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    Nanoparticle based stabilization of ir fluorescent dyes
    1.
    发明申请
    Nanoparticle based stabilization of ir fluorescent dyes 审中-公开
    荧光染料的纳米粒子稳定化

    公开(公告)号：US20070148074A1

    公开(公告)日：2007-06-28

    申请号：US10542185

    申请日：2004-01-15

    申请人： Mostafa Sadoqi ,  Jun Shao ,  Vishal Saxena ,  Sunil Kumar

    发明人： Mostafa Sadoqi ,  Jun Shao ,  Vishal Saxena ,  Sunil Kumar

    IPC分类号： C01B25/26

    CPC分类号： A61K41/0057 ,  A61K49/0034 ,  A61K49/0093 ,  G01N33/54346

    摘要： This invention relates to a highly effective nanoparticle system for stabilizing near-infrared (near-IR) fluorescent dyes such as indocyanine (ICG) in order to enhance the dye's utility for biomedical application. This invention further relates to nanoparticles comprised of biodegradable polymer materials such as poly(dl-lactide-co-glycolide)(PLGA). The invention also relates to methods of preparing the nanoparticle-entrapped dyes, as well as methods for using them in bioimaging, diagnosis, and treatment of disease. The present invention also relates to compositions and kits comprising nanoparticle-entrapped dyes.

    摘要翻译： 本发明涉及用于稳定近红外（近红外）荧光染料如吲哚菁（ICG）的高效纳米颗粒体系，以提高染料在生物医学应用中的应用。 本发明还涉及由可生物降解的聚合物材料如聚（dl-丙交酯 - 共 - 乙交酯）（PLGA）组成的纳米颗粒。 本发明还涉及制备纳米颗粒捕获的染料的方法，以及将其用于疾病的生物成像，诊断和治疗中的方法。 本发明还涉及包含纳米颗粒捕获的染料的组合物和试剂盒。

    METHOD AND SYSTEM FOR KEY EXCHANGE AND METHOD AND APPARATUS FOR REDUCING PARAMETER TRANSMISSION BANDWIDTH
    3.
    发明申请
    METHOD AND SYSTEM FOR KEY EXCHANGE AND METHOD AND APPARATUS FOR REDUCING PARAMETER TRANSMISSION BANDWIDTH 有权
    关键交换方法与系统及减少参数传输带宽的方法及装置

    公开(公告)号：US20090271628A1

    公开(公告)日：2009-10-29

    申请号：US12482821

    申请日：2009-06-11

    申请人： Zhenfu Cao ,  Xiaolei Dong ,  Jun Shao ,  Jiwei Wei

    发明人： Zhenfu Cao ,  Xiaolei Dong ,  Jun Shao ,  Jiwei Wei

    IPC分类号： H04L9/00

    CPC分类号： H04L9/0841

    摘要： The embodiments of the present disclosure disclose a method and apparatus for reducing the parameter transmission bandwidth. The parameter sender reduces the values of the parameters before sending the parameters to the parameter receiver. This scheme reduces the bandwidth consumed during parameter transmission, thus makes the transmission more efficient. The embodiment of the present disclosure also discloses a method for key exchange. This method reduces the values of the transmission parameters before sending the transmission parameters. This saves the bandwidth compared with the protocol in the prior art. Besides, the embodiment of the present disclosure discloses a system for key exchange. The parameter sender sends the transmission parameters to the bandwidth processing unit. The bandwidth processing unit performs a modulo operation on the received transmission parameters and then sends the processed transmission parameters to the parameter receiver, thus reducing the bandwidth consumed in the transmission of transmission parameters.

