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    Agents and use thereof
    1.
    发明授权
    Agents and use thereof 失效
    代理商及其用途

    公开(公告)号：US07741275B2

    公开(公告)日：2010-06-22

    申请号：US11793708

    申请日：2005-12-16

    申请人： Mona Ståhle ,  Johan Heilborn ,  Margareta Frohm Nilsson ,  Gunter Weber

    发明人： Mona Ståhle ,  Johan Heilborn ,  Margareta Frohm Nilsson ,  Gunter Weber

    IPC分类号： A61K38/00 ,  A61K39/395

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/4723 ,  C07K16/3092 ,  C07K2317/31

    摘要： The present invention provides agents for inhibiting the proliferation of cancer cells, wherein the agent inhibits the biological activity of hCAP18/LL-37. In a preferred embodiment, the agent alters the transcription, translation and/or binding properties of hCAP18/LL-37. Preferably, the agent is selected from the group consisting of short interfering RNA (siRNA) molecules, antisense oligonucleotides and compounds with binding affinity for hCAP18/LL-37. The invention further provides methods for inhibiting the proliferation of cancer cells in a patient, as well as methods and kits for diagnosing cancer.

    摘要翻译： 本发明提供抑制癌细胞增殖的药剂，其中所述药物抑制hCAP18 / LL-37的生物活性。 在优选的实施方案中，所述试剂改变hCAP18 / LL-37的转录，翻译和/或结合性质。 优选地，试剂选自短干扰RNA（siRNA）分子，反义寡核苷酸和对hCAP18 / LL-37具有结合亲和力的化合物。 本发明还提供了用于抑制患者中癌细胞增殖的方法，以及用于诊断癌症的方法和试剂盒。

    Process for producing particulate, water-soluble cellulose derivatives using a superheated gas mixture containing steam
    2.
    发明授权
    Process for producing particulate, water-soluble cellulose derivatives using a superheated gas mixture containing steam 有权
    使用含有蒸汽的过热气体混合物生产微粒状水溶性纤维素衍生物的方法

    公开(公告)号：US07259257B2

    公开(公告)日：2007-08-21

    申请号：US09785905

    申请日：2001-02-16

    申请人： Hartwig Schlesiger ,  Martin Morning ,  Gunter Weber ,  Volker Eckhardt ,  Gerd Sonnenberg ,  René Kiesewetter

    发明人： Hartwig Schlesiger ,  Martin Morning ,  Gunter Weber ,  Volker Eckhardt ,  Gerd Sonnenberg ,  René Kiesewetter

    IPC分类号： C08B11/20

    CPC分类号： C08J3/12 ,  C08B11/20 ,  C08J2301/08

    摘要： The present invention relates to a new, particularly economical process for preparing particulate water-soluble cellulose derivatives. The process involves forming a feed composition of swollen and/or dissolved cellulose derivative, and water. The feed composition is contacted with a superheated gas mixture, in a sieve-free high rotational speed gas jet impact mill, and the cellulose derivative of the feed composition is converted into a solid state form of finely particulate particles. The superheated gas mixture, with which the feed composition is contacted, is selected from: (i) a superheated gaseous mixture of steam and an inert gas; and (ii) a superheated gas mixture of steam and air. The superheated gas mixture has a steam content of 40 wt. % to 99 wt. %, based on the total weight of the superheated gas mixture.

    摘要翻译： 本发明涉及一种制备颗粒状水溶性纤维素衍生物的新的，特别经济的方法。 该方法包括形成溶胀和/或溶解的纤维素衍生物和水的进料组合物。 在无筛的高转速气体冲击式研磨机中使进料组合物与过热气体混合物接触，并将进料组合物的纤维素衍生物转化为固态形式的细颗粒颗粒。 进料组合物与其接触的过热气体混合物选自：（i）蒸汽和惰性气体的过热气态混合物; 和（ii）蒸汽和空气的过热气体混合物。 过热气体混合物的蒸汽含量为40wt。 ％至99重量％ ％，基于过热气体混合物的总重量。

