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    Hydroxypyridine derivatives their production and use
    1.
    发明授权
    Hydroxypyridine derivatives their production and use 失效
    羟基吡啶衍生物的生产和使用

    公开(公告)号：US5891895A

    公开(公告)日：1999-04-06

    申请号：US834123

    申请日：1997-04-14

    申请人： Mitsuru Shiraishi ,  Tsuyoshi Maekawa ,  Toshifumi Watanabe

    发明人： Mitsuru Shiraishi ,  Tsuyoshi Maekawa ,  Toshifumi Watanabe

    IPC分类号： C07D213/65 ,  C07D213/89 ,  A61K31/44 ,  C07D213/53

    CPC分类号： C07D213/89 ,  C07D213/65

    摘要： Hydroxypyridine derivatives of the formula ##STR1## wherein R.sup.1 is a branched C.sub.3-8 alkyl group or a C.sub.3-8 cycloalkyl group, each of which may be substituted;R.sup.2 is a halogen atom, a C.sub.1-4 alkyl group or a C.sub.1-4 alkoxy group;X is an oxygen atom or NR.sup.3 in which R.sup.3 is a hydrogen atom or a C.sub.1-4 alkyl group;R.sup.4, R.sup.5 and R.sup.6 are independently (1) a hydrogen atom, (2) a halogen atom, (3) a cyano group, (4) a nitro group, (5) a C.sub.1-4 acyl group, (6) a C.sub.1-4 alkoxy group which may be substituted with halogen, (7) a C.sub.1-4 alkyl group which may be substituted with halogen or (8) a mercapto group which may be substituted with a C.sub.1-4 alkyl group;m is 0 to 3; andn is 0 or 1;provided that all of R.sup.4, R.sup.5 and R.sup.6 are not hydrogen atom, or a salt thereof, which have potassium channel opening activity and are useful as therapeutic agents of cardiovascular diseases such as angina pectoris, hypertension, etc.

    摘要翻译： 其中R 1是支链C 3-8烷基或C 3-8环烷基，其中每一个可以被取代; R2是卤素原子，C1-4烷基或C1-4烷氧基; X是氧原子或NR 3，其中R 3是氢原子或C 1-4烷基; R4，R5和R6独立地为（1）氢原子，（2）卤素原子，（3）氰基，（4）硝基，（5）C1-4酰基，（6）C1 -4-烷氧基，（7）可被卤素取代的C 1-4烷基或（8）可被C 1-4烷基取代的巯基; m为0〜3; 并且n为0或1; 条件是所有R4，R5和R6不是氢原子，或其盐，其具有钾通道开放活性，并且可用作心血管疾病如心绞痛，高血压等的治疗剂。

    FUSED RING COMPOUND AND USE THEREOF
    3.
    发明申请
    FUSED RING COMPOUND AND USE THEREOF 有权
    熔化环化合物及其用途

    公开(公告)号：US20100197683A1

    公开(公告)日：2010-08-05

    申请号：US12696147

    申请日：2010-01-29

    申请人： Tsuyoshi Maekawa ,  Hideyuki Igawa

    发明人： Tsuyoshi Maekawa ,  Hideyuki Igawa

    IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/519 ,  C07D413/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/00 ,  A61P3/10 ,  A61P1/16 ,  A61P27/02

    CPC分类号： C07D487/04 ,  A61K31/519

    摘要： Provided is a novel compound represented by the following formula Wherein each symbol is as defined in the specification, or a salt thereof, which has an angiotensin II receptor antagonistic activity and a peroxisome proliferator-activated receptor γ agonistic activity, and is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and/or metabolic diseases such as diabetes and the like, and the like.

