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公开(公告)号：US06736834B1
公开(公告)日：2004-05-18
申请号：US10074738
申请日：2001-10-29
申请人： Mukesh Kumar , H. Gene Hawkins
发明人： Mukesh Kumar , H. Gene Hawkins
IPC分类号： A61F712
CPC分类号： A61L27/58 , A61B17/866 , A61B17/8863 , A61B2017/00004 , A61B2050/0056 , A61B2050/0083 , A61B2050/0085 , H05B3/146
摘要： A heating device for maintaining an elevated temperature of a polymer resorbable implant is disclosed. The heating device has a pair of members coupled by a hinge. At least one of the members defines a sealed cavity containing a heated liquid which maintains the temperature of the resorbable polymer implant above the implant's glass transition temperature. The members of the device being rotatable about a hinge to allow encapsulation of the resorbable implant adjacent to the heat bearing liquid while maintaining a separation between the liquid and the implant device.
摘要翻译： 公开了一种用于保持聚合物可吸收植入物的升高温度的加热装置。 加热装置具有通过铰链联接的一对构件。 这些构件中的至少一个限定了包含加热液体的密封空腔，其保持可再吸收的聚合物植入物的温度高于植入物的玻璃化转变温度。 该装置的构件可围绕铰链旋转，以允许将可再吸收的植入物邻近承热液体封闭，同时保持液体和植入装置之间的间隔。
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公开(公告)号：US20120261546A1
公开(公告)日：2012-10-18
申请号：US13531735
申请日：2012-06-25
IPC分类号： B29C33/26
CPC分类号： A61F2/36 , A61F2/30 , A61F2/3094 , A61F2/3662 , A61F2/38 , A61F2/40 , A61F2002/3009 , A61F2002/30332 , A61F2002/30471 , A61F2002/30604 , A61F2002/30672 , A61F2002/30957 , A61F2002/3611 , A61F2002/365 , A61F2220/0033 , A61F2220/0091 , A61F2250/0091 , A61F2310/00353 , B28B7/0029 , B28B7/0044 , B28B23/024
摘要： The present teachings provide a modular articulating cement spacer mold for forming a temporary implant comprising a mold first portion, a mold second portion, and a ventilation forming surface feature on an interior surface of at least one of the mold first portion or the mold second portion. The first mold portion and the second mold portion have corresponding interior surfaces that form a cavity therebetween.
摘要翻译： 本发明提供了一种用于形成临时植入物的模块化关节式水泥隔离器模具，其包括模具第一部分，模具第二部分和通气形成表面特征，其在模具第一部分或模具第二部分中的至少一个的内表面上 。 第一模具部分和第二模具部分具有在其间形成空腔的对应内表面。
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3.发明授权Crosslinked polymeric material with enhanced strength and process for manufacturing 有权具有增强强度的交联聚合物材料和制造方法公开(公告)号：US08137608B2
公开(公告)日：2012-03-20
申请号：US12849640
申请日：2010-08-03
CPC分类号： C08J3/24 , A61F2/3094 , A61F2/34 , A61L27/16 , B29C47/0016 , B29C47/003 , B29C47/884 , B29C55/30 , B29K2023/0683 , B29K2623/0683 , B29L2031/7532 , C08J2323/06 , C08L23/06
摘要： A radiation crosslinked (50 kGy), pressure-treated UHMWPE material has been developed by applying compressive force on a crosslinked polymer in a direction orthogonal to an axial direction. The deformed material is then cooled while held in a deformed state. The resulting material is anisotropic, with enhanced strength oriented along the axial direction. The directionally engineered material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted highly crosslinked UHMWPEs.
摘要翻译： 已经通过在与轴向正交的方向上对交联聚合物施加压缩力来开发经辐射交联（50kGy）的经加压处理的UHMWPE材料。 然后将变形的材料冷却，同时保持在变形状态。 所得到的材料是各向异性的，具有沿轴向取向的增强强度。 即使在含有五个大气压的氧气的压力容器（ASTM F2003）中，即使在加速老化四周之后，定向工程材料也是氧化稳定的。 由于其氧化稳定性，变形处理材料是透气包装和气体灭菌的合适的候选物，迄今为止，这已经被保留用于重熔的高度交联的UHMWPE。
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4.发明授权公开(公告)号：US07993401B2
公开(公告)日：2011-08-09
申请号：US12035018
申请日：2008-02-21
IPC分类号： A61F2/02 , A61F2/28 , A61F2/30 , C08F110/02
CPC分类号： A61F2/3094 , A61F2/30 , A61L27/16 , B29C47/0021 , B29C47/54 , B29C47/8805 , B29C55/30 , B29C2035/085 , B29K2023/0683 , B29K2105/25 , C08F110/02 , C08L23/06 , C08F2500/01 , C08F2500/11
摘要： Solid-state deformation processing of crosslinked high molecular weight polymers such as UHMWPE, for example by extrusion below the melt transition, produces materials with a combination of high tensile strength and high oxidative stability. The materials are especially suitable for use as bearing components in artificial hip and other implants. Treated bulk materials are anisotropic, with enhanced strength oriented along the axial direction. The material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted crosslinked UHMWPE.
