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13 条记录 (耗时 0.022 秒)

    Human marco scavenger receptor
    7.
    发明授权
    Human marco scavenger receptor 失效
    人类marco清道夫受体

    公开(公告)号：US5916766A

    公开(公告)日：1999-06-29

    申请号：US794795

    申请日：1997-02-04

    申请人： Nabil Elshourbagy ,  John Adamou ,  Mitchell Gross ,  Paul Lysko

    发明人： Nabil Elshourbagy ,  John Adamou ,  Mitchell Gross ,  Paul Lysko

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/705 ,  C07K16/28 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91 ,  G01N33/566 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  C07K14/705 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026 ,  G01N2333/705

    摘要： Human Marco scavenger receptor polypeptides (HMarcoSR) and DNA (RNA) encoding such HMarcoSR and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HMarcoSR for the treatment of various cardivascular disorders, gangrene, and loss of fuunction in the extremeties. Antagonists against such HMarcoSR and their use as a therapeutic to treat various cardivascular disorders, gangrene, and loss of fuunction in the extremeties are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HMarcoSR and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类Marco清道夫受体多肽（HMarcoSR）和编码这种HMarcoSR的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种HMarcoSR治疗各种心血管疾病，坏疽和功能丧失的方法。 还公开了针对这种HMarcoSR的拮抗剂及其作为治疗用于治疗各种心血管疾病，坏疽和功能丧失的二恶英的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HMarcoSR的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44)
    8.
    发明授权
    Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44) 失效
    编码降钙素基因相关肽受体共因子（HOUNDC44）的多核苷酸

    公开(公告)号：US5710024A

    公开(公告)日：1998-01-20

    申请号：US686178

    申请日：1996-07-23

    申请人： John E. Adamou ,  Nabil Elshourbagy

    发明人： John E. Adamou ,  Nabil Elshourbagy

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  A61P1/00 ,  A61P3/00 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/08 ,  C07K14/72 ,  C12N1/21 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12R1/19 ,  C12N15/63 ,  C12N15/85

    CPC分类号： C07K14/72 ,  A01K2217/05 ,  A61K48/00 ,  C12N2799/026

    摘要： Human CGRP-RCF polypeptides and DNA (RNA) encoding such CGRP-RCF and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such CGRP-RCF for the treatment of diabetes, migrane, pain and inflammation, Parkinson's disease, acute heart failure, hypotension, urinary retention, osteoporosis, hypertension, angina pectoris, myocardial infarction, ulcers, asthma, allergies, psychosis, depression, vomiting, benign prostatic hypertrophy, Paget's disease, obesity, cancer, gigantism and the like. Antagonists against such CGRP-RCF and their use as a therapeutic to treat diabetes, migrane, pain and inflammation, Parkinson's disease, acute heart failure, hypotension, urinary retention, osteoporosis, hypertension, angina pectoris, myocardial infarction, ulcers, asthma, allergies, psychosis, depression, vomiting, benign prostatic hypertrophy, Paget's disease, obesity, cancer, gigantism and the like are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the CGRP-RCF and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人CGRP-RCF多肽和编码这种CGRP-RCF的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种CGRP-RCF治疗糖尿病，偏头痛，疼痛和炎症，帕金森病，急性心力衰竭，低血压，尿潴留，骨质疏松症，高血压，心绞痛，心肌梗塞，溃疡，哮喘，过敏， 精神病，抑郁症，呕吐，良性前列腺肥大，佩吉特氏病，肥胖症，癌症，巨人症等。 针对这种CGRP-RCF的拮抗剂及其用作治疗糖尿病，偏头痛，疼痛和炎症，帕金森病，急性心力衰竭，低血压，尿潴留，骨质疏松症，高血压，心绞痛，心肌梗塞，溃疡，哮喘，过敏， 还公开了精神病，抑郁症，呕吐，良性前列腺肥大，佩吉特氏病，肥胖症，癌症，巨人症等。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码CGRP-RCF的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Polynucleotides encoding mouse urotensin-II Receptor (UTB-R)
    9.
    发明授权
    Polynucleotides encoding mouse urotensin-II Receptor (UTB-R) 失效
    编码小鼠泌尿生长素-II受体（UTB-R）的多核苷酸

    公开(公告)号：US06428982B1

    公开(公告)日：2002-08-06

    申请号：US09587754

    申请日：2000-06-06

    申请人： Nabil Elshourbagy ,  Usman Shabon ,  Derk J. Bergsma

    发明人： Nabil Elshourbagy ,  Usman Shabon ,  Derk J. Bergsma

    IPC分类号： C07K2104

    CPC分类号： C07K14/723 ,  A61K38/00

    摘要： Urotensin-II Receptor (UTB-R) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Urotensin-II Receptor (UTB-R) polypeptides and polynucleotides in therapy, and diagnostic assays for such.

    摘要翻译： 公开了用于通过重组技术产生这种多肽的多肽和多核苷酸和Urotensin-II受体（UTB-R）多肽和方法。 还公开了在治疗中利用尿激素-II受体（UTB-R）多肽和多核苷酸的方法，以及用于其的诊断测定法。

    Nucleic acids encoding the G-protein coupled receptor HNFDS78
    10.
    发明授权
    Nucleic acids encoding the G-protein coupled receptor HNFDS78 失效
    编码G蛋白偶联受体HNFDS78的核酸

    公开(公告)号：US06287801B1

    公开(公告)日：2001-09-11

    申请号：US08681192

    申请日：1996-07-22

    申请人： Derk Bergsma ,  Nabil Elshourbagy ,  Henry Sarau ,  Steven Ruben

    发明人： Derk Bergsma ,  Nabil Elshourbagy ,  Henry Sarau ,  Steven Ruben

    IPC分类号： C12N1512

    CPC分类号： G01N33/68 ,  A61K38/00 ,  C07K14/705 ,  C12N2799/026 ,  G01N2333/726 ,  G01N2500/00

    摘要： Human G-Protein Coupled Receptor HNFDS78 polypeptides and DNA (RNA) encoding such G-Protein Coupled Receptor HNFDS78 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such G-Protein Coupled Receptor HNFDS78 for the treatment of diseases, such as, atherosclerosis, inflammatory disease, and infectious disease. Antagonists against such G-Protein Coupled Receptor HNFDS78 and their use as a therapeutic to treat disease are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding G-protein coupled receptors and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人G-蛋白偶联受体HNFDS78多肽和编码这种G蛋白偶联受体HNFDS78的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种G蛋白偶联受体HNFDS78用于治疗疾病如动脉粥样硬化，炎性疾病和感染性疾病的方法。 还公开了抗这种G蛋白偶联受体HNFDS78的拮抗剂及其作为治疗疾病的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码G蛋白偶联受体的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。