    摘要翻译： 提供了由下式表示的新化合物，其中每个符号如说明书中所定义，或其盐，其具有血管紧张素II受体拮抗活性和过氧化物酶体增殖物激活受体γ激动活性，并且可用作试剂 用于预防或治疗诸如高血压等循环系统疾病和/或代谢疾病如糖尿病等。

    Function regulator for retinoid relative receptor
    4.
    发明授权
    Function regulator for retinoid relative receptor 失效
    类视黄醇相对受体的功能调节剂

    公开(公告)号：US07223791B2

    公开(公告)日：2007-05-29

    申请号：US10481033

    申请日：2002-06-25

    申请人： Tsuyoshi Maekawa ,  Jun Kunitomo ,  Hiroyuki Odaka ,  Hiroyuki Kimura

    发明人： Tsuyoshi Maekawa ,  Jun Kunitomo ,  Hiroyuki Odaka ,  Hiroyuki Kimura

    IPC分类号： A61K31/341

    CPC分类号： C07D207/337 ,  A61K31/00 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4418 ,  A61K31/625 ,  C07D213/61 ,  C07D249/08 ,  C07D261/08 ,  C07D271/107 ,  C07D307/54 ,  C07D333/24

    摘要： The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulating agent comprising a compound represented by the formula: wherein one of R1 and R2 is an optionally substituted monocyclic aromatic hydrocarbon group or an optionally substituted monocyclic aromatic heterocyclic group containing one heteroatom, and the other is a hydrogen atom and the like; B is a 5- or 6-membered heterocycle (except 1,3-azole); A is an optionally substituted aromatic hydrocarbon group or an optionally substituted aromatic heterocyclic group; and R3 is a hydrogen atom and the like, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of diabetes mellitus, hyperlipidemia, impaired glucose tolerance or the like.

    摘要翻译： 本发明提供了一种类视黄醇相关受体（视黄酸受体除外）的功能调节剂，其包含由下式表示的化合物：其中R 1和R 2中的一个为 任选取代的单环芳族烃基或含有一个杂原子的任选取代的单环芳族杂环基，另一个是氢原子等; B是5-或6-元杂环（除了1,3-唑）; A是任选取代的芳族烃基或任选取代的芳族杂环基; R 3是氢原子等或其盐，其可用作预防或治疗糖尿病，高脂血症，葡萄糖耐量异常等的药剂。

    Method of producing radial tire for construction vehicle
    6.
    发明申请
    Method of producing radial tire for construction vehicle 失效
    生产施工车辆子午线轮胎的方法

    公开(公告)号：US20060048883A1

    公开(公告)日：2006-03-09

    申请号：US10544106

    申请日：2004-03-05

    申请人： Tsuyoshi Maekawa ,  Heikichi Nakanome ,  Ken Takahashi

    发明人： Tsuyoshi Maekawa ,  Heikichi Nakanome ,  Ken Takahashi

    IPC分类号： B29D30/00

    CPC分类号： B29D30/36 ,  B29D30/0645 ,  B29D2030/0647

    摘要： A method of producing a radial tire for a construction vehicle, the method enabling a vast reduction in facility costs. A first green tire is formed in a first step molding machine and then removed from it. After that, a vulcanizer bladder unit is installed on the tire. The tire is inflated by the vulcanizer bladder unit and then again placed in the first step molding machine with the vulcanizer bladder unit installed. After that, on the first step molding machine, belts and tread rubber are adhered to the outer periphery of the tire to form a completed green tire. Then the completed green tire, with the vulcanizer bladder unit, is assembled in a vulcanizing mold for vulcanization.