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5.发明授权公开(公告)号：US07927536B2
公开(公告)日：2011-04-19
申请号：US12849677
申请日：2010-08-03
IPC分类号： C08F110/02 , A61L27/16
CPC分类号： A61F2/3094 , A61F2/30 , A61L27/16 , B29C47/0021 , B29C47/54 , B29C47/8805 , B29C55/30 , B29C2035/085 , B29K2023/0683 , B29K2105/25 , C08F110/02 , C08L23/06 , C08F2500/01 , C08F2500/11
摘要： Solid-state deformation processing of crosslinked high molecular weight polymers such as UHMWPE, for example by extrusion below the melt transition, produces materials with a combination of high tensile strength and high oxidative stability. The materials are especially suitable for use as bearing components in artificial hip and other implants. Treated bulk materials are anisotropic, with enhanced strength oriented along the axial direction. The material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted crosslinked UHMWPE.
摘要翻译： 交联的高分子量聚合物如UHMWPE的固态变形处理例如通过在熔融转变以下挤出产生具有高拉伸强度和高氧化稳定性的组合的材料。 这些材料特别适用于人造髋关节和其他植入物中的轴承部件。 处理的散装材料是各向异性的，其强度沿轴向方向取向。 即使在含有五个大气压的氧气的压力容器中，即使加速老化四周后，材料也是氧化稳定的（ASTM F2003）。 由于其氧化稳定性，变形处理材料是透气包装和气体灭菌的合适的候选者，迄今为止，这已经被保留用于再熔交联的UHMWPE。
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6.发明申请公开(公告)号：US20100314800A1
公开(公告)日：2010-12-16
申请号：US12849677
申请日：2010-08-03
IPC分类号： B29C47/54
CPC分类号： A61F2/3094 , A61F2/30 , A61L27/16 , B29C47/0021 , B29C47/54 , B29C47/8805 , B29C55/30 , B29C2035/085 , B29K2023/0683 , B29K2105/25 , C08F110/02 , C08L23/06 , C08F2500/01 , C08F2500/11
摘要： Solid-state deformation processing of crosslinked high molecular weight polymers such as UHMWPE, for example by extrusion below the melt transition, produces materials with a combination of high tensile strength and high oxidative stability. The materials are especially suitable for use as bearing components in artificial hip and other implants. Treated bulk materials are anisotropic, with enhanced strength oriented along the axial direction. The material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted crosslinked UHMWPE.
摘要翻译： 交联的高分子量聚合物如UHMWPE的固态变形处理例如通过在熔融转变以下挤出产生具有高拉伸强度和高氧化稳定性的组合的材料。 这些材料特别适用于人造髋关节和其他植入物中的轴承部件。 处理的散装材料是各向异性的，其强度沿轴向方向取向。 即使在含有五个大气压的氧气的压力容器中，即使加速老化四周后，材料也是氧化稳定的（ASTM F2003）。 由于其氧化稳定性，变形处理材料是透气包装和气体灭菌的合适的候选者，迄今为止，这已经被保留用于再熔交联的UHMWPE。
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公开(公告)号：US07637729B2
公开(公告)日：2009-12-29
申请号：US11955601
申请日：2007-12-13
申请人： William Hartman , H. Gene Hawkins , Kristen Martin , Jacob Wilson
发明人： William Hartman , H. Gene Hawkins , Kristen Martin , Jacob Wilson
IPC分类号： A61F2/36
CPC分类号： A61F2/30 , A61F2/3094 , A61F2/36 , A61F2002/30672 , A61F2002/30957 , A61F2250/0059 , A61F2310/00353 , B28B1/24 , B28B7/0029
摘要： The present teachings provide a modular articulating cement spacer mold for forming a temporary implant. The modular spacer mold includes a head component mold defining a first opening, a head connector positioned within the first opening of the head component mold, a stem component mold defining a second opening, and a stem connector to fit within the second opening of the stem component mold to mateably engage the head connector. Related kits and methods of forming a temporary implant are provided.
