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公开(公告)号：US20110190314A1
公开(公告)日：2011-08-04
申请号：US13080071
申请日：2011-04-05
申请人： Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人： Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号： A61K31/4439 , C07D413/04 , C07D413/14 , A61K31/444 , A61K31/497 , A61K31/496 , A61P25/00 , A61P25/28 , A61P25/32 , A61P25/30 , A61P25/18 , A61P9/10 , A61P29/00 , A61P31/00
CPC分类号： A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要： The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译： 本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂，其使用方法和相关制品的组合物。
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公开(公告)号：US20080167286A1
公开(公告)日：2008-07-10
申请号：US11953625
申请日：2007-12-10
申请人： Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人： Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号： A61K31/397 , A61K31/4439 , C07D413/04 , A61P25/00
CPC分类号： A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要： The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译： 本发明涉及包含神经元烟碱性受体配体和α4β2阳性变构调节剂的组合物，其使用方法和相关制造方法。
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公开(公告)号：US09186407B2
公开(公告)日：2015-11-17
申请号：US13080071
申请日：2011-04-05
申请人： Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人： Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号： A01N43/82 , A61K31/41 , A01N43/40 , A61K31/44 , C07D413/00 , C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/443 , A61K31/444 , A61K45/06
CPC分类号： A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要： The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译： 本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂，其使用方法和相关制品的组合物。
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公开(公告)号：US08586746B2
公开(公告)日：2013-11-19
申请号：US13012130
申请日：2011-01-24
申请人： Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson , William H. Bunnelle , Diana L. Nersesian
发明人： Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson , William H. Bunnelle , Diana L. Nersesian
IPC分类号： C07D221/22 , C07D221/06
CPC分类号： C07D487/04
摘要： The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.Radiolabelled compounds useful for evaluating the binding affinity to α7 nicotinic acetylcholine receptors also are described.
摘要翻译： 本发明涉及胺取代的氮杂 - 金刚烷衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。 还描述了可用于评估对α7烟碱乙酰胆碱受体的结合亲和力的放射性标记化合物。
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公开(公告)号：US20110118301A1
公开(公告)日：2011-05-19
申请号：US13012130
申请日：2011-01-24
申请人： Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson , William H. Bunnelle , Diana L. Nersesian
发明人： Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson , William H. Bunnelle , Diana L. Nersesian
IPC分类号： A61K31/439 , C07D409/12 , C07D401/12 , C07D495/04 , A61P25/00 , A61P25/28 , A61P25/18 , A61P29/00 , A61P15/08 , A61P9/10 , C07D403/04
CPC分类号： C07D487/04
摘要： The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.Radiolabelled compounds useful for evaluating the binding affinity to α7 nicotinic acetylcholine receptors also are described.
摘要翻译： 本发明涉及胺取代的氮杂 - 金刚烷衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。 还描述了可用于评估对α7烟碱乙酰胆碱受体的结合亲和力的放射性标记化合物。
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公开(公告)号：US07897766B2
公开(公告)日：2011-03-01
申请号：US11517064
申请日：2006-09-07
申请人： Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson , William H. Bunnelle , Diana L. Nersesian
发明人： Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson , William H. Bunnelle , Diana L. Nersesian
IPC分类号： C07D221/28 , C07D221/22 , A61K31/439
CPC分类号： C07D487/04
摘要： The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.Radiolabelled compounds useful for evaluating the binding affinity to α7 nicotinic acetylcholine receptors also are described.
摘要翻译： 本发明涉及胺取代的氮杂 - 金刚烷衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。 还描述了可用于评估对α7烟碱乙酰胆碱受体的结合亲和力的放射性标记化合物。
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公开(公告)号：US20120219967A1
公开(公告)日：2012-08-30
申请号：US13367102
申请日：2012-02-06
申请人： Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
发明人： Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
CPC分类号： C07K14/70571 , C07K14/723 , C07K2319/00
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
摘要翻译： 本发明描述了新的胆碱能/ 5-羟色胺能嵌合受体，并且提供了适合于筛选配体的方法和组合物，例如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。
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公开(公告)号：US20090123945A1
公开(公告)日：2009-05-14
申请号：US12146088
申请日：2008-06-25
申请人： Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
发明人： Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
CPC分类号： C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
摘要翻译： 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适用于筛选配体的方法和组合物，例如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。
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公开(公告)号：US08759504B2
公开(公告)日：2014-06-24
申请号：US13367102
申请日：2012-02-06
申请人： Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
发明人： Murali Gopalakrishnan , Jinhe Li , Steven C. Cassar , John Malysz , David J. Anderson , Earl J. Gubbins , Daniel C. Bertrand
IPC分类号： C12N15/62 , G01N33/567 , C07K14/705
CPC分类号： C07K14/70571 , C07K14/723 , C07K2319/00
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
摘要翻译： 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供了适合于筛选诸如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂的配体的方法和组合物。
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公开(公告)号：US10071310B2
公开(公告)日：2018-09-11
申请号：US14805552
申请日：2015-07-22
IPC分类号： G10L17/00 , G10L15/00 , H04L29/06 , A63F13/424 , A63F13/215 , A63F13/79 , A63F13/54
CPC分类号： A63F13/424 , A63F13/12 , A63F13/215 , A63F13/54 , A63F13/79 , A63F2300/1081 , A63F2300/50 , A63F2300/6072 , A63F2300/6081 , G10L15/00 , G10L17/00 , H04L65/00
摘要： A thick-game client device includes all of the game data processing on-board while a thin-game client device includes only a small portion of game data processing such as to render visual displays while the majority of the game data processing is network based. A thick-voice client devices includes all of the voice processing on-board while a thin-voice client device includes only a small portion of the voice processing such as to generate acoustic parameter data discussed below while the remainder of the voice processing occurs at a voice services node. It will be appreciated that a client device may be thick with respect to both game processing and voice processing, may be thick with respect to one type of processing and thin with respect to the other, or may be thin with respect to both types of processing.
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