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    DEVICE FOR DIAGNOSING TISSUE INJURY
    1.
    发明申请
    DEVICE FOR DIAGNOSING TISSUE INJURY 审中-公开
    用于诊断组织损伤的装置

    公开(公告)号：US20110118583A1

    公开(公告)日：2011-05-19

    申请号：US12736720

    申请日：2008-05-07

    申请人： Makoto Yuasa ,  Tsuyoshi Maekawa ,  Motoki Fujita ,  Shigeru Kido

    发明人： Makoto Yuasa ,  Tsuyoshi Maekawa ,  Motoki Fujita ,  Shigeru Kido

    IPC分类号： A61B5/04

    CPC分类号： A61B5/14503 ,  A61B5/01 ,  A61B5/02152 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/4076 ,  A61B5/412 ,  A61B5/6852 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2210/0693

    摘要： The device for diagnosing tissue injury of the invention has a catheter insertable into the body and a radical sensor provided in the catheter, and is characterized in that the radical sensor has a sensor electrode capable of measuring superoxide anion radicals provided at a tip end of the catheter, a lead wire connector for a sensor provided at a basal portion of the catheter, and a lead wire for a sensor for connecting the sensor electrode portion to the lead wire connector for a sensor. With the device, in vivo free radicals typified by superoxide anions in systemic organ or tissue injury caused by cerebral ischemia reperfusion injury, severe infection or sepsis can be promptly and quantitatively monitored, and whether the in vivo tissue conditions are good or not can be accurately diagnosed.

    摘要翻译： 用于诊断本发明的组织损伤的装置具有可插入体内的导管和设置在导管中的根部传感器，其特征在于，该自由基传感器具有能够测量超氧阴离子自由基的传感器电极， 导管，用于设置在导管的基部的传感器的引线连接器，以及用于传感器的引线，用于将传感器电极部分连接到用于传感器的引线连接器。 使用该装置，可以迅速和定量地监测体内自由基以及由脑缺血再灌注损伤引起的系统性器官或组织损伤中的超氧阴离子代谢，可以准确地监测体内组织条件是否良好 诊断出

    CATALYST MATERIAL AND PROCESS FOR PREPARING THE SAME
    4.
    发明申请
    CATALYST MATERIAL AND PROCESS FOR PREPARING THE SAME 审中-公开
    催化材料及其制备方法

    公开(公告)号：US20100015506A1

    公开(公告)日：2010-01-21

    申请号：US12523879

    申请日：2008-01-22

    申请人： Naoko Iwata ,  Makoto Yuasa ,  Kenichi Oyaizu ,  Ken Tanaka ,  Yuichi Iai ,  Masakuni Yamamoto ,  Shinichi Sasaki ,  Shigeru Kido

    发明人： Naoko Iwata ,  Makoto Yuasa ,  Kenichi Oyaizu ,  Ken Tanaka ,  Yuichi Iai ,  Masakuni Yamamoto ,  Shinichi Sasaki ,  Shigeru Kido

    IPC分类号： H01M4/00 ,  B01J31/18 ,  B01J31/00

    CPC分类号： H01M4/921 ,  H01M4/9008 ,  H01M4/9075 ,  H01M4/9083 ,  H01M4/925 ,  H01M4/926

    摘要： A catalyst material that bears active species densely, thereby having higher catalytic performance and serviceability, for example, as an electrode for fuel cells. A catalyst material, wherein a conductive material whose surface physically adsorbs a polymerizable ligand having an electrochemically polymerizable heterocycle and an electron-withdrawing group bonded to the heterocycle or is coated with polynuclear complex molecules formed by electrochemical polymerization of the polymerizable ligand having an electrochemically polymerizable heterocycle and an electron-withdrawing group bonded to the heterocycle. A catalytic metal is coordinated to the adsorption layer of the polymerizable ligand having an electrochemically polymerizable heterocycle and an electron-withdrawing group bonded to the heterocycle, or to the coating layer of the polynuclear complex molecules.

