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公开(公告)号：US09561255B2
公开(公告)日：2017-02-07
申请号：US13685202
申请日：2012-11-26
IPC分类号： A61K38/05 , A61K38/39 , A61K31/734 , A61K31/715 , A61K8/64 , A61K9/00 , A61K9/06 , A61K47/10 , A61K47/42 , A61L15/28 , A61L26/00 , A61Q19/00 , A61K9/12 , A61K47/36 , A61Q19/02 , A61Q19/08 , A61K47/48 , C07K5/062
CPC分类号： A61K38/05 , A61K8/64 , A61K9/0014 , A61K9/06 , A61K9/12 , A61K31/715 , A61K31/734 , A61K38/39 , A61K47/10 , A61K47/36 , A61K47/42 , A61K47/542 , A61K2800/48 , A61L15/28 , A61L26/0023 , A61L2400/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , C07K5/06026 , C08L5/04
摘要： It is an object of the present invention to provide a cosmetic or external skin preparation that has an improved feel in use, e.g., excellent stretching on the skin surface, excellent permeation into the skin, and no stickiness, or crinkles. A cosmetic or an external skin preparation, and a medical instrument, comprising at least one lipid peptide-based gelator that contains a low-molecular lipid peptide of Formula (1): (where R1 to R3 are independently an organic group) or a pharmaceutically usable salt thereof.
摘要翻译： 本发明的目的是提供一种具有改善使用感的化妆品或外用皮肤制剂，例如在皮肤表面上的优异拉伸，对皮肤的渗透性，无粘性或皱纹。 一种化妆品或外用皮肤制剂和医疗器械，其包含至少一种含有式（1）的低分子量脂质肽的脂质基于肽的凝胶剂：（其中R 1至R 3独立地为有机基团）或 其药学上可用的盐。
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公开(公告)号：US11452688B2
公开(公告)日：2022-09-27
申请号：US16554015
申请日：2019-08-28
IPC分类号： A61K9/00 , A61K47/10 , A61K47/12 , A61K47/42 , A61K47/18 , A61K47/26 , A61Q19/00 , A61K9/06 , A61K38/28 , A61K31/728 , A61K8/02 , A61K8/34 , A61K8/36 , A61K8/60 , A61K8/64
摘要： A transdermally absorbable base material including: a lipid peptide compound including at least one of compound of Formula (1) below and the similar compounds or pharmaceutically usable salts thereof; a surfactant; a specific polyhydric alcohol; a fatty acid; and water, wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group that optionally has a branched chain having a carbon atom number of 1 or 2; R3 is a —(CH2)n—X group; n is a number of 1 to 4; and X is amino group, guanidino group, —CONH2 group, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms, or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms.
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公开(公告)号：US09782331B2
公开(公告)日：2017-10-10
申请号：US14904284
申请日：2014-07-03
发明人： Takayuki Imoto
IPC分类号： A61K8/04 , C09K3/00 , B01J13/00 , A61K8/64 , A61Q19/00 , A61K9/06 , A61K47/42 , C07K5/062 , C07K5/083 , C07K5/103 , A61K8/44 , A61K8/34 , A61K8/37 , A61K8/41 , A61K8/55 , A61K8/73 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/36 , A61K47/38
CPC分类号： A61K8/04 , A61K8/042 , A61K8/342 , A61K8/345 , A61K8/375 , A61K8/416 , A61K8/442 , A61K8/55 , A61K8/64 , A61K8/731 , A61K8/733 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/186 , A61K47/24 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2800/10 , A61K2800/48 , A61K2800/52 , A61K2800/5922 , A61K2800/805 , A61Q19/00 , B01J13/00 , B01J13/0052 , C07K5/06026 , C07K5/0806 , C07K5/1008 , C09K3/00
摘要： An object is to provide dispersion containing lipid peptide type compound useful as low molecular weight gelator, such as lipid dipeptide and lipid tripeptide, and dissolution accelerator capable of dissolving the lipid peptide type compound at lower temperature and more easily. It is also an object to provide dispersion that can form hydrogel by simpler method and under milder condition (low temperature) and from which gel can be obtained as gel having high thermal stability, and provide method for forming the gel. Dispersion including: a lipid peptide type compound in which peptide portion formed by repetition of at least two or more identical or different amino acids is bonded to lipid portion including C10-24 aliphatic group; dissolution accelerator having, in molecules thereof, hydrophilic portion and hydrophobic portion, the hydrophilic portion having betaine structure; and water; and method for producing hydrogel by use of the dispersion.
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公开(公告)号：US10105294B2
公开(公告)日：2018-10-23
申请号：US15679432
申请日：2017-08-17
发明人： Takayuki Imoto
IPC分类号： A61K8/04 , C09K3/00 , B01J13/00 , A61K8/64 , A61Q19/00 , A61K9/06 , A61K47/42 , C07K5/062 , C07K5/083 , C07K5/103 , A61K8/44 , A61K8/34 , A61K8/37 , A61K8/41 , A61K8/55 , A61K8/73 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/36 , A61K47/38
摘要： An object is to provide dispersion containing lipid peptide type compound useful as low molecular weight gelator, such as lipid dipeptide and lipid tripeptide, and dissolution accelerator capable of dissolving the lipid peptide type compound at lower temperature and more easily. It is also an object to provide dispersion that can form hydrogel by simpler method and under milder condition (low temperature) and from which gel can be obtained as gel having high thermal stability, and provide method for forming the gel. Dispersion including: a lipid peptide type compound in which peptide portion formed by repetition of at least two or more identical or different amino acids is bonded to lipid portion including C10-24 aliphatic group; dissolution accelerator having, in molecules thereof, hydrophilic portion and hydrophobic portion, the hydrophilic portion having betaine structure; and water; and method for producing hydrogel by use of the dispersion.