    摘要翻译： 本公开的实施例公开了一种用于减少参数传输带宽的方法和装置。 在将参数发送给参数接收器之前，参数发送器减少参数的值。 该方案减少参数传输期间消耗的带宽，从而使传输更有效率。 本公开的实施例还公开了一种用于密钥交换的方法。 该方法在发送传输参数之前减少传输参数的值。 这节省了与现有技术中的协议相比的带宽。 此外，本公开的实施例公开了一种用于密钥交换的系统。 参数发送方将传输参数发送到带宽处理单元。 带宽处理单元对所接收的传输参数进行模运算，然后将经处理的传输参数发送到参数接收机，从而减少传输参数传输中消耗的带宽。

    NOVEL OXINDOLE DERIVATIVE
    7.
    发明申请
    NOVEL OXINDOLE DERIVATIVE 失效
    新的氧化物衍生物

    公开(公告)号：US20100076049A1

    公开(公告)日：2010-03-25

    申请号：US12513332

    申请日：2007-11-05

    申请人： Noriaki Shinobu ,  Jun Shao ,  Masataka Kobayashi ,  Takao Mori

    发明人： Noriaki Shinobu ,  Jun Shao ,  Masataka Kobayashi ,  Takao Mori

    IPC分类号： A61K31/403 ,  C07D209/04 ,  A61P35/00

    CPC分类号： C07D405/14 ,  C07D403/14 ,  C07D409/14

    摘要： A compound or a pharmaceutically acceptable salt thereof of the present invention is represented by the following general formula (I): [wherein, R1 to R8 may have a hydrogen atom, a halogen atom, a hydroxy group, a C1-C6 alkyl group, a C2-C8 alkenyl group, a C1-C6 alkylcarbonyl group or —COOR9 (wherein R9 represents a hydrogen atom, a C1-C6 alkyl group or a C2-C8 alkenyl group) as a substituent; and X represents a sulfur atom, an oxygen atom or NR10 (wherein R10 represents a hydrogen atom, a halogen atom, a hydroxy group, a C1-C6 alkyl group, a C2-C8 alkenyl group or a C1-C6 alkoxy group)].

    摘要翻译： 本发明的化合物或其药学上可接受的盐由以下通式（I）表示：[其中，R 1至R 8可以具有氢原子，卤素原子，羟基，C 1 -C 6烷基， C2-C8烯基，C1-C6烷基羰基或-COOR9（其中R9表示氢原子，C1-C6烷基或C2-C8烯基）作为取代基; X表示硫原子，氧原子或NR 10（式中，R 10表示氢原子，卤素原子，羟基，C 1〜C 6烷基，C 2〜C 8烯基或C 1〜C 6烷氧基）] 。

    Mobile device assisted secure computer network communication
    10.
    发明授权
    Mobile device assisted secure computer network communication 有权
    移动设备辅助安全计算机网络通信

    公开(公告)号：US08209744B2

    公开(公告)日：2012-06-26

    申请号：US12122126

    申请日：2008-05-16

    申请人： Bin Zhu ,  Min Feng ,  Xu Yin ,  Yang Yang ,  Yao Zhang ,  Jun Shao

    发明人： Bin Zhu ,  Min Feng ,  Xu Yin ,  Yang Yang ,  Yao Zhang ,  Jun Shao

    IPC分类号： G06F21/00

    CPC分类号： H04L63/0869 ,  G06Q10/02 ,  H04L63/0838 ,  H04L63/0853 ,  H04L63/18 ,  H04L2463/082

    摘要： Mobile device assisted secure computer network communications embodiments are presented that employ a mobile device (e.g., a mobile phone, personal digital assistant (PDA), and the like) to assist in user authentication. In general, this is accomplished by having a user enter a password into a client computer which is in contact with a server associated with a secure Web site. This password is integrated with a secret value, which is generated in real time by the mobile device. The secret value is bound to both the mobile device's hardware and the secure Web site being accessed, such that it is unique to both. In this way, a different secret value is generated for each secure Web site accessed, and another user cannot impersonate the user and log into a secure Web site unless he or she knows the password and possesses the user's mobile device simultaneously.

    摘要翻译： 提出了使用移动设备（例如，移动电话，个人数字助理（PDA）等）的移动设备辅助的安全计算机网络通信实施例来协助用户认证。 一般来说，这是通过使用户将密码输入到与与安全网站相关联的服务器联系的客户端计算机来实现的。 这个密码是与移动设备实时生成的秘密值集成的。 秘密值绑定到移动设备的硬件和被访问的安全网站，这两者都是唯一的。 以这种方式，为所访问的每个安全网站生成不同的秘密值，而另一个用户不能模拟用户并登录到安全网站，除非他或她知道密码并同时拥有用户的移动设备。