平面移动。 配合装置自由地旋转于芯片（103）。
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2.发明申请公开(公告)号：US20110171089A1
公开(公告)日：2011-07-14
申请号：US13119246
申请日：2009-10-19
申请人： Minoru Asogawa , Hayataro Kochi
发明人： Minoru Asogawa , Hayataro Kochi
IPC分类号： B01L9/00
CPC分类号： G01N35/04
摘要： Provided is an immobilization device for fitting a connecting member of a chip and a connecting member of a cover together, where a spatial clearance between the chip and cover is small. The immobilization device includes a substrate (102), a cover means (101) including a fitting means to fit with a chip (103) placed on the substrate (102), a rotating arm means (201) rotatably joined to a first joining means (301) of the substrate (102) and to a second joining means (302) of the cover means (101), and a parallel maintaining means (203) for fitting the fitting means and the chip (103) together with the fitting means and the chip (103) maintained in substantially parallel by the first joining means (301) or the second joining means (302) moving along a chip surface or a plane parallel to the chip surface. The fitting means rotates freely against the chip (103).
摘要翻译： 提供一种用于将芯片的连接构件和盖的连接构件配合在一起的固定装置，其中芯片和盖子之间的空间间隙小。 固定装置包括基板（102），包括装配有放置在基板（102）上的芯片（103）的装配装置的盖装置（101），旋转臂装置（201），其可旋转地连接到第一连接装置 （101）的第二连接装置（302）以及用于将装配装置和芯片（103）与装配装置（103）一起装配的平行保持装置（203） 并且所述芯片（103）通过所述第一接合装置（301）或所述第二接合装置（302）基本平行地保持，所述第一接合装置沿着芯片表面或平行于所述芯片表面的平面移动。 配合装置自由地旋转于芯片（103）。
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公开(公告)号：US08202722B2
公开(公告)日：2012-06-19
申请号：US12679358
申请日：2008-09-16
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/505 , B01L7/52 , B01L2200/0689 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/1822 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , G01N2035/00158 , G01N2035/00346
摘要： For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed other than a connecting port with a channel connected to the vessel, and expands and contracts for injection and discharge of the sample. The vessel portion expands correspondingly to the injection when the sample is injected through an inflow path serving as the channel into the vessel portion contracting in a non-contacting state with the heat transfer member. A predetermined amount of sample is injected into the vessel portion so as to expand the vessel portion, and the vessel portion comes into contact with the heat transfer member. The vessel portion is heated or cooled through the heat transfer member.
摘要翻译： 为了通过与容器部分保持接触的传热构件来加热或冷却包含在容器部分中的样品，使用具有由弹性构件形成的部分的容器部分，其膨胀和收缩用于注射和排出 样品，除了具有连接到容器的通道的连接端口之外，并且扩展并收缩样品的注入和排出。 当样品通过用作通道的流入路径注入到与传热构件非接触状态收缩的容器部分中时，容器部分对应于注射膨胀。 将预定量的样品注入到容器部分中以使容器部分膨胀，并且容器部分与传热构件接触。 容器部分通过传热构件被加热或冷却。
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公开(公告)号：US20110000561A1
公开(公告)日：2011-01-06
申请号：US12920256
申请日：2009-03-18
IPC分类号： F03B11/02
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N35/1095 , G01N2035/00158 , G01N2035/1034 , Y10T137/8593 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A channel control mechanism for a microchip has a laminated structure formed of members including elastic members, and includes: a sample reservoir for packing a sample therein; a reaction reservoir in which mixture and reaction of the sample are performed; and a channel formed in a middle layer of the laminated structure, for bringing the sample reservoir and the reaction reservoir into communication with each other. The channel control mechanism performs the reaction and analysis in such a manner that the sample is delivered into the reaction reservoir through the channel. A shutter channel (pressurizing channel) is provided in a layer different from a layer in which the channel is formed so that the pressurizing channel partially overlaps the channel. The channel is closed through applying a pressurized medium to the shutter channel (pressurizing channel), and the channel is opened through releasing a pressure of the pressurized medium.
