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    Method of detecting lung disease
    5.
    发明授权
    Method of detecting lung disease 有权
    检测肺部疾病的方法

    公开(公告)号：US06214536B1

    公开(公告)日：2001-04-10

    申请号：US09433757

    申请日：1999-11-04

    申请人： Richard C. Boucher, Jr.

    发明人： Richard C. Boucher, Jr.

    IPC分类号： C12Q100

    CPC分类号： A61K9/0078 ,  A61K31/66 ,  A61K33/14 ,  A61K45/06 ,  A61K31/70 ,  A61K31/495 ,  A61K31/7004 ,  A61K31/165 ,  A61K31/14 ,  A61K2300/00

    摘要： A method of facilitating the obtaining of a mucus sample from at least one lung of a subject comprises administering to at least one lung of the subject, in an amount effective to hydrate lung mucous secretions and/or stimulate cilia beat frequency therein, uridine 5′-triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof, and, optionally, concurrently administering to said at least one lung a physiologically acceptable salt in an amount effective to hydrate lung mucus secretions therein. A sputum or mucus sample is then collected from said at least one lung, which sample can then be analyzed for lung disease. Pharmaceutical compositions useful for carrying out the method comprise UTP or a salt thereof, alone or in combination with a physiologically acceptable salt, or a pharmaceutically acceptable salt of either thereof. The composition may be a liquid/liquid suspension composition or a dry powder composition.

    摘要翻译： 促进从受试者的至少一个肺获得粘液样品的方法包括给予受试者的至少一个肺，其量有效地水合肺粘膜分泌物和/或刺激其中的纤毛节拍频率，尿苷5' 三磷酸盐，其活性类似物或其药学上可接受的盐，并且任选地，以有效水合物中的肺粘液分泌物的量向所述至少一个肺施用生理上可接受的盐。 然后从所述至少一个肺采集痰液或粘液样品，然后可以分析该样品的肺部疾病。 可用于实施该方法的药物组合物包含UTP或其盐单独或与其生理学上可接受的盐或其药学上可接受的盐组合。 组合物可以是液体/液体悬浮液组合物或干粉组合物。

    Method of treating lung disease with uridine triphosphates
    7.
    发明授权
    Method of treating lung disease with uridine triphosphates 失效
    用尿苷三磷酸治疗肺部疾病的方法

    公开(公告)号：US5292498A

    公开(公告)日：1994-03-08

    申请号：US717747

    申请日：1991-06-19

    申请人： Richard C. Boucher, Jr.

    发明人： Richard C. Boucher, Jr.

    IPC分类号： C07H19/10 ,  A61K20060101 ,  A61K31/00 ,  A61K31/675 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7072 ,  A61L9/04 ,  A61P11/00 ,  A61P11/10 ,  A61P11/12

    CPC分类号： A61K31/70

    摘要： A method of hydrating mucous secretions in the lungs of a subject in need of such treatment is disclosed. The method comprises administering to the lungs of the subject a uridine triphosphate such as uridine 5'-triphosphate (UTP) or uridine 5'-O-(3-thiotriphosphate) (UTP.gamma.S) in an amount effective to hydrate lung mucous secretions. The method is useful for treating patients aflicted with cystic fibrosis. Pharmaceutical formulations and methods of making the same are also disclosed.

    摘要翻译： 公开了一种对需要这种治疗的受试者的肺中的粘液分泌物进行水合的方法。 所述方法包括以有效水合肺粘膜的量向受试者的肺部施用尿苷三磷酸如尿苷5'-三磷酸（UTP）或尿苷5'-O-（3-硫代三磷酸酯）（UTP（γ）S） 分泌物。 该方法可用于治疗患有囊性纤维化的患者。 还公开了药物制剂及其制备方法。

    Animal model for chronic obstructive pulmonary disease and cystic fibrosis
    8.
    发明授权
    Animal model for chronic obstructive pulmonary disease and cystic fibrosis 有权
    慢性阻塞性肺疾病和囊性纤维化的动物模型

    公开(公告)号：US08952214B2

    公开(公告)日：2015-02-10

    申请号：US12823243

    申请日：2010-06-25

    申请人： Richard C. Boucher, Jr. ,  Wanda O'Neal ,  Barbara Grubb ,  Marcus Mall

    发明人： Richard C. Boucher, Jr. ,  Wanda O'Neal ,  Barbara Grubb ,  Marcus Mall

    IPC分类号： A01K67/027

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0306 ,  C07H21/04 ,  C07K14/705

    摘要： A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter construct directs expression of the epithelial sodium channel β subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.

    摘要翻译： 描述了一种非人类转基因哺乳动物，其基因组包含与编码上皮钠通道的异源DNA可操作地连接的启动子构建体; 亚基，其中所述启动子构建体指导上皮钠通道的表达; 所述动物的肺上皮细胞中的亚单位，并且其中所述转基因哺乳动物与相应的野生型哺乳动物相比具有增加的肺粘液滞留。 该动物用于筛选用于治疗肺部疾病如囊性纤维化和慢性阻塞性肺疾病的活性的化合物。