    Control method for guiding the movement of materials to be transported
    3.
    发明申请
    Control method for guiding the movement of materials to be transported 失效
    引导待运输材料运动的控制方法

    公开(公告)号：US20050167461A1

    公开(公告)日：2005-08-04

    申请号：US10941557

    申请日：2004-09-15

    申请人： Hakan Koc ,  Raimund Kram ,  Richard Schneider ,  Gunter Weber

    发明人： Hakan Koc ,  Raimund Kram ,  Richard Schneider ,  Gunter Weber

    IPC分类号： B65G43/08 ,  B65H23/188

    CPC分类号： B65G43/08

    摘要： The invention relates to an open-loop control process for the motional guidance of conveyed material (32) in a conveying device (30) and to a corresponding conveying device (30). The conveying device (30) has a movable means (36) for realizing the conveyance and a first motion detector (42) for measuring a first actual position value (x1act) for the movable means (36) and a second motion detector (40) for measuring a second actual position value (x2act) for the conveyed material (32). The control is herein realized with a position control having a position control clock (Tpc) and with a speed control (GR) having a relatively faster speed control clock (Tsc), in which, in the position control clock (Tpc), desired position values (xcmd) are preset as the command variable and, in the speed control clock (Tsc), registered first actual position values (x1act) are fed back to the position control, in which the position control is provided, at least in part, in an open-loop control part (NC) and the speed control (GR) is provided in a drive part (A), and in which a control variable (R) is fed back into the position control, which control variable is dependent on second actual position values (x2act) registered in the position control clock (Tpc). A high accuracy and dynamic can thereby be obtained.

    摘要翻译： 本发明涉及一种用于在输送装置（30）和对应的输送装置（30）中运送的材料（32）的运动引导的开环控制过程。 输送装置（30）具有用于实现输送的可移动装置（36）和用于测量可移动装置（36）的第一实际位置值（x 1＆lt;＆lt;＆lt;＆gt;）的第一运动检测器 ）和第二运动检测器（40），用于测量所输送的材料（32）的第二实际位置值（x 2＆lt;＆lt;＆gt;）。 这里的控制通过具有位置控制时钟（T >PCS）的位置控制以及速度控制（GR）具有相对较快的速度控制时钟（T < ），其中在位置控制时钟（T ）中，期望的位置值（x> cmd）被预设为命令变量，并且在速度控制时钟 注册的第一实际位置值（x 1＆lt;＆lt;＆gt;）被反馈到其中提供位置控制的位置控制，至少部分地在 在驱动部（A）中设置有开环控制部（NC）和速度控制（GR），其中控制变量（R）反馈到位置控制中，该控制变量取决于第二 注册在位置控制时钟（TPCPC）中的实际位置值（x 2 <动作）。 由此可以获得高精度和动态。

    Transmission gear wheel with damping capability
    4.
    发明授权
    Transmission gear wheel with damping capability 失效
    传动齿轮具有阻尼能力

    公开(公告)号：US6047607A

    公开(公告)日：2000-04-11

    申请号：US83204

    申请日：1998-05-22

    申请人： Gunter Weber ,  Heinrich Samitsch ,  Eduard Mohorko

    发明人： Gunter Weber ,  Heinrich Samitsch ,  Eduard Mohorko

    IPC分类号： F16H55/18

    CPC分类号： F16H55/18 ,  Y10T74/19623 ,  Y10T74/19898 ,  Y10T74/19916

    摘要： A transmission gear wheel has at least two gear wheel elements which are provided with teeth on their circumference and which, coaxially and non-displaceably with respect to one another in the circumferential direction. Mutually offset teeth connect the elements with one another such that, for the engagement of a meshing gear wheel, the existing tooth flank play is reduced or discontinued. At least the teeth of one gear wheel element are constructed such with respect to their elasticity that, during the engagement of meshing gear wheel, at least starting at a defined transmitted torque, the offset in the circumferential direction of the tooth transmitting this torque is at least partially discontinued with respect to the tooth of the other gear wheel element by means of a deformation.

