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    Skin Lightening Compositions
    2.
    发明申请
    Skin Lightening Compositions 审中-公开

    公开(公告)号：US20140154190A1

    公开(公告)日：2014-06-05

    申请号：US14175360

    申请日：2014-02-07

    申请人： Yoko Niki ,  Masaki Yoshida ,  Masamitsu Ichihashi ,  Hideya Ando ,  Daniel B. Yarosh ,  Mary S. Matsui

    发明人： Yoko Niki ,  Masaki Yoshida ,  Masamitsu Ichihashi ,  Hideya Ando ,  Daniel B. Yarosh ,  Mary S. Matsui

    IPC分类号： A61K8/49 ,  A61Q17/04 ,  A61Q19/02

    CPC分类号： A61K8/4946 ,  A61K8/49 ,  A61K2800/782 ,  A61Q17/04 ,  A61Q19/02

    摘要： Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: wherein: R1 and R2 are same or different and are each selected from the group consisting of hydrogen, alkyl, carbomethoxy, carboethoxy, alkoxy, and alkanoyl, any of which may be halogen-substituted, and halogen; R6 is selected from the group consisting of hydrogen, methyl, and ethyl; and R3, R4 and R5 are the same or different and are each selected from the group consisting of hydrogen, methyl, methoxy, ethoxy, methoxyethoxy, ethoxyethoxy, propoxy, propoxymethoxy, and the like, any of which may be halogen-substituted; or having the structure: wherein: R2 is hydrogen, lower alkyl or hydroxy lower alkyl; R3 is lower alkyl, —CH2CN, hydroxy lower alkyl, —NO, —CH2N═C or (wherein R6 and R7 are independently selected from the group consisting of hydrogen and lower alkyl) or hydrogen provided R2 is not hydrogen; R4 is Z-T-W wherein Z represents —O—, —NH— or a single bond; T represents a straight- or branched-chain lower-alkylene group; when Z is a single bond, T also represents an ethenylene or a propenylene group wherein the unsaturated carbon is at the single bond; when Z is —O—, T also represents an allylene group wherein the saturated carbon is at the oxygen; and W represents hydrogen, when T is allylene and Z is —O—, and Ar, wherein Ar is selected from thienyl, pyridinyl, furanyl, phenyl and substituted phenyl wherein there are one or more substituents on the phenyl independently selected from halogen or lower alkyl; and R5 is hydrogen, halogen or lower alkyl; or pharmaceutically-, cosmetically- and dermatologically-acceptable salts, solvates, and bioprecursors, and stereoisomers and enantiomers of these compounds, free from or mixed with other enantiomers or stereoisomers; and such compounds in compositions with a pharmaceutically-, cosmetically- or dermatologically-acceptable carrier thereof comprising a safe and effective amount of the skin lightening or depigmenting compound.

    Preservation of ergothioneine
    3.
    发明授权
    Preservation of ergothioneine 有权
    保护ergothioneine

    公开(公告)号：US08933245B2

    公开(公告)日：2015-01-13

    申请号：US13671955

    申请日：2012-11-08

    申请人： Daniel B. Yarosh

    发明人： Daniel B. Yarosh

    IPC分类号： A61K47/12 ,  A61K8/00 ,  A61K8/30

    CPC分类号： A61K8/00 ,  A23L3/3508 ,  A23L33/175 ,  A61K8/19 ,  A61K8/20 ,  A61K8/23 ,  A61K8/24 ,  A61K8/36 ,  A61K8/365 ,  A61K8/4946 ,  A61K8/676 ,  A61K2800/10 ,  A61K2800/52 ,  A61Q19/00

    摘要： Compositions comprising ergothioneine and a trimethylamine absorber are provided. Also provided are methods for preventing, reducing or minimizing the fishy, amine odor, due to trimethylamine, that is associated with the processing and/or storage of a preparation containing ergothioneine, by combining with the ergothioneine, during processing or prior to storage, a trimethylamine absorber in an amount sufficient to prevent the detection of any trimethylamine odor by the human nose. A method is further provided for ameliorating the methylamine odor associated with an aqueous ergothioneine-containing preparation after it has developed a fishy trimethylamine odor.