    摘要翻译： 作为燃料电池用电极，具有活性物质密实地具有较高催化性能和适用性的催化剂材料。 一种催化剂材料，其中表面物理吸附具有电化学可聚合杂环的可聚合配体和与该杂环键合的吸电子基团的导电材料，或涂覆有由具有电化学可聚合杂环的可聚合配体的电化学聚合形成的多核络合物分子 和与杂环键合的吸电子基团。 催化金属与可聚合配体的吸附层配位，其具有结合到杂环的电化学可聚合杂环和吸电子基团，或与多核络合物分子的涂层配位。

    Porphyrin-based electrode catalyst
    5.
    发明申请
    Porphyrin-based electrode catalyst 审中-公开
    卟啉类电极催化剂

    公开(公告)号：US20090048096A1

    公开(公告)日：2009-02-19

    申请号：US11920152

    申请日：2006-05-10

    申请人： Naoko Iwata ,  Tetsuo Nagami ,  Hidetaka Nishikoori ,  Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Mizuki Kitao ,  Takuya Imai ,  Shigeru Kido

    发明人： Naoko Iwata ,  Tetsuo Nagami ,  Hidetaka Nishikoori ,  Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Mizuki Kitao ,  Takuya Imai ,  Shigeru Kido

    IPC分类号： B01J31/18

    CPC分类号： H01M4/9008 ,  B01J31/1815 ,  B01J37/086 ,  B01J2531/845 ,  C07D487/22 ,  H01M4/9083

    摘要： This invention provides a macrocyclic-organic-compound-based catalyst for reducing oxygen having high oxygen-reducing activity. This oxygen-reducing catalyst comprises a conductive support and, supported thereon, a porphyrin complex represented by formula (I): wherein Rs each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a halogen atom, an amino group, a hydroxyl group, a nitro group, a phenyl group, or a cyano group or adjacent Rs together form a methylene chain having 2 to 6 carbon atoms or aromatic ring; R's each independently represent a thienyl group; and M represents a metal atom selected from the group consisting of Cu, Zn, Fe, Co, Ni, Ru, Pb, Rh, Pd, Pt, Mn, Sn, Au, Mg, Cd, Al, In, Ge, Cr, and Ti, provided that M may bind to a halogen atom, an oxygen atom, —OH, a nitrogen atom, NO, or ═CO.

    摘要翻译： 本发明提供了一种用于还原具有高氧还原活性的氧的大环 - 有机 - 化合物基催化剂。 该氧还原催化剂包括导电载体，并在其上负载由式（I）表示的卟啉络合物：其中R 5各自独立地表示氢原子，具有1至6个碳原子的烷基，卤素原子，氨基 ，羟基，硝基，苯基或氰基或相邻的Rs一起形成具有2至6个碳原子的亚甲基或芳香环; R各自独立地表示噻吩基; 并且M表示选自Cu，Zn，Fe，Co，Ni，Ru，Pb，Rh，Pd，Pt，Mn，Sn，Au，Mg，Cd，Al，In，Ge，Cr， 和Ti，条件是M可以与卤素原子，氧原子，-OH，氮原子，NO或-CO结合。

    PROCESS FOR PREPARING CATALYST MATERIAL
    8.
    发明申请
    PROCESS FOR PREPARING CATALYST MATERIAL 审中-公开
    制备催化材料的方法

    公开(公告)号：US20090246601A1

    公开(公告)日：2009-10-01

    申请号：US12282060

    申请日：2007-03-09

    申请人： Naoko Iwata ,  Makoto Yuasa ,  Kenichi Oyaizu ,  Ken Tanaka ,  Yuichi Iai ,  Masakuni Yamamoto ,  Shinichi Sasaki ,  Shigeru Kido

    发明人： Naoko Iwata ,  Makoto Yuasa ,  Kenichi Oyaizu ,  Ken Tanaka ,  Yuichi Iai ,  Masakuni Yamamoto ,  Shinichi Sasaki ,  Shigeru Kido

