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公开(公告)号：US11230726B2
公开(公告)日：2022-01-25
申请号：US16476000
申请日：2017-12-27
申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , TOHOKU UNIVERSITY , KUMIAI CHEMICAL INDUSTRY CO., LTD.
发明人： Takashi Kubo , Masayuki Machida , Maiko Umemura , Keietsu Abe , Akira Yoshimi , Tomonori Fujioka , Shigenari Yamaguchi , Kiyoshi Kawai
摘要： This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.
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公开(公告)号：US11174297B2
公开(公告)日：2021-11-16
申请号：US16085502
申请日：2017-03-16
申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , KUMIAI CHEMICAL INDUSTRY CO., LTD.
IPC分类号： C12N9/96 , C07K14/37 , C07K7/64 , C12P21/02 , C12N9/10 , C12N9/02 , C12N15/70 , C12N15/75 , C12N15/77 , C12N15/78 , C12N15/81 , C12N1/14
摘要： An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
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公开(公告)号：US11946086B2
公开(公告)日：2024-04-02
申请号：US17549492
申请日：2021-12-13
申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , TOHOKU UNIVERSITY , KUMIAI CHEMICAL INDUSTRY CO., LTD.
发明人： Takashi Kubo , Masayuki Machida , Maiko Umemura , Keietsu Abe , Akira Yoshimi , Tomonori Fujioka , Shigenari Yamaguchi , Kiyoshi Kawai
摘要： This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.
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公开(公告)号：US11919928B2
公开(公告)日：2024-03-05
申请号：US17499599
申请日：2021-10-12
IPC分类号： C07K14/37 , C07K7/64 , C12N9/02 , C12N9/10 , C12N15/70 , C12N15/75 , C12N15/77 , C12N15/78 , C12N15/81 , C12P21/02 , C12N1/14
CPC分类号： C07K14/37 , C07K7/64 , C12N9/0077 , C12N9/10 , C12N9/1007 , C12N15/70 , C12N15/75 , C12N15/77 , C12N15/78 , C12N15/81 , C12P21/02 , C12N1/14
摘要： An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
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