    摘要翻译： 提供了包含麦角硫素和三甲胺吸收剂的组合物。 还提供了用于通过在加工过程中或储存前与麦角硫素组合来预防，减少或最小化与由加入和/或储存含有麦角硫杆菌素的制剂相关的三甲胺引起的鱼腥味，胺气味， 三甲胺吸收剂，其量足以防止人鼻子检测到任何三甲胺气味。 进一步提供一种方法，用于改善与含有麦角硫脑酸的制剂相关的甲胺气味，因为它已经形成了鱼腥味的三甲胺气味。

    Method for treating UV-induced suppression of contact hypersensitivity by administration of T4 endonuclease
    4.
    发明授权
    Method for treating UV-induced suppression of contact hypersensitivity by administration of T4 endonuclease 失效
    通过施用T4内切核酸酶治疗UV诱导的接触性超敏反应抑制的方法

    公开(公告)号：US5302389A

    公开(公告)日：1994-04-12

    申请号：US931218

    申请日：1992-08-17

    申请人： Margaret L. Kripke ,  Daniel B. Yarosh

    发明人： Margaret L. Kripke ,  Daniel B. Yarosh

    IPC分类号： A61K8/14 ,  A61K8/66 ,  A61K9/127 ,  A61K38/46 ,  A61Q17/04 ,  A61Q19/00 ,  A61K37/22 ,  A61K37/54

    CPC分类号： A61K8/66 ,  A61K38/465 ,  A61K8/14 ,  A61K9/1272 ,  A61Q17/04 ,  A61Q19/00 ,  C12Y301/21002

    摘要： Exposing the skin to UV radiation interferes with the induction of the T-cell mediated immune response, including both delayed (DHS) and contact (CHS) hyper-sensitivity immune responses initiated at non-irradiated sites. The present inventors have discovered that DNA is at least one of the targets for UV-induced hypersensitivity, and demonstrate that the application of DNA repair enzymes can reverse the damaging effects of UV irradiation on both the DHS and CHS response. The usefulness of the invention in this regard was tested using a model immunosuppression system in mice. In these studies, mice were first exposed to UV radiation and then liposomes were used to deliver a dimer-specific excision repair enzyme to their epidermis in situ. The application of liposomal T4 endonuclease V encapsulated to the UV-irradiated skin both decreased the number of cyclobutane pyrimidine dimers in the epidermis and prevented suppression of both delayed and contact hypersensitivity responses. Moreover, the formation of suppressor lymphoid cells was inhibited. These studies illustrate that the delivery of lesion-specific DNA repair enzymes to living skin after UV irradiation is an effective tool for restoring immune function and suggest that this approach may be broadly applicable to preventing other alterations caused by DNA damage, including preventing or reversing viral activation (e.g., herpes virus activation), oncogene expression, or autoimmune episodes.

    摘要翻译： 将皮肤暴露于紫外线辐射干扰T细胞介导的免疫应答的诱导，包括在非照射部位发起的延迟（DHS）和接触（CHS）超敏感性免疫应答。 本发明人已经发现，DNA是UV诱导的超敏反应的至少一个目标，并且证明DNA修复酶的应用可以逆转UV照射对DHS和CHS响应的破坏作用。 使用小鼠中的模型免疫抑制系统测试本发明在这方面的有用性。 在这些研究中，首先将小鼠暴露于紫外线辐射，然后使用脂质体将原位二聚体特异性切除修复酶递送至其表皮。 脂质体T4内切核酸酶V包封在紫外线照射皮肤上的应用减少了表皮中环丁烷嘧啶二聚体的数量，并阻止了延迟和接触超敏反应的抑制。 此外，抑制性淋巴样细胞的形成被抑制。 这些研究表明，紫外线照射后病毒特异性DNA修复酶对活体皮肤的传递是恢复免疫功能的有效工具，并表明该方法可广泛适用于预防DNA损伤引起的其他改变，包括预防或逆转病毒 激活（例如，疱疹病毒激活），癌基因表达或自身免疫发作。

    Purification and administration of DNA repair enzymes
    5.
    发明授权
    Purification and administration of DNA repair enzymes 失效
    DNA修复酶的纯化和给药

    公开(公告)号：US5296231A

    公开(公告)日：1994-03-22

    申请号：US623888

    申请日：1990-12-26

    申请人： Daniel B. Yarosh

    发明人： Daniel B. Yarosh

    IPC分类号： C12N15/09 ,  A61K8/00 ,  A61K8/14 ,  A61K8/36 ,  A61K8/66 ,  A61K9/127 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P17/00 ,  A61P35/00 ,  A61Q17/00 ,  C12N9/10 ,  C12N9/16 ,  C12N9/22 ,  A61K37/22 ,  A61K37/52 ,  A61K37/59

