公开(公告)号：US20240342708A1

公开(公告)日：2024-10-17

申请号：US18610057

申请日：2024-03-19

Applicant: National Research Council of Canada

Inventor： Ryan Denomme ,  Lidija Malic ,  Daniel Brassard ,  Keith Morton ,  Teodor Veres

IPC: B01L3/00 ,  G01N21/552 ,  G01N33/543

CPC classification number: B01L3/502715 ,  B01L3/502746 ,  B01L3/502784 ,  B01L3/502792 ,  G01N21/554 ,  G01N33/54386 ,  B01L2300/0645 ,  B01L2300/0663 ,  G01N2201/023 ,  G01N2201/061

Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

公开(公告)号：US11675183B2

公开(公告)日：2023-06-13

申请号：US17123233

申请日：2020-12-16

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  BANK OF CANADA

Inventor： Daniel Brassard ,  Lidija Malic ,  Keith J. Morton ,  Teodor Veres ,  Charles D. MacPherson ,  Theodoros Garanzotis

IPC: B42D25/29 ,  G02F1/01 ,  G02B26/02 ,  G02B1/00 ,  B42D25/405 ,  B82Y20/00 ,  B82B1/00 ,  B42D25/36 ,  G06Q30/018 ,  G02F1/17

CPC classification number: G02B26/026 ,  B42D25/29 ,  B42D25/36 ,  B42D25/405 ,  B82B1/003 ,  B82Y20/00 ,  G02B1/005 ,  G02F1/0128 ,  G06Q30/0185 ,  G02B2207/101 ,  G02F1/172 ,  G02F2201/38

Abstract: A security device that exhibits at least one dynamic response upon change of orientation of the security device with respect to gravity, wherein the security device includes a hollow capsule completely filled with a liquid and one or more microscopic elements. In addition, the dynamic response continues after cessation of the change of orientation with respect to gravity. The dynamic response includes a transition of the one or more microscopic elements from substantial mechanical equilibrium to non-equilibrium upon action of the change of orientation with respect to gravity and back to substantial mechanical equilibrium after cessation of the change of orientation with respect to gravity. During the dynamic response, the one or more microscopic elements undergo at least one of a rotational motion and a translational motion relative to the liquid.

公开(公告)号：US10921579B2

公开(公告)日：2021-02-16

申请号：US15539488

申请日：2015-12-23

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  BANK OF CANADA

Inventor： Daniel Brassard ,  Lidija Malic ,  Keith J. Morton ,  Teodor Veres ,  Charles D. MacPherson ,  Theodoros Garanzotis

IPC: G02B26/00 ,  G02B26/02 ,  G02B1/00 ,  B42D25/405 ,  B42D25/29 ,  B82Y20/00 ,  B82B1/00 ,  B42D25/36 ,  G02F1/01 ,  G06Q30/00 ,  G02F1/17

Abstract: A security device that elicits at least one dynamic response upon acceleration, or upon change of orientation with respect to gravity, wherein the dynamic response continues after cessation of the acceleration or the change of orientation. In addition, the dynamic response can be optical, such that it is visually observable by an unaided human eye. Alternatively, the response can be machine readable. In some cases, the dynamic response has duration of from about 0.01 s to about 100 s, or from about Is to about 10 s.

公开(公告)号：US20220274112A1

公开(公告)日：2022-09-01

申请号：US17618037

申请日：2020-07-09

Applicant: National Research Council of Canada

Inventor： Daniel Brassard ,  Lidija MALIC ,  Keith MORTON ,  Teodor VERES

IPC: B01L3/00

Abstract: A technique for supplying droplet content of an oil-encapsulated (OE) digital microfluidic (DμF) network to a region that is sensitive to oil contact involves sealing off a boundary surrounding the sensitive region with a volume of liquid that is miscible with payload of the OE-droplets. The sensitive region may be an opening to a microfluidic channel, or a sensor surface. The sealing off may be provided by transporting an unencapsulated droplet over the OE-DμF chip, either from a reservoir prior to oil encapsulation of the reservoir, or from a non-oil encapsulated reservoir; or by injecting the liquid into the microfluidic channel. A suitable treatment of the boundary may anchor the liquid to the boundary, and prevent removal by ordinary OE-DμF operations. A remainder of the surfaces of unit cells the DμF chip may provide higher droplet contact angle.