    IPC分类号： H01M4/86 ,  H01M4/88

    CPC分类号： C25D9/02 ,  H01M4/9008 ,  H01M4/9075 ,  H01M4/9083 ,  H01M4/92 ,  H01M4/925 ,  H01M4/926

    摘要： The present invention is intended to provide a catalyst material that supports active species densely, thereby having higher catalytic performance and serviceability as, for example, an electrode for fuel cells. To achieve the above object, the present invention provides a process for preparing a catalyst material, including: an electrochemical polymerization step of electrochemically polymerizing a heteromonocyclic compound so that the surface of a conductive material is coated with polynuclear complex molecules derived from the heteromonocyclic compound; and a metallation step of coordinating a catalytic metal to the coating layer of the polynuclear complex molecules, characterized in that the potential applied in the electrochemical polymerization is 0.8 to 1.5 V.

    摘要翻译： 本发明旨在提供一种致密地支持活性物质的催化剂材料，从而具有比如燃料电池用电极更高的催化性能和适用性。 为了实现上述目的，本发明提供一种制备催化剂材料的方法，包括：电化学聚合步骤，使异单环化合物电化学聚合，使得导电材料的表面被衍生自异单环化合物的多核复合分子包被; 以及将催化金属配位到多核络合物分子的被覆层的金属化步骤，其特征在于，在电化学聚合中施加的电位为0.8〜1.5V。

    Reactive oxygen species measuring device
    10.
    发明申请
    Reactive oxygen species measuring device 有权
    活性氧物质测量装置

    公开(公告)号：US20060289313A1

    公开(公告)日：2006-12-28

    申请号：US10547142

    申请日：2004-02-24

    申请人： Makoto Yuasa ,  Fumio Mizoguchi ,  Hitoshi Takebayashi ,  Masahiko Abe ,  Masumi Koishi ,  Shigeru Kido ,  Masamitsu Nagahama ,  Masayuki Kawasaki ,  Masahiko Yokosuka ,  Takashi Ishihara ,  Rizwangul Ibrahim

    发明人： Makoto Yuasa ,  Fumio Mizoguchi ,  Hitoshi Takebayashi ,  Masahiko Abe ,  Masumi Koishi ,  Shigeru Kido ,  Masamitsu Nagahama ,  Masayuki Kawasaki ,  Masahiko Yokosuka ,  Takashi Ishihara ,  Rizwangul Ibrahim

    IPC分类号： G01F1/64 ,  C07D487/22

    CPC分类号： G01N27/404 ,  A61B5/14542 ,  A61B5/14865 ,  G01N27/3271

    摘要： A reactive oxygen species measuring device according to the present invention comprises a reactive oxygen species sensor provided with an electrode assembly capable of detecting the presence of reactive oxygen species or the like in terms of an electric current, a power source means for applying a measuring voltage to the reactive oxygen species sensor, and a reactive oxygen species concentration measuring means for measuring a concentration of the reactive oxygen species or the like from the current detected by the reactive oxygen species sensor. According to the present invention, a concentration of reactive oxygen species or the like such as in vivo or in vitro superoxide anion radical (O2−.) can be measured reliably, and the entire device can be formed in a smaller size and always mounted to a living body. In addition, the measured data can be transmitted to a remote place or location, and further, the health condition of a living body or the like determined in the remote place can be returned to a measuring place and informed, and thus, the health condition of the living body can be monitored by measuring and monitoring reactive oxygen species.

    摘要翻译： 根据本发明的活性氧物质测量装置包括具有电极组件的活性氧物质传感器，该电极组件能够根据电流检测活性氧等的存在，用于施加测量电压的电源装置 和活性氧物质浓度测定单元，用于从活性氧物质传感器检测出的电流测定活性氧等的浓度。 根据本发明，可以可靠地测量活体氧等的浓度，例如体内或体外超氧阴离子自由基（O 2 O 2 - ）， 并且整个装置可以形成为较小的尺寸并且总是安装在生物体上。 此外，测量数据可以被传送到偏远的地方或位置，而且在偏远的地方确定的生物体的健康状态可以返回到测量地点，从而得到健康状况 可以通过测量和监测活性氧来监测活体。