    CPC分类号： C12N9/1007 ,  A61K9/127 ,  C12N9/22 ,  A61K38/00

    摘要： Methods for purifying DNA repair enzymes are provided in which an aqueous solution of a DNA repair enzyme in an impure state is applied to a molecular sieve column having an exclusion limit which will retard the DNA repair enzyme but will not retard contaminants larger than the DNA repair enzyme. The DNA repair enzyme in an enhanced state of purity is eluted isocratically from the molecular sieve column in an elution buffer and applied directly to a DNA affinity column in the same buffer without intermediate dialysis, ultrafiltration, or other procedures. The DNA repair enzyme is eluted from the DNA affinity column using, for example, a salt gradient. The method is rapid, inexpensive, simple to perform, and has been found to produce a homogeneous final product. In accordance with other aspects of the invention, the purified DNA repair enzymes are encapsulated in liposomes and administered to living cells in situ. This form of administration has been found to be non-toxic to the cells and to result in increased incision of damaged DNA, enhanced DNA repair synthesis, and increased cell survival after exposure to ultraviolet light. In certain preferred embodiments, DNA repair enzymes are administered in pH sensitive liposomes.

    摘要翻译： PCT No.PCT / US89 / 02873。 371日期1990年12月26日第 102（e）1990年12月26日的PCT日期1989年6月27日PCT。提供了用于纯化DNA修复酶的方法，其中将不纯的状态的DNA修复酶的水溶液施加到具有排除的分子筛柱 这将限制DNA修复酶，但不会阻止大于DNA修复酶的污染物。 增强纯度的DNA修复酶从洗脱缓冲液中的分子筛柱中洗脱等离子体洗脱，并直接施用于相同缓冲液中的DNA亲和柱，无需中间透析，超滤或其他方法。 使用例如盐梯度从DNA亲和柱洗脱DNA修复酶。 该方法快速，便宜，操作简单，并且已被发现产生均匀的最终产物。 根据本发明的其它方面，将纯化的DNA修复酶包封在脂质体中，并在原位施用于活细胞。 已经发现这种给药形式对细胞无毒，并且在暴露于紫外线之后导致损伤的DNA的切口增加，DNA修复合成增加，以及增加的细胞存活。 在某些优选的实施方案中，DNA修复酶在pH敏感的脂质体中施用。

    Preservation Of Ergothioneine
    6.
    发明申请
    Preservation Of Ergothioneine 审中-公开
    维生素E

    公开(公告)号：US20140128615A1

    公开(公告)日：2014-05-08

    申请号：US13671955

    申请日：2012-11-08

    申请人： Daniel B. Yarosh

    发明人： Daniel B. Yarosh

    IPC分类号： A61K47/12

    CPC分类号： A61K8/00 ,  A23L3/3508 ,  A23L33/175 ,  A61K8/19 ,  A61K8/20 ,  A61K8/23 ,  A61K8/24 ,  A61K8/36 ,  A61K8/365 ,  A61K8/4946 ,  A61K8/676 ,  A61K2800/10 ,  A61K2800/52 ,  A61Q19/00

    摘要： Compositions comprising ergothioneine and a trimethylamine absorber are provided. Also provided are methods for preventing, reducing or minimizing the fishy, amine odor, due to trimethylamine, that is associated with the processing and/or storage of a preparation containing ergothioneine, by combining with the ergothioneine, during processing or prior to storage, a trimethylamine absorber in an amount sufficient to prevent the detection of any trimethylamine odor by the human nose. A method is further provided for ameliorating the methylamine odor associated with an aqueous ergothioneine-containing preparation after it has developed a fishy trimethylamine odor.

    摘要翻译： 提供了包含麦角硫素和三甲胺吸收剂的组合物。 还提供了用于通过在加工过程中或储存前与麦角硫素组合来预防，减少或最小化与由加入和/或储存含有麦角硫素的制剂相关的三甲胺引起的鱼腥味，胺气味， 三甲胺吸收剂，其量足以防止人鼻子检测到任何三甲胺气味。 进一步提供一种方法，用于改善与含有麦角硫脑酸的制剂相关的甲胺气味，因为它已经形成了鱼腥味的三甲胺气味。

    Purification and administration of DNA repair enzymes
    9.
    发明授权
    Purification and administration of DNA repair enzymes 失效
    DNA修复酶的纯化和给药