公开(公告)号：US20220221402A1

公开(公告)日：2022-07-14

申请号：US17681802

申请日：2022-02-27

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Ryan Denomme ,  Lidija Malic ,  Daniel Brassard ,  Keith Morton ,  Teodor Veres

IPC: G01N21/552 ,  B01L3/00

Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

公开(公告)号：US20250085203A1

公开(公告)日：2025-03-13

申请号：US18462752

申请日：2022-03-09

Applicant: National Research Council of Canada

Inventor： Byeong-Ui MOON ,  Liviu CLIME ,  Daniel Brassard ,  Keith MORTON ,  Teodor VERES

IPC: G01N1/40 ,  B01L3/00 ,  C12N15/10

Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.

公开(公告)号：US11278890B2

公开(公告)日：2022-03-22

申请号：US17265162

申请日：2019-08-06

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Ryan Denomme ,  Lidija Malic ,  Daniel Brassard ,  Keith Morton ,  Teodor Veres

IPC: B01L3/00 ,  G01N21/552 ,  G01N33/543

Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

公开(公告)号：US10702868B2

公开(公告)日：2020-07-07

申请号：US15124236

申请日：2015-03-04

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Teodor Veres ,  Daniel Brassard ,  Liviu Clime ,  Francois Normandin

IPC: B01L3/00 ,  G01N35/00 ,  B01F9/00 ,  B01F13/00 ,  B01F13/02 ,  B01F15/00 ,  B01F15/02 ,  G05D7/06 ,  G01N35/04 ,  B01L7/00

Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.

公开(公告)号：US10551610B2

公开(公告)日：2020-02-04

申请号：US15539508

申请日：2015-12-23

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  BANK OF CANADA

Inventor： Daniel Brassard ,  Lidija Malic ,  Keith J. Morton ,  Teodor Veres ,  Charles D. Macpherson ,  Theodoros Garanzotis

IPC: G02B26/00 ,  G02B26/08 ,  G02F1/29 ,  G02B26/02 ,  G02B1/00 ,  B42D25/405 ,  B42D25/29 ,  B82B1/00 ,  B42D25/36 ,  G02F1/01 ,  G06Q30/00 ,  G02F1/167 ,  G02F1/17

Abstract: Gravitational Janus microparticle having, a center-of-mass, a center-of-volume, and a non¬uniform density, wherein: the center-of-mass and the center-of-volume are distinct. When suspended in a fluid, the microparticle substantially aligns with either: i) the gravitational field; or ii) the direction of an acceleration, such that the Janus microparticle is in substantial rotation equilibrium. After perturbation from substantial rotational equilibrium, the Janus microparticle reversibly rotates to return to substantial rotational equilibrium. The gravitational Janus microparticle may comprise at least two portions, each having distinct physical and/or chemical characteristics, wherein at least one portion provides a detectable effect following rotation and alignment of the microparticle.

公开(公告)号：US20250147300A1

公开(公告)日：2025-05-08

申请号：US18721305

申请日：2022-12-21

Applicant: Bank of Canada ,  National Research Council of Canada

Inventor： Daniel Brassard ,  Alex Boutin ,  Charles Douglas Macpherson ,  Badr Omrane

IPC: G02B26/00 ,  B42D25/29 ,  B42D25/324 ,  B42D25/342 ,  B42D25/36

Abstract: Disclosed are devices with dynamic optical properties suitable for use as security or authentication devices, for example for documents or items of importance or value, in order to help prevent counterfeit of the same. Such devices, at least in selected embodiments, enable observation of dynamic changes or moving entities within the device by collective or enhanced imaging of the dynamic changes or moveable entities, the motion or position of which may otherwise be difficult to observe, or indiscernible to, the naked eye.