公开(公告)号：US20140162067A1

公开(公告)日：2014-06-12

申请号：US14099626

申请日：2013-12-06

Applicant: Nanyang Technological University

Inventor： Mohammad Mehdi Shahjamali ,  Can Xue ,  Yin Chiang Freddy Boey

IPC: C23C18/44

CPC classification number: C23C18/44 ,  C23C18/1635 ,  C23C18/1637 ,  C23C18/165 ,  Y10T428/2991

Abstract: A method forms a bimetallic core-shell nanostructure. The bimetallic core-shell nanostructure comprises a core comprising silver and a shell comprising gold. The bimetallic core-shell nanostructure may be used in various technical fields, such as surface-enhanced Raman scattering (SERS), photovoltaic cells, biomedical, bioimaging and biosensing applications.

Abstract translation: 一种方法形成双金属核 - 壳纳米结构。 双金属核 - 壳纳米结构包括包含银和包含金的壳的芯。 双金属核 - 壳纳米结构可用于各种技术领域，如表面增强拉曼散射（SERS），光伏电池，生物医学，生物成像和生物传感应用。

公开(公告)号：US11672784B2

公开(公告)日：2023-06-13

申请号：US16094827

申请日：2017-04-19

Applicant: Nanyang Technological University ,  Singapore Health Services Pte Ltd

Inventor： Subramanian Venkatraman ,  Jayaganesh V. Natarajan ,  Yin Chiang Freddy Boey ,  Jodhbir Singh Mehta ,  Tina Tzee Ling Howden ,  Xu Wen Ng ,  Anthony Herr Cheun Ng

IPC: A61K31/436 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61P27/04

CPC classification number: A61K31/436 ,  A61K9/0048 ,  A61K9/127 ,  A61K9/5123 ,  A61P27/04

Abstract: According to the present disclosure, the use of a nanoliposome in the manufacture of a medicament for the prophylaxis and/or treatment of anterior segment ocular diseases is provided. The nanoliposome comprises a plurality of unsaturated and/or saturated lipids forming at least one lipid bilayer encapsulating a hydrophobic drug comprising tacrolimus, wherein the hydrophobic drug and the plurality of unsaturated and/or saturated lipids have a weight ratio of up to 0.2. The present disclosure also provides for such a nanoliposome and a method of preventing and/or treating anterior segment ocular diseases based on the nanoliposomes.

公开(公告)号：US09486302B2

公开(公告)日：2016-11-08

申请号：US14059231

申请日：2013-10-21

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： Yin Chiang Freddy Boey ,  Zheng Wang ,  Joseph Tang

IPC: A61F2/00 ,  A61L27/34 ,  A61L27/56 ,  A61L31/10 ,  A61L31/14 ,  B32B27/08 ,  B32B5/14 ,  B32B9/02 ,  B32B9/04 ,  B32B27/16 ,  B32B27/18 ,  B32B27/30 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36 ,  B32B27/40 ,  B32B3/26 ,  B32B3/30 ,  A61L31/04 ,  A61F2/24

CPC classification number: A61F2/0063 ,  A61F2/2481 ,  A61F2250/0031 ,  A61F2250/0067 ,  A61L27/34 ,  A61L27/56 ,  A61L31/048 ,  A61L31/10 ,  A61L31/146 ,  B32B3/266 ,  B32B3/30 ,  B32B5/142 ,  B32B9/02 ,  B32B9/04 ,  B32B9/045 ,  B32B27/08 ,  B32B27/16 ,  B32B27/18 ,  B32B27/302 ,  B32B27/304 ,  B32B27/308 ,  B32B27/32 ,  B32B27/322 ,  B32B27/34 ,  B32B27/36 ,  B32B27/40 ,  B32B2255/10 ,  B32B2255/26 ,  B32B2264/02 ,  B32B2264/10 ,  B32B2270/00 ,  B32B2307/538 ,  B32B2307/546 ,  B32B2307/706 ,  B32B2307/744 ,  B32B2307/746 ,  B32B2535/00 ,  C08L2201/12 ,  C08L27/16

Abstract: The present invention generally relates to the field of prostheses for surgical applications, to methods of their manufacturing and to methods of treating a patient by implanting them into a patient. More particularly, the present invention relates to prostheses having a multi-layered sheet structure and their use in hernia repair, the repair of anatomical defects of the abdominal wall, diaphragm, and chest wall, correction of defects in the genitourinary system, and repair of traumatically damaged organs such as the spleen, liver or kidney.