    摘要翻译： 一种生产用于建筑车辆的子午线轮胎的方法，该方法能够大大降低设备成本。 第一生胎在第一步成型机中形成，然后从其中取出。 之后，在轮胎上安装硫化器囊单元。 轮胎由硫化器囊单元充气，然后再次放置在第一步成型机中，并安装硫化器囊。 之后，在第一阶段成型机中，皮带和胎面橡胶粘附在轮胎的外周上，形成完毕的生胎。 然后将完成的带有硫化胶囊单元的生胎组装在用于硫化的硫化模具中。

    Relay terminal
    7.
    发明授权
    Relay terminal 有权
    中继终端

    公开(公告)号：US06404652B1

    公开(公告)日：2002-06-11

    申请号：US09436209

    申请日：1999-11-08

    申请人： Yasuhiro Takebayashi ,  Kazushige Matsuoka ,  Taisuke Ueda ,  Ryo Sugihara ,  Hirofumi Iwanaga ,  Tsuyoshi Maekawa

    发明人： Yasuhiro Takebayashi ,  Kazushige Matsuoka ,  Taisuke Ueda ,  Ryo Sugihara ,  Hirofumi Iwanaga ,  Tsuyoshi Maekawa

    IPC分类号： H02B101

    CPC分类号： H01R9/2408 ,  H01H50/047 ,  H01H50/14

    摘要： A relay terminal includes a plurality of relays, a connector for entering control signals to control the relays and outputting contact inputs from their relay contacts, and a terminal block corresponding to the input and output signals of the relays, which are held as a single unit. The holding construction of the plurality of relays and the terminal block employs a two step overlapping holding construction in which the relays are held in an upper step and the terminal block is held in a lower step, resulting in a reduction in the width of the relay terminal and an increase in a package density when the relay terminal is mounted on a vertical installation wall within a control panel.

    摘要翻译： 继电器端子包括多个继电器，用于输入控制信号以控制继电器并从其继电器触点输出触点输入的连接器，以及与继电器的输入和输出信号相对应的端子块，其被保持为单个单元 。 多个继电器和端子排的保持结构采用两步重叠保持结构，其中继电器保持在上部阶段，并且端子块保持在较低的台阶，导致继电器的宽度减小 并且当中继端子安装在控制面板内的垂直安装壁上时，封装密度增加。

    Fused ring compound and use thereof
    8.
    发明授权
    Fused ring compound and use thereof 有权
    熔融环化合物及其用途

    公开(公告)号：US08283353B2

    公开(公告)日：2012-10-09

    申请号：US12696147

    申请日：2010-01-29

    申请人： Tsuyoshi Maekawa ,  Hideyuki Igawa

    发明人： Tsuyoshi Maekawa ,  Hideyuki Igawa

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC分类号： C07D487/04 ,  A61K31/519

    摘要： Provided is a novel compound represented by the following formula Wherein each symbol is as defined in the specification, or a salt thereof, which has an angiotensin II receptor antagonistic activity and a peroxisome proliferator-activated receptor γ agonistic activity, and is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and/or metabolic diseases such as diabetes and the like, and the like.

    摘要翻译： 提供了由下式表示的新化合物，其中每个符号如说明书中所定义，或其盐，其具有血管紧张素II受体拮抗活性和过氧化物酶体增殖物激活受体γ激动活性，并且可用作试剂 用于预防或治疗诸如高血压等循环系统疾病和/或代谢疾病如糖尿病等。

    Substituted pyrimidines and [1,2, 4] triazoles and the use thereof for treating prophylaxis, cardiovascular diseases, metabolic diseases and/or central nervous system diseases
    9.
    发明授权
    Substituted pyrimidines and [1,2, 4] triazoles and the use thereof for treating prophylaxis, cardiovascular diseases, metabolic diseases and/or central nervous system diseases 失效
    取代的嘧啶和[1,2,4]三唑及其用于治疗预防，心血管疾病，代谢疾病和/或中枢神经系统疾病的用途

    公开(公告)号：US07998968B2

    公开(公告)日：2011-08-16

    申请号：US12625622

    申请日：2009-11-25

    申请人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Hideyuki Igawa ,  Minoru Sasaki ,  Kouhei Asano ,  Tsuyoshi Maekawa ,  Koji Fuji

    发明人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Hideyuki Igawa ,  Minoru Sasaki ,  Kouhei Asano ,  Tsuyoshi Maekawa ,  Koji Fuji