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公开(公告)号：US10071044B2
公开(公告)日：2018-09-11
申请号：US15305437
申请日：2015-05-14
发明人： Takayuki Imoto
IPC分类号： A61K8/64 , A61K8/36 , A61K8/67 , A61K47/22 , A61K47/18 , A61K47/10 , A61K47/12 , A61K8/34 , A61Q19/00 , A61K47/34 , A61K9/08 , A61K47/42
CPC分类号： A61K8/64 , A61K8/345 , A61K8/361 , A61K8/676 , A61K9/08 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/22 , A61K47/34 , A61K47/42 , A61K2800/10 , A61K2800/48 , A61Q19/00
摘要： A thickened composition that does not lose viscosity even in the presence of an organic acid. A thickened composition, including a polyhydric alcohol, water, an organic acid, and a lipid peptide-type compound containing at least one of a compound of Formula (1) to Formula (3) below and a pharmaceutically usable salt of compound of Formula (1) to Formula (3), where R1 is a C9-23 aliphatic group, R2 is a hydrogen atom or a C1-4 alkyl group that optionally has a C1-2 branched chain, R3 is a —(CH2)n—X group, n is a number of 1 to 4, X is an amino group, guanidino group, —CONH2 group, a 5-membered ring group optionally containing 1 to 3 nitrogen atom(s), a 6-membered ring group optionally containing 1 to 3 nitrogen atom(s), or a condensed heterocycle group that contains a 5-membered ring and a 6-membered ring optionally containing 1 to 3 nitrogen atom(s).
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公开(公告)号：US20150202586A1
公开(公告)日：2015-07-23
申请号：US14410330
申请日：2013-06-25
发明人： Takayuki Imoto , Takehisa Iwama
IPC分类号： B01J13/00
摘要： There is provided a dispersion containing a lipid peptide type compound useful as a low molecular weight gelator and a solvent capable of dissolving the lipid peptide type compound at a lower temperature. There is provided also a dispersion from which a hydrogel can be formed by a simpler method and from which a gel can be obtained as a gel having high thermal stability, and provide a method for forming the gel. A dispersion including a lipid peptide type compound in which a peptide portion having an amino acid repeating bonding structure is bonded to a lipid portion consisting of a C9-23 aliphatic group; and at least one alcohol selected from the group consisting of 1,2-alkanediol, 1,3-alkanediol, and ethylene glycol monoalkyl ether or a mixed solution of the at least one alcohol and water; and a method for producing a hydrogel by use of the dispersion.
摘要翻译： 提供了含有可用作低分子量凝胶剂的脂质肽型化合物和能够在较低温度下溶解脂质肽型化合物的溶剂的分散体。 还提供了一种通过更简单的方法可以形成水凝胶的分散体，并且可以从其获得作为具有高热稳定性的凝胶的凝胶，并提供形成凝胶的方法。 包含其中具有氨基酸重结合结构的肽部分与由C 9-23脂肪族基团组成的脂质部分结合的脂质肽型化合物的分散体; 和选自1,2-链烷二醇，1,3-链烷二醇和乙二醇单烷基醚的至少一种醇或至少一种醇和水的混合溶液; 以及使用该分散体制造水凝胶的方法。
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公开(公告)号：US10421055B2
公开(公告)日：2019-09-24
申请号：US14410330
申请日：2013-06-25
发明人： Takayuki Imoto , Takehisa Iwama
IPC分类号： B01J13/00 , A61K8/64 , A61K9/00 , A61K8/33 , A61K8/34 , A61Q19/00 , A61K8/04 , A61K47/42 , A61K9/06
摘要： There is provided a dispersion containing a lipid peptide type compound useful as a low molecular weight gelator and a solvent capable of dissolving the lipid peptide type compound at a lower temperature. There is provided also a dispersion from which a hydrogel can be formed by a simpler method and from which a gel can be obtained as a gel having high thermal stability, and provide a method for forming the gel. A dispersion including a lipid peptide type compound in which a peptide portion having an amino acid repeating bonding structure is bonded to a lipid portion consisting of a C9-23 aliphatic group; and at least one alcohol selected from the group consisting of 1,2-alkanediol, 1,3-alkanediol, and ethylene glycol monoalkyl ether or a mixed solution of the at least one alcohol and water; and a method for producing a hydrogel by use of the dispersion.
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公开(公告)号：US10092496B2
公开(公告)日：2018-10-09
申请号：US15107960
申请日：2014-12-25
发明人： Takayuki Imoto , Tsubasa Kashino
IPC分类号： A61K8/64 , A61K9/00 , A61K9/06 , A61Q19/00 , A61K8/02 , A61K8/34 , A61K8/36 , A61K8/67 , A61K8/86 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22
摘要： A solid base material for skin external application has a breaking strength high enough to be used for a stick-shaped base material and the like. A solid base material for skin external application has: a surfactant; water; and a lipid peptide compound including at least one of compounds of Formula (1) and the analogous thereof or pharmaceutically usable salts of the compound: wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom, or a C1-4 alkyl group that may have a C1 or C2 branched chain; R3 is a —(CH2)n—X group, where n is a number from 1 to 4, and X is amino group, guanidino group, —CONH2 group, or a 5-membered or 6-membered ring that may have 1 to 3 nitrogen atoms or a condensed heterocycle composed of 5-membered and 6-membered rings that may have 1 to 3 nitrogen atoms.
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