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1.发明申请Method And Compositions For Improving Selective Catabolysis in Cells Of Keratin Surfaces 审中-公开用于改善角蛋白表面细胞中选择性分解的方法和组合物公开(公告)号：US20150071895A1
公开(公告)日：2015-03-12
申请号：US14019598
申请日：2013-09-06
申请人： Nadine A. Pernodet , Kelly Dong , Edward Pelle , Daniel B. Yarosh
发明人： Nadine A. Pernodet , Kelly Dong , Edward Pelle , Daniel B. Yarosh
摘要： A skin care composition for stimulating selective catabolysis in cells of keratin surfaces comprising at least one autophagy activator and at least one proteasome activator, and a method for improving selective catabolysis in cells of keratin surfaces by treating with the composition.
摘要翻译： 用于刺激包含至少一种自噬激活剂和至少一种蛋白酶体活化剂的角蛋白表面细胞中选择性分解的皮肤护理组合物，以及通过用所述组合物处理改善角蛋白表面细胞中选择性分解的方法。
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公开(公告)号：US08962571B2
公开(公告)日：2015-02-24
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
IPC分类号： A61K38/06
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US20120219537A1
公开(公告)日：2012-08-30
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US20110268688A1
公开(公告)日：2011-11-03
申请号：US12993549
申请日：2009-06-17
CPC分类号： A61K9/0014 , A61K8/347 , A61K8/361 , A61K8/375 , A61K8/498 , A61K8/55 , A61K8/894 , A61K47/14 , A61K47/24 , A61Q19/06
摘要： A topical composition comprising at least one adipogenesis inhibitor and at least one adipocyte lipolytic agent and, optionally, at least one skin tightening agent; a method for improving the appearance of facial or body skin, treating the appearance of cellulite, or treating the face or body to improve the appearance of skin and uneven skin surfaces.
摘要翻译： 一种局部组合物，其包含至少一种脂肪形成抑制剂和至少一种脂肪细胞脂肪分解剂和任选的至少一种皮肤紧固剂; 改善面部或身体皮肤外观，治疗脂肪团的外观，或治疗面部或身体以改善皮肤外观和不均匀皮肤表面的方法。
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5.发明申请Topical Preparations Comprising Grape Seed, Folic Acid, Biotin, Bifidobacterium longum and Echinacea purpurea 审中-公开葡萄籽，叶酸，生物素，长双歧杆菌和紫锥菊的局部制剂公开(公告)号：US20150098934A1
公开(公告)日：2015-04-09
申请号：US14045487
申请日：2013-10-03
CPC分类号： A61K8/97 , A61K8/345 , A61K8/44 , A61K8/4953 , A61K8/606 , A61K8/67 , A61K8/673 , A61K8/73 , A61K8/99 , A61Q19/00
摘要： Topical compositions comprising grape seed and at least three of folic acid, biotin, Bifidobacterium longum extract and Echinacea purpurea.
摘要翻译： 包含葡萄籽和至少三种叶酸，生物素，长双歧杆菌提取物和紫锥菊的局部组合物。
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6.发明授权Skin repair compositions comprising circadian gene activators and a synergistic combination of Sirt1 gene activators 有权皮肤修复组合物包含昼夜节律基因激活剂和Sirt1基因激活剂的协同组合公开(公告)号：US08703161B2
公开(公告)日：2014-04-22
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US08193155B2
公开(公告)日：2012-06-05
申请号：US12367705
申请日：2009-02-09
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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8.发明申请Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators 有权皮肤修复组合包含昼夜节律基因激活剂和Sirt1基因激活子的协同组合公开(公告)号：US20100028317A1
公开(公告)日：2010-02-04
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US20090220481A1
公开(公告)日：2009-09-03
申请号：US12367705
申请日：2009-02-09
申请人： DANIEL H. MAES , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： DANIEL H. MAES , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
IPC分类号： A61K38/43
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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公开(公告)号：US20050244359A1
公开(公告)日：2005-11-03
申请号：US11116515
申请日：2005-04-28
申请人： Edward Pelle , Thomas Mammone
发明人： Edward Pelle , Thomas Mammone
IPC分类号： A61K6/00 , A61K8/36 , A61K8/92 , A61K31/20 , A61Q17/00 , A61Q19/00 , C12P7/64 , A61K7/075 , A61K7/06 , A61K7/08
摘要： The present invention relates to methods of topically applying compositions useful in enhancing triglyceride concentration in the lipid barrier of the skin comprising an effective amount of palmitoleic acid, or derivatives thereof, as the sole fatty acid component in combination with a pharmaceutically or cosmetically acceptable carrier. Such compositions are useful in the treatment or prevention of dry skin and conditions in which the skin's lipid barrier is defective or damaged.
摘要翻译： 本发明涉及局部施用用于增强皮肤脂质屏障中的甘油三酯浓度的组合物的方法，其包含有效量的棕榈油酸或其衍生物作为唯一的脂肪酸组分与药学上或化学上可接受的载体的组合。 这样的组合物可用于治疗或预防皮肤的皮肤脂质屏障有缺陷或损伤的条件。
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