摘要翻译： 用于微芯片的通道控制机构具有由包括弹性构件的构件形成的层压结构，并且包括：用于在其中包装样品的样品容器; 反应容器，其中进行混合物和样品的反应; 以及形成在层叠结构的中间层中的通道，用于使样本储存器和反应容器彼此连通。 通道控制机构以通过通道将样品输送到反应容器中的方式进行反应和分析。 快门通道（加压通道）设置在与形成通道的层不同的层中，使得加压通道与通道部分重叠。 通过将加压介质施加到闸门通道（加压通道）来关闭通道，并且通过释放加压介质的压力来打开通道。
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公开(公告)号：US20090277790A1
公开(公告)日：2009-11-12
申请号：US12297204
申请日：2007-04-12
申请人： Minoru Asogawa , Masatoshi Sugisawa , Shinji Okui
发明人： Minoru Asogawa , Masatoshi Sugisawa , Shinji Okui
IPC分类号： G01N27/453 , G01N27/447
摘要： An individual identification method for identifying an individual by analyzing a DNA sample through electrophoresis, comprises: a first analysis step of analyzing an identifier-attached DNA sample which is given an identifier for an individual; a step of storing a result obtained by analyzing the identifier-attached DNA sample together with a corresponding identifier in a database; a second analysis step of analyzing a new sample which is a DNA sample subjected to individual identification with an accuracy lower than the accuracy when the identifier-attached DNA sample is analyzed, and using the result as a new sample analysis result; and a step of searching the database based on the new sample analysis result.
摘要翻译： 用于通过电泳分析DNA样品来识别个体的个体识别方法包括：分析给予个体标识符的标识符附着DNA样品的第一分析步骤; 将通过分析标识符附着的DNA样本获得的结果与相应的标识符一起存储在数据库中的步骤; 第二分析步骤，以分析标识符附着的DNA样品的精度以下的精度分析作为进行个体识别的DNA样品的新样品，并使用该结果作为新的样本分析结果; 并且基于新的样本分析结果搜索数据库的步骤。
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公开(公告)号：US10139134B2
公开(公告)日：2018-11-27
申请号：US13996949
申请日：2011-12-19
申请人： Minoru Asogawa , Hisashi Hagiwara
发明人： Minoru Asogawa , Hisashi Hagiwara
摘要： A microchip includes a vessel portion, an elastic member, and a flow channel which leads a liquid sample to the vessel portion. After a liquid sample is put in the vessel portion, the liquid sample is heated while pressure is applied with respect to an inner portion of the vessel portion.
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公开(公告)号：US08470266B2
公开(公告)日：2013-06-25
申请号：US12677471
申请日：2008-09-05
IPC分类号： G01N31/00
CPC分类号： G01N1/28 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0683 , G01N35/00029 , G01N2035/00089 , G01N2035/00277 , G01N2035/00544
摘要： Provided is a sample packing device for packing a sample with respect to a microchip for performing reaction of a micro component contained in the sample, the microchip at least including: a sample reservoir; a reaction reservoir; and a channel connected between the sample reservoir and the reaction reservoir, in which a package including a sample chamber packed in advance with the sample is mounted on the microchip so as to pack the sample in the sample chamber into the sample reservoir.
