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公开(公告)号：US09259404B2
公开(公告)日：2016-02-16
申请号：US14389082
申请日：2013-03-25
申请人： NESTEC S.A.
发明人： Francia Jacqueline Arce Vera , Bertrand Bourqui , Timo Buetler , Stephane Duboux , Jane Durga , Francis Foata , Philippe Alexandre Guy , Nicolas Page , Serge Andre Dominique Rezzi , Pierre Magistretti , Evelyne Ruchti , Sylvain Lengacher , Igor Allaman
CPC分类号： A61K31/19 , A23L33/10 , A23V2002/00 , A23Y2300/29 , A61K35/74 , C12N1/20 , C12P7/40 , A23V2200/322 , A23V2250/206
摘要： The present invention relates generally to compositions with a health benefit. In particular, the invention relates to the field of brain health, for example brain protection, maintenance of cognitive function, prevention of cognitive decline and prevention of cognitive disorders. A subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of cognitive decline.
摘要翻译： 本发明一般涉及具有健康益处的组合物。 特别地，本发明涉及脑健康领域，例如脑保护，认知功能的维持，预防认知衰退和预防认知障碍。 本发明的主题是包含用于治疗或预防认知衰退的4-氧代-2-戊烯酸的组合物。
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公开(公告)号：US20150105296A1
公开(公告)日：2015-04-16
申请号：US14491691
申请日：2014-09-19
申请人： Nestec S.A.
发明人： Sebastiano Collino , Ivan Montoliu Roura , Francois-Pierre Martin , Philippe Alexandre Guy , Serge Andre Dominique Rezzi
CPC分类号： G01N33/92 , G01N33/50 , G01N33/6812 , G01N33/6893 , G01N2405/08 , G01N2800/7042
摘要： Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using hydroxy-sphingomyelin SM-OH-22:1 as biomarker.
摘要翻译： 使用基于NMR / MS的代谢组学和靶向脂质组学方法，发明人已经探索了老年人和年轻成年人的老龄化和长寿的代谢表型。 本发明人已经鉴定出降低发展与衰老有关的慢性炎症性疾病的风险的生物标志物，并提出了一种诊断生活方式的方法，该方法允许使用羟基鞘磷脂SM-OH-22：1作为生物标志物延迟和/或避免老化相关的慢性炎性疾病。
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公开(公告)号：US20150080264A1
公开(公告)日：2015-03-19
申请号：US14552944
申请日：2014-11-25
申请人： Nestec S.A.
发明人： Francois-Pierre Martin , Ivan Montoliu Roura , Philippe Alexandre Guy , Serge Andre Dominique Rezzi
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N33/48 , G01N2405/04 , G01N2800/044 , Y10T436/24
摘要： The present invention generally relates to the field of biomarkers. In particular, the present invention relates to biomarkers such as PC-O 44:6 that can be used, for example for detecting and/or quantifying visceral adiposity and/or changes in visceral adiposity. This biomarker may also be used to diagnosing the effect of a change in lifestyle on visceral adiposity in a subject.
摘要翻译： 本发明一般涉及生物标志物领域。 特别地，本发明涉及可用于例如检测和/或定量内脏肥胖和/或内脏肥胖变化的生物标志物例如PC-O 44：6。 该生物标志物也可用于诊断生物体改变对受试者内脏肥胖的影响。
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公开(公告)号：US09817003B2
公开(公告)日：2017-11-14
申请号：US14491396
申请日：2014-09-19
申请人： Nestec S.A.
发明人： Sebastiano Collino , Ivan Montoliu Roura , Francois-Pierre Martin , Philippe Alexandre Guy , Serge Andre Dominique Rezzi
CPC分类号： G01N33/92 , A23L33/30 , A23V2002/00 , G01N33/49 , G01N33/6812 , G01N33/6848 , G01N33/6893 , G01N2405/00 , G01N2800/50 , G01N2800/7095 , Y10T436/182 , Y10T436/24
摘要： Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort including centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using 9-oxo-ODE as biomarker.
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公开(公告)号：US09201081B2
公开(公告)日：2015-12-01
申请号：US14552944
申请日：2014-11-25
申请人： Nestec S.A.
发明人： Francois-Pierre Martin , Ivan Montoliu Roura , Philippe Alexandre Guy , Serge Andre Dominique Rezzi
CPC分类号： G01N33/92 , G01N33/48 , G01N2405/04 , G01N2800/044 , Y10T436/24
摘要： The present invention generally relates to the field of biomarkers. In particular, the present invention relates to biomarkers such as PC-O 44:6 that can be used, for example for detecting and/or quantifying visceral adiposity and/or changes in visceral adiposity. This biomarker may also be used to diagnosing the effect of a change in lifestyle on visceral adiposity in a subject.
摘要翻译： 本发明一般涉及生物标志物领域。 特别地，本发明涉及可用于例如检测和/或定量内脏肥胖和/或内脏肥胖变化的生物标志物例如PC-O 44：6。 该生物标志物也可用于诊断生物体改变对受试者内脏肥胖的影响。
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公开(公告)号：US09201064B2
公开(公告)日：2015-12-01
申请号：US14491491
申请日：2014-09-19
申请人： Nestec S.A.