    摘要翻译： 传动齿轮具有至少两个齿轮元件，它们在其圆周上设置有齿，并且在圆周方向上相对于彼此同轴且不可移位。 相互偏移的齿将元件彼此连接，使得为了啮合啮合齿轮，现有的齿面间隙减小或停止。 至少一个齿轮元件的齿是相对于它们的弹性构成的，即在啮合齿轮的啮合过程中，至少从规定的传递扭矩开始，传递该扭矩的齿的圆周方向上的偏移在 通过变形相对于另一个齿轮元件的齿最少部分停止。

    Scrubbing and oxidation of hydrogen sulfide with removal of dissolved oxygen from scrubbing solution before reuse
    8.
    发明授权
    Scrubbing and oxidation of hydrogen sulfide with removal of dissolved oxygen from scrubbing solution before reuse 失效
    在再利用前从洗涤溶液中除去溶解氧的硫化氢的洗涤和氧化

    公开(公告)号：US4526773A

    公开(公告)日：1985-07-02

    申请号：US551311

    申请日：1983-11-14

    申请人： Gunter Weber

    发明人： Gunter Weber

    IPC分类号： B01D53/52 ,  C01B17/05 ,  C10K1/12 ,  B01D53/34

    CPC分类号： B01D53/52 ,  C01B17/05 ,  C10K1/124

    摘要： In a continuous process for the removal of H.sub.2 S from a gaseous mixture involving: (a) simultaneous absorption and oxidation of H.sub.2 S to form elemental sulfur; (b) regeneration of the oxidizing agent, e.g., vanadate, by treating the used scrubbing liquid with air; and (c) recycling the regenerated scrubbing liquid to the scrubbing step, to avoid the formation of sulfates and thiosulfates, the dissolved oxygen is substantially prevented from appearing in the scrubbing solution before reuse.

    摘要翻译： 在从气体混合物中除去H 2 S的连续方法中，包括：（a）同时吸收和氧化H 2 S以形成元素硫; （b）通过用空气处理使用的洗涤液体来再生氧化剂，例如钒酸盐; 和（c）将再生洗涤液再循环到洗涤步骤中，以避免形成硫酸盐和硫代硫酸盐，在再利用之前基本上防止溶解氧出现在洗涤溶液中。

    Motor vehicle door lock
    9.
    发明授权
    Motor vehicle door lock 失效
    机动车门锁

    公开(公告)号：US4289342A

    公开(公告)日：1981-09-15

    申请号：US85360

    申请日：1979-10-16

    申请人： Wulf W. Bemm ,  Gunter Weber

    发明人： Wulf W. Bemm ,  Gunter Weber

    IPC分类号： E05B81/06 ,  E05B81/16 ,  E05B81/42 ,  E05B81/54 ,  E05B85/24 ,  E05C3/12

    CPC分类号： E05B81/06 ,  E05B81/16 ,  E05B81/42 ,  E05B81/54 ,  E05B85/24 ,  Y10T292/0854 ,  Y10T292/1082

    摘要： A motor vehicle door lock comprises a ratchet locking mechanism, behind the preferably bolt-shaped catch of which there can engage the flanks of two locking teeth which are arranged one behind the other and which are arranged on a pivotable locking lever which is pressed into the locking position by spring pressure and which, upon a movement of the catch relative to the lever during the locking of the door, can be pivoted by the catch against the spring pressure. For the opening of the lock there engages in the locking lever (9) or is secured thereto, a driving member (28), by means of which the locking lever can be removed from the catch (2) to such an extent that the respective abutting tooth edge becomes disengaged.

    摘要翻译： 机动车门锁包括棘轮锁定机构，在优选的螺栓形锁扣之后，其可以与两个锁定齿的侧面接合，两个锁定齿的侧面一个在另一个后面布置，并且布置在可枢转的锁定杆上，该锁定杆被压入 通过弹簧压力锁定位置，并且在锁定门期间卡扣相对于杠杆的运动可以克服弹簧压力而被卡扣枢转。 为了打开锁，其中接合锁定杆（9）或固定在其上的驱动构件（28），借助于该驱动构件，锁定杆可从捕获器（2）移除到相应的 抵接齿边缘脱开。