    IPC分类号： A61K31/505

    CPC分类号： C07D413/10 ,  C07D413/14 ,  C07D417/14

    摘要： A compound represented by the formula (I): wherein R1 is an oxo group, ═N—R or the like; a group represented by the formula: is a group represented by the formula: R2 is a group represented by the formula: R3 and R4 are each H, or C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, di(C1-C6)alkylamino or C1-C6 alkylthio, each of which is optionally substituted; and R5 is H, or C1-C6 alkyl, C2-C6 alkenyl, cyclic group, each of which is optionally substituted, —CO—R8 or —O—R8′, or a salt thereof. For example, the compound may be substituted pyrimidines and pharmaceutical compositions of the formula (I) where X=—CR3; X1=—CR2 or —NR2; and X2=—CR5 or —NR5. The compound of the present invention is useful as a drug for the prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases.

    摘要翻译： 由式（I）表示的化合物：其中R 1是氧代基，或= N-R等; 由下式表示的基团是由下式表示的基团：R 2是由下式表示的基团：R 3和R 4各自为H或C 1 -C 6烷基，C 3 -C 6环烷基，C 1 -C 6烷氧基，C 1 -C 6 烷基氨基，二（C 1 -C 6）烷基氨基或C 1 -C 6烷硫基，其各自任选被取代; 和R 5为H或C 1 -C 6烷基，C 2 -C 6烯基，环状基团，各自为任选取代的-CO-R 8或-O-R 8'或其盐。 例如，化合物可以是取代的嘧啶和式（I）的药物组合物，其中X = -CR 3; X1 = -CR2或-NR2; X2 = -CR5或-NR5。 本发明的化合物可用作预防或治疗心血管疾病，代谢疾病和/或中枢神经系统疾病的药物。

    DEVICE FOR DIAGNOSING TISSUE INJURY
    10.
    发明申请
    DEVICE FOR DIAGNOSING TISSUE INJURY 审中-公开
    用于诊断组织损伤的装置

    公开(公告)号：US20110118583A1

    公开(公告)日：2011-05-19

    申请号：US12736720

    申请日：2008-05-07

    申请人： Makoto Yuasa ,  Tsuyoshi Maekawa ,  Motoki Fujita ,  Shigeru Kido

    发明人： Makoto Yuasa ,  Tsuyoshi Maekawa ,  Motoki Fujita ,  Shigeru Kido

    IPC分类号： A61B5/04

    CPC分类号： A61B5/14503 ,  A61B5/01 ,  A61B5/02152 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/4076 ,  A61B5/412 ,  A61B5/6852 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2210/0693

    摘要： The device for diagnosing tissue injury of the invention has a catheter insertable into the body and a radical sensor provided in the catheter, and is characterized in that the radical sensor has a sensor electrode capable of measuring superoxide anion radicals provided at a tip end of the catheter, a lead wire connector for a sensor provided at a basal portion of the catheter, and a lead wire for a sensor for connecting the sensor electrode portion to the lead wire connector for a sensor. With the device, in vivo free radicals typified by superoxide anions in systemic organ or tissue injury caused by cerebral ischemia reperfusion injury, severe infection or sepsis can be promptly and quantitatively monitored, and whether the in vivo tissue conditions are good or not can be accurately diagnosed.

    摘要翻译： 用于诊断本发明的组织损伤的装置具有可插入体内的导管和设置在导管中的根部传感器，其特征在于，该自由基传感器具有能够测量超氧阴离子自由基的传感器电极， 导管，用于设置在导管的基部的传感器的引线连接器，以及用于传感器的引线，用于将传感器电极部分连接到用于传感器的引线连接器。 使用该装置，可以迅速和定量地监测体内自由基以及由脑缺血再灌注损伤引起的系统性器官或组织损伤中的超氧阴离子代谢，可以准确地监测体内组织条件是否良好 诊断出