发明人： Sebastiano Collino , Ivan Montoliu Roura , Francois-Pierre Martin , Philippe Alexandre Guy , Serge Andre Dominique Rezzi
IPC分类号： G01N33/68 , G01N33/48 , G01N33/543
CPC分类号： G01N33/54306 , G01N33/6842 , G01N33/6848 , G01N33/6893 , G01N2800/50 , G01N2800/60 , G01N2800/7042 , G01N2800/7095 , Y10T436/173845 , Y10T436/182 , Y10T436/200833 , Y10T436/203332 , Y10T436/24
摘要： Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort including centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose an in vitro method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using phenylacetylglutamine (PAG) as biomarker.
摘要翻译： 使用基于NMR / MS的代谢组学和靶向脂质组学方法，发明人已经探索了包括百岁老人，老年人和年轻成年人在内的老龄化和长寿的代谢表型。 本发明人已经鉴定了降低发展与衰老有关的慢性炎症性疾病的风险的生物标志物，并提出了使用苯乙酰谷氨酰胺（PAG）作为生物标志物来延缓和/或避免老化相关的慢性炎性疾病的生活方式的体外诊断方法。
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公开(公告)号：US20150075262A1
公开(公告)日：2015-03-19
申请号：US14553133
申请日：2014-11-25
申请人： Nestec S.A.
发明人： Francois-Pierre Martin , Ivan Montoliu Roura , Philippe Alexandre Guy , Serge Andre Dominique Rezzi
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , C07F9/09 , G01N33/48 , G01N2405/04 , G01N2800/044
摘要： The present invention generally relates to the field of biomarkers. In particular, the present invention relates to biomarkers such as PC-O 44:4 that can be used, for example for detecting and/or quantifying visceral adiposity and/or changes in visceral adiposity. This biomarker may also be used to diagnosing the effect of a change in lifestyle on visceral adiposity in a subject.
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公开(公告)号：US09693942B2
公开(公告)日：2017-07-04
申请号：US14389429
申请日：2013-03-25
申请人： NESTEC S.A.
发明人： Francia Jacqueline Arce Vera , Bertrand Bourqui , Timo Buetler , Stephane Duboux , Francis Foata , Marjorie Guitard , Philippe Alexandre Guy , Nicolas Page , Serge Andre Dominique Rezzi
IPC分类号： A61K8/365 , A61Q19/02 , A61K31/19 , A23L1/30 , A61K8/99 , A23K1/16 , A23L2/52 , A23K20/105 , A23L33/10 , A23L33/135
CPC分类号： A61K8/365 , A23K20/105 , A23L2/52 , A23L33/10 , A23L33/135 , A23V2002/00 , A23Y2300/29 , A61K8/99 , A61K31/19 , A61K2800/40 , A61K2800/92 , A61Q19/02 , A23V2200/318 , A23V2250/206
摘要： The present invention relates generally to the field of enhancing skin appearance. One aspect of the invention aims to provide a composition comprising 4-oxo-2-pentenoic acid for use in the reduction or prevention of regions of the skin with darker pigmentation. The present invention also relates to cosmetic use of a composition comprising 4-oxo-2-pentenoic acid for the reduction or prevention of regions of the skin with darker pigmentation.
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公开(公告)号：US09486425B2
公开(公告)日：2016-11-08
申请号：US14389069
申请日：2013-03-25
申请人： NESTEC S.A.
发明人： Francia Jacqueline Arce Vera , Bertrand Bourqui , Timo Buetler , Stephane Duboux , Francis Foata , Philippe Alexandre Guy , Nicolas Page , Serge Andre Dominique Rezzi
CPC分类号： A61K31/19 , A23L33/10 , A23V2002/00 , A23Y2300/29 , A61K35/74 , A23V2200/32 , A23V2250/206
摘要： The present invention relates generally to compositions with a health benefit. In particular, the invention relates to treatment or prevention of liver disorders. A subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of liver disorders. A further subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of liver disorders linked to an insufficient activity of phase II enzymes in the liver.
摘要翻译： 本发明一般涉及具有健康益处的组合物。 特别地，本发明涉及肝病的治疗或预防。 本发明的主题是包含用于治疗或预防肝脏疾病的4-氧代-2-戊烯酸的组合物。 本发明的另一个主题是包含4-氧代-2-戊烯酸的组合物，其用于治疗或预防与肝脏中II期酶活性不足相关的肝脏疾病。
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公开(公告)号：US20150096357A1
公开(公告)日：2015-04-09
申请号：US14569347
申请日：2014-12-12
申请人： Nestec S.A.
发明人： Francois-Pierre Martin , Ivan Montoliu Roura , Philippe Alexandre Guy , Serge Andre Dominique Rezzi
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N33/48 , G01N2405/04 , G01N2800/044
摘要： The present invention generally relates to the field of biomarkers. In particular, the present invention relates to biomarkers such as PC-O 42:4 that can be used, for example for detecting and/or quantifying visceral adiposity and/or changes in visceral adiposity. This biomarker may also be used to diagnosing the effect of a change in lifestyle on visceral adiposity in a subject.
摘要翻译： 本发明一般涉及生物标志物领域。 特别地，本发明涉及可用于例如检测和/或定量内脏肥胖和/或内脏肥胖变化的生物标志物如PC-O 42：4。 该生物标志物也可用于诊断生物体改变对受试者内脏肥胖的影响。
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