Abstract translation: 本发明一般涉及用于外科应用的假体领域，其制造方法以及通过将患者植入患者来治疗患者的方法。 更具体地，本发明涉及具有多层片结构的假体及其在疝修补中的应用，修复腹壁，隔膜和胸壁的解剖缺陷，修正泌尿生殖系统中的缺陷以及修复 创伤性损伤的器官如脾脏，肝脏或肾脏。

公开(公告)号：US09782346B2

公开(公告)日：2017-10-10

申请号：US14862963

申请日：2015-09-23

Applicant: Nanyang Technological University ,  Singapore Health Services Pte Ltd

Inventor： Subramanian Venkatraman ,  Yin Chiang Freddy Boey ,  Tina Wong ,  Jodhbir Metha

IPC: A61K9/24 ,  A61K9/00 ,  A61K9/16 ,  A61F9/00 ,  A61L31/12 ,  A61L31/14 ,  B05D5/00 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61K31/19 ,  A61K31/5575 ,  A61K31/573 ,  B29C39/02 ,  B29D11/02 ,  C08L67/04 ,  C08L69/00 ,  B29K67/00 ,  B29K105/00

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61K9/1647 ,  A61K31/19 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L31/125 ,  A61L31/148 ,  A61L2430/16 ,  B05D5/00 ,  B29C39/02 ,  B29C39/025 ,  B29D11/023 ,  B29K2067/04 ,  B29K2067/046 ,  B29K2105/0035 ,  B29K2105/0073 ,  B29K2995/0056 ,  B29K2995/006 ,  C08L67/04 ,  C08L69/005

Abstract: Provided is a biodegradable ocular implant for sustained drug delivery, including a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

公开(公告)号：US20140044861A1

公开(公告)日：2014-02-13

申请号：US14059231

申请日：2013-10-21

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： Yin Chiang Freddy Boey ,  Zheng Wang ,  Joseph Tang

IPC: A61F2/00

CPC classification number: A61F2/0063 ,  A61F2/2481 ,  A61F2250/0031 ,  A61F2250/0067 ,  A61L27/34 ,  A61L27/56 ,  A61L31/048 ,  A61L31/10 ,  A61L31/146 ,  B32B3/266 ,  B32B3/30 ,  B32B5/142 ,  B32B9/02 ,  B32B9/04 ,  B32B9/045 ,  B32B27/08 ,  B32B27/16 ,  B32B27/18 ,  B32B27/302 ,  B32B27/304 ,  B32B27/308 ,  B32B27/32 ,  B32B27/322 ,  B32B27/34 ,  B32B27/36 ,  B32B27/40 ,  B32B2255/10 ,  B32B2255/26 ,  B32B2264/02 ,  B32B2264/10 ,  B32B2270/00 ,  B32B2307/538 ,  B32B2307/546 ,  B32B2307/706 ,  B32B2307/744 ,  B32B2307/746 ,  B32B2535/00 ,  C08L2201/12 ,  C08L27/16

Abstract: The present invention generally relates to the field of prostheses for surgical applications, to methods of their manufacturing and to methods of treating a patient by implanting them into a patient. More particularly, the present invention relates to prostheses having a multi-layered sheet structure and their use in hernia repair, the repair of anatomical defects of the abdominal wall, diaphragm, and chest wall, correction of defects in the genitourinary system, and repair of traumatically damaged organs such as the spleen, liver or kidney.

Abstract translation: 本发明一般涉及用于外科应用的假体领域，其制造方法以及通过将患者植入患者来治疗患者的方法。 更具体地，本发明涉及具有多层片结构的假体及其在疝修补中的应用，修复腹壁，隔膜和胸壁的解剖缺陷，修正泌尿生殖系统中的缺陷以及修复 创伤性损伤的器官如脾脏，肝脏或肾脏。

公开(公告)号：US20170246175A1

公开(公告)日：2017-08-31

申请号：US15513010

申请日：2015-09-23

Applicant: Nanyang Technological University

Inventor： Subramanian Venkatraman ,  Yin Chiang Freddy Boey ,  Jayaganesh V. Natarajan

IPC: A61K31/5377 ,  A61K31/728 ,  A61K9/08 ,  A61K9/00 ,  A61K9/127 ,  A61K31/5575

CPC classification number: A61K31/5377 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/08 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/1277 ,  A61K31/5575 ,  A61K31/728

Abstract: Various embodiments relate to the field of liposomal formulations for drug delivery, in particular, liposomal formulations for ocular drug delivery. More specifically, various embodiments relate to sustained timolol maleate delivery from liposomes for glaucoma therapy and ocular hypertension.

公开(公告)号：US09441301B2

公开(公告)日：2016-09-13

申请号：US14099626

申请日：2013-12-06

Applicant: Nanyang Technological University

Inventor： Mohammad Mehdi Shahjamali ,  Can Xue ,  Yin Chiang Freddy Boey

IPC: C23C18/44 ,  C23C18/16

CPC classification number: C23C18/44 ,  C23C18/1635 ,  C23C18/1637 ,  C23C18/165 ,  Y10T428/2991

Abstract: A method forms a bimetallic core-shell nanostructure. The bimetallic core-shell nanostructure comprises a core comprising silver and a shell comprising gold. The bimetallic core-shell nanostructure may be used in various technical fields, such as surface-enhanced Raman scattering (SERS), photovoltaic cells, biomedical, bioimaging and biosensing applications.

Abstract translation: 一种方法形成双金属核 - 壳纳米结构。 双金属核 - 壳纳米结构包括包含银和包含金的壳的芯。 双金属核 - 壳纳米结构可用于各种技术领域，如表面增强拉曼散射（SERS），光伏电池，生物医学，生物成像和生物传感应用。