摘要翻译： 本发明提供了一种样品包装装置，用于相对于微芯片填充样品以进行样品中包含的微量成分的反应，所述微芯片至少包括：样品储存器; 反应池; 以及连接在样品储存器和反应容器之间的通道，其中将包含样品室的样品室预先包装在样品中的包装被安装在微芯片上，以便将样品室中的样品包装到样品容器中。
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公开(公告)号：US20110002812A1
公开(公告)日：2011-01-06
申请号：US12677471
申请日：2008-09-05
IPC分类号： G01N33/50
CPC分类号： G01N1/28 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0683 , G01N35/00029 , G01N2035/00089 , G01N2035/00277 , G01N2035/00544
摘要： Provided is a sample packing device for packing a sample with respect to a microchip for performing reaction of a micro component contained in the sample, the microchip at least including: a sample reservoir; a reaction reservoir; and a channel connected between the sample reservoir and the reaction reservoir, in which a package including a sample chamber packed in advance with the sample is mounted on the microchip so as to pack the sample in the sample chamber into the sample reservoir.
摘要翻译： 本发明提供了一种样品包装装置，用于相对于微芯片填充样品以进行样品中包含的微量成分的反应，所述微芯片至少包括：样品储存器; 反应池; 以及连接在样品储存器和反应容器之间的通道，其中将包含样品室的样品室预先包装在样品中的包装被安装在微芯片上，以便将样品室中的样品包装到样品容器中。
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公开(公告)号：US20100221814A1
公开(公告)日：2010-09-02
申请号：US12679358
申请日：2008-09-16
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/505 , B01L7/52 , B01L2200/0689 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/1822 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , G01N2035/00158 , G01N2035/00346
摘要： For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed other than a connecting port with a channel connected to the vessel, and expands and contracts for injection and discharge of the sample. The vessel portion expands correspondingly to the injection when the sample is injected through an inflow path serving as the channel into the vessel portion contracting in a non-contacting state with the heat transfer member. A predetermined amount of sample is injected into the vessel portion so as to expand the vessel portion, and the vessel portion comes into contact with the heat transfer member. The vessel portion is heated or cooled through the heat transfer member.
摘要翻译： 为了通过与容器部分保持接触的传热构件来加热或冷却包含在容器部分中的样品，使用具有由弹性构件形成的部分的容器部分，其膨胀和收缩用于注射和排出 样品，除了具有连接到容器的通道的连接端口之外，并且膨胀和收缩用于样品的注入和排出。 当样品通过用作通道的流入路径注入到与传热构件非接触状态收缩的容器部分中时，容器部分对应于注射膨胀。 将预定量的样品注入到容器部分中以使容器部分膨胀，并且容器部分与传热构件接触。 容器部分通过传热构件被加热或冷却。
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10.发明申请Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system 审中-公开Microchip，使用微芯片的溶剂置换法，浓缩法和质谱系统公开(公告)号：US20060070951A1
公开(公告)日：2006-04-06
申请号：US10536597
申请日：2003-11-28
申请人： Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya , Minoru Asogawa
发明人： Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya , Minoru Asogawa
CPC分类号： B01D67/0062 , B03C5/00 , G01N1/40
摘要： A particular component in a sample is recovered in a high concentration and solvent-replaced. A separator 100 is placed on a microchip and includes a channel 112 for flowing the particular component. The channel 112 includes a sample feeding channel 300 as well as a filtrate discharge channel 302 and a sample recovering part 308 which are branched from the sample feeding channel 300. There is formed a filter 304 for preventing passage of the particular component, at the inlet of the filtrate discharge channel 302 from the sample feeding channel 300. Furthermore, there is formed a damming area (hydrophobic area) 306 for preventing entering of a liquid sample while allowing for passage of the liquid sample by applying an external force equal to or larger than a given level, at the inlet of the sample recovering part 308 from the sample feeding channel 300.
摘要翻译： 样品中的特定组分以高浓度回收并进行溶剂置换。 分离器100放置在微芯片上，并且包括用于流动特定部件的通道112。 通道112包括样品供给通道300以及从样品供给通道300分支的滤液排出通道302和样品回收部分308。 在滤液排出通道302的入口处，从样品供给通道300形成防止特定成分通过的过滤器304。 此外，在样品回收部的入口处形成防止液体样品进入的阻止区域（疏水区域）306，同时允许通过施加等于或大于给定水平的外力使液体样品通过 308。
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