    公开(公告)号：US5272079A

    公开(公告)日：1993-12-21

    申请号：US14358

    申请日：1993-02-05

    申请人： Daniel B. Yarosh

    发明人： Daniel B. Yarosh

    IPC分类号： A61K9/127 ,  A61K38/00 ,  C12N9/10 ,  C12N9/22 ,  A61K37/52 ,  A61K37/54 ,  C12N9/16

    CPC分类号： C12N9/1007 ,  A61K9/127 ,  C12N9/22 ,  A61K38/00

    摘要： Methods for purifying DNA repair enzymes are provided in which an aqueous solution of a DNA repair enzyme in an impure state is applied to a molecular sieve column having an exclusion limit which will retard the DNA repair enzyme but will not retard contaminants larger than the DNA repair enzyme. The DNA repair enzyme in an enhanced state of purity is eluted isocratically from the molecular sieve column in an elution buffer and applied directly to a DNA affinity column in the same buffer without intermediate dialysis, ultrafiltration, or other procedures. The DNA repair enzyme is eluted from the DNA affinity column using, for example, a salt gradient. The method is rapid, inexpensive, simple to perform, and has been found to produce a homogeneous final product. In accordance with other aspects of the invention, the purified DNA repair enzymes are encapsulated in liposomes and administered to living cells in situ. This form of administration has been found to be non-toxic to the cells and to result in increased incision of damaged DNA, enhanced DNA repair synthesis, and increased cell survival after exposure to ultraviolet light. In certain preferred embodiments, DNA repair enzymes are administered in pH sensitive liposomes.

    摘要翻译： 提供纯化DNA修复酶的方法，其中将不纯的状态的DNA修复酶的水溶液施加到具有排除极限的分子筛柱上，该分子筛柱将延迟DNA修复酶，但不会延迟大于DNA修复的污染物 酶。 增强纯度的DNA修复酶从洗脱缓冲液中的分子筛柱中洗脱等离子体洗脱，并直接施用于相同缓冲液中的DNA亲和柱，无需中间透析，超滤或其他方法。 使用例如盐梯度从DNA亲和柱洗脱DNA修复酶。 该方法快速，便宜，操作简单，并且已被发现产生均匀的最终产物。 根据本发明的其它方面，将纯化的DNA修复酶包封在脂质体中，并在原位施用于活细胞。 已经发现这种给药形式对细胞无毒，并且在暴露于紫外线之后导致损伤的DNA的切口增加，DNA修复合成增加，以及增加的细胞存活。 在某些优选的实施方案中，DNA修复酶在pH敏感的脂质体中施用。

    Purification and administration of DNA repair enzymes
    10.
    发明授权
    Purification and administration of DNA repair enzymes 失效
    DNA修复酶的纯化和施用

    公开(公告)号：US5077211A

    公开(公告)日：1991-12-31

    申请号：US215566

    申请日：1988-07-06

    申请人： Daniel B. Yarosh

    发明人： Daniel B. Yarosh

    IPC分类号： C12N15/09 ,  A61K8/00 ,  A61K8/14 ,  A61K8/36 ,  A61K8/66 ,  A61K9/127 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P17/00 ,  A61P35/00 ,  A61Q17/00 ,  C12N9/10 ,  C12N9/16 ,  C12N9/22

    CPC分类号： C12N9/1007 ,  A61K9/127 ,  C12N9/22 ,  A61K38/00

    摘要： Methods for purifying DNA repair enzymes are provided in which an aqueous solution of a DNA repair enzyme in an impure state is applied to a molecular sieve column having an exclusion limit which will retard the DNA repair enzyme but will not retard contaminants larger than the DNA repair enzyme. The DNA repair enzyme in an enhanced state of purity is eluted isocratically from the molecular sieve column in an elution buffer and applied directly to a DNA affinity column in the same buffer without intermediate dialysis, ultrafiltration, or other procedures. The DNA repair enzyme is eluted from the DNA affinity column using, for example, a salt gradient. The method is rapid, inexpensive, simple to perform, and has been found to produce a homogeneous final product. In accordance with other aspects of the invention, the purified DNA repair enzymes are encapsulated in liposomes and administered to living cells in situ. This form of administration has been found to be non-toxic to the cells and to result in increased incision of damaged DNA, enhanced DNA repair synthesis, and increased cell survival after exposure to ultraviolet light.

    摘要翻译： 提供纯化DNA修复酶的方法，其中将不纯的状态的DNA修复酶的水溶液施加到具有排阻极限的分子筛柱上，该分子筛柱将延迟DNA修复酶，但不会延迟大于DNA修复的污染物 酶。 增强纯度的DNA修复酶在洗脱缓冲液中从分子筛柱中洗脱等离子体洗脱，并直接施用于相同缓冲液中的DNA亲和柱，无需中间透析，超滤或其他方法。 使用例如盐梯度从DNA亲和柱洗脱DNA修复酶。 该方法快速，便宜，操作简单，并且已被发现产生均匀的最终产物。 根据本发明的其它方面，将纯化的DNA修复酶包封在脂质体中，并在原位施用于活细胞。 已经发现这种给药形式对细胞无毒，并且在暴露于紫外线之后导致损伤的DNA的切口增加，DNA修复合成增加，以及增加的细胞存活。