摘要翻译： 本教导提供了一种用于形成临时植入物的模块化关节式水泥间隔器模具。 模块化间隔模具包括限定第一开口的头部部件模具，位于头部部件模具的第一开口内的头部连接器，限定第二开口的杆部件模具以及装配在杆部的第二开口内的杆连接器 组件模具可适配地接合头连接器。 提供了形成临时植入物的相关试剂盒和方法。
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公开(公告)号：US08920152B2
公开(公告)日：2014-12-30
申请号：US13531735
申请日：2012-06-25
CPC分类号： A61F2/36 , A61F2/30 , A61F2/3094 , A61F2/3662 , A61F2/38 , A61F2/40 , A61F2002/3009 , A61F2002/30332 , A61F2002/30471 , A61F2002/30604 , A61F2002/30672 , A61F2002/30957 , A61F2002/3611 , A61F2002/365 , A61F2220/0033 , A61F2220/0091 , A61F2250/0091 , A61F2310/00353 , B28B7/0029 , B28B7/0044 , B28B23/024
摘要： The present teachings provide a modular articulating cement spacer mold for forming a temporary implant comprising a mold first portion, a mold second portion, and a ventilation forming surface feature on an interior surface of at least one of the mold first portion or the mold second portion. The first mold portion and the second mold portion have corresponding interior surfaces that form a cavity therebetween.
摘要翻译： 本发明提供了一种用于形成临时植入物的模块化关节式水泥隔离器模具，其包括模具第一部分，模具第二部分和通气形成表面特征，其在模具第一部分或模具第二部分中的至少一个的内表面上 。 第一模具部分和第二模具部分具有在其间形成空腔的对应内表面。
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9.发明授权Crosslinked polymeric material with enhanced strength and process for manufacturing 有权具有增强强度的交联聚合物材料和制造方法公开(公告)号：US07780896B2
公开(公告)日：2010-08-24
申请号：US12328414
申请日：2008-12-04
CPC分类号： C08J3/24 , A61F2/3094 , A61F2/34 , A61L27/16 , B29C47/0016 , B29C47/003 , B29C47/884 , B29C55/30 , B29K2023/0683 , B29K2623/0683 , B29L2031/7532 , C08J2323/06 , C08L23/06
摘要： A radiation crosslinked (50 kGy), pressure-treated UHMWPE material has been developed by applying compressive force on a crosslinked polymer in a direction orthogonal to an axial direction. The deformed material is then cooled while held in a deformed state. The resulting material is anisotropic, with enhanced strength oriented along the axial direction. The directionally engineered material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted highly crosslinked UHMWPEs.
摘要翻译： 已经通过在与轴向正交的方向上对交联聚合物施加压缩力来开发经辐射交联（50kGy）的经加压处理的UHMWPE材料。 然后将变形的材料冷却，同时保持在变形状态。 所得到的材料是各向异性的，具有沿轴向取向的增强强度。 即使在含有五个大气压的氧气的压力容器（ASTM F2003）中，即使在加速老化四周之后，定向工程材料也是氧化稳定的。 由于其氧化稳定性，变形处理材料是透气包装和气体灭菌的合适的候选物，迄今为止，这已经被保留用于重熔的高度交联的UHMWPE。
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10.发明授权公开(公告)号：US07547405B2
公开(公告)日：2009-06-16
申请号：US11402561
申请日：2006-04-12
申请人： David Wayne Schroeder , Jordan H. Freedman , James E. Gunter , Brian D. Salyer , H. Gene Hawkins
发明人： David Wayne Schroeder , Jordan H. Freedman , James E. Gunter , Brian D. Salyer , H. Gene Hawkins
CPC分类号： C08J3/28
摘要： Solid-state deformation processing of crosslinked high molecular weight polymers such as UHMWPE, for example by extrusion below the melt transition, produces materials with a desirable combination of physical and chemical properties. Crosslinked bulk materials are heated to a compression deformable temperature, and pressure is applied to change a transverse dimension of the material. After cooling and stress relieving, a treated bulk material is obtained that has enhanced tensile strength in the axial direction orthogonal to the dimension change. In preferred embodiments, medical implant bearing materials are machined from the treated bulk material with the in vivo load bearing axis substantially parallel or coincident with the axial direction of the treated bulk material.
摘要翻译： 交联的高分子量聚合物如UHMWPE的固态变形处理例如通过在熔融转变以下挤出产生具有所需物理和化学性质组合的材料。 将交联的散装材料加热至压缩变形温度，施加压力以改变材料的横向尺寸。 在冷却和减轻应力之后，获得了与尺寸变化正交的轴向拉伸强度提高的经处理的散装材料。 在优选实施例中，医疗植入物轴承材料由经处理的散装材料加工，其中体内承载轴线基本上与经处理的散装材料的轴